IF 6.8 2区医学

Rhinology Pub Date : 2026-04-16 DOI: 10.4193/Rhin26.079

K Åberg, A Asarnoj, A Asarnoj, L O Cardell, I Kull, A Bergström, E Melén, M Holmström, M van Hage, M Westman

{"title":"Chronic rhinosinusitis in a birth cohort: symptom trajectories and early-life risk factors up to young adulthood.","authors":"K Åberg, A Asarnoj, A Asarnoj, L O Cardell, I Kull, A Bergström, E Melén, M Holmström, M van Hage, M Westman","doi":"10.4193/Rhin26.079","DOIUrl":"https://doi.org/10.4193/Rhin26.079","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is common worldwide in adults, but development of CRS has rarely been studied longitudinally in birth-cohorts. The aim was to investigate development of upper airway symptoms from childhood to young adulthood and to identify early risk factors for CRS at 24 years, in a population-based birth cohort.Method: 3037 subjects from the BAMSE (Barn/children Allergy Milieu Stockholm Epidemiology) cohort had complete question-naire answers on CRS at the 24-year-follow-up. Subjects fulfilling European Position Paper on Rhinosinusitis (EPOS) criteria of CRS at 16 and/or 24 years (n=141) were invited to a clinical examination with nasal endoscopy and interviews. Among these, 68 had clinically verified CRS symptoms. Symptoms and clinical status were compared with questionnaire-based answers on symptoms and potential risk factors for CRS, in early childhood.Results: Among subjects with CRS symptoms at 24 years, > 60% reported upper airway symptoms already at 16 years. In the same group, a significant association was observed with a history of otitis media < 1 year and with heredity for atopic diseases. Moreover, the proportion of atopic features such as asthma, allergic rhinitis and eczema were significantly higher at 4, 8 and 16 years in this group. No clear association was found between CRS at 24 years and early RS infection, antibiotic use.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologics for chronic rhinosinusitis with nasal polyps: a real-world prospective cohort study. 慢性鼻窦炎伴鼻息肉的生物制剂：一项真实世界的前瞻性队列研究。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-16 DOI: 10.4193/Rhin26.004

M Blauwblomme, A-S Viskens, E Bonne, E Borgers, C Cox, G De Vos, L Derycke, A-S Eeckels, S Halewyck, V Hox, P Janssen, P Janssen, W Lemmens, F Rogister, K Speleman, M Syssauw, O Vanderveken, E Vandewalle, S Vanhee, B Verhaeghe, A V Vroegop, T Van Zele, P Gevaert, P W Hellings

{"title":"Biologics for chronic rhinosinusitis with nasal polyps: a real-world prospective cohort study.","authors":"M Blauwblomme, A-S Viskens, E Bonne, E Borgers, C Cox, G De Vos, L Derycke, A-S Eeckels, S Halewyck, V Hox, P Janssen, P Janssen, W Lemmens, F Rogister, K Speleman, M Syssauw, O Vanderveken, E Vandewalle, S Vanhee, B Verhaeghe, A V Vroegop, T Van Zele, P Gevaert, P W Hellings","doi":"10.4193/Rhin26.004","DOIUrl":"https://doi.org/10.4193/Rhin26.004","url":null,"abstract":"Background: Monoclonal antibody therapies targeting type 2 inflammation for chronic rhinosinusitis with nasal polyps (CRSwNP) have shown efficacy in randomized controlled trials (RCTs), however prospective real-world comparative data across all appro-ved biologics remain limited. We aimed to evaluate the real-world effectiveness of omalizumab, mepolizumab, and dupilumab in patients with severe CRSwNP.Methodology: A prospective, multicentre, real-world phase IV study in Belgium, enrolling 360 patients with severe CRSwNP initiating treatment with omalizumab (n=65), mepolizumab (n=242), or dupilumab (n=53) between March 2022 and April 2025. Clinical data were collected at baseline and after 6 months. The therapeutic response was evaluated based on EUFOREA criteria.Results: After 6 months, nasal polyp score (NPS), olfactory function, and patient-reported outcomes improved across all biologics, with concurrent improvements in asthma control within each treatment group. A good-to-excellent multidomain therapeutic response was achieved in 51% of patients, and treatment continuation beyond 6 months was observed in 74% of omalizumab-, 81% of mepolizumab-, and 92% of dupilumab-treated patients. No severe adverse events were reported.Conclusion: In this real-world cohort, the three registered biologics provided significant clinical benefit in severe CRSwNP, with numerically larger improvements observed in patients treated with dupilumab.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between olfactory function and quality of life in COVID-19 patients. COVID-19患者嗅觉功能与生活质量的关系

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-16 DOI: 10.4193/Rhin24.174

S Winkelmann, M A Nasr, A Korth, B Voss, N Behrend, P Pudszuhn, C Maetzler, A Hermes, K Franzpoetter, A-K Ruß, D Pape, S Störk, F A Montellano, M Witzenrath, T Keil, M Krawczak, W Lieb, S Schreiber, T Bahmer, M Laudien

引用次数: 0

Anterior superior alveolar nerve dysfunction after lateral nasal wall surgery: a prospective observation. 鼻外侧壁手术后的前上肺泡神经功能障碍：一项前瞻性观察。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-11 DOI: 10.4193/Rhin26.046

A Machado, M Castelo-Branco Sousa, H R Briner, D Simmen

引用次数: 0

Exhaled breath condensate metabolomics reveals conserved networks and bidirectional crosstalk in asthma and CRSwNP. 呼气冷凝水代谢组学揭示哮喘和CRSwNP中的保守网络和双向串扰。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-10 DOI: 10.4193/Rhin25.428

Y Yang, W Zhang, L Cui, H Yu, Y Chen, D Wang, J Wang, Y Zhang, X Song

{"title":"Exhaled breath condensate metabolomics reveals conserved networks and bidirectional crosstalk in asthma and CRSwNP.","authors":"Y Yang, W Zhang, L Cui, H Yu, Y Chen, D Wang, J Wang, Y Zhang, X Song","doi":"10.4193/Rhin25.428","DOIUrl":"https://doi.org/10.4193/Rhin25.428","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist. However, the metabolic inter-play between those diseases is poorly understood. We aimed to perform metabolomic profiling of exhaled breath condensate (EBC) from CRSwNP and asthma patients and investigate possible interaction pathways.Methodology: EBC samples from the upper and lower airways of patients with CRSwNP, asthma, and control subjects were analyzed using untargeted metabolomics. Metabolite consistency and conserved modules between the upper and lower airways were quantified. WGCNA, trend cluste-ring analysis, and a pathway enrichment analysis of differential metabolite expression were performed.Results: A total of 252 metabolites were identified, with a strong correlation between the upper and lower airway profiles. WGCNA analysis showed that each module of the upper or lower airway was conserved, with at least 1 module included in the consensus network. The key enriched pathways for lower airway metabolites showed a continuous increasing or decreasing trend in the control, CRSwNP, and asthma groups, and mainly involved the impact of CRSwNP on asthma. The main enriched pathways for upper airway differential metabolites in the control, asthma, and CRSwNP groups were related to the impact of asthma on nasal polyps. N-(8Z,11Z,14Z-eicosatrienoyl) ethanolamine was significantly down-regulated in the EBC of CRSwNP and asthma patients, and was negatively correlated with the risk for CRSwNP and asthma onset. Leukotriene F4 (LTF4) was up-regulated in the EBC of CRSwNP and asthma patients, and was positively correlated with the risk for CRSwNP onset.Conclusion: Non-invasive EBC metabolomics revealed conserved metabolic networks and bidirectional perturbations between CRSwNP and asthma, providing new evidence for the "unified airway" hypothesis.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choanal atresia repair in Germany â€" a comprehensive investigation of the current state of care. 后肛门闭锁修复在德国-护理现状的综合调查。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.318

M-S Yilmaz Topcuoglu, P J Schuler, J H Westhoff, O Sommerburg, L Wucherpfennig, I Baumann

{"title":"Choanal atresia repair in Germany â€\" a comprehensive investigation of the current state of care.","authors":"M-S Yilmaz Topcuoglu, P J Schuler, J H Westhoff, O Sommerburg, L Wucherpfennig, I Baumann","doi":"10.4193/Rhin25.318","DOIUrl":"10.4193/Rhin25.318","url":null,"abstract":"Background: There is often a discrepancy between official recommendations and actual clinical practice on repair of congenital choanal atresia (CA). The objective of this study was to evaluate the current state of care for CA patients in Germany.Methods: An online survey was conducted in which 108 German ENT departments were consulted on various aspects of CA management, including preoperative diagnosis, surgical procedures, and postoperative care.Results: 65% of the ENT departments only perform CA repairs at over 3 years of age. Flexible nasal endoscopy (69%), hearing tests (41%), and computed tomography (52%) were preoperative diagnosis tools. Posterior vomer was resected in 56% of the ENT departments. Scar- (60%), granulation tissue (38%), and insufficient vomer resections (21%) caused recurrences. Stents were used by 38%.Conclusions: Elective unilateral CA repair should be performed in time to minimise symptoms. Preoperative hearing tests should be introduced as routine to identify CA patients with hearing problems. The utilisation of preoperative computed tomography should be discussed individually. Only just over half of the participating ENT departments resected posterior vomer parts. This is a significant starting point with the potential to improve the recurrence rates of this patient cohort. Stent use is still quite common iin Germany. This should be changed in the future.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"259-267"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment escalation and sustained disease control in chronic rhinosinusitis: a retrospective surgical cohort study. 慢性鼻窦炎的治疗升级和持续疾病控制：一项回顾性手术队列研究

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.301

M Clari-Comes, D Martin-Jimenez, R Moreno-Luna, M Gonzalez-Garcia, A Cuvillo, I Alobid, S Sanchez-Gomez

{"title":"Treatment escalation and sustained disease control in chronic rhinosinusitis: a retrospective surgical cohort study.","authors":"M Clari-Comes, D Martin-Jimenez, R Moreno-Luna, M Gonzalez-Garcia, A Cuvillo, I Alobid, S Sanchez-Gomez","doi":"10.4193/Rhin25.301","DOIUrl":"10.4193/Rhin25.301","url":null,"abstract":"Background: The impact of endoscopic sinus surgery (ESS) extent on long-term disease control and therapeutic escalation in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. This study aims to evaluate the clinical applicability of endoscopy-based criteria for therapeutic escalation and to determine the impact of surgical extent on the risk and timing of treatment intensification.Methods: A retrospective cohort study with 3-year follow-up was conducted. CRSwNP patients who underwent ESS were included and classified according to Lamella Ostium Extent Mucosa (LOEM) system (t1â€\"t4). Baseline characteristics and disease severity measures were assessed. Therapeutic escalation was defined by endoscopic criteria. Predictors of escalation and the effect of ESS extent on escalation timing across clinical phenotypes were analyzed using multivariate logistic regression, Kaplan-Meier curves and Cox regressions.Results: In the overall sample (n=172), patients who required escalation showed higher SNOT-22 scores and poorer olfactory function. More extensive ESS (LOEM t3â€\"t4) was associated with significantly reduced escalation risk and prolonged disease control. Post hoc analyses confirmed significant pairwise differences favoring extensive (t3â€\"t4) over limited (t1â€\"t2) surgery. Subgroup analyses demonstrated greater benefits in older subjects, atopic patients, revision surgeries and patients with eosinophils >300cells/Î¼L. Higher baseline SNOT-22 scores remained an independent predictor of escalation after ESS.Conclusions: Surgical extent appears to influence both escalation risk and timing. More extensive ESS may provide more sustained control, particularly in revision cases and biomarker-defined subgroups, supporting its integration into personalized algorithms.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"237-247"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical appraisal of methodological rigor in a systematic review on post-COVID-19 vaccination-associated olfactory dysfunction. 对covid -19疫苗接种后相关嗅觉功能障碍系统评价方法严谨性的批判性评价

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.440

T Gupta, J K Verma

引用次数: 0

Integration of transcriptomic data identifies CD163 as a key link between chronic rhinosinusitis with nasal polyps and COVID-19. 整合转录组学数据确定CD163是慢性鼻窦炎伴鼻息肉与COVID-19之间的关键环节。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin24.462

B Yang, J-Q Zhang, Y Yuan, M Gu, C Hong, C-Y Qiu, X-Y Zou, M-P Lu, L Cheng

{"title":"Integration of transcriptomic data identifies CD163 as a key link between chronic rhinosinusitis with nasal polyps and COVID-19.","authors":"B Yang, J-Q Zhang, Y Yuan, M Gu, C Hong, C-Y Qiu, X-Y Zou, M-P Lu, L Cheng","doi":"10.4193/Rhin24.462","DOIUrl":"10.4193/Rhin24.462","url":null,"abstract":"Background: Emerging evidence has highlighted a potential link between chronic rhinosinusitis with nasal polyps (CRSwNP) and coronavirus disease 2019 (COVID-19). However, the exact mechanism driving this association is not well understood. We aimed to explore the biological pathways and differentially expressed genes (DEGs) involved in CRSwNP and COVID-19 by performing bioinformatic analyses.Methods: Data from the GEO database was analyzed using the \"limma\" package to identify DEGs. Techniques like weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks, and machine learning were employed to pinpoint key genes. Single-sample gene set enrichment analysis (ssGSEA) was used to assess immune cell infiltration. Key gene expression in macrophages was verified using single-cell analysis and immunofluorescence. Genetranscription factor-microRNA (gene-TF-miRNA) regulatory networks were constructed via NetworkAnalyst. Potential therapeutic agents were identified through DGIdb. Nasal polyps and control nasal tissues were surgically obtained for validation purposes.Results: The findings revealed 19 co-DEGs common to both CRSwNP and COVID-19, which were enriched in pathways related to inflammation and the immune response. Among these genes, CD163 was identified as the key gene. The infiltration of CD163+ macrophages was substantially greater in the nasal tissues of CRSwNP and COVID-19 patients than in those of control subjects. Fluticasone was determined to be a promising drug that targets CD163.Conclusion: This study highlights CD163 as a promising diagnostic marker for CRSwNP and COVID-19, suggesting that targeting CD163 may be pivotal in the management of these conditions.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"224-236"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD. 解码嗅觉功能障碍的神经基础：CRS-OD的多模态MRI研究。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.096

C Zhang, Q Wang, C Jiang, Z Tian, J Sha, X Wang, W Zhou, T Cui, Y Zang, K Xu

{"title":"Decoding the neural basis of olfactory dysfunction: a multimodal MRI study in CRS-OD.","authors":"C Zhang, Q Wang, C Jiang, Z Tian, J Sha, X Wang, W Zhou, T Cui, Y Zang, K Xu","doi":"10.4193/Rhin25.096","DOIUrl":"10.4193/Rhin25.096","url":null,"abstract":"Background: Chronic rhinosinusitis with olfactory dysfunction (CRS-OD) affects both peripheral and central olfactory pathways. Persistent olfactory loss may induce neuroplastic changes in brain regions involved in olfactory processing. We hypothesized that CRS-OD is associated with gray matter atrophy in olfactory-related regions, accompanied by alterations in global functional connectivity as a manifestation of compensatory or maladaptive reorganization. To test this, we performed voxel-based morphometry (VBM) to identify gray matter differences, followed by seed-based functional connectivity (FC) analysis using the altered regions.Methodology: We prospectively recruited 23 CRS-OD patients and 23 healthy controls (HCs). All patients presented with persistent olfactory dysfunction lasting 6 to 240 months. All participants underwent MRI scanning at the same time point. Olfactory function was assessed in CRS-OD patients using the Threshold-Discrimination-Identification (TDI) test, the Questionnaire of Olfactory Disorders (QOD), and the Olfactory-Evoked Cognitive Score (OECS). MRI analyses included VBM, FC, and olfactory bulb volume on DRIVen Equilibrium turbo spin echo (TSE) images.Results: CRS-OD patients exhibited significantly reduced olfactory bulb (OB) volumes compared to HCs and gray matter atrophy in the inferior frontal orbital gyrus, parahippocampal gyrus, hippocampus, thalamus, and putamen. FC analysis revealed decreased connectivity in sensory-integration networks and increased FC in the superior occipital gyrus, suggesting compensatory reorganization.Conclusions: CRS-OD is characterized by OB atrophy, gray matter atrophy, and disrupted FC, reflecting both peripheral and central neural alterations. Multimodal MRI may provide new insights into CRS-OD pathophysiology, warranting further longitudinal studies.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"188-196"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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