Rhinology最新文献_第2页

Responders to biologics in severe uncontrolled chronic rhinosinusitis with nasal polyps: a multicentric observational real-life study. 严重不受控制的慢性鼻窦炎伴鼻息肉患者对生物制剂的反应：一项多中心观察性现实研究。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.284

G Mortuaire, E Bequignon, C Daveau, J-F Papon, J-P Lecanu, V Favier, L de Gabory, C Vandersteen, L Castillo, N Saroul, B Verillaud, F Carsuzaa, C Rumeau, R Jankowski, J Michel, G de Bonnecaze, V Escabasse, A Coste, G Lefevre, O Malard

{"title":"Responders to biologics in severe uncontrolled chronic rhinosinusitis with nasal polyps: a multicentric observational real-life study.","authors":"G Mortuaire, E Bequignon, C Daveau, J-F Papon, J-P Lecanu, V Favier, L de Gabory, C Vandersteen, L Castillo, N Saroul, B Verillaud, F Carsuzaa, C Rumeau, R Jankowski, J Michel, G de Bonnecaze, V Escabasse, A Coste, G Lefevre, O Malard","doi":"10.4193/Rhin24.284","DOIUrl":"10.4193/Rhin24.284","url":null,"abstract":"Background: Clinical trials have demonstrated the effectiveness of biologics in treating chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world evidence regarding patient outcomes and predictors of clinical response remains limited.Methodology: In this multicentric 18-month follow-up study, 326 adult patients who initiated biologic therapy for severe uncontrolled CRSwNP were included. Patient characteristics, including clinical and inflammatory markers, and comorbidities were collected at baseline and at 3, 6, 12, and 18 months of follow-up. We examined success rates based on current guidelines and identified potential factors associated to clinical response at 6 months.Results: We observed a significant decrease of Sino-Nasal Outcomes Test-22 (SNOT-22) from a median score (interquartile range) of 60.5 (47-74) at baseline to 26.0 (11-41) at 3 months. A significant decrease of nasal symptoms and endoscopic nasal polyp score was observed at 3 months. After 6 months of biologic treatment, 59% of patients were classified as excellent responders according to the EUFOREA-EPOS 2023 criteria. Multivariate analysis revealed a suggestive association between baseline eosinophil blood count, type of biologic and an excellent response at 6 months.Conclusions: This real-world study confirms the effectiveness of biologics as an add-on therapy in patients with severe uncontrolled CRSwNP. Biologics lead to rapid and sustained improvement in clinical symptoms. A significant proportion of patients exhibit an excellent response, with no need for systemic corticosteroids.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"22-31"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of nasal fracture management and subsequent surgical outcomes across demographics. 对不同人口统计学特征的鼻骨骨折处理和后续手术效果进行分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.334

D Karasik, S Politano, T J O'Neil, T Baglam, C C Rabbani, J Thuener

引用次数: 0

Influence of septal deviation side on preoperative eustachian tube dysfunction and the effectiveness of septoplasty in alleviating eustachian tube dysfunction. 鼻中隔偏曲侧对术前咽鼓管功能障碍的影响以及鼻中隔成形术缓解咽鼓管功能障碍的效果。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.267

C Lee, E Lee, M Park, D Kim, Y G Jung, H Y Kim, G Ryu, S D Hong

{"title":"Influence of septal deviation side on preoperative eustachian tube dysfunction and the effectiveness of septoplasty in alleviating eustachian tube dysfunction.","authors":"C Lee, E Lee, M Park, D Kim, Y G Jung, H Y Kim, G Ryu, S D Hong","doi":"10.4193/Rhin24.267","DOIUrl":"10.4193/Rhin24.267","url":null,"abstract":"Background: The Eustachian Tube Dysfunction Questionnaire 7 (ETDQ-7) serves as a valuable tool for assessing eustachian tube dysfunction (ETD). We investigated the impact of septal deviation side on ETD using preoperative ETDQ-7 scores and evaluated the effectiveness of septoplasty based on postoperative ETDQ-7 scores.Methodology: We conducted a retrospective analysis of patients with septal deviation who were scheduled for septoplasty. ETDQ-7 surveys were conducted preoperative and 1 and 3 months postoperative.Results: 120 patients were included, with 72 completing the ETDQ-7 at all three time points. The average prevalence of ETD was 29.2%. Preoperative ETDQ-7 scores showed no significant difference between convex and concave nasal sides. However, the prevalence of ETD was significantly higher on the convex side (28.3% vs. 15.8%), especially in unilateral ETD cases. Preoperatively, the positive ETD group had significantly higher ETDQ-7 scores on the convex side while no significant difference was found between concave and convex sides in the negative ETD group. Postoperatively, the positive ETD group showed significant improvement in ETDQ-7 scores with significantly higher on the convex side (66.7% vs. 33.3%). ETDQ-7 scores improved after septoplasty, with more improvement in the positive ETD group.Conclusions: Septoplasty significantly improves ETD, particularly in the preoperative positive ETD group, by reducing ETDQ-7 scores. The prevalence of ETD was higher on the convex side preoperatively, and the positive ETD group exhibited significant postoperative improvements, especially on the convex side. This suggests that the direction of septal deviation influences ETD prevalence and surgery outcomes, although septoplasty alleviates ETD on both sides.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"63-69"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of olfactory training using aromatic traditional Chinese medicine in managing olfactory dysfunction induced by SARS-CoV-2. 使用芳香中药进行嗅觉训练治疗 SARS-CoV-2 引起的嗅觉功能障碍的临床疗效。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.035

X-F Qiao, L-Y Han, Y-F Li, H Li, H-M Zhen, H-R Dang, Y Chen, X Li

{"title":"Clinical efficacy of olfactory training using aromatic traditional Chinese medicine in managing olfactory dysfunction induced by SARS-CoV-2.","authors":"X-F Qiao, L-Y Han, Y-F Li, H Li, H-M Zhen, H-R Dang, Y Chen, X Li","doi":"10.4193/Rhin24.035","DOIUrl":"10.4193/Rhin24.035","url":null,"abstract":"Objective: The aim of this study is to assess the clinical efficacy of olfactory training using aromatic traditional Chinese medicine (TCM) for addressing severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced olfactory dysfunction, while also exploring the factors that influence the observed efficacy.Methods: 172 outpatients with SARS-CoV-2-related olfactory dysfunction were randomized into two groups. The experimental group received olfactory training with TCM aromatics (ginger, Pericarpium Citri Reticulatae, Santali Albi Lignum, Styrax), while the control group used non-TCM aromatics (phenyl ethanol-rose, menthol-mint, citronellal-lemon, eugenol-clove) for 24 weeks. Olfactory function was assessed using the Sniffin' Sticks test and TDI (threshold-discrimination-identification) scores at baseline, 1, 3, and 6 months post-treatment.Results: Response rates at 1, 3, and 6 months post-treatment were 3.66%, 25.61%, and 43.90% in the experimental group, and 4.94%, 23.46%, and 43.21% in the control group. The TDI scores of the experimental group and the control group were statistically different before and after treatment. At 3 and 6 months post-treatment, TDI scores increased significantly, with enhanced odor discrimination and identification capabilities in both groups compared to pre-treatment, while the odor detection threshold was not improved compared with that before treatment. At the 3- and 6-month follow-ups, experimental group showed significantly higher self-rated sleep and anxiety scores than controls, indicating notable improvement in both after treatment.Conclusion: Olfactory training with aromatic TCM offers an effective treatment for SARS-CoV-2-induced olfactory dysfunction, improving odor discrimination, identification without significant differences compared to conventional aromatics, besides, it may also improve anxiety and sleep quality.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"77-84"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between cigarette smoking and nasopharyngeal cancer risk: a meta-analysis. 吸烟与鼻咽癌风险之间的关系：一项荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.265

I Possenti, A Martini, V Bagnardi, C Specchia, W Garavello, A Odone, L J M Smits, S Gallus, A Lugo

{"title":"Association between cigarette smoking and nasopharyngeal cancer risk: a meta-analysis.","authors":"I Possenti, A Martini, V Bagnardi, C Specchia, W Garavello, A Odone, L J M Smits, S Gallus, A Lugo","doi":"10.4193/Rhin24.265","DOIUrl":"10.4193/Rhin24.265","url":null,"abstract":"Introduction: Nasopharyngeal cancer (NPC) is a relatively rare yet aggressive malignancy, primarily affecting regions of East and Southeast Asia. This study aims at providing an up-to-date quantification of the association between cigarette smoking and NPC risk, overall and by histological subsites.Methods: We conducted a systematic review and meta-analysis of case-control and cohort studies on the association between cigarette smoking and NPC risk published up to May 2023. The methodology used is original and efficient and includes both a comprehensive umbrella review and a traditional review. We estimated pooled relative risks (RR) of NPC according to smoking status, intensity, duration, and time since quitting.Results: Among 46 eligible articles, 40 original studies were included in this meta-analysis. Compared with never smokers, the pooled RR of NPC was 1.61 for current, 1.28 for former, and 1.62 for ever smokers. The RR for ever compared with never smokers was 2.37 for squamous cell NPC and 1.06 for undifferentiated NPC. NPC risk significantly increased linearly with smoking intensity and duration, and decreased linearly with increasing time since quitting.Conclusion: This meta-analysis confirms the link between tobacco smoking and NPC, highlighting the significant risk posed even by moderate cigarette consumption. Additionally, our findings underscore the differential risk between squamous cell and undifferentiated subtypes of NPC, shedding light on the distinct implications for NPC prevention strategies.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"13-21"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between intravenous olfactory test and taste disorder in patients with olfactory disorder. 嗅觉障碍患者静脉嗅觉测试与味觉障碍的关系。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.005

R Sakurai, E Mori, Y Kishimoto, H Tanaka, N Yanagi, Y Tsurumoto, M Nagai, R Sekine, M Tei, N Otori

{"title":"The relationship between intravenous olfactory test and taste disorder in patients with olfactory disorder.","authors":"R Sakurai, E Mori, Y Kishimoto, H Tanaka, N Yanagi, Y Tsurumoto, M Nagai, R Sekine, M Tei, N Otori","doi":"10.4193/Rhin24.005","DOIUrl":"10.4193/Rhin24.005","url":null,"abstract":"Background: The intravenous olfactory test (alinamin test [AT]) is a retronasal olfactory assessment and may evaluate the flavour disorder; however, studies assessing whether AT accurately determines the severity of taste disorders are lacking. Our study aims to evaluate the relationship between AT and subjective taste disorders in the patiensts with olfactory disorder.Methods: Between April 2019 and March 2020, 228 patients visited our smell clinic reporting olfactory disorders. Of these, 193 patients who underwent AT were included in this study. We evaluated the differences in AT response, latency time, and duration time between patients with and without subjective taste disorder. We also assessed the degree of subjective taste disorder experienced by patients using the visual analogue scale (VAS) and the correlation between latency and duration time of AT. To assess taste perception more broadly, we inquired about the presence of disorder using the term \"taste\" rather than \"flavour\" without focusing on any specific type of taste disorder.Results: Of the included 193 patients, 62 reported awareness of a taste disorder. The duration time of AT was significantly shorter in patients with subjective taste disorder. A weak correlation was found between the VAS scores for subjective taste disorders and the duration time of AT.Conclusions: Our results showed that among the patients with olfactory disorders, the duration time of AT was reduced for those with subjective taste disorders.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"70-76"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical intranasal anesthesia impairs trigeminal function and airflow perception.

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin

C Migneault-Bouchard, F J M Boselie, J Frasnelli

{"title":"Topical intranasal anesthesia impairs trigeminal function and airflow perception.","authors":"C Migneault-Bouchard, F J M Boselie, J Frasnelli","doi":"10.4193/Rhin","DOIUrl":"https://doi.org/10.4193/Rhin","url":null,"abstract":"Background: Impairment of airflow perception by the intranasal trigeminal system may explain chronic nasal obstruction (CNO),especially in cases where no major deformity or mucosal inflammation can explain reduced airflow. We aim to characterize the effect of topical intranasal anesthesia on intranasal trigeminal sensitivity and consequently the sensation of nasal obstruction.Methodology: We performed a crossover study of 16 healthy subjects, randomised for either treatment (topical intranasal anesthesia with 10% Xylocaine) or placebo (saline solution). We used the Trigeminal Lateralization Task (TLT) with eucalyptol to assess trigeminal sensitivity. We measured nasal patency objectively with Peak Nasal Inspiratory Flow (PNIF), and subjectively with a Visual Analog Scale (VAS), the Empty Nose Syndrome 6-Item Questionnaire (ENS6Q), and the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire.Results: Topical intranasal anesthesia significantly reduced intranasal trigeminal sensitivity. Further, after topical intranasal anesthesia,reduced trigeminal sensitivity was associated with the subjectively reduced nasal patency, as highlighted by ENS6Q and NOSE scores.Conclusions: Topical intranasal anesthesia reduces intranasal trigeminal function resulting in subjectively reduced nasal patency. In future studies, the relation of reduced intranasal trigeminal function and subjective nasal obstruction needs to be addressed to open an avenue for potential interventions for an important portion of ENT patients.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":"63 1","pages":"85-91"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro selection of human cerebrospinal fluid-specific aptamers using clinical samples. 利用临床样本体外筛选人脑脊液特异性适配体。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.341

A Abiri, X Chen, B Latifi, F P K Hsu, A Luptak, M Khine, E C Kuan

{"title":"In vitro selection of human cerebrospinal fluid-specific aptamers using clinical samples.","authors":"A Abiri, X Chen, B Latifi, F P K Hsu, A Luptak, M Khine, E C Kuan","doi":"10.4193/Rhin24.341","DOIUrl":"10.4193/Rhin24.341","url":null,"abstract":"Background: Cerebrospinal fluid (CSF) leaks may occur due to numerous etiologies and are associated with severe morbidity. Currently in the U.S., confirming the presence of a CSF leak requires protein electrophoresis testing, oftentimes involving specialized processing, and there exists no point-of-care (POC) device for CSF detection. We aimed to discover a single-stranded deoxyribonucleic acid (ssDNA) aptamer capable of selectively binding to CSF-specific biomarkers, with the future goal of developing an aptamer-based POC CSF detection device.Methods: To identify a candidate aptamer, we performed Systematic Evolution of Ligands by EXponential enrichment (SELEX) using a DNA library containing a randomized 63-nucleotide (nt) stretch flanked by 2 primer-binding sites. Quantitative polymerase chain reaction (qPCR) and fluorescence anisotropy (FA) assessed aptamer binding affinity and kinetics.Results: Following 14 SELEX cycles, 2 dominant and functionally viable 98-nt ssDNA sequences (C2 and C3) were found. C2 and C3 demonstrated ~586x and ~82x higher affinity for CSF compared to serum, respectively. Increases in FA upon aptamer exposure to higher CSF concentrations demonstrated a K1/2 of 5.0% and 14.1% for C2 and C3, respectively.Conclusions: In vitro selection of a diverse pool of ssDNA sequences yielded 2 aptamers with high selectivity for CSF-specific biomarkers, with potential for integration into a rapid POC electrochemical diagnostic system.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"103-112"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omalizumab reduces allergic rhinitis symptoms due to Japanese cedar pollen by improving eosinophilic inflammation. 奥马珠单抗可通过改善嗜酸性粒细胞炎症，减轻日本杉树花粉引起的过敏性鼻炎症状。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.105

K Hirano, I Suzaki, N Okuzawa, A Oki, Y Otani, M Takeuchi, A Minoura, K Murakami, Y Ihara, H Kato, Y Watanabe, T Shimane

{"title":"Omalizumab reduces allergic rhinitis symptoms due to Japanese cedar pollen by improving eosinophilic inflammation.","authors":"K Hirano, I Suzaki, N Okuzawa, A Oki, Y Otani, M Takeuchi, A Minoura, K Murakami, Y Ihara, H Kato, Y Watanabe, T Shimane","doi":"10.4193/Rhin24.105","DOIUrl":"10.4193/Rhin24.105","url":null,"abstract":"Seasonal allergic rhinitis caused by Japanese cedar pollen (SAR-JCP) is a serious social problem in Japan, affecting 38.8% of the population. Omalizumab, a recombinant humanised monoclonal anti-immunoglobulin (Ig)E antibody, reduces serum-free IgE levels by 84â€\"99%. The reduction of serum-free IgE levels induced by omalizumab ultimately downregulates FcÎ#181;RI expression in basophils and mast cells. Omalizumab significantly reduces nasal symptoms and improves the quality of life in patients with allergic rhinitis ; however, other than a decrease in free IgE, its biomarker activity is unclear. Allergic rhinitis reactions are more pronounced in nasal secretions and mucosa than in serum; however, no studies have examined the changes in proteins in nasal secretions after omalizumab administration. In this study, we aimed to elucidate the pathophysiology of the effect of omalizumab. This may serve as a basis for the identification of new biomarkers through the examination of proinflammatory proteins in nasal secretions, which may reflect the pathophysiology more accurately than peripheral blood.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"116-117"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy. 鼻分泌物追踪上皮2型对过敏原特异性免疫治疗的反应。

IF 4.8 2区医学

Rhinology Pub Date : 2025-02-01 DOI: 10.4193/Rhin24.038

C A Jakwerth, U M Zissler, M Oelsner, L Pechtold, L Zur Bonsen, M Plaschke, J Kau, M Davidovic, M Mootz, B Haller, A M Chaker, C B Schmidt-Weber

{"title":"Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy.","authors":"C A Jakwerth, U M Zissler, M Oelsner, L Pechtold, L Zur Bonsen, M Plaschke, J Kau, M Davidovic, M Mootz, B Haller, A M Chaker, C B Schmidt-Weber","doi":"10.4193/Rhin24.038","DOIUrl":"10.4193/Rhin24.038","url":null,"abstract":"Background: Allergen-specific immunotherapy (AIT) is a disease-modifying therapy and is effective to reduce the symptoms of grass pollen-allergy. The airway epithelium of these patients releases inflammatory mediators including type-2 cytokines, which are associated with cellular processes involved in the symptomatic response of the affected tissue. Aim of the study was to identify epithelial biomarkers indicating AIT progress.Methods: In an exploratory, observational allergy cohort, we longitudinally phenotyped 56 grass pollen-allergic patients undergoing AIT for over three years and 18 controls using nasal secretions at critical time windows during therapy to assess peak-season responses along the course of therapy. Type-2 cytokine protein levels were analyzed using the high-sensitivity multiplex electrochemiluminescence mesoscale technique.Results: The type-2 cytokines CCL26 and POSTN oscillated seasonally, in contrast to TSLP and IL-33. However, only POSTN was reduced over the three-year AIT progression. In addition to POSTN, IL-24 and IL-37 levels were continuously reduced during AIT, while IFN-g and CCL27 were increased. Compared to healthy individuals, AIT did not restore healthy secretion levels but rather induced a novel homeostasis CONCLUSION: Nasal secretions trace the epithelial response during different phases of AIT. We demonstrate that AIT only partially controls the epithelial type 2 cytokine CCL26, which also adapts to seasonal changes, while POSTN and IL-24 are potential indicators of therapy success. Therefore, nasal secretions represent a promising, non-invasive tool for monitoring seasonal progress of AIT.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"43-53"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0