Rhinology最新文献

{"title":"EBV genome-guided transcriptomic re-annotation reveals molecular subtypes of nasopharyngeal carcinoma informing prognosis and treatment.","authors":"Q Ding, Y Pan, W Lin, H Yang, X Chen, H Li, Y Weng, S Qiu","doi":"10.4193/Rhin25.274","DOIUrl":"https://doi.org/10.4193/Rhin25.274","url":null,"abstract":"<p><strong>Background: </strong>Non-keratinizing nasopharyngeal carcinoma (NPC) is closely related to Epstein-Barr virus (EBV) infection. Patients with NPC often exhibit diverse treatment responses due to tumor heterogeneity. Thus, identifying molecular subgroups based on EBV involvement holds promise for refining personalized treatment strategies and improving treatment outcomes in NPC patients.</p><p><strong>Methods: </strong>193 treatment-naïve NPC specimens with comprehensive clinical and pathological data were procured from Fujian Cancer Hospital. RNA sequencing was employed to acquire the gene expression profiles, followed by the re-annotation of 100 EBV-associated genes leveraging the EBV sequence. Molecular subtypes were conducted via consensus clustering, with an external NPC cohort serving as a validation dataset. Scissor method was applied to identify survival-associated cell subpopulations from single-cell data, following comprehensive bioinformatic analyses.</p><p><strong>Results: </strong>Three molecular subtypes of NPC-CoriLyt, Cneg, and CEB1-were identified, each with specific clinical profiles. The CEB1 subtype is distinguished by its heightened metabolic activity and immunosuppressive environment. A hub-gene-based risk model for these subtypes strongly predicted disease-free survival, with replicated results in the validated cohort. The model's predictive accuracy was high, with areas under the curve for 1, 3, and 5-year survival rates at 0.79, 0.86, and 0.88, respectively. M2-type macrophages exhibit a high-risk score profile and play a critical role in EBV infection, with prominent activation of the TNF-II and TGF-β signaling pathways.</p><p><strong>Conclusions: </strong>This study introduced a new EBV-related transcriptomics-based classification system for NPC that showed great promise in predicting patient survival outcomes.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional anatomy of the junction between the posterior ethmoidal region and the sphenoid sinus.","authors":"M Eördögh, A A Menabbawy, L Bárány, M Kirsch, R Reisch, G Baksa, H W S Schroeder, W Hosemann, H R Briner","doi":"10.4193/Rhin24.565","DOIUrl":"https://doi.org/10.4193/Rhin24.565","url":null,"abstract":"<p><strong>Background: </strong>The anatomy of the sphenoethmoidal recess is of clinical importance, however, the literature focuses on the superior turbinate and the sphenoid ostium. We analyzed the entire junction of the posterior ethmoidal region and the sphenoid sinus (SEJ) to define possible regularities.</p><p><strong>Methods: </strong>We analyzed the junction between the posterior ethmoidal region and the sphenoid sinus on CT scans of 100 paranasal sinuses from 50 individuals using the 3D Slicer software.</p><p><strong>Results: </strong>The SEJ had two components: medially the sphenoethmoidal recess, laterally the wall between these aeriated regions, the latter built by the basal lamella of the superior turbinate (4BL) in 92.0%. The 4BL was a constant structure (100.0%), its most frequent phenotype was a frontally oriented pentangular wall without dehiscences (44.0%). There were no bony walls between the 3BL and the anterior wall of the sphenoid sinus in 49.0% and there was one wall in 42.0%. The 4BL had three complicating factors: firstly, it shifted to anterior, if the supreme turbinate was present (43.0%). Secondly, the pneumatization of the 4BL and the superior turbinate (25.0%) was related to an incomplete-dehiscent anterior 4BL wall. Thirdly, sphenoethmoidal cells (36.0%) led to a bony contact of the optic canal and the 4BL (33.0%).</p><p><strong>Conclusions: </strong>The 4BL is an important landmark for endoscopic sinus and skull base surgery with highly constant morphology and a typical phenotype. Surgeons should be aware that after dissection of the 3BL the next wall is likely the 4BL which mostly merges to the ASW. This study can help surgeons to detect anatomical variations and improve their intraoperative orientation.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nasal cytology in the evaluation of candidates for olfactory implantation.","authors":"M Gelardi","doi":"10.4193/Rhin25.459","DOIUrl":"https://doi.org/10.4193/Rhin25.459","url":null,"abstract":"<p><p>I read with great interest the recent consensus document on olfactory implants (1). This excellent and comprehensive work represents a significant milestone in the translational pathway towards sensory neuroprostheses for patients with persistent olfactory dysfunction (OD).</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"endoscoRegional disparities in cost-effectiveness of biologics for CRSwNP warrant tailored treatment strategies.","authors":"M Xian, C Wang, L Zhang","doi":"10.4193/Rhin25.291","DOIUrl":"https://doi.org/10.4193/Rhin25.291","url":null,"abstract":"<p><p>We read with great interest the recent study by Fieux et al. (1), which developed an evaluation model based on clinical practices, public health insurance, and private insurance systems in France. Through rigorous cost-effectiveness analysis, the authors concluded that initiating biologic therapy in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) without previous endoscopic sinus surgery (ESS) imposes excessive economic burdens. This finding aligns with the current guideline regarding the indications for biological treatment in CRSwNP, which reserves biologics primarily for patients with prior ESS history.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroinflammation and neural activity in the olfactory bulb drives olfactory dysfunction in a rat model of eosinophilic chronic rhinosinusitis.","authors":"Z Zhang, Y Du, S Xiong, W Cao, H Jiang, J Wang, M Li, Y Hu, F Ma, Y Zhang","doi":"10.4193/Rhin25.164","DOIUrl":"https://doi.org/10.4193/Rhin25.164","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is a common cause of olfactory dysfunction (OD), and eosinophilic CRS is one of the subtypes characterized by eosinophilic infiltration. Animal models of olfactory dysfunction in eosinophilic CRS are necessary for exploring potential therapeutic strategies. Glucocorticoids are therapeutic for eosinophilic CRS-OD and the mechanism of action requires further exploration.</p><p><strong>Methodology: </strong>The eosinophilic CRS-OD rat model was induced by intranasal administration of ovalbumin (OVA) and Aspergillus oryzae protease (AP) for 8 weeks, followed by intraperitoneal injection of dexamethasone. Olfactory function was assessed behaviorally, neuronal activity electrophysiologically, and neurotransmitter/inflammatory factor levels via high-performance liquid chromatography (HPLC). Histological analyses of nasal tissue and the olfactory bulb were performed.</p><p><strong>Results: </strong>All OVA/AP-induced eosinophilic CRS-OD rats developed chronic nasal inflammation and olfactory dysfunction. Reduced olfactory bulb (OB) volume was accompanied by thinning of the olfactory neuron layer (ONL) and the glomerular layer (GL). The OB exhibited increased microglia and elevated inflammatory cytokine expression. Further analysis revealed decreased glutamate (Glu), increased γ-aminobutyric acid (GABA), and a significant reduction in the spontaneous firing rate (SFR) of mitral/tufted cells (M/Ts) within the OB. Dexamethasone treatment significantly ameliorated olfactory impairment in this model, decreasing OB microglia numbers and inflammatory cytokine levels, and significantly increasing M/T SFR.</p><p><strong>Conclusions: </strong>Microglia-mediated neuroinflammation contributes to abnormal neural activity in the olfactory bulb, which may be one mechanism for the development of eosinophilic CRS-OD. The neuroprotective effect of dexamethasone, mediated through microglial inhibition, highlights microglia as an important therapeutic target for eosinophilic CRS-OD.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Web-application guided bimodal olfactory training for COVID-19 patients: a randomized trial.","authors":"C Vandersteen, M Payne, C Becker, S Bernier, A Derreumaux, N Guevara, L Castillo, A Plonka, V Manera, X Fernandez, A Gros","doi":"10.4193/Rhin24.273","DOIUrl":"https://doi.org/10.4193/Rhin24.273","url":null,"abstract":"<p><strong>Background: </strong>Many Post-Acute COVID-19 Syndrome (PACS) patients continue to experience persistent dysosmia up to two years post-pandemic. Cognitive and semantic memory functions, along with olfactory associative areas, may be affected in PACS without olfactory recovery. Visual-olfactory bimodal olfactory training may stimulate these areas. This study evaluates the olfactory recovery using a new bi-modal training kit, MaMadeleine™, assisted by a web application.</p><p><strong>Methodology: </strong>A prospective randomised study (Nov 2021-June 2022) included PACS patients aged ≥14 with post-infectious olfactory dysfunction. Patients were randomized for two months of simple (A) or semantic (B) visual-olfactory training. Evaluations included clinical assessments, Sniffin' Sticks Tests, and quality-of-life questionnaires. Adherence to treatment was monitored via the web application.</p><p><strong>Results: </strong>We included 83 patients, on average 13±5.6 months after COVID-19. Olfactory training using MaMadeleine™ led to subjective orthoand retro-nasal olfactory improvement in 79.4% (n=58) and 58.9% (n=43) of patients, respectively, with Sniffin' Sticks Test scores increasing from 26.5±7.5 to 29.1±7.4. Both groups saw a 20% decrease in parosmia and phantosmia. No significant differences in recovery were observed between groups, although exploratory findings in a small subgroup (n=10) with semantic memory impairment suggest a possible benefit of bimodal training, warranting further investigation. Quality of life improved significantly in both groups. Adherence was better in group B than in group A.</p><p><strong>Conclusions: </strong>MaMadeleine™ training improves subjective olfactory function, psychophysical test results, and quality of life in PACS patients with olfactory dysfunction. Multimodal training enhances adherence. Further studies are needed in semantic memory-impaired patients.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving sleep in severe CRSwNP: an RCT on the effect of mepolizumab and FESS on OSA, sleep disturbances and quality of life.","authors":"A S Homøe, E K Kiaer, K Aanæs, J Tidemandsen, P Jennum, V Backer","doi":"10.4193/Rhin25.228","DOIUrl":"https://doi.org/10.4193/Rhin25.228","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) often leads to poor sleep quality and fatigue. Many patients with CRSwNP are also at risk for obstructive sleep apnea (OSA). This study examined how mepolizumab and/or endoscopic sinus surgery (FESS) affect sleep quality and OSA in patients with severe uncontrolled CRSwNP.</p><p><strong>Methods: </strong>In a randomised trial with 58 patients, participants received mepolizumab alone or combined with FESS. Sleep quality was measured using FOSQ-10 and ESS, and OSA severity via AHI from home sleep apnea tests.</p><p><strong>Results: </strong>At baseline, 70% of participants had OSA (AHI ≥ 5), with 34.6% having moderate-to-severe OSA. After six months, there were significant improvements in sleep quality (SNOT-22, FOSQ-10, ESS) in both groups but no significant change in objective OSA measures (AHI, ODI). Patients with OSA showed a reduction in severity, however non-significant. There were no severe adverse events (SAE) during the follow-up.</p><p><strong>Conclusions: </strong>Mepolizumab, with or without FESS, improved subjective sleep quality and reduced fatigue but did not significantly affect OSA severity. This suggests that while treatment eases sleep-related symptoms, it may not resolve underlying OSA, particularly in more severe cases.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhino(septo)plasty Informed Consent. Consensus by the European Rhinoplasty Course Faculty-EUFOREA.","authors":"P W Hellings, D Bertossi, C Cingi, S Claeys, J Constantinidis, D M Conti, A D'Souza, F Declau, H Foda, W Fokkens, P Gevaert, W Gubisch, S Halewyck, G Lekakis, G Liva, A Mesbahi, C Mcintosh, G Nolst Trenite, V Picavet, E Prokopakis, E Robotti, S Vandenbroeck, A Van Hoolst, T Vansweevelt, W Wagner","doi":"10.4193/Rhin24.204","DOIUrl":"10.4193/Rhin24.204","url":null,"abstract":"<p><strong>Background: </strong>Patients seeking rhino(septo)plasty need to be adequately informed by their surgeon or surgical team members about the procedure, the expected outcomes, complication risks and post-operative care, and the available alternatives. A consensus on the content of an informed consent in rhino(septo)plasty is currently lacking despite the high unmet need.</p><p><strong>Methodology: </strong>The extended international faculty of the European Rhinoplasty Course in Brussels organized by EUFOREA has generated an overview of the current literature on rhinoplasty outcomes and complication rates, and available informed consents. A proposal for informed consent was elaborated, consensus reached and checked for legal validity.</p><p><strong>Results: </strong>An overview of reported outcomes and complication rates of rhino(septo)plasty are provided. Additionally, contents of existing consent forms for rhino(septo)plasty surgery are compared with requirements found in literature on informed consent, leading to a proposal of informed consent including relevant information according to expert consensus.</p><p><strong>Conclusions: </strong>An informed consent form for rhino(septo)plasty is proposed by the international faculty of the European Rhinoplasty Course, that might serve rhinoplasty surgeons in the development of their informd consent documents.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"523-533"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective cohort study comparing the effects of different middle turbinate treatments on olfactory function recovery in CRSwNP patients after FESS.","authors":"F Jian, J Lao, R Ge, Q Yang, S Wu","doi":"10.4193/Rhin24.320","DOIUrl":"10.4193/Rhin24.320","url":null,"abstract":"<p><strong>Background: </strong>The factors affecting postoperative olfactory recovery in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear. This study explores postoperative pathological classification and the impact of different middle turbinate management strategies on olfactory recovery.</p><p><strong>Methodology: </strong>Seventy-two CRSwNP patients undergoing functional endoscopic sinus surgery (FESS) with ≥6 months follow-up were classified into eosinophilic (ECRSwNP) and non-eosinophilic (nECRSwNP) groups. Based on middle turbinate management, patients were further divided into resection (partial/complete) and preservation groups. Olfactory scores, clinical characteristics, and nasal endoscopy findings were analyzed, and multifactorial analysis identified factors influencing olfactory recovery.</p><p><strong>Results: </strong>TDI scores in the ECRSwNP group remained lower than those in the nECRSwNP group preoperatively and postoperatively. However, olfactory score improvement and the proportion of significantly improved patients did not differ significantly between the two groups. Middle turbinate management was associated with greater olfactory improvement, particularly in nECRSwNP patients. Although the complete middle turbinate resection group had lower preoperative olfactory scores than the partial resection group, no significant difference was observed in postoperative olfactory improvement between the two approaches.Higher preoperative polyp scores and middle turbinate management predicted olfactory improvement.</p><p><strong>Conclusions: </strong>FESS significantly improves the olfactory function in CRSwNP patients, and the extent of olfactory improvement is independent of pathological type. Patients with higher preoperative Lildholdt polyp scores and those who underwent middle turbinate management during FESS were more likely to exhibit improved olfactory function at 6 months postoperatively.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"551-564"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonality in the incidence of acute sinusitis, air pollutant levels, and climate.","authors":"S-H Hung, Y-F Cheng, H-C Lin, C-S Chen","doi":"10.4193/Rhin25.054","DOIUrl":"10.4193/Rhin25.054","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging evidence from epidemiological studies highlights the interaction between air quality metrics and sinusitis occurrence. This study investigates the relationship between acute sinusitis incidence, air pollutant levels, and climatic conditions in Taiwan from 2008 to 2017.</p><p><strong>Methods: </strong>This study extracted outpatient claims data from the Longitudinal Health Insurance Database 2010. We computed seasonal incidence rates of acute sinusitis episodes per 1000 population over 120 months, stratifying the data by gender and three age groups: 20-44, 45-64, and 65 years and older. Addressing the seasonal variability inherent in our dataset, we utilized Auto-Regressive Moving Average (ARMA) models to analyze each variable as a univariate time series influenced by its historical values.</p><p><strong>Results: </strong>The analysis reveals that, except relative humidity, all other climatic factors including CO, NO2, SO2, PM10, O3, ambient temperature and rainfall demonstrated significant crude correlations with the rates of acute sinusitis. The ARIMA test suggested that seasonality plays a significant role in influencing sinusitis episodes across all age groups. Specifically, individuals experience significantly higher incidence rates during winter compared to spring. These findings underscore winter as a period with notably higher incidence rates of acute sinusitis, even after adjusting for meteorological and air pollution variables.</p><p><strong>Conclusions: </strong>This study provides comprehensive evidence of the significant associations between acute sinusitis incidence, air quality, and climatic factors in Taiwan.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"576-583"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}