Rhinology最新文献_第2页

Distinct inflammatory features and nasal TH2 cell profiles in allergic patients with chronic rhinosinusitis. 慢性鼻窦炎变应性患者明显的炎症特征和鼻腔TH2细胞谱

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.195

H Bae, G Kim, S Lee, M-S Koo, H-J Cho, C-H Kim, M-S Rha

{"title":"Distinct inflammatory features and nasal TH2 cell profiles in allergic patients with chronic rhinosinusitis.","authors":"H Bae, G Kim, S Lee, M-S Koo, H-J Cho, C-H Kim, M-S Rha","doi":"10.4193/Rhin25.195","DOIUrl":"10.4193/Rhin25.195","url":null,"abstract":"Background: Various factors affect the immunopathogenesis of chronic rhinosinusitis (CRS). Although the relationship between allergies and CRS has attracted considerable attention, it remains controversial. Notably, little is known about whether the clinical characteristics and immunological profiles differ based on allergic sensitization status among patients with CRS.Methodology: This study included 209 patients with CRS with nasal polyps (CRSwNP) who underwent endoscopic sinus surgery, and their nasal polyp tissues were obtained. Patients were divided into two groups according to allergic sensitization status: \"allergic\" and \"non-allergic\" groups. The clinical characteristics and immunological profiles were compared between the two groups. Ex vivo phenotypes of nasal CD4+ T cells were analyzed using flow cytometry.Results: Compared to the non-allergic group, the allergic group exhibited a significantly higher prevalence of comorbid asthma, serum total IgE levels, SNOT-22 scores, JESREC scores, blood/ tissue eosinophil counts, the proportion of eosinophilic histologic type, and lower gustatory function test scores. Additionally, the frequencies of nasal T helper 2 (TH2) and proallergic TH2 (TH2A) cells were significantly higher in the allergic group than in both the non-allergic and the control groups, and these frequencies were significantly correlated with eosinophilic inflammation.Conclusions: Our study demonstrates that allergic sensitization is closely associated with eosinophilic inflammation, as indicated by elevated levels of blood/tissue eosinophils and nasal TH2A cells, and by worse symptom scores in CRSwNP. Given the distinct immunological features of allergic patients, considering allergic sensitization within nasal tissue when managing CRSwNP is crucial.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"197-205"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling nasal trigeminal sensitivity to predict outcomes after nasal obstruction surgery. 分析鼻三叉神经敏感性预测鼻塞手术后的预后。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.306

M Saro-Buendia, M Mata, A Garcia-Pinero, L Milian, P Suarez-Urquiza, M Armengot-Carceller

{"title":"Profiling nasal trigeminal sensitivity to predict outcomes after nasal obstruction surgery.","authors":"M Saro-Buendia, M Mata, A Garcia-Pinero, L Milian, P Suarez-Urquiza, M Armengot-Carceller","doi":"10.4193/Rhin25.306","DOIUrl":"10.4193/Rhin25.306","url":null,"abstract":"Background: Predicting symptom improvement after nasal airway obstruction surgery remains difficult, as objective airflow metrics correlate poorly with patient-reported outcomes. Since trigeminal afferents are key in sensing nasal airflow, this study evaluated whether individual differences in nasal chemosensory functionâ€\"particularly trigeminal sensitivityâ€\"are associated with subjective airflow perception and predict outcomes in patients undergoing surgery for nasal obstruction.Methodology: A prospective cohort study was conducted in 43 participants (32 patients with nasal airway obstruction scheduled for surgery, 11 healthy controls). Trigeminal sensitivity was assessed using measures including the menthol lateralisation detection thresholds, TRPV1/TRPM8 gene expression, and the trigeminal subtest of the Barcelona Smell Test-24. Olfactory and gustatory function were also evaluated. Nasal obstruction perception was measured pre- and postoperatively using the NOSE-e questionnaire and a visual analogue scale. Patients were followed for a mean of 10.9 months.Results: Trigeminal sensitivity did not differ significantly between patients and controls. However, baseline trigeminal Barcelona Smell Test-24 scores correlated with greater improvement in NOSE-e scores and satisfaction. Patients with NOSE-e improvement >6 points had lower baseline trigeminal scores than those with lesser gains. No other baseline chemosensory measures were correlated with postoperative outcomes.Conclusions: Trigeminal sensitivityâ€\"particularly as assessed by the Barcelona Smell Test-24 testâ€\"may serve as a predictor of both symptom improvement and overall satisfaction after surgery for nasal airway obstruction, underscoring the importance of sensory processing in shaping patient-perceived surgical outcomes.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"206-214"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional disparities in cost-effectiveness of biologics for CRSwNP should not modify the strategy. CRSwNP生物制剂成本效益的地区差异不应改变该策略。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.548

M Fieux, F Carsuzaa, M Chang, P H Hwang, Z M Patel, S Tringali, V Favier, J Margier

引用次数: 0

Integrated omics-based analysis reveals distinct microbial-metabolite interaction networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps in a Chinese population. 综合组学分析揭示了中国人群嗜酸性粒细胞和非嗜酸性粒细胞慢性鼻窦炎伴鼻息肉中不同的微生物-代谢物相互作用网络。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.166

H Zhang, X Zi, X Li, T Gao, H Zhang, H Zhang, X Liang, L Zhi, P Jin

{"title":"Integrated omics-based analysis reveals distinct microbial-metabolite interaction networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps in a Chinese population.","authors":"H Zhang, X Zi, X Li, T Gao, H Zhang, H Zhang, X Liang, L Zhi, P Jin","doi":"10.4193/Rhin25.166","DOIUrl":"10.4193/Rhin25.166","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition often classified into eosinophilic (Eos) and non-eosinophilic (nonEos) subtypes. While microbial dysbiosis and metabolic disturbance are known contributors to CRSwNP, the interplay between sinonasal microbiota and local metabolic activity remains unclear.Methods: We conducted 16S rRNA gene sequencing and untargeted metabolomics on sinonasal swabs and tissue samples from patients with Eos-CRSwNP (n = 14), nonEos CRSwNP (n = 7), and healthy controls (n = 14). Microbial diversity, taxonomic differences, and metabolic alterations were analyzed. Spearman correlation and network modeling were used to explore phenotype-specific microbiotaâ€\"metabolite interactions and pathway enrichment.Results: Eos CRSwNP was characterized by reduced microbial diversity and increased abundance of Staphylococcus and Corynebacterium, along with elevated levels of fumaric acid, linoleic acid, and arachidonic acidâ€\"metabolites linked to oxidative stress and lipid-mediated inflammation. In contrast, nonEos-CRSwNP exhibited greater microbial richness, with enrichment of Streptococcus, Anaerococcus, and Clostridium XlVa, and metabolic shifts in amino acid and nitrogen metabolism, including increased glutamine, taurine, and ethanolamine phosphate. Correlation analysis revealed phenotype-specific networks connecting core microbial genera and metabolites, suggesting distinct inflammatory microenvironments between subtypes.Conclusion: Our integrated multi-omics analysis highlights divergent microbial and metabolic signatures in Eos and nonEos CRSwNP. These findings offer mechanistic insights into subtype-specific disease processes and may guide the future development of targeted diagnostic and therapeutic strategies.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"248-258"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-dose steroid nasal spray is better than nasal irrigation in nonoperated chronic rhinosinusitis: a randomized clinical trial. 大剂量类固醇鼻喷雾剂治疗非手术性慢性鼻窦炎优于鼻冲洗：一项随机临床试验。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin24.532

G R Lima Luz-Matsumoto, E Cabernite Marchetti, L Lobato Gregorio, F Mesquita Callegari, E Macoto Kosugi

{"title":"High-dose steroid nasal spray is better than nasal irrigation in nonoperated chronic rhinosinusitis: a randomized clinical trial.","authors":"G R Lima Luz-Matsumoto, E Cabernite Marchetti, L Lobato Gregorio, F Mesquita Callegari, E Macoto Kosugi","doi":"10.4193/Rhin24.532","DOIUrl":"10.4193/Rhin24.532","url":null,"abstract":"Background: To compare the efficacy of high-dose nasal steroid administered via high-volume irrigation versus spray delivery in patients with chronic rhinosinusitis (CRS) who have not undergone previous sinonasal surgery.Methodology: A double-blind randomized clinical trial was conducted. The study comprised two groups receiving 1,000 Î¼g/day of nasal budesonide through two distinct methods over a 3-month period: irrigation and spray delivery. Patients with severe CRS who had never undergone surgery and were on the waiting list for surgery in a public health service were included. Primary outcomes included changes in quality-of-life scores and secondary outcomes included changes in clinical control questionnaire results and nasal endoscopy findings. Assessments were conducted on the total sample, CRS with nasal polyps (CRSwNP), CRS without nasal polyps (CRSsNP), and according to the newly defined phenotypes of diffuse primary CRS (central compartment atopic disease [CCAD], eosinophilic chronic rhinosinusitis [eCRS] and non-eosinophilic CRS [neCRS]).Results: Sixth-seven patients completed the study, with 34 in the Irrigation Group and 33 in the Spray Group. The Spray Group demonstrated superior efficacy in improving endoscopic outcomes across the total sample, particularly among CRSwNP and CCAD. No treatment demonstrated superiority in improving the SNOT-22 score. Furthermore, the Spray Group revealed greater efficacy in reducing the number of uncontrolled patients, as evaluated by the clinical control questionnaire, both in the total sample and CRSwNP.Conclusions: High-dose steroid nasal spray outperformed high-volume steroid nasal irrigation in improving nasal endoscopy outcomes across the total sample, especially in CRSwNP and CCAD.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"161-170"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of ear complaints in patients with severe chronic rhinosinusitis with nasal polyps. 重度慢性鼻窦炎伴鼻息肉患者耳部主诉的患病率。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.524

H B E Elzinga, J J Otten, R J L van der Lans, P Merkus, E van Spronsen, W J Fokkens, PolyREG Consortium, S Reitsma

引用次数: 0

Association between allergic rhinitis and attention deficit hyperactivity disorder symptoms in pediatric patients: the impact of seasonal variability. 儿童患者变应性鼻炎与注意缺陷多动障碍症状之间的关系：季节变化的影响

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.185

A Sogut, A Selmanoglu, C Genis, Z Sengul Emeksiz, E Cop, E Dibek Misirlioglu

{"title":"Association between allergic rhinitis and attention deficit hyperactivity disorder symptoms in pediatric patients: the impact of seasonal variability.","authors":"A Sogut, A Selmanoglu, C Genis, Z Sengul Emeksiz, E Cop, E Dibek Misirlioglu","doi":"10.4193/Rhin25.185","DOIUrl":"10.4193/Rhin25.185","url":null,"abstract":"Backround: Allergic rhinitis (AR) patients may experience attention deficits (AD), concentration impairment, and learning difficulties. This study aimed to compare AD hyperactivity disorder (ADHD) symptoms in grass pollenâ€\"allergic AR patients and controls and to assess their seasonal variation.Methodology: The study included children aged 6â€\"12 with AR who presented to Ankara Bilkent City Hospital between April 15 and June 15 in 2022 and 2023. The Visual Analog Scale (VAS) was used to assess disease severity, and the Conners Parent Rating Scale (CPRS) was employed to evaluate ADHD symptoms. For comparison, the CPRS was also administered to an age-matched control group consisting of children without known allergies or chronic diseases.Results: The study included 146 AR patients (8.9Â±1.7 years) and 150 controls (9.0Â±1.8 years). During the grass pollen season, AR patients showed increased rates of AD, hyperactivity, and school absenteeism, along with a decline in academic performance. Compared to the control group, AR patients exhibited significantly higher AD, hyperactivity, and total CPRS scores. Logistic regression analysis identified male sex, high nasal VAS score, and snoring as independent risk factors for AD, while a high ocular VAS score was an independent risk factor for hyperactivity.Conclusions: Exacerbation of AR symptoms during the grass pollen season leads to a significant increase in ADHD symptoms and a decline in academic performance. Regular monitoring and symptom control in AR patients are crucial for maintaining academic and social success.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"179-187"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory dysfunction in CHARGE syndrome: a systematic review of prevalence, assessment methods, and clinical correlates. 嗅觉功能障碍的CHARGE综合征：患病率，评估方法和临床相关性的系统回顾。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.391

G M Spencer, K Karim, P Coyle, E K Bhargava, K L Whitcroft

{"title":"Olfactory dysfunction in CHARGE syndrome: a systematic review of prevalence, assessment methods, and clinical correlates.","authors":"G M Spencer, K Karim, P Coyle, E K Bhargava, K L Whitcroft","doi":"10.4193/Rhin25.391","DOIUrl":"10.4193/Rhin25.391","url":null,"abstract":"Background: Olfactory dysfunction (OD) is an underrecognized feature of CHARGE syndrome (CS), often associated with CHD7 mutations and structural anomalies of the olfactory system. This systematic review examines the burden, assessment methods, and clinical correlates of OD in CS.Methodology: A systematic review was conducted in accordance with PRISMA guidelines and registered with PROSPERO (CRD420251040500). A comprehensive search of six databases up to May 2025 was performed. Two independent reviewers screened, extracted data, and assessed study quality. A narrative synthesis was performed.Results: From 1,643 records, 16 studies met inclusion criteria. Most were retrospective cohort studies and employed clinical diagnostic criteria for CS, with a subset reporting CHD7 mutation data. OD was most frequently identified radiologically. Psychophysical testing and self/parent reports were less common. Neurodevelopmental delays, feeding/swallowing issues, and reduced quality of life were reported in association with OD, but causal relationships remain unclear.Conclusions: OD is highly prevalent in CS, often exceeding 80%, yet remains underrecognized. Radiologic imaging and electrophysiological techniques may be alternatives when psychophysical testing is not feasible. Future research should focus on validating paediatric-specific and developmentally appropriate olfactory assessments and integrating olfaction into quality-of-life frameworks. OD should be considered for inclusion in revised CHARGE diagnostic criteria.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"146-160"},"PeriodicalIF":6.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrepancy between self-reported and actual topical steroid use in CRS-patients with nasal polyps. crs -鼻息肉患者自我报告与实际使用局部类固醇的差异。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin25.385

C Haase, K E J Hã Kansson, K Aanes, C S Ulrik, B A Esbensen, R Horne, V Backer

引用次数: 0

Targeting outcomes with precision. 精准定位结果。

IF 6.8 2区医学

Rhinology Pub Date : 2026-04-01 DOI: 10.4193/Rhin26.902

M B Soyka

引用次数: 0