IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin24.509

A-S Viskens, L Bollens, E Borgers, S Halewyck, V Hox, M Jorissen, W Lemmens, F Rogister, K Speleman, L Van Gerven, O Vanderveken, B Verhaeghe, A Vroegop, K Martens, P W Hellings

{"title":"Effect of biological treatment in uncontrolled severe chronic rhinosinusitis with nasal polyps in Belgium: a multicentre real-world data study.","authors":"A-S Viskens, L Bollens, E Borgers, S Halewyck, V Hox, M Jorissen, W Lemmens, F Rogister, K Speleman, L Van Gerven, O Vanderveken, B Verhaeghe, A Vroegop, K Martens, P W Hellings","doi":"10.4193/Rhin24.509","DOIUrl":"https://doi.org/10.4193/Rhin24.509","url":null,"abstract":"Background: Double-blinded placebo-controlled trials have revealed the efficacy of mepolizumab and omalizumab in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world efficacy (RWE) data, data on therapeutic response and level of disease control for both biologicals are lacking.Methodology: 167 patients with uncontrolled severe CRSwNP, meeting national reimbursement criteria, were included with follow-up over 24 weeks. Primary outcomes included changes in nasal congestion (NCS), nasal polyp score (NPS), VAS-scores, SNOT-22, ACQ-5, and AQLQ scores. Secondary outcomes were therapeutic response and disease control according to EUFOREA/EPOS criteria.Results: Of the 167 CRSwNP patients, 144 received mepolizumab and 23 omalizumab. After 24 weeks, Patient reported outcomes and NPS significantly improved for both biologicals, with significant effects seen at 12 weeks, with further reduction in NPS by 24 weeks in mepolizumab patients. 74% of patients on omalizumab and 81% of patients on mepolizumab continued their therapy beyond 24 weeks, with 47% and 45% of patients on omalizumab and mepolizumab respectively showing an excellent therapeutic response, with only one out of seven having no/poor response. Disease control was reached in one third of the patients at 24 weeks.Conclusions: Both mepolizumab and omalizumab significantly improved patient-reported outcomes after 24-weeks, with major effects already observed at 12 weeks. Follow-up beyond 24-weeks might reveal additional effects on both control and remission.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial. 嗅觉训练治疗COVID-19相关嗅觉丧失：一项随机双盲对照试验

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin24.081

T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano

{"title":"Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial.","authors":"T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano","doi":"10.4193/Rhin24.081","DOIUrl":"https://doi.org/10.4193/Rhin24.081","url":null,"abstract":"Background: Olfactory training is the most widely recommended treatment for smell loss; however, there are no randomised placebo-controlled trials evaluating its effectiveness in COVID-19. We aimed to evaluate the efficacy of isolated training and factors associated to olfactory recovery.Methods: This is a prospective randomised double-blind controlled trial, using standard olfactory training (OT) and placebo (PB) in COVID-19 patients experiencing smell loss. They were followed up for 180 days and assessed with the Connecticut olfactory test (CCCRC) and with subjective methods on a monthly basis.Results: A total of 123 participants completed follow-up: 68 in the OT group and 55 in the PB group. Overall, 84.5% achieved normosmia, with full recovery (FR) significantly higher in PB. At baseline, OT had lower olfactory scores and higher corticosteroid use. Multivariate analysis showed no significant differences in outcomes between groups. Baseline olfactory test scores were the strongest predictors of recovery. Exploratory analyses stratified participants by time to treatment initiation (early ≤ 30 days; late > 30 days), showing a 58% higher chance of FR in the early group for similar CCCRC scores, regardless of management type.Conclusions: OT is not superior to PB for treating COVID-19-related smell loss. Better results of first evaluation indicate great chance of full recovery and the use of systemic corticosteroid, in persistent olfactory loss, has not affected outcome.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review. 中药治疗急慢性鼻窦炎的系统综述。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin23.526

K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis

{"title":"Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review.","authors":"K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis","doi":"10.4193/Rhin23.526","DOIUrl":"https://doi.org/10.4193/Rhin23.526","url":null,"abstract":"Background: Traditional medicine and herbal medicine are relatively commonly utilized by patients for the treatment of acute (ARS) and chronic rhinosinusitis (CRS). The aim of this study is to review the literature to evaluate scientific evidence regarding the use of herbal preparations in the treatment of rhinosinusitis.Methodology: We reviewed all published studies until February 2024 in PubMed, EMBASE, and Cochrane, using the followingkeywords: herbal medicine and nasal diseases, herbs and nasal diseases, Traditional Chinese Medicine (TCM) and nasal diseases, traditional medicine and nasal diseases, phytotherapy and nasal diseases.Results: Thirty-three clinical studies met the purpose of this review and were assessed. These studies examine the effect of eleven herbal preparations for the treatment of ARS and CRS.Conclusions: Herbal preparation BNO-1016 presents significant evidence in the literature regarding its use in the treatment of ARS, while the TCM preparation Xiangju might be a useful component in the treatment of CRS. Specific traditional herbal medicinal products, therefore, show promising results for the treatment of rhinosinusitis, and their use should be examined further. Given the relatively high demand for medicinal herbs, therapeutic use of those preparations should be explored further.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world observational data on olfactory dysfunction of the Smell & Taste Clinic of UZ Leuven (Belgium) from 2021-2024. 鲁汶大学（比利时）嗅觉与味觉诊所2021-2024年嗅觉功能障碍的真实世界观察数据

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin23.383

M Clijsters, S Bischoff, J van Waterschoot, E Hens, V Nyongesa, P Van Bulck, M Jorissen, L Van Gerven

{"title":"Real-world observational data on olfactory dysfunction of the Smell & Taste Clinic of UZ Leuven (Belgium) from 2021-2024.","authors":"M Clijsters, S Bischoff, J van Waterschoot, E Hens, V Nyongesa, P Van Bulck, M Jorissen, L Van Gerven","doi":"10.4193/Rhin23.383","DOIUrl":"10.4193/Rhin23.383","url":null,"abstract":"Background: The COVID-19 pandemic led to a surge in olfactory dysfunction (OD), increasing the need for specialized care. Thi study explores the prevalence, characteristics, and clinical implications of OD in a specialized Smell & Taste Clinic established at the ENT-HNS department of the University Hospitals Leuven (UZ Leuven) in 2021.Methodology: We included consecutive patients with OD in the observational longitudinal ProspeRoâ€™Scent registry at UZ Leuven between September 2021 and April 2024. Chemosensory assessment was done with psychophysical tests (Sniffinâ€™ Sticks TDI and Taste sprays) and questionnaires.Results: Of the 203 unique, consecutive patients, COVID-19-associated OD (C19OD) was the predominant etiology (50.2%), followed by idiopathic (25.1%), and post-traumatic (8.9%) OD. Parosmia was present in 60.2% of patients, with the highest prevalence in C19OD cases (80.9%). Sniffinâ€™ Sticks TDI testing indicated that patients with parosmia had better olfactory thresholds and discrimination scores than patients without. During follow-up (n=116; average 7.7 months), 31% of C19OD patients exhibited clinically relevant improvement in TDI scores, compared to 13% for the other etiologies. Quality of life, as assessed by sQOD-NS, was not significantly different between etiologies but correlated with higher parosmia scores.Conclusions: C19OD patients suffered more from parosmia, correlating with worse quality of life, but had better baseline TDI scores and demonstrated a higher likelihood of clinically relevant improvement over time compared to other etiologies.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"163-171"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Budesonide nasal irrigation for chronic rhinosinusitis: a meta-analysis of therapeutic outcomes and safety profile. 布地奈德鼻腔冲洗治疗慢性鼻窦炎：治疗结果和安全性的荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.349

N Magboul, A F Alharbi, A T Alqutub, S Almatrafi, A Alroqi, S H Aldousary, S R Alromaih, A S Alrasheed, S A Alsaleh

{"title":"Budesonide nasal irrigation for chronic rhinosinusitis: a meta-analysis of therapeutic outcomes and safety profile.","authors":"N Magboul, A F Alharbi, A T Alqutub, S Almatrafi, A Alroqi, S H Aldousary, S R Alromaih, A S Alrasheed, S A Alsaleh","doi":"10.4193/Rhin24.349","DOIUrl":"10.4193/Rhin24.349","url":null,"abstract":"Background: Corticosteroids are used in managing Chronic Rhinosinusitis (CRS) through several formulations, including oral steroids and nasal sprays. More recently, incorporating concentrated budesonide respules into high-volume saline irrigations has been proposed to enhance the penetration of topical steroids into the paranasal sinuses. We aim to evaluate the safety and efficacy of budesonide nasal irrigation (BNI) in managing CRS.Methodology: A systematic review with meta-analysis was performed following PRISMA guidelines. Data were extracted independently from the eligible studies. In double-arm and single-arm meta-analyses, continuous outcomes were pooled using mean difference (MD) with a 95% confidence interval (CI).Results: Twenty-six studies were reviewed, comprising 1464 patients. BNI had better outcomes than saline nasal irrigation (SNI) regarding Sino-Nasal Outcome Test score (SNOT-22). Lund-Kennedy Endoscopy scores (LKES) changed from baseline. Regarding safety, there was no significant difference between BNI and SNI regarding Intraocular Pressure (IOP). Single-arm analysis showed a pooled mean serum cortisol level within the normal range after BNI.Conclusions: BNI demonstrated improved SNOT-22 and LKES scores, with normal post-treatment IOP and cortisol levels, indicating a beneficial impact on CRS while maintaining safety.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"130-144"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery. 运动分析对内窥镜鼻窦手术精神运动技能的客观评价。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin22.320

K Miyaji, M Suzuki, R Watanabe, K Matoba, A Nakazono, Y Nakamaru, K Ebina, T Abe, D Hinder, A J Psaltis, P J Wormald, A Homma, A Konno

{"title":"Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery.","authors":"K Miyaji, M Suzuki, R Watanabe, K Matoba, A Nakazono, Y Nakamaru, K Ebina, T Abe, D Hinder, A J Psaltis, P J Wormald, A Homma, A Konno","doi":"10.4193/Rhin22.320","DOIUrl":"10.4193/Rhin22.320","url":null,"abstract":"Background: This study aims to digitalize surgical maneuvers in ESS using a motion capture system under standardized conditions provided by 3D printed-sinus models.Methodology: Forty-seven otolaryngologists performed ESS on 3D printed models manufactured from computed tomography (CT) images of actual patients. Participants were classified to 3 groups according to the objective structured technical skills assessment score. All surgical maneuverers performed during ESS were captured by a motion capture system. The path length, velocity, acceleration, and jerk were calculated for each surgical instrument and compared among the groups. Principle Component Analysis (PCA) was utilized to identify which metrics reflected surgical skill level. In addition, ten registrars repeated the surgical dissection. Their motion metrics were also compared between first training and the repeated training and then subjected to the PCA.Results: Several metrics such as the angular acceleration and jerk of the cutting forceps were identified by PCA as possible indicators distinguishing the different skill levels for the ESS maneuvers. PCA analysis in the repetitive training also found the angular metrics of the upturned-cutting forceps correlating to their skill improvement.Conclusions: Combined with the validated 3D-printed sinus models, the motion capture system provided the objective evaluation of the surgical performances of ESS.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"190-199"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the Sino-Nasal Outcome Test-25 (SNOT-25) measure for patients with nasal septal perforation. 鼻中隔穿孔患者的鼻结果测试-25 （SNOT-25）测量的验证。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.443

S P Williams, S C Leong

引用次数: 0

Remission in chronic rhinosinusitis with nasal polyps (CRSwNP). 伴有鼻息肉的慢性鼻炎（CRSwNP）病情缓解。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.457

P W Hellings, E De Corso, V Backer, M Bernal-Sprekelsen, Y Chan, D M Conti, M E Cornet, W J Fokkens, P Gevaert, J Han, C Hopkins, B N Landis, S Lau, S Lee, V J Lund, J Mullol, A Peters, S Schneider, B Senior

引用次数: 0

Patient preferences for treatment of chronic rhinosinusitis with nasal polyps. 患者对治疗伴有鼻息肉的慢性鼻窦炎的偏好。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.475

J Sutphin, S Okafor, S D Reed, A Deb, J Silver, M J Wallace, J-C Yang, R Abi Hachem, D W Jang

引用次数: 0

Advanced paranasal sinuses osteomas: a retrospective multicentric analysis on surgical management outcomes and intra- and postsurgical complications. 晚期鼻窦骨瘤：对手术治疗结果和手术内及术后并发症的回顾性多中心分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.165

V Rampinelli, M Ferrari, I Dohin, A Vinciguerra, D Mattavelli, T Saccardo, G Testa, C Conti, C Frigerio, B Verillaud, G Ajasllari, P Gaudioso, D Cazzador, A Aga, S Taboni, A Daniele Arioso, L Neri, D Borsetto, A Wolf, C Rodriguez-Van Strahlen, M Turri-Zanoni, E Emanuelli, A Schreiber, P Battaglia, F Pagella, M Bignami, C Piazza, P Castelnuovo, P Nicolai, P Herman

{"title":"Advanced paranasal sinuses osteomas: a retrospective multicentric analysis on surgical management outcomes and intra- and postsurgical complications.","authors":"V Rampinelli, M Ferrari, I Dohin, A Vinciguerra, D Mattavelli, T Saccardo, G Testa, C Conti, C Frigerio, B Verillaud, G Ajasllari, P Gaudioso, D Cazzador, A Aga, S Taboni, A Daniele Arioso, L Neri, D Borsetto, A Wolf, C Rodriguez-Van Strahlen, M Turri-Zanoni, E Emanuelli, A Schreiber, P Battaglia, F Pagella, M Bignami, C Piazza, P Castelnuovo, P Nicolai, P Herman","doi":"10.4193/Rhin24.165","DOIUrl":"10.4193/Rhin24.165","url":null,"abstract":"Background: This study examines the management and outcomes of large paranasal sinus osteomas (PSO), especially those abutting or encasing critical structures of the skull base and orbit.Methodology: A multicentric retrospective analysis was conducted between June 2007 and September 2023. The study included surgically treated (regardless the type of approach chosen) PSO, exceeding 3 cm in diameter and/or located in critical anatomical areas. An analysis was performed to assess the association between the critical relationships, size, presence of residual disease, and incidence of intra- and postoperative complications.Results: The series included 160 patients. Most PSO were diagnosed due to clinical symptoms, predominantly for those located in the frontal sinus. Residual disease was observed in 9.4% of patients, with its occurrence influenced by PSO size and relationships with specific anatomical structures. Thirty-five/160 (21.9%) of patients experienced one or more intra-and/or postoperative complications. Intraoperative complications were associated with the proximity of PSO to the cribriform plate. Long-term complications were more frequently observed in cases involving the anterior and posterior plate of the frontal bone.Conclusions: This study highlights the complexities involved in managing large PSO, demonstrating that size and anatomical relationships of these osteomas can critically influence surgical decisions, residual disease, and complication rate. The study's retrospective design limited the collection of standardized symptom outcomes, highlighting the need for future studies to address this apect.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"209-220"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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