Rhinology最新文献_第4页

Impact of air quality on tissue eosinophilia and clinical severity of chronic rhinosinusitis. 空气质量对慢性鼻窦炎嗜酸性粒细胞增多和临床严重程度的影响。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-11 DOI: 10.4193/Rhin26.324

A Q Le, T Tran, J Samuthpongtorn, K Seresirikachorn, W Chitsuthipakorn, M P Hoang, L V Tran, M T Q Le, S Chusakul, J Kanchanaumporn, P Wungcharoen, K Snidvongs

引用次数: 0

ICAM1 promotes the invasion and metastasis of Epstein-Barr virus (EBV) positive nasopharyngeal carcinoma (NPC) cells by regulating the CCR7-JAK3/STAT3 axis to modulate PD-L1 expression. ICAM1通过调控CCR7-JAK3/STAT3轴调控PD-L1表达，促进eb病毒（EBV）阳性鼻咽癌（NPC）细胞的侵袭转移。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-11 DOI: 10.4193/Rhin25.579

Y Liu, R Fu, W Sun, P Chen

{"title":"ICAM1 promotes the invasion and metastasis of Epstein-Barr virus (EBV) positive nasopharyngeal carcinoma (NPC) cells by regulating the CCR7-JAK3/STAT3 axis to modulate PD-L1 expression.","authors":"Y Liu, R Fu, W Sun, P Chen","doi":"10.4193/Rhin25.579","DOIUrl":"https://doi.org/10.4193/Rhin25.579","url":null,"abstract":"Background: In patients with locally advanced, metastatic, or recurrent nasopharyngeal carcinoma (NPC), immunotherapy, especially with programmed cell death ligand 1 (PD-L1) inhibitors, is increasingly being applied for clinical treatment and has shown promising results. Intercellular adhesion molecule 1 (ICAM1) is closely associated with the occurrence and progression of NPC induced by Epstein-Barr virus (EBV) infection and is related to the high expression of PD-L1 and immune suppression in tumour tissues. However, the specific mechanisms are unclear.Methodology: We used two GEO datasets, GSE68799 and GSE102349, for bioinformatics analysis and performed immunohistochemistry (IHC) on 75 clinical NPC tissue samples. The results from both methods were combined to validate the relationships among ICAM, PD-L1, and patients with late-stage EBV-positive NPC. To elucidate the underlying mechanism, we used Western blotting, coimmunoprecipitation (Co-IP), and immunofluorescence (IF) to investigate the role of ICAM1 in the promotion of NPC cell malignancy.Results: We found that ICAM1 was highly expressed in EBV-positive NPC tissues and was associated with poor prognosis. Silencing ICAM1 expression decreased the malignant behaviour of NPC cells and PD-L1 expression. The mechanistic study revealed that ICAM1 increased PD-L1 expression, especially at the cell membrane, by activating the JAK3/STAT3 signalling pathway through interactions with CCR7 and its ligands CCL19 and CCL21.Conclusion: The results of this study indicate that ICAM1 may serve as a therapeutic target for patients with recurrent, metastatic EBV-positive NPC.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Endoscopic endonasal versus transcranial approaches for trigeminal schwannomas" - the emerging role of the endoscopic transorbital approach. 对“经鼻内镜与经颅内镜治疗三叉神经鞘瘤”的评论，-内镜经眶入路的新作用。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin26.039

I Dallan, S Serioli, D-S Kong

引用次数: 0

Chronic rhinosinusitis in a birth cohort: symptom trajectories and early-life risk factors up to young adulthood. 慢性鼻窦炎在出生队列：症状轨迹和早期生活的危险因素，直到青年成年。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin26.079

K Aberg, A Asarnoj, A Asarnoj, L O Cardell, I Kull, A Bergstrom, E Melen, M Holmstrom, M van Hage, M Westman

{"title":"Chronic rhinosinusitis in a birth cohort: symptom trajectories and early-life risk factors up to young adulthood.","authors":"K Aberg, A Asarnoj, A Asarnoj, L O Cardell, I Kull, A Bergstrom, E Melen, M Holmstrom, M van Hage, M Westman","doi":"10.4193/Rhin26.079","DOIUrl":"10.4193/Rhin26.079","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is common worldwide in adults, but development of CRS has rarely been studied longitudinally in birth-cohorts. The aim was to investigate development of upper airway symptoms from childhood to young adulthood and to identify early risk factors for CRS at 24 years, in a population-based birth cohort.Method: 3037 subjects from the BAMSE (Barn/children Allergy Milieu Stockholm Epidemiology) cohort had complete question-naire answers on CRS at the 24-year-follow-up. Subjects fulfilling European Position Paper on Rhinosinusitis (EPOS) criteria of CRS at 16 and/or 24 years (n=141) were invited to a clinical examination with nasal endoscopy and interviews. Among these, 68 had clinically verified CRS symptoms. Symptoms and clinical status were compared with questionnaire-based answers on symptoms and potential risk factors for CRS, in early childhood.Results: Among subjects with CRS symptoms at 24 years, > 60% reported upper airway symptoms already at 16 years. In the same group, a significant association was observed with a history of otitis media < 1 year and with heredity for atopic diseases. Moreover, the proportion of atopic features such as asthma, allergic rhinitis and eczema were significantly higher at 4, 8 and 16 years in this group. No clear association was found between CRS at 24 years and early RS infection, antibiotic use.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"494-501"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTSS as a novel biomarker for tissue remodeling in CRSwNP: insights from multi-omics research. CTSS作为CRSwNP组织重塑的新生物标志物：来自多组学研究的见解。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin25.504

C Li, Y Huang, J Yan, Y Yan, Y Guo, K Li, Y Wen, J Li, Y Wei, W Wen, Z Xu

{"title":"CTSS as a novel biomarker for tissue remodeling in CRSwNP: insights from multi-omics research.","authors":"C Li, Y Huang, J Yan, Y Yan, Y Guo, K Li, Y Wen, J Li, Y Wei, W Wen, Z Xu","doi":"10.4193/Rhin25.504","DOIUrl":"10.4193/Rhin25.504","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory, relapsing upper airway inflammatory disorder cha-racterized by prominent tissue remodeling. Current therapeutic options remain suboptimal. We aimed to identify novel potential targets and biomarkers using integrative multi-omics.Methodology: We performed Mendelian randomization (MR) analyses integrating blood expression quantitative trait loci (eQTL) from eQTLGen and plasma protein quantitative trait loci (pQTL) from deCODE with nasal polyps (NP) genome-wide association study data from 8,496 NP patients and 371,520 controls. Significant targets underwent validation via bulk/single-cell RNA sequen-cing, immunohistochemistry, and immunofluorescence.Results: MR analyses identified 6 targets causally linked to NP risk in both eQTL and pQTL analyses. Therein, cathepsin S (CTSS) increased the risk of NP, exclusively demonstrating colocalization with NP and exhibiting significant upregulation in NP tissue. Single-cell data showed CTSS mainly express in monocyte/macrophages, and CTSS-high subsets enriched in CRSwNP vs. Control. Immunohistochemistry and immunofluorescence further confirmed high CTSS expression in NP. Moreover, CTSS expression cor-related with tissue remodeling pathways and associated with CRSwNP clinical severity.Conclusions: CTSS may contribute to the pathogenesis of CRSwNP by modulating tissue remodeling. CTSS is a noval biomarker for CRSwNP.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"541-552"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From persistent olfactory dysfunction to permanent loss: investigating quality of life in acquired and congenital anosmia. 从持续性嗅觉功能障碍到永久性丧失：研究获得性和先天性嗅觉缺失的生活质量。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin25.138

W-Y Lee, Y-C Liao, C-H Shu, Y-T Chao

{"title":"From persistent olfactory dysfunction to permanent loss: investigating quality of life in acquired and congenital anosmia.","authors":"W-Y Lee, Y-C Liao, C-H Shu, Y-T Chao","doi":"10.4193/Rhin25.138","DOIUrl":"10.4193/Rhin25.138","url":null,"abstract":"Background: Growing awareness of permanent olfactory dysfunction has raised concerns about its impact on quality of life (QoL). This study examined the effect of permanent anosmia on QoL by comparing patients with acquired anosmia of varying durations, including cases persisting for over a decade and cases of isolated congenital anosmia (ICA).Methodology: A total of 59 patients with post-viral or idiopathic anosmia who sought medical evaluation due to olfactory com-plaints completed the Questionnaire of Olfactory Disorders (QOD), which measured impairment, coping ability, and subjective disturbance. Patients were categorized into three groups: persistent acquired anosmia (PerA, duration 6 months - 2 years), prolon-ged acquired anosmia (ProA, duration >= 10 years), and ICA to reflect distinct populations. Patients with intermediate or uncertain duration were excluded to avoid recall bias.Results: Perceived impairment, as reflected by QOD-NS and work domain of QOD-VAS, was higher in the PerA and ProA groups than in the ICA group. No significant differences in QOD-NS and QOD-VAS were observed between PerA and ProA groups. The ProA group exhibited better coping ability, as indicated by higher QOD-PS scores, than did the PerA group, suggesting coping over time. Coping scores in the ProA and ICA groups were comparable, indicating long-term adjustment in anosmic individuals.Conclusions: Acquired anosmia has a greater impact on QoL than does congenital anosmia. Individuals with prolonged acquired anosmia exhibited better subjective coping.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"512-520"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of consensus building. 建立共识的重要性。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin26.904

A R Sedaghat

引用次数: 0

The elongated ciliated cells derived from nasal polyps are distinctly different from ciliated cells in different parts of the nasal mucosa. 鼻息肉的纤毛细胞与鼻黏膜不同部位的纤毛细胞有明显的差异。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin25.225

H Deng, M Pang, Q Yang, H Qiu

{"title":"The elongated ciliated cells derived from nasal polyps are distinctly different from ciliated cells in different parts of the nasal mucosa.","authors":"H Deng, M Pang, Q Yang, H Qiu","doi":"10.4193/Rhin25.225","DOIUrl":"10.4193/Rhin25.225","url":null,"abstract":"Background: Ciliary abnormalities are implicated in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), but whether these changes are site-specific traits or confined to specific cell populations remains unknown. Here, we systematically examined ciliated cells throughout the sinonasal tract to characterize disease-specific ciliary alterations and identify a distinct population of elongated ciliated cells in nasal polyps (NPs).Methods: Nasal biopsy specimens were obtained from patients with CRSwNP (n=32) and non-CRSwNP (n=22). hNECs were differentiated at the air-liquid interface (ALI). Tissue sections, cytospin preparations, and ALI cultures were immunostained for Î±-tubulin. Cilia length, length of horizontal axis, and length of vertical axis of ciliated cells were recorded.Results: Cilia length was significantly greater in CRSwNP patients than in non-CRSwNP controls (8.17 Â± 3.35 Î¼m vs. 5.67 Â± 1.64 Î¼m). Within NPs tissues, we identified a distinct population of elongated ciliated cells (ECCs) exhibiting marked inner/outer cilia length disparity, with outer cilia reaching up to 20.0 Î¼m. These ECCs accounted for 8.10% Â± 3.56% of total ciliated cells in NPs. Notably, ECCs-like cells were also detected in polypoid-transformed mucosa adjacent to NPs and persisted after ALI culture. In contrast, ciliated cell dimensions did not differ between groups or across the nasal anatomical sites examined.Conclusion: A population of ciliated cells characterized by abnormally elongated cilia and concomitant impairment of ciliary function can be found in NPs, which may represent a key pathogenic factor in the development and progression of CRSwNP.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"531-540"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulators do not appear effective for post-viral parosmia. 神经调节剂似乎对病毒后鼻咽癌无效。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin25.162

K Resler, B R Castro, Z M Patel

引用次数: 0

Linking form to function: a scoping review of the evolution of paranasal sinuses in mammals. 形式与功能的联系：哺乳动物鼻窦进化的范围综述。

IF 5.7 2区医学

Rhinology Pub Date : 2026-08-01 DOI: 10.4193/Rhin25.419

L E Ebbert, N Kumar, M K Ebbert, T Pace, P Lanca Gomes, L A Marks, D Lal

{"title":"Linking form to function: a scoping review of the evolution of paranasal sinuses in mammals.","authors":"L E Ebbert, N Kumar, M K Ebbert, T Pace, P Lanca Gomes, L A Marks, D Lal","doi":"10.4193/Rhin25.419","DOIUrl":"https://doi.org/10.4193/Rhin25.419","url":null,"abstract":"Background: The evolutionary origin and function of paranasal sinuses remain unclear. We investigated their presence, distribution, and drainage orientation across mammalian orders, to better understand their evolutionary development and roles.Methodology: A scoping review of anatomical, radiological, and descriptive literature was conducted in Ovid MEDLINE database (1946-2024). Data on sinus presence, type, and drainage pathways were extracted from representative species across mammalian orders. Phylogenetic (grouping by evolutionary ancestry) and phenetic (grouping by anatomical similarity) analyses were used to identify evolutionary patterns.Results: Final review included 24 articles. Sinus prevalence in mammalian orders was maxillary (50%), frontal (44%), sphenoid (33%) and ethmoid (20%). Frontal sinuses were more common in behaviorally complex orders (71% vs. 22%). Frontal and maxillary sinuses predominated in terrestrial and arboreal mammals, while aquatic and volant mammals largely lacked sinuses. Phenetic clustering by sinus characteristics often contradicted phylogeny, suggesting parallel evolution driven by environment over ancestry. Despite variation in morphology, drainage pathways remained conserved.Conclusions: Paranasal sinus distribution in mammals appears more ecologically than phylogenetically determined, with convergent evolution likely influencing their presence. Conserved drainage patterns suggest developmental constraints over selective advantages. Further studies incorporating underrepresented mammalian orders and sinus size quantification are needed to refine our understanding of paranasal sinus function and evolution.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":"64 4","pages":"434-443"},"PeriodicalIF":5.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0