Scandinavian Cardiovascular Journal最新文献

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Accuracy of subtraction fractional flow reserve with computed tomography in identifying early revascularization in patients with coronary artery disease. 计算机断层扫描减影分数血流储备在识别冠心病患者早期血管再通方面的准确性。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/14017431.2024.2373082
Tingting Zhu, Defu Li, Jinhan Qiao, Qian Li, Yinghao Xu, Bing Ge, Liming Xia
{"title":"Accuracy of subtraction fractional flow reserve with computed tomography in identifying early revascularization in patients with coronary artery disease.","authors":"Tingting Zhu, Defu Li, Jinhan Qiao, Qian Li, Yinghao Xu, Bing Ge, Liming Xia","doi":"10.1080/14017431.2024.2373082","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373082","url":null,"abstract":"<p><strong>Objectives: </strong>The diagnostic performance of fractional flow reserve with computed tomography (FFR-CT) is affected by the presence of calcified plaque. Subtraction can remove the influence of calcification in coronary computed tomography angiography (CCTA) to increase confidence in the diagnosis of coronary artery stenosis. Our purpose is to investigate the accuracy of post-subtraction FFR-CT in predicting early revascularization.</p><p><strong>Design: </strong>Based on CCTA data of 237 vessels from 79 patients with coronary artery disease, subtraction CCTA images were obtained at a local post-processing workstation, and the conventional and post-subtraction FFR-CT measurements and the difference in proximal and distal FFR-CT values of the narrowest segment of the vessel (ΔFFR-CT) were analyzed for their accuracy in predicting early coronary artery hemodynamic reconstruction.</p><p><strong>Results: </strong>With FFR-CT ≤ 0.8 as the criterion, the accuracy of conventional and post-subtraction FFR-CT measurements in predicting early revascularization was 73.4% and 77.2% at the patient level, and 64.6% and 72.2% at the vessel level, respectively. The specificity of post-subtraction FFR-CT measurements was significantly higher than that of conventional FFR-CT at both the patient and vessel levels (P of 0.013 and 0.015, respectively). At the vessel level, the area under the curve of receiver operating characteristic was 0.712 and 0.797 for conventional and post-subtraction ΔFFR-CT, respectively, showing a difference (P = 0.047), with optimal cutoff values of 0.07 and 0.11, respectively.</p><p><strong>Conclusion: </strong>The post-subtraction FFR-CT measurements enhance the specificity in predicting early revascularization. The post-subtraction ΔFFR-CT value of the stenosis segment > 0.11 may be an important indicator for early revascularization.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study. 冠状动脉旁路移植手术和经皮冠状动脉介入治疗术后的心房颤动发生率:前瞻性 AFAF 队列研究。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-05-02 DOI: 10.1080/14017431.2024.2347297
Anders Wickbom, Espen Fengsrud, Joakim Alfredsson, Johan Engdahl, Torbjörn Kalm, Anders Ahlsson
{"title":"Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study.","authors":"Anders Wickbom, Espen Fengsrud, Joakim Alfredsson, Johan Engdahl, Torbjörn Kalm, Anders Ahlsson","doi":"10.1080/14017431.2024.2347297","DOIUrl":"10.1080/14017431.2024.2347297","url":null,"abstract":"<p><p><i>Objectives.</i> Atrial fibrillation is a common arrhythmia in patients with ischemic heart disease. This study aimed to determine the cumulative incidence of new-onset atrial fibrillation after percutaneous coronary intervention or coronary artery bypass grafting surgery during 30 days of follow-up. <i>Design.</i> This was a prospective multi-center cohort study on atrial fibrillation incidence following percutaneous coronary intervention or coronary artery bypass grafting for stable angina or non-ST-elevation acute coronary syndrome. Heart rhythm was monitored for 30 days postoperatively by in-hospital telemetry and handheld thumb ECG recordings after discharge were performed. The primary endpoint was the cumulative incidence of atrial fibrillation 30 days after the index procedure. <i>Results.</i> In-hospital atrial fibrillation occurred in 60/123 (49%) coronary artery bypass graft and 0/123 percutaneous coronary intervention patients (<i>p</i> < .001). The cumulative incidence of atrial fibrillation after 30 days was 56% (69/123) of patients undergoing coronary artery bypass grafting and 2% (3/123) of patients undergoing percutaneous coronary intervention (<i>p</i> < .001). CABG was a strong predictor for atrial fibrillation compared to PCI (OR 80.2, 95% CI 18.1-354.9, <i>p</i> < .001). Thromboembolic stroke occurred in-hospital in one coronary artery bypass graft patient unrelated to atrial fibrillation, and at 30 days in two additional patients, one in each group. There was no mortality. <i>Conclusion.</i> New-onset atrial fibrillation during 30 days of follow-up was rare after percutaneous coronary intervention but common after coronary artery bypass grafting. A prolonged uninterrupted heart rhythm monitoring strategy identified additional patients in both groups with new-onset atrial fibrillation after discharge.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocardiographic abnormalities and NT-proBNP levels at long-term follow-up of patients with dyspnea after pulmonary embolism. 肺栓塞后呼吸困难患者长期随访时的心电图异常和 NT-proBNP 水平。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-27 Epub Date: 2024-07-03 DOI: 10.1080/14017431.2024.2373090
Lars T Nilsson, Therese Andersson, Bo Carlberg, Lars Å Johansson, Stefan Söderberg
{"title":"Electrocardiographic abnormalities and NT-proBNP levels at long-term follow-up of patients with dyspnea after pulmonary embolism.","authors":"Lars T Nilsson, Therese Andersson, Bo Carlberg, Lars Å Johansson, Stefan Söderberg","doi":"10.1080/14017431.2024.2373090","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373090","url":null,"abstract":"<p><strong>Objectives: </strong>Electrocardiogram (ECG) and measurement of plasma brain natriuretic peptides (BNP) are established markers of right ventricular dysfunction (RVD) in the setting of acute pulmonary embolism (PE) but their value at long-term follow-up is largely unknown. The purpose of this prospective study was to determine the prevalence of ECG abnormalities, describe levels of N-terminal proBNP (NT-proBNP), and establish their association with dyspnea at long-term follow-up after PE.</p><p><strong>Design: </strong>All Swedish patients diagnosed with acute PE in 2005 (<i>n</i> = 5793) were identified through the Swedish National Patient Registry. Surviving patients in 2007 (<i>n</i> = 3510) were invited to participate. Of these, 2105 subjects responded to a questionnaire about dyspnea and comorbidities. Subjects with dyspnea or risk factors for development of chronic thromboembolic pulmonary hypertension were included in the study in a secondary step, which involved collection of blood samples and ECG registration.</p><p><strong>Results: </strong>Altogether 49.3% had a completely normal ECG. The remaining participants had a variety of abnormalities, 7.2% had atrial fibrillation/flutter (AF). ECG with any sign of RVD was found in 7.2% of subjects. Right bundle branch block was the most common RVD sign with a prevalence of 6.4%. An abnormal ECG was associated with dyspnea. AF was associated with dyspnea, whereas ECG signs of RVD were not. 61.2% of subjects had NT-proBNP levels above clinical cut-off (>125 ng/L). The degree of dyspnea did not associate independently with NT-proBNP levels.</p><p><strong>Conclusions: </strong>We conclude that the value of ECG and NT-proBNP in long term follow-up after PE lies mostly in differential diagnostics.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reply to the letter to the editor "Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions". 回复致编辑的信 "对接受经皮冠状动脉介入治疗慢性全闭塞患者少报、淡化不良事件并夸大获益的常见做法"。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-25 Epub Date: 2024-07-02 DOI: 10.1080/14017431.2024.2373102
Lauri Mansikkaniemi, Hirokazu Miyashita, Juha Sinisalo, Juhani Stewart, Petri Laine
{"title":"A reply to the letter to the editor \"Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions\".","authors":"Lauri Mansikkaniemi, Hirokazu Miyashita, Juha Sinisalo, Juhani Stewart, Petri Laine","doi":"10.1080/14017431.2024.2373102","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373102","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions. 在接受经皮冠状动脉介入治疗慢性全闭塞患者中,低报和淡化不良事件、夸大获益的常见做法。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-25 Epub Date: 2024-07-03 DOI: 10.1080/14017431.2024.2373070
Mohammad Reza Movahed
{"title":"Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions.","authors":"Mohammad Reza Movahed","doi":"10.1080/14017431.2024.2373070","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373070","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperglycemia-simulating environment attenuated experimentally induced calcification in cultured human aortic valve interstitial cells. 模拟高血糖环境可减轻实验诱导的培养人主动脉瓣间质细胞钙化。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-05-09 Epub Date: 2024-05-17 DOI: 10.1080/14017431.2024.2353070
Arsenii Zabirnyk, Daria Evensen, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Kåre-Olav Stensløkken, Jarle Vaage
{"title":"Hyperglycemia-simulating environment attenuated experimentally induced calcification in cultured human aortic valve interstitial cells.","authors":"Arsenii Zabirnyk, Daria Evensen, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Kåre-Olav Stensløkken, Jarle Vaage","doi":"10.1080/14017431.2024.2353070","DOIUrl":"https://doi.org/10.1080/14017431.2024.2353070","url":null,"abstract":"<p><p><i>Objectives:</i> The role of diabetes mellitus as a risk factor for the development of calcific aortic valve disease has not been fully clarified. Aortic valve interstitial cells (VICs) have been suggested to be crucial for calcification of the valve. Induced calcification in cultured VICs is a good <i>in vitro</i> model for aortic valve calcification. The purpose of this study was to investigate whether increased glucose levels increase experimentally induced calcification in cultured human VICs. <i>Design:</i> VICs were isolated from explanted calcified aortic valves after valve replacement. Osteogenic medium induced calcification of cultured VICs at different glucose levels (5, 15, and 25 mM). Calcium deposits were visualized using Alizarin Red staining and measured spectrophotometrically. <i>Results:</i> The higher the glucose concentration, the lower the level of calcification. High glucose (25 mM) reduced calcification by 52% compared with calcification at a physiological (5 mM) glucose concentration (correlation and regression analysis: <i>r</i> = -0.55, <i>p</i> = .025 with increased concentration of glucose). <i>Conclusions: In vitro</i> hyperglycemia-like conditions attenuated calcification in VICs. High glucose levels may trigger a series of events that secondarily stimulate calcification of VICs <i>in vivo</i>.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycotic aortic aneurysms: characteristic macroscopic findings in a case series 霉菌性主动脉瘤:一个病例系列的特征性宏观发现
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-04-14 DOI: 10.1080/14017431.2024.2341696
Tim Somers, Hedwig M. J. M. Nies, Ilse J. E. Kouijzer, Pui Yuen Lee, Wim J. Morshuis, Guillaume S. C. Geuzebroek
{"title":"Mycotic aortic aneurysms: characteristic macroscopic findings in a case series","authors":"Tim Somers, Hedwig M. J. M. Nies, Ilse J. E. Kouijzer, Pui Yuen Lee, Wim J. Morshuis, Guillaume S. C. Geuzebroek","doi":"10.1080/14017431.2024.2341696","DOIUrl":"https://doi.org/10.1080/14017431.2024.2341696","url":null,"abstract":"Infected or mycotic aortic aneurysms (MAAs) are a rare type of aneurysms. Due to the high risk of rupture, MAAs are life-threatening conditions. Early diagnosis and treatment are necessary, yet MAA...","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early and mid-term results after endovascular repair of thoracoabdominal aortic aneurysms using the off-the-shelf multibranched t-Branch device: a national multi-center study 使用现成的多分支 t-Branch 装置进行胸腹主动脉瘤血管内修复术后的早期和中期效果:一项全国性多中心研究
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-04-13 DOI: 10.1080/14017431.2024.2335906
Håvard Ulsaker, Henrik Halvorsen, Audun Ole Braaten, Eric Dorenberg, Beate Rikken Lindberg, Kåre Christian Nordhus, Øyvind Jakobsen, Reidar Brekken, Arne Seternes, Frode Manstad-Hulaas
{"title":"Early and mid-term results after endovascular repair of thoracoabdominal aortic aneurysms using the off-the-shelf multibranched t-Branch device: a national multi-center study","authors":"Håvard Ulsaker, Henrik Halvorsen, Audun Ole Braaten, Eric Dorenberg, Beate Rikken Lindberg, Kåre Christian Nordhus, Øyvind Jakobsen, Reidar Brekken, Arne Seternes, Frode Manstad-Hulaas","doi":"10.1080/14017431.2024.2335906","DOIUrl":"https://doi.org/10.1080/14017431.2024.2335906","url":null,"abstract":"Objective: The multibranched off-the-shelf Zenith® t-Branch (Cook Medical, Bloomington, IN) device is commonly chosen for endovascular repair of thoracoabdominal aortic aneurysms. The aim of this s...","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term outcomes after heart transplantation using donor hearts preserved with ex vivo perfusion. 使用体外灌注保存的供体心脏进行心脏移植后的短期结果。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2023-12-01 Epub Date: 2023-10-11 DOI: 10.1080/14017431.2023.2267804
William Herrik Nielsen, Finn Gustafsson, Peter Skov Olsen, Peter Bo Hansen, Kasper Rossing, Nikolaj Bang Lilleør, Peter Hasse Møller-Sørensen, Christian Holdflod Møller
{"title":"Short-term outcomes after heart transplantation using donor hearts preserved with ex vivo perfusion.","authors":"William Herrik Nielsen,&nbsp;Finn Gustafsson,&nbsp;Peter Skov Olsen,&nbsp;Peter Bo Hansen,&nbsp;Kasper Rossing,&nbsp;Nikolaj Bang Lilleør,&nbsp;Peter Hasse Møller-Sørensen,&nbsp;Christian Holdflod Møller","doi":"10.1080/14017431.2023.2267804","DOIUrl":"10.1080/14017431.2023.2267804","url":null,"abstract":"<p><p>The standard Conventional Cold Storage (CCS) during heart transplantation procurement is associated with time-dependent ischemic injury to the graft, which is a significant independent risk factor for post-transplant early morbidity and mortality - especially when cold ischemic time exceeds four hours. Since 2018, Rigshospitalet (Copenhagen, Denmark) has been utilising <i>ex vivo</i> perfusion (Organ Care System, OCS) in selected cases. The objective of this study was to compare the short-term clinical outcomes of patients transplanted with OCS compared to CCS. <i>Methods</i>: This retrospective single-centre study was based on consecutive patients undergoing a heart transplant between January 2018 and April 2021. Patients were selected for the OCS group when the cold ischemic time was expected to exceed four hours. The primary outcome measure was six-month event-free survival. <i>Results</i>: In total, 48 patients were included in the study; nine were transplanted with an OCS heart. The two groups had no significant differences in baseline characteristics. Six-month event-free survival was 77.8% [95% CI: 54.9-100%] in the OCS group and 79.5% [95% CI: 67.8-93.2%] in the CCS group (<i>p</i> = 0.91). While the OCS group had a median out-of-body time that was 183 min longer (<i>p</i> < 0.0001), the cold ischemic time was reduced by 51 min (<i>p</i> = 0.007). <i>Conclusion:</i> In a Scandinavian setting, our data confirms that utilising OCS in heart procurement allows for a longer out-of-body time and a reduced cold ischemic time without negatively affecting safety or early post-transplant outcomes.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41211189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in cardiac output, rhythm regularity, and symptom severity after electrical cardioversion of atrial fibrillation. 心房颤动电复律后心输出量、节律规律和症状严重程度的变化。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2023-12-01 DOI: 10.1080/14017431.2023.2236341
Sofia Klavebäck, Helga Skúladóttir, Joakim Olbers, Jan Östergren, Frieder Braunschweig
{"title":"Changes in cardiac output, rhythm regularity, and symptom severity after electrical cardioversion of atrial fibrillation.","authors":"Sofia Klavebäck, Helga Skúladóttir, Joakim Olbers, Jan Östergren, Frieder Braunschweig","doi":"10.1080/14017431.2023.2236341","DOIUrl":"10.1080/14017431.2023.2236341","url":null,"abstract":"<p><strong>Objectives: </strong>Symptoms in atrial fibrillation (AF) range from none to disabling. The physiological correlates of AF symptoms are not well characterized. This study investigated the association between physiological parameters and symptom severity before and after electrical cardioversion (EC) of AF.</p><p><strong>Design: </strong>We studied 44 patients with persistent AF (age 66.2 ± 7.9 years, 16% females) 4 ± 2 days before and 5 ± 2 days after EC. Physiological parameters included cardiac output (CO; non-invasive inert gas rebreathing), heart rate (HR), RR variability and resting and ambulatory blood pressure (BP). Symptoms and quality of life (QoL) were assessed by the modified European Heart Rhythm Association score (mEHRA), the Atrial Fibrillation Effect on Quality of Life (AFEQT) and the Symptom Checklist for frequency and severity of symptoms (SCL).</p><p><strong>Results: </strong>28 of 44 patients were still in sinus rhythm (SR) at post EC evaluation. Those in SR had a decreased HR (-15.4 ± 13.1 bpm, <i>p</i> < 0.001), and an increased CO (+0.8 ± 0.7 L/min, <i>p</i> < 0.001) as compared to those with recurrent AF. Changes in CO after EC correlated with symptom improvement as scored by AFEQT (<i>r</i> = 0.36; <i>p</i> < 0.05), AFEQT symptoms subscore (<i>r</i> = 0.46; <i>p</i> < 0.01), SCL for frequency (<i>r</i> = 0.62; <i>p</i> < 0.01) and severity (<i>r</i> = 0.33; <i>p</i> < 0.05) of symptoms, and the mEHRA score (<i>r</i> = 0.50; <i>p</i> < 0.01). A decrease in RR variability showed similar correlations with these measures of symptom improvement.</p><p><strong>Conclusions: </strong>Improvements in symptoms and quality of life experienced by patients after electrical conversion of atrial fibrillation are correlated with an increase in CO and a decreased RR variability.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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