Scandinavian Cardiovascular Journal最新文献_第10页

ICD harm and benefit: risk scores applied to the Swedish ICD-treated LQTS population ICD的危害和益处：应用于瑞典ICD治疗的LQTS人群的风险评分

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-12-01 DOI: 10.1080/14017431.2022.2060524

Emilia Sundström, S. Jensen, Ulla-Britt Diamant, U. Wiklund, A. Rydberg

{"title":"ICD harm and benefit: risk scores applied to the Swedish ICD-treated LQTS population","authors":"Emilia Sundström, S. Jensen, Ulla-Britt Diamant, U. Wiklund, A. Rydberg","doi":"10.1080/14017431.2022.2060524","DOIUrl":"https://doi.org/10.1080/14017431.2022.2060524","url":null,"abstract":"Abstract Objectives. The use of implantable cardioverter defibrillators (ICDs) in long QT syndrome (LQTS) patients is essential in high-risk patients. However, it is sometimes used in patients without high-risk profiles for whom the expected benefit may be lower than the risk of ICD harm. Here, we evaluated ICD benefit and harm by assessing risk according to risk scores and pre-ICD clinical characteristics. Design. We studied 109 Swedish LQTS patients drawn from the Swedish ICD and Pacemaker Registry with data collected from medical records. In addition to clinical characteristics, we used two risk scores to assess pre-ICD risk, and evaluated ICD benefit and harm. Results. Twenty percent of all patients received ≥1 appropriate shock with a first appropriate shock incidence rate of 4.3 per 100 person-years. A long QTc (≥550 ms) and double mutations were significantly associated with appropriate shock. Low risk scores among patients without pre-ICD aborted cardiac arrest were not significantly associated with low risk of first appropriate shock. The incidence rates of a first inappropriate shock and first complication were 3.0 and 7.6 per 100 person-years, respectively. Conclusion. Our findings on ICD harm emphasize the importance of careful individual pre-ICD consideration. When we applied two risk scores to patients without pre-ICD aborted cardiac arrest, we could not validate their ability to identify patients with low risk of appropriate shocks and patients who were assessed as having a low risk still received appropriate shocks. This further supports the complexity of risk stratification and the difficulty of using risk scores.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"48 - 55"},"PeriodicalIF":2.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48359481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between periprocedural myocardial injury and long-term all-cause mortality in patients undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis. 经导管主动脉瓣置换术患者围手术期心肌损伤与长期全因死亡率之间的关系：一项系统回顾和荟萃分析

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-12-01 DOI: 10.1080/14017431.2022.2139412

Wentao Chen, Yilong Han, Chunlin Wang, Wenqiang Chen

{"title":"Association between periprocedural myocardial injury and long-term all-cause mortality in patients undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis.","authors":"Wentao Chen, Yilong Han, Chunlin Wang, Wenqiang Chen","doi":"10.1080/14017431.2022.2139412","DOIUrl":"10.1080/14017431.2022.2139412","url":null,"abstract":"Objective. The purpose of this meta-analysis was to investigate the effect of periprocedural myocardial injury (PPMI) on long-term all-cause mortality in patients undergoing transcatheter aortic valve replacement (TAVR) and to explore potential factors associated with mortality risk. Design. The PubMed, Embase, and Cochrane Library databases were searched up to April 2022. Studies reporting the effect of PPMI on the risk of long-term all-cause mortality were included. The summary odds ratio (OR) was calculated using a random effects model. Additionally, meta-regression and subgroup analyses were conducted according to specific research characteristics to explore sources of heterogeneity. Results. Fourteen studies involving 6,415 patients who underwent TAVR showed that the occurrence of PPMI was associated with a higher risk of long-term mortality. Subgroup analysis showed that in the group of aged ≥82 years, men accounted for less than 50%, coronary artery disease patients accounted for more than 50%, and the proportion of patients with chronic kidney disease accounted for more than 60%, the proportion of patients with atria fibrillation accounted for less than 30%, and the Society of Thoracic Surgeons predicted risk of mortality score was >8 points, patients with PPMI had higher long-term all-cause mortality than those without PPMI. Conclusions. Among the patients who underwent TAVR, those who developed PPMI had higher long-term all-cause mortality.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"387-393"},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity 非吸烟者血管痉挛性心绞痛患者血浆谷氨酸升高与血浆胱氨酸和抗氧化能力有关

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-13 DOI: 10.1080/14017431.2022.2085884

Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Shintaro Takano, W. Fujita, M. Kitayama, H. Nakanishi, Kazuyuki Saito, Yasuyuki Kawai, K. Kajinami

{"title":"Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity","authors":"Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Shintaro Takano, W. Fujita, M. Kitayama, H. Nakanishi, Kazuyuki Saito, Yasuyuki Kawai, K. Kajinami","doi":"10.1080/14017431.2022.2085884","DOIUrl":"https://doi.org/10.1080/14017431.2022.2085884","url":null,"abstract":"Abstract Objectives. Endothelial dysfunction caused by oxidative stress plays an important role in the development of vasospastic angina pectoris (VSAP). Glutamate causes endothelial dysfunction by generating oxidative stress, and it inhibits cystine import into endothelial cells via the cystine/glutamate antiporter (XC –), which leads to depletion of antioxidant glutathione. However, whether glutamate and cystine are implicated in the pathogenesis of VSAP remains unclear. We investigated plasma glutamate and cystine levels, oxidative stress markers and antioxidant capacity in non-smoker patients with VSAP to determine whether glutamate and cystine are associated with the development of VSAP. We assessed 49 non-smokers assigned to groups with (n = 27) and without (n = 22) VSAP, and also measured plasma glutamate, cystine, nitrotyrosine, reactive oxygen metabolites and biological antioxidant potential. Results. Plasma glutamate and cystine values were significantly higher in the group with, than without VSAP (59.8 ± 25.7 vs. 43.5 ± 18.7 µmol/L, p = .016 and 35.3 ± 14.2 vs. 25.2 ± 9.1 µmol/L, p = .0056, respectively). Plasma glutamate and cystine values were significantly and positively associated (r = 0.32, p = .027). Levels of the oxidative stress markers nitrotyrosine and reactive oxygen metabolites, and biological antioxidant potential of as a measure of antioxidant capacity, did not significantly differ between the two groups. However, glutamate and biological antioxidant potential values were significantly and negatively associated (r = −0.3, p = .036). Conclusion. Plasma glutamate levels were increased in patients with VSAP who did not smoke, and they were positively associated with plasma cystine and negatively associated with the biological antioxidant potential levels.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"180 - 186"},"PeriodicalIF":2.2,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42900339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quality of life following renal sympathetic denervation in treatment-resistant hypertensive patients: a two-year follow-up study 肾交感神经去神经支配治疗难治性高血压患者的生活质量：一项为期两年的随访研究

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-10 DOI: 10.1080/14017431.2022.2084562

T. A. Hanssen, Anna Subbotina, A. Miroslawska, M. Solbu, T. Steigen

{"title":"Quality of life following renal sympathetic denervation in treatment-resistant hypertensive patients: a two-year follow-up study","authors":"T. A. Hanssen, Anna Subbotina, A. Miroslawska, M. Solbu, T. Steigen","doi":"10.1080/14017431.2022.2084562","DOIUrl":"https://doi.org/10.1080/14017431.2022.2084562","url":null,"abstract":"Abstract Objective. Hypertension is a significant health burden. In the last 10 years, renal sympathetic denervation has been tested as a potential treatment option for a select group of patients with treatment-resistant hypertension. The aim of this study was to broadly assess the quality of life in patients undergoing renal sympathetic denervation with two years’ follow-up. Materials and methods. Patients with treatment-resistant hypertension being treated by hypertension specialists were eligible for inclusion in this study. Bilateral renal sympathetic denervation was performed with the Symplicity Catheter System. Quality of life was measured using standardised questionnaires (Short Form 36, 15 D and a single-item question) and an open question before denervation, after six months and after two years. Results. A total of 23 patients were included. The typical participant was male, 53 years, had a mean office blood pressure of 162/108 mmHg, body mass index of 32 kg/m2, and was prescribed 4.8 blood pressure lowering drug classes. At baseline, both physical and mental aspects of quality of life were affected negatively by the treatment-resistant hypertension. Over time, there were modest improvements in quality of life. The largest improvements were seen at six months. Simultaneously, the mean number of blood pressure lowering drug classes was reduced to 4.2. Conclusion. Following renal sympathetic denervation treatment, some aspects of health related quality of life showed an improved trend during follow-up. The observed improvement may reflect the impact of a reduced number of blood pressure lowering drug classes. Clinical Trial Number registered: NCT01630928","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"174 - 179"},"PeriodicalIF":2.2,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43161960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients 新冠肺炎死亡患者心脏无组织性心肌炎的形态学变化

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-09 DOI: 10.1080/14017431.2022.2085320

Ali Razaghi, A. Szakos, Riham Al-Shakarji, Mikael Björnstedt, Laszlo Szekely

{"title":"Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients","authors":"Ali Razaghi, A. Szakos, Riham Al-Shakarji, Mikael Björnstedt, Laszlo Szekely","doi":"10.1080/14017431.2022.2085320","DOIUrl":"https://doi.org/10.1080/14017431.2022.2085320","url":null,"abstract":"Abstract Objective. Patients with underlying heart diseases have a higher risk of dying from Covid-19. It has also been suggested that Covid-19 affects the heart through myocarditis. Despite the rapidly growing research on the management of Covid-19 associated complications, most of the ongoing research is focused on the respiratory complications of Covid-19, and little is known about the prevalence of myocarditis. Design. This study aimed to characterize myocardial involvement by using a panel of antibodies to detect hypoxic and inflammatory changes and the presence of SARS-CoV-2 proteins in heart tissues obtained during the autopsy procedure of Covid-19 deceased patients. Thirty-seven fatal COVID-19 cases and 21 controls were included in this study. Results. Overall, the Covid-19 hearts had several histopathological changes like the waviness of myocytes, fibrosis, contract band necrosis, infiltration of polymorphonuclear neutrophils, vacuolization, and necrosis of myocytes. In addition, endothelial damage and activation were detected in heart tissue. However, viral replication was not detected using RNA in situ hybridization. Also, lymphocyte infiltration, as a hallmark of myocarditis, was not seen in this study. Conclusion. No histological sign of myocarditis was detected in any of our cases; our findings are thus most congruent with the hypothesis of the presence of a circulating endothelium activating factor such as VEGF, originating outside of the heart, probably from the hypoxic part of the Covid-19 lungs.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"166 - 173"},"PeriodicalIF":2.2,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44718182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The risk factors for radial artery and saphenous vein graft occlusion are different 桡动脉和隐静脉移植物闭塞的危险因素不同

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-02 DOI: 10.1080/14017431.2022.2079716

Ramez Bahar, S. E. Hermansen, Øystein Dahl-Eriksen, R. Busund, P. Dahl, A. Iqbal, J. Mannsverk, T. Myrmel, T. Steigen, T. Trovik, D. Sørlie, K. Bartnes

{"title":"The risk factors for radial artery and saphenous vein graft occlusion are different","authors":"Ramez Bahar, S. E. Hermansen, Øystein Dahl-Eriksen, R. Busund, P. Dahl, A. Iqbal, J. Mannsverk, T. Myrmel, T. Steigen, T. Trovik, D. Sørlie, K. Bartnes","doi":"10.1080/14017431.2022.2079716","DOIUrl":"https://doi.org/10.1080/14017431.2022.2079716","url":null,"abstract":"Abstract Objectives. To determine risk factors for radial artery and saphenous vein graft occlusion during long-term follow-up after coronary artery bypass grafting (CABG). Methods: From a cohort of 119 patients who had received a radial artery graft, 76 – of whom 55 also had at least one saphenous vein graft – underwent a preplanned direct angiography and anthropometric, biochemical, and endothelial function assessment 7.6–12.1 (mean 8.9) years after CABG. Comorbidity, medication, and smoking habits were also recorded. The association between these parameters and conduit longevity was analyzed in univariable and multivariable logistic regression models. Results: Radial artery graft occlusions were associated with higher plasma levels of high-sensitive C-reactive protein and patency was best among patients with pharmacologically treated hypertension. The sole independent risk factor identified for saphenous vein graft occlusion was tobacco smoking 8–12 years postoperatively. Conclusion: Our data support the contention that the pathogenesis of radial artery graft failure is distinct from vein graft disease and is related to hypertension status and systemic inflammation. These risk factors are potential targets for preventive measures. Accordingly, the study supports the eventual design of personalized secondary prevention regimens. Clinical registration number: ISRCTN23118170","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"127 - 131"},"PeriodicalIF":2.2,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43148528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of mechanical versus biological valve prosthesis in native mitral valve infective endocarditis 机械瓣膜置换术与生物瓣膜置换术治疗先天性二尖瓣感染性心内膜炎的远期疗效比较

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-02 DOI: 10.1080/14017431.2022.2079712

Markus Malmberg, V. Anttila, P. Rautava, J. Gunn, V. Kytö

{"title":"Long-term outcomes of mechanical versus biological valve prosthesis in native mitral valve infective endocarditis","authors":"Markus Malmberg, V. Anttila, P. Rautava, J. Gunn, V. Kytö","doi":"10.1080/14017431.2022.2079712","DOIUrl":"https://doi.org/10.1080/14017431.2022.2079712","url":null,"abstract":"Abstract Objectives. To study the long-term outcomes of mitral valve replacement with mechanical or biological valve prostheses in native mitral valve infective endocarditis patients. Desing. We conducted a retrospective, nationwide, multicenter cohort study with patients aged ≤70 years who were treated with mitral valve replacement for native mitral valve infective endocarditis in Finland between 2004 and 2017. Results. The endpoints were all-cause mortality, ischemic stroke, major bleeding, and mitral valve reoperations. The results were adjusted for baseline features (age, gender, comorbidities, history of drug abuse, concomitant surgeries, operational urgency, and surgical center). The median follow-up time was 6.1 years. The 12-year cumulative mortality rates were 36% for mechanical prostheses and 74% for biological prostheses (adj. HR 0.40; CI: 0.17–0.91; p = 0.03). At follow-up, the ischemic stroke had occurred in 19% of patients with mechanical prosthesis and 33% of those with a biological prosthesis (adj. p = 0.52). The major bleeding rates within the 12-year follow-up period were 30% for mechanical prosthesis and 13% for a biological prosthesis (adj. p = 0.29). The mitral valve reoperation rates were 13% for mechanical prosthesis and 12% for a biological prosthesis (adj. p = 0.50). Drug abuse history did not have a significant modifying impact on the results (interaction p = 0.51 for mortality and ≥0.13 for secondary outcomes). Conclusion. The use of mechanical mitral valve prosthesis is associated with lower long-term mortality compared to the biological prosthesis in non-elder native mitral valve infective endocarditis patients. The routine choice of biological mitral valve prostheses for this patient group is not supported by the results.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"132 - 137"},"PeriodicalIF":2.2,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45444299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Improved health-related quality of life in patients 6 and 12 months after surgical aortic valve replacement 主动脉瓣置换术后6个月和12个月患者健康相关生活质量的改善

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-02 DOI: 10.1080/14017431.2022.2079715

Riikka Henttunen, M. Kohonen, J. Laurikka

{"title":"Improved health-related quality of life in patients 6 and 12 months after surgical aortic valve replacement","authors":"Riikka Henttunen, M. Kohonen, J. Laurikka","doi":"10.1080/14017431.2022.2079715","DOIUrl":"https://doi.org/10.1080/14017431.2022.2079715","url":null,"abstract":"Abstract Objectives. Quality of life (QoL) is possibly the most important variable for the patient when subjective results of heart procedures are evaluated. The purpose of this study was to analyze the change in the quality of life 1 year after surgical aortic valve replacement (SAVR). Design. A Finnish single-center prospective cohort intervention study was performed from 2013 to 2018. QoL was assessed with the EQ-5D-3L VAS questionnaire before surgery and 6 and 12 months after surgery. We used univariate analysis to assess the change in the number of people experiencing problems and logistic regression analysis to assess the patients’ characteristics on the change in QoL. Results. At one year follow-up, patients’ quality of life improved in all EQ-5D dimensions. The greatest decreases in patients experiencing problems 12 months after surgery occurred in the dimension “mobility” (–24.1% change in reporting problems, p < .01), “self-care” (–32.9%, p < .01), and “pain or discomfort” (–25.7%, p < .01). Before surgery mean of EQ visual analogue scale (VAS, from 0 to 100) was 63.0 (SD 17.7, n = 604), and 12 months after surgery 81.2 (SD 13.8, n = 367, p < .001). In multivariable analysis, preoperative obesity was associated with better quality of life (OR 3.39, 95% CI 1.007–11.439) in “daily activities” and patients’ higher operative risk was associated with better “self-care” after surgery. Conclusions. SAVR can improve the 1-year quality of life in all dimensions of EQ–5D and self-rated overall health (VAS).","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"121 - 126"},"PeriodicalIF":2.2,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49015118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study 在一般人群中，尿类骨质疏松与舒张功能障碍和颈动脉病变有关。Tromsø研究的横截面数据

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-06-02 DOI: 10.1080/14017431.2022.2079714

R. M. Andreassen, J. Kronborg, H. Schirmer, E. Mathiesen, T. Melsom, B. Eriksen, T. Jenssen, M. Solbu

{"title":"Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study","authors":"R. M. Andreassen, J. Kronborg, H. Schirmer, E. Mathiesen, T. Melsom, B. Eriksen, T. Jenssen, M. Solbu","doi":"10.1080/14017431.2022.2079714","DOIUrl":"https://doi.org/10.1080/14017431.2022.2079714","url":null,"abstract":"Abstract Objectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and subclinical CVD. Design. From the Tromsø Study (2007/2008), we included all men and women who had measurements of urinary orosomucoid (n = 7181). Among these, 6963 were examined with ultrasound of the right carotid artery and 2245 with echocardiography. We assessed the associations between urinary markers and subclinical CVD measured as intima media thickness of the carotid artery, presence and area of carotid plaque and diastolic dysfunction (DD). UOCR and UACR were dichotomized as upper quartile versus the three lowest. Results. High UOCR, adjusted for UACR, age, cardiovascular risk factors and kidney function, was associated with presence of DD in men (OR: 3.18, 95% CI [1.27, 7.95], p = .013), and presence of plaque (OR: 1.20, 95% CI [1.01, 1.44], p = .038) and intima media thickness in women (OR: 1.34, 95% CI [1.09, 1.65], p = .005). Analyses showed no significant interaction between sex and UOCR for any endpoints. UACR was not significantly associated with DD, but the associations with intima media thickness and plaque were of magnitudes comparable to those observed for UOCR. Conclusions. UOCR was positively associated with subclinical CVD. We need prospective studies to confirm whether UOCR is a clinically useful biomarker and to study possible sex differences.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"148 - 156"},"PeriodicalIF":2.2,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49240189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Long-term survival of Icelandic women following acute myocardial infarction 冰岛妇女急性心肌梗死后的长期生存率

IF 2.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2022-05-31 DOI: 10.1080/14017431.2022.2075561

H. Gardarsdottir, M. Sigurdsson, K. Andersen, I. Gudmundsdottir

{"title":"Long-term survival of Icelandic women following acute myocardial infarction","authors":"H. Gardarsdottir, M. Sigurdsson, K. Andersen, I. Gudmundsdottir","doi":"10.1080/14017431.2022.2075561","DOIUrl":"https://doi.org/10.1080/14017431.2022.2075561","url":null,"abstract":"Abstract Objective. To evaluate the impact of sex on treatment and survival after acute myocardial infarction (AMI) in Iceland. Methods. A retrospective, nationwide cohort study of patients with STEMI (2008–2018) and NSTEMI (2013–2018) and obstructive coronary artery disease. Patient and procedural information were obtained from a registry and electronic health records. Survival was estimated with Kaplan–Meier method and Cox regression analysis used to identify risk factors for long-term mortality. Excess mortality from the AMI episode was estimated by comparing the survival with age- and sex-matched population in Iceland at 30-day interval. Results. A total of 1345 STEMI-patients (24% women) and 1249 NSTEMI-patients (24% women) were evaluated. Women with STEMI (mean age: 71 ± 11 vs. 67 ± 12) and NSTEMI (mean age: 69 ± 13 vs. 62 ± 12) were older and less likely to have previous cardiovascular disease. There was neither sex difference in the extent of coronary artery disease nor treatment. Although crude one-year post-STEMI survival was lower for women (88.7% vs. 93.4%, p = .006), female sex was not an independent risk factor after adjusting for age and co-morbidities after STEMI and was protective for NSTEMI (HR 0.67, 95% CI: 0.46–0.97). There was excess 30-day mortality in both STEMI and NSTEMI for women compared with sex-, age- and inclusion year-matched Icelandic population, but thereafter the mortality rate was similar. Conclusion. Women and men with AMI in Iceland receive comparable treatment including revascularization and long-term survival appears similar. Prognosis after NSTEMI is better in women, whereas higher early mortality after STEMI may be caused by delays in presentation and diagnosis.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"114 - 120"},"PeriodicalIF":2.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46007329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1