Scandinavian Cardiovascular Journal最新文献

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Renal denervation in patients who do not respond to cardiac resynchronization therapy 对心脏再同步治疗无反应患者的肾去神经支配
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-19 DOI: 10.1080/14017431.2022.2060526
Päivi Pietilä-Effati, Mathias Höglund, A. Käräjämäki, Filip Höglund, Anne-Maria Nabb, Eija Matila, M. Koistinen
{"title":"Renal denervation in patients who do not respond to cardiac resynchronization therapy","authors":"Päivi Pietilä-Effati, Mathias Höglund, A. Käräjämäki, Filip Höglund, Anne-Maria Nabb, Eija Matila, M. Koistinen","doi":"10.1080/14017431.2022.2060526","DOIUrl":"https://doi.org/10.1080/14017431.2022.2060526","url":null,"abstract":"Abstract Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorates the hemodynamic state. We tested the hypothesis that controlling sympathetic overactivity by renal denervation (RDN) could be beneficial in nonresponders for CRT. In our HeartF-RDN study (ClinalTrials.gov. NCT02638324), RDN could not reverse the progression of HF in subjects with New York Heart Association Classification (NYHA) III-IV stage symptoms.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"103 - 106"},"PeriodicalIF":2.2,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46553539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Brain structure and stroke risk score in subjects without a history of atrial fibrillation 无房颤病史受试者的脑结构和卒中风险评分
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-13 DOI: 10.1080/14017431.2022.2074094
M. Wykrętowicz, Łukasz Gąsiorowski, Anna Kłusek-Zielińska, K. Katulska
{"title":"Brain structure and stroke risk score in subjects without a history of atrial fibrillation","authors":"M. Wykrętowicz, Łukasz Gąsiorowski, Anna Kłusek-Zielińska, K. Katulska","doi":"10.1080/14017431.2022.2074094","DOIUrl":"https://doi.org/10.1080/14017431.2022.2074094","url":null,"abstract":"Abstract CHA2DS2-VASc score system aids in clinical decision-making in subjects with atrial fibrillation (AF). Little is known on the association between CHA2DS2-VASc scores and brain structure in patients without cardiac arrhythmia. Detailed brain architecture analysis was performed. Assessment of bivariate correlation between the volume of segmented brain structures and Z-scores of CHA2DS2-VASc showed that higher risk scores correlated negatively and significantly with various brain framework. Our study confirms that a cluster of risk factors incorporated in a well-established risk score correlated with brain tissue volume independently of the presence of an arrhythmia.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"100 - 102"},"PeriodicalIF":2.2,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42621884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid type II and frozen elephant trunk in acute Stanford type A aortic dissections II型和冷冻象鼻在急性斯坦福A型主动脉夹层中的应用
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-12 DOI: 10.1080/14017431.2022.2074095
J. Sule, C. Chua, Caven Teo, A. Choong, F. Sazzad, T. Kofidis, V. Sorokin
{"title":"Hybrid type II and frozen elephant trunk in acute Stanford type A aortic dissections","authors":"J. Sule, C. Chua, Caven Teo, A. Choong, F. Sazzad, T. Kofidis, V. Sorokin","doi":"10.1080/14017431.2022.2074095","DOIUrl":"https://doi.org/10.1080/14017431.2022.2074095","url":null,"abstract":"Abstract Objectives. Composite frozen elephant trunk is an increasingly popular solution for complex aortic pathologies. This review aims to compare outcomes of zone 0 type II hybrid (hybrid II) with the composite frozen elephant trunk (FET) technique in managing acute Stanford type A aortic dissections. Methods. PubMed and Embase were systematically searched using PRISMA protocol. 11 relevant studies describing the outcomes of hybrid II arch repair and FET techniques in patients with type A aortic dissection were included in the meta-analysis. The study focused on early post-operative 30-day outcomes analysing mortality, stroke, spinal cord injury, renal impairment requiring dialysis, bleeding and lung infection. Results. 1305 patients were included in the analysis – 343 receiving hybrid II repair and 962 treated with the FET. Meta-analysis of proportions showed Hybrid II was associated with less early mortality [5.0 (CI 3.1–7.8) vs 8.1 (CI 6.5–10.0) %], stroke [2.3 (CI 1.1–4.6) vs 7.0 (CI 5.5–8.8) %], spinal cord injury [2.0 (CI 0.9–4.3) vs 3.8 (CI 2.8–5.3) %], renal impairment requiring dialysis [7.9 (CI 5.5–11.2) vs 11.8 (CI 9.8–14.0) %], reoperation for bleeding [3.9 (CI 1.8–8.4) vs 10.6 (CI 8.1–13.8) %] and lung infection [14.8 (CI 10.8–20.0) vs 20.7 (CI 16.9–25.1) %]. Conclusion. Hybrid II should be considered in favour of FET technique in acute Stanford type A dissection patients who are at higher risk due to age and comorbidities.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"91 - 99"},"PeriodicalIF":2.2,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44648568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients 院外心脏骤停昏迷复苏患者的炎症标志物与生存之间的关系
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-12 DOI: 10.1080/14017431.2022.2074093
Anne Toftgaard Pedersen, J. Kjaergaard, C. Hassager, M. Frydland, J. Hartvig Thomsen, Anika Klein, H. Schmidt, J. Møller, S. Wiberg
{"title":"Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients","authors":"Anne Toftgaard Pedersen, J. Kjaergaard, C. Hassager, M. Frydland, J. Hartvig Thomsen, Anika Klein, H. Schmidt, J. Møller, S. Wiberg","doi":"10.1080/14017431.2022.2074093","DOIUrl":"https://doi.org/10.1080/14017431.2022.2074093","url":null,"abstract":"Abstract Objectives Prognostication after out-of-hospital cardiac arrest (OHCA) remains challenging. The inflammatory response after OHCA has been associated with increased mortality. This study investigates the associations and predictive value between inflammatory markers and outcome in resuscitated OHCA patients. Design The study is based on post hoc analyses of a double-blind controlled trial, where resuscitated OHCA patients were randomized to receive either exenatide or placebo. Blood was analyzed for levels of inflammatory markers the day following admission. Primary endpoint was time to death for up to 180 days. Secondary endpoints included 180-day mortality and poor neurological outcome after 180 days, defined as a cerebral performance category (CPC) of 3 to 5. Results Among 110 included patients we found significant associations between higher leucocyte quartile and increasing mortality in univariable analysis (OR 2.6 (95%CI 1.6–4.2), p < .001), as well as in multivariable analysis (OR 2.1 (95%CI 1.1–4.0), p = .02). A significant association was found between higher neutrophil quartile and increasing mortality in univariable analysis (OR 3.0 (95%CI 1.8–5.0), p < .001) as well as multivariable analysis (OR 2.4 (95%CI 1.2–4.6), p = .01). Leucocyte and neutrophil levels were predictive of poor outcome after 180 days with area under the receiver operating characteristics curves of 0.79 and 0.81, respectively. We found no associations between CRP and lymphocyte levels versus outcome. Conclusions Total leucocyte count and neutrophil levels measured the first day following OHCA were significantly associated with 180-day all-cause mortality and may potentially act as early predictors of outcome. Clinical trial registration www.clinicaltrials.gov, unique identifier: NCT02442791","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"85 - 90"},"PeriodicalIF":2.2,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42966246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Less invasive aortic valve replacement using the trifecta bioprosthesis 使用三瓣生物假体的微创主动脉瓣置换术
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-10 DOI: 10.1080/14017431.2022.2071460
A. Agnino, Ascanio Graniero, P. Gerometta, L. Giroletti, G. Albano, C. Roscitano, A. Anselmi
{"title":"Less invasive aortic valve replacement using the trifecta bioprosthesis","authors":"A. Agnino, Ascanio Graniero, P. Gerometta, L. Giroletti, G. Albano, C. Roscitano, A. Anselmi","doi":"10.1080/14017431.2022.2071460","DOIUrl":"https://doi.org/10.1080/14017431.2022.2071460","url":null,"abstract":"Abstract Objectives. The safety and effectiveness of the Trifecta GT bioprosthesis (introduced in 2016) in less invasive aortic valve replacement are scarcely investigated. Our aim was to evaluate the immediate and initial follow-up results of this device in the context of less invasive surgery. We discuss patient-specific strategies for the selection of the surgical approach. Methods. A retrospective review of 133 patients undergoing AVR with the Trifecta GT through three less invasive accesses (UMS, Upper ministernotomy; RMS, Reversed ministernotomy; RAMT, Right anterior minithoracotomy) was performed. In-hospital, follow-up and hemodynamic performance (PPM, Patient-prosthesis mismatch) data were collected. Results. Among patients, 79% received UMS, 11% RMS and 10% RAMT. Selection of approach was based on preoperative anatomical analysis (CT-scan) and planned concomitant procedures. There was no operative mortality, no valve-related adverse events. There were 36 concomitant procedures. No significant intergroup differences occurred in cardiopulmonary bypass, aortic clamp, mechanical ventilation time, ICU stay and average bleeding. There were two cases of moderate PPM (1.5%) and no instances of severe PPM; there were no significant (≥2/4) perivalvular leaks. Average mean gradient at discharge was 8 ± 3 mmHg. At follow-up (average: 2.5 ± 0.9 years, 100% complete, 315 patient years) there was no mortality and no valve-related adverse event. Hemodynamic performance was maintained at follow-up. Conclusions. The optimal device for less invasive AVR needs to be individualized, as well as the selection of the surgical approach. The use of the Trifecta GT bioprosthesis appears to be reproductible whatever less invasive approach is employed, with confirmed excellent hemodynamic performance.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"79 - 84"},"PeriodicalIF":2.2,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48877140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Validation of an automated measurement method for determination of the ankle-brachial index 踝臂指数自动测量方法的验证
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-05-02 DOI: 10.1080/14017431.2022.2069855
Fatima Zebari, Vishal Amlani, M. Langenskiöld, J. Nordanstig
{"title":"Validation of an automated measurement method for determination of the ankle-brachial index","authors":"Fatima Zebari, Vishal Amlani, M. Langenskiöld, J. Nordanstig","doi":"10.1080/14017431.2022.2069855","DOIUrl":"https://doi.org/10.1080/14017431.2022.2069855","url":null,"abstract":"Abstract Objective. Lower extremity atherosclerotic disease (LEAD) diagnosis is largely based on ankle-brachial index (ABI) recordings. Equipment that could automatically determine ABI may facilitate LEAD identification within a broad range of health services. We aimed to test the measurement properties of an automated oscillometric ABI measurement device (MESI ABPI MD®) as compared to manual reference ABI measurements in patients with and without LEAD. Design. A total of 153 patients with and without LEAD visiting a vascular surgery clinic underwent manual and automated ABI measurements. In total, 306 limbs were investigated. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess the automated ABI device overall validity, with the manual method as reference. Correlation analysis (Spearman) was used to assess patterns of correlation between measurement methods while Bland–Altman plots were used to quantify measurement agreement. Results. Sensitivity and specificity for the automated ABI device were 75 and 67% whereas PPV and NPV were 72 and 71%, respectively. The correlation coefficient (automated versus manual measurements) was r = 0.552, p < .01. Bland-Altman plots revealed proportional bias and a tendency by the automated device to overestimate lower ABI values and underestimate higher ABI values. The best agreement between automated and manual ABI recordings was observed within the normal ABI range. Conclusions. The ABPI MD® device performance was unfavorable. The automated device tended to overestimate lower ABI values while underestimating higher values, which may lead to underdiagnosis of LEAD. Our data do not support the use of this automated ABI measurement device in clinical practice.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"73 - 78"},"PeriodicalIF":2.2,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49626235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of free arterial and saphenous vein grafting in outcomes after coronary bypass surgery 游离动脉和隐静脉移植在冠状动脉搭桥术后疗效的比较
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-04-08 DOI: 10.1080/14017431.2022.2060525
V. Abromaitiene, J. Greisen, H. Kimose, Zidryne Karaliunaite, C. Jakobsen
{"title":"Comparison of free arterial and saphenous vein grafting in outcomes after coronary bypass surgery","authors":"V. Abromaitiene, J. Greisen, H. Kimose, Zidryne Karaliunaite, C. Jakobsen","doi":"10.1080/14017431.2022.2060525","DOIUrl":"https://doi.org/10.1080/14017431.2022.2060525","url":null,"abstract":"Abstract Objectives. The goal of this study was to examine whether the use of free arterial grafts could reduce the need for repeated revascularization and all-cause mortality in patients undergoing coronary artery grafting. Design. The cohort study included 17,354 consecutive adults with isolated coronary artery grafting from 2000 to 2016 in three cardiac surgery centers. Data were obtained from the Western Denmark Heart Registry. Propensity matching with 24 factors was used to establish comparable groups of patients receiving either vein grafts (n = 1019) or free arterial grafts (n = 1019) for outcome analysis. Results. The need for repeated revascularization and all-cause mortality was similar in both graft groups at 10 years of follow-up. Creatine-Kinase MB Isoenzyme >100 μg/L increased the risk of repeated revascularization rate after 1, 5 and 10 years. Conclusions. Long-term outcomes in revascularization and survival are comparable after free arterial or saphenous vein grafting.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"42 - 47"},"PeriodicalIF":2.2,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42838839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Respiratory failure and bioelectrical phase angle are independent predictors for long-term survival in acute heart failure 呼吸衰竭和生物电相角是急性心力衰竭患者长期生存的独立预测因子
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-04-07 DOI: 10.1080/14017431.2022.2060527
P. Scicchitano, M. Ciccone, M. Iacoviello, P. Guida, M. De Palo, A. Potenza, M. Basile, P. Sasanelli, Francesco Trotta, M. Sanasi, P. Caldarola, F. Massari
{"title":"Respiratory failure and bioelectrical phase angle are independent predictors for long-term survival in acute heart failure","authors":"P. Scicchitano, M. Ciccone, M. Iacoviello, P. Guida, M. De Palo, A. Potenza, M. Basile, P. Sasanelli, Francesco Trotta, M. Sanasi, P. Caldarola, F. Massari","doi":"10.1080/14017431.2022.2060527","DOIUrl":"https://doi.org/10.1080/14017431.2022.2060527","url":null,"abstract":"Abstract Background. The assessment of long-term mortality in acute decompensated heart failure (ADHF) is challenging. Respiratory failure and congestion play a fundamental role in risk stratification of ADHF patients. The aim of this study was to investigate the impact of arterial blood gases (ABG) and congestion on long-term mortality in patients with ADHF. Methods and results. We enrolled 252 patients with ADHF. Brain natriuretic peptide (BNP), blood urea nitrogen (BUN), phase angle as assessed by means of bioimpedance vector analysis, and ABG analysis were collected at admission. The endpoint was all-cause mortality. At a median follow-up of 447 d (interquartile range [IQR]: 248–667), 72 patients died 1–840 d (median 106, IQR: 29–233) after discharge. Respiratory failure types I and II were observed in 78 (19%) and 53 (20%) patients, respectively. The ROC analyses revealed that the cut-off points for predicting death were: BNP > 441 pg/mL, BUN > 1.67 mmol/L, partial pressure in oxygen (PaO2) ≤69.7 mmHg, and phase angle ≤4.9°. Taken together, these four variables proved to be good predictors for long-term mortality in ADHF (area under the curve [AUC] 0.78, 95% CI 0.72–0.78), thus explaining 60% of all deaths. A multiparametric score based on these variables was determined: each single-unit increase promoted a 2.2-fold augmentation of the risk for death (hazard ratio [HR] 2.2, 95% CI 1.8–2.8, p< .0001). Conclusions. A multiparametric approach based on measurements of BNP, BUN, PaO2, and phase angle is a reliable approach for long-term prediction of mortality risk in patients with ADHF.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"28 - 34"},"PeriodicalIF":2.2,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48962719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Cost-effectiveness of screening for atrial fibrillation in a single primary care center at a 3-year follow-up 在单一初级保健中心进行3年随访的心房颤动筛查的成本效益
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-04-07 DOI: 10.1080/14017431.2022.2060523
F. Ghazal, M. Aronsson, F. Al-Khalili, M. Rosenqvist, L. Levin
{"title":"Cost-effectiveness of screening for atrial fibrillation in a single primary care center at a 3-year follow-up","authors":"F. Ghazal, M. Aronsson, F. Al-Khalili, M. Rosenqvist, L. Levin","doi":"10.1080/14017431.2022.2060523","DOIUrl":"https://doi.org/10.1080/14017431.2022.2060523","url":null,"abstract":"Abstract Objectives The aim of this study was to estimate the cost-effectiveness of intermittent electrocardiogram (ECG) screening for atrial fibrillation (AF) among 70–74-year old individuals in primary care. We also aimed to assess adherence to anticoagulants, severe bleeding, stroke and mortality among screening-detected AF cases at three-year follow-up. Methods A post hoc analysis based on a cross-sectional screening study for AF among 70–74-year old patients, who were registered at a single primary care center, was followed for three years for mortality. Data about adherence to anticoagulants, incidence of stroke and severe bleeding among screening-detected AF cases, were collected from patient’s records. Markov model and Monte Carlo simulation were used to assess the cost-effectiveness of the screening program. Results The mortality rate among screening-detected AF cases (n = 16) did not differ compared to the 274 individuals with no AF (hazard ratio 0.86, CI 0.12–6.44). Adherence to anticoagulants was 92%. There was no stroke or severe bleeding. The incremental cost-effectiveness ratio of screening versus no screening was EUR 2389/quality-adjusted life year (QALY) gained. The screening showed a 99% probability of being cost-effective compared to no screening at a willingness-to-pay threshold of EUR 20,000 per QALY. Conclusion Screening for AF among 70–74-year olds in primary care using intermittent ECG appears to be cost-effective at 3-year follow-up with high anticoagulants adherence and no increased mortality.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"35 - 41"},"PeriodicalIF":2.2,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47659302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Administration of intracoronary adenosine before stenting for the prevention of no-reflow in patients with ST-elevation myocardial infarction st段抬高型心肌梗死患者支架置入术前冠状动脉内腺苷的应用
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2022-03-07 DOI: 10.1080/14017431.2022.2035807
M. Sadeghian, Seyyed Hossein Mousavi, Zahra Aamaraee, A. Shafiee
{"title":"Administration of intracoronary adenosine before stenting for the prevention of no-reflow in patients with ST-elevation myocardial infarction","authors":"M. Sadeghian, Seyyed Hossein Mousavi, Zahra Aamaraee, A. Shafiee","doi":"10.1080/14017431.2022.2035807","DOIUrl":"https://doi.org/10.1080/14017431.2022.2035807","url":null,"abstract":"Abstract Objectives: No-reflow phenomenon during the primary percutaneous intervention (PCI) for ST-elevation myocardial infarction (STEMI) is accompanied by a poor clinical outcome and mortality. We aimed to determine the effect of intracoronary adenosine in preventing the no-reflow phenomenon, as detected by three different methods, in patients who underwent primary (PCI). Design. In this single-blinded randomized controlled trial, patients with acute STEMI who presented to our center and underwent primary PCI were randomized to the intervention group who received intracoronary adenosine before stenting or the control group who received the standard treatment. No-reflow phenomenon was detected using thrombolysis in myocardial infarction (TIMI) flow grade, TIMI frame count, and myocardial blush grade (MBG). The incidence of the no-reflow phenomenon was then compared between the intervention and control groups. Results. The adenosine group consisted of 110 patients (age = 57 ± 11 years; 92 (84%) male) while 118 patients were in the control group (age = 59 ± 12 years; 89 (75%) male). There was no difference between the study groups in baseline characteristics. The frequency of no-reflow phenomenon was lower in the adenosine group as assessed by TIMI flow grade (15 [14%] vs. 41 [35%]), MBG (23 [21%] vs. 63 [53%]) and TIMI frame count (16 [14%] vs. 50 [42%]) (p < .001 for all). This effect remained significant after adjustment for confounding variables. Conclusion. Intracoronary adenosine could effectively prevent the no-reflow phenomenon in STEMI patients who underwent primary PCI.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"56 1","pages":"23 - 27"},"PeriodicalIF":2.2,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47117135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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