Rhinology最新文献_第2页

Integrating pretreatment 18F-FDG PET-CT parameters, peripheral blood indicators and clinical characteristics in predicting chemotherapy plus immunotherapy outcomes for de novo metastatic nasopharyngeal carcinoma. 整合预处理18F-FDG PET-CT参数、外周血指标及临床特征预测新转移性鼻咽癌化疗加免疫治疗结果

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-14 DOI: 10.4193/Rhin24.547

L-W Gu, Y-C Li, S-Y Xue, B-B Xiao, D-X Wen, L-P Wu, X Zhang, L-Q Tang, L Guo, L-T Liu

{"title":"Integrating pretreatment 18F-FDG PET-CT parameters, peripheral blood indicators and clinical characteristics in predicting chemotherapy plus immunotherapy outcomes for de novo metastatic nasopharyngeal carcinoma.","authors":"L-W Gu, Y-C Li, S-Y Xue, B-B Xiao, D-X Wen, L-P Wu, X Zhang, L-Q Tang, L Guo, L-T Liu","doi":"10.4193/Rhin24.547","DOIUrl":"https://doi.org/10.4193/Rhin24.547","url":null,"abstract":"Background: To develop a prognostic nomogram based on pretreatment 18F-FDG PET-CT radiomics parameters, peripheral blood indicators and clinical characteristics for risk stratification in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) receiving immunochemotherapy.Methodology: The eligible patients were randomly divided into training (n=183) and validation (n=79) cohorts. Least absolute shrinkage and selection operator regression was used for variable selection. Multivariate Cox regression analysis was performed to identify independent prognostic factors for progression-free survival (PFS). The predictive accuracy and discriminative ability of the nomogram were determined with a concordance index (C-index) and calibration curve.Results: Multivariate Cox analysis suggested that total lesion glycolysis, number of metastases, Epstein-Barr virus DNA, N-stage, lactate dehydrogenase, and total bilirubin were independent predictors of PFS and were used to develop a nomogram that could classify patients into low- and high-risk groups. The C-index of the nomogram for predicting disease progression was 0.75, which was significantly higher than the C-indices of the TNM stage and EBV DNA. The patients were then stratified into low- and high-risk groups based on the calculated scores. The median PFS was significantly higher in the low-risk group than in the high-risk group.Conclusions: The proposed nomogram with PET-CT parameters, peripheral blood indicators and clinical characteristics resulted in accurate prognostic prediction for patients with dmNPC receiving chemotherapy plus PD-1 inhibitors and could provide risk stratification for these patients.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-HDAC7 expression related to poor prognosis in sinonasal mucosal melanoma. hdac - 7高表达与鼻黏膜黑色素瘤预后不良相关

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-14 DOI: 10.4193/Rhin24.463

D Zheng, C Liu, X Pu, X Deng, Y Chen, S Li

{"title":"High-HDAC7 expression related to poor prognosis in sinonasal mucosal melanoma.","authors":"D Zheng, C Liu, X Pu, X Deng, Y Chen, S Li","doi":"10.4193/Rhin24.463","DOIUrl":"https://doi.org/10.4193/Rhin24.463","url":null,"abstract":"Background: Sinonasal mucosal melanoma (SNMM) is a rare malignant melanoma. Histone deacetylase 7 (HDAC7) is involved in the development of various tumours, but its function in SNMM remains underexplored.Methodology: We retrospectively studied 30 patients with SNMM treated between 2013 and 2023. Immunohistochemistry was used to assess HDAC7, β-catenin, c-Myc, and Ki-67 expression. Relationships among HDAC7 expression, clinical characteristics, prognosis, β-catenin, c-Myc, and Ki-67 were analysed.Results: HDAC7 was overexpressed in SNMM tissues compared to normal tissues. Expression was higher in stage IV compared to stage III and in T4 grade compared to T3 grade. The median overall survival (OS) was 29 months, with 8 patients alive. High-HDAC7 expression (in 13 patients) correlated with poorer OS and disease-free survival (DFS). HDAC7's carcinogenic role in SNMM may be mediated by β-catenin/c-Myc. Univariate analysis for OS revealed high-HDAC7, high c-Myc, positive surgical margins, T4 grade, and stage IV were significant factors leading to SNMM's poor prognosis. However, HDAC7 expression was the only independent prognostic factor. Additionally, a nomogram model showed promising results but was not validated in another cohort.Conclusions: High-HDAC7 expression is associated with advanced T grade, clinical stage, and poor prognosis in SNMM. HDAC7 may influence cell proliferation, invasion and migration by activating the Wnt/β-catenin/c-Myc signalling pathway.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mouse model of Staphylococcus aureus- and Pseudomonas aeruginosa-induced neutrophilic chronic rhinosinusitis. 金黄色葡萄球菌和铜绿假单胞菌诱导的嗜中性粒细胞慢性鼻窦炎小鼠模型。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-11 DOI: 10.4193/Rhin24.545

A Sánchez-Montalvo, A Ziani-Zeryouh, M Lecocq, B Steelant, S Gohy, P Hellings, D Bullens, C Pilette, V Hox

{"title":"Mouse model of Staphylococcus aureus- and Pseudomonas aeruginosa-induced neutrophilic chronic rhinosinusitis.","authors":"A Sánchez-Montalvo, A Ziani-Zeryouh, M Lecocq, B Steelant, S Gohy, P Hellings, D Bullens, C Pilette, V Hox","doi":"10.4193/Rhin24.545","DOIUrl":"https://doi.org/10.4193/Rhin24.545","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is a highly prevalent upper airway disease. Its pathogenesis remains poorly understood, especially non-eosinophilic CRS. Currently, no validated mouse model exists to study disease mechanisms, indicating an important research gap. We aimed at establishing a reproducible mouse model of non-eosinophilic CRS to allow further research on its pathophysiology.Methodology: Mice were infected with relevant bacteria for sinus disease via surgical insertion of a nasal tampon in their nasal cavity. Inflammatory features in sinus mucosa were evaluated after 4, 8 and 12 weeks on decalcified skulls by histology and immunohistochemistry and by cytospins and enzyme-linked immunoassay on nasal lavage.Results: S. aureus-inoculated mice showed better survival than S. pneumoniae- and P. aeruginosa- inoculated mice. S. aureus and, to lesser extent, P. aeruginosa were still detectable in the nasal lavage up to 12 weeks. Mice with S. aureus and P. aeruginosa-induced CRS showed significant hypertrophia of the epithelium, neutrophilic infiltration and fibrosis in the sinus mucosa, with increased non-Type 2 cytokines in the nasal lavage.Conclusions: S. aureus and P. aeruginosa are more potent inducers of neutrophilic inflammation than S. pneumoniae in mice. This model allows us to further study non-eosinophilic chronic rhinosinusitis pathophysiology in vivo.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of biological treatment in uncontrolled severe chronic rhinosinusitis with nasal polyps in Belgium: a multicentre real-world data study. 比利时未控制的严重慢性鼻窦炎伴鼻息肉的生物治疗效果：一项多中心真实世界数据研究。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin24.509

A-S Viskens, L Bollens, E Borgers, S Halewyck, V Hox, M Jorissen, W Lemmens, F Rogister, K Speleman, L Van Gerven, O Vanderveken, B Verhaeghe, A Vroegop, K Martens, P W Hellings

{"title":"Effect of biological treatment in uncontrolled severe chronic rhinosinusitis with nasal polyps in Belgium: a multicentre real-world data study.","authors":"A-S Viskens, L Bollens, E Borgers, S Halewyck, V Hox, M Jorissen, W Lemmens, F Rogister, K Speleman, L Van Gerven, O Vanderveken, B Verhaeghe, A Vroegop, K Martens, P W Hellings","doi":"10.4193/Rhin24.509","DOIUrl":"https://doi.org/10.4193/Rhin24.509","url":null,"abstract":"Background: Double-blinded placebo-controlled trials have revealed the efficacy of mepolizumab and omalizumab in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world efficacy (RWE) data, data on therapeutic response and level of disease control for both biologicals are lacking.Methodology: 167 patients with uncontrolled severe CRSwNP, meeting national reimbursement criteria, were included with follow-up over 24 weeks. Primary outcomes included changes in nasal congestion (NCS), nasal polyp score (NPS), VAS-scores, SNOT-22, ACQ-5, and AQLQ scores. Secondary outcomes were therapeutic response and disease control according to EUFOREA/EPOS criteria.Results: Of the 167 CRSwNP patients, 144 received mepolizumab and 23 omalizumab. After 24 weeks, Patient reported outcomes and NPS significantly improved for both biologicals, with significant effects seen at 12 weeks, with further reduction in NPS by 24 weeks in mepolizumab patients. 74% of patients on omalizumab and 81% of patients on mepolizumab continued their therapy beyond 24 weeks, with 47% and 45% of patients on omalizumab and mepolizumab respectively showing an excellent therapeutic response, with only one out of seven having no/poor response. Disease control was reached in one third of the patients at 24 weeks.Conclusions: Both mepolizumab and omalizumab significantly improved patient-reported outcomes after 24-weeks, with major effects already observed at 12 weeks. Follow-up beyond 24-weeks might reveal additional effects on both control and remission.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial. 嗅觉训练治疗COVID-19相关嗅觉丧失：一项随机双盲对照试验

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin24.081

T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano

{"title":"Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial.","authors":"T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano","doi":"10.4193/Rhin24.081","DOIUrl":"https://doi.org/10.4193/Rhin24.081","url":null,"abstract":"Background: Olfactory training is the most widely recommended treatment for smell loss; however, there are no randomised placebo-controlled trials evaluating its effectiveness in COVID-19. We aimed to evaluate the efficacy of isolated training and factors associated to olfactory recovery.Methods: This is a prospective randomised double-blind controlled trial, using standard olfactory training (OT) and placebo (PB) in COVID-19 patients experiencing smell loss. They were followed up for 180 days and assessed with the Connecticut olfactory test (CCCRC) and with subjective methods on a monthly basis.Results: A total of 123 participants completed follow-up: 68 in the OT group and 55 in the PB group. Overall, 84.5% achieved normosmia, with full recovery (FR) significantly higher in PB. At baseline, OT had lower olfactory scores and higher corticosteroid use. Multivariate analysis showed no significant differences in outcomes between groups. Baseline olfactory test scores were the strongest predictors of recovery. Exploratory analyses stratified participants by time to treatment initiation (early ≤ 30 days; late > 30 days), showing a 58% higher chance of FR in the early group for similar CCCRC scores, regardless of management type.Conclusions: OT is not superior to PB for treating COVID-19-related smell loss. Better results of first evaluation indicate great chance of full recovery and the use of systemic corticosteroid, in persistent olfactory loss, has not affected outcome.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review. 中药治疗急慢性鼻窦炎的系统综述。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-09 DOI: 10.4193/Rhin23.526

K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis

{"title":"Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review.","authors":"K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis","doi":"10.4193/Rhin23.526","DOIUrl":"https://doi.org/10.4193/Rhin23.526","url":null,"abstract":"Background: Traditional medicine and herbal medicine are relatively commonly utilized by patients for the treatment of acute (ARS) and chronic rhinosinusitis (CRS). The aim of this study is to review the literature to evaluate scientific evidence regarding the use of herbal preparations in the treatment of rhinosinusitis.Methodology: We reviewed all published studies until February 2024 in PubMed, EMBASE, and Cochrane, using the followingkeywords: herbal medicine and nasal diseases, herbs and nasal diseases, Traditional Chinese Medicine (TCM) and nasal diseases, traditional medicine and nasal diseases, phytotherapy and nasal diseases.Results: Thirty-three clinical studies met the purpose of this review and were assessed. These studies examine the effect of eleven herbal preparations for the treatment of ARS and CRS.Conclusions: Herbal preparation BNO-1016 presents significant evidence in the literature regarding its use in the treatment of ARS, while the TCM preparation Xiangju might be a useful component in the treatment of CRS. Specific traditional herbal medicinal products, therefore, show promising results for the treatment of rhinosinusitis, and their use should be examined further. Given the relatively high demand for medicinal herbs, therapeutic use of those preparations should be explored further.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world observational data on olfactory dysfunction of the Smell & Taste Clinic of UZ Leuven (Belgium) from 2021-2024. 鲁汶大学（比利时）嗅觉与味觉诊所2021-2024年嗅觉功能障碍的真实世界观察数据

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin23.383

M Clijsters, S Bischoff, J van Waterschoot, E Hens, V Nyongesa, P Van Bulck, M Jorissen, L Van Gerven

{"title":"Real-world observational data on olfactory dysfunction of the Smell & Taste Clinic of UZ Leuven (Belgium) from 2021-2024.","authors":"M Clijsters, S Bischoff, J van Waterschoot, E Hens, V Nyongesa, P Van Bulck, M Jorissen, L Van Gerven","doi":"10.4193/Rhin23.383","DOIUrl":"10.4193/Rhin23.383","url":null,"abstract":"Background: The COVID-19 pandemic led to a surge in olfactory dysfunction (OD), increasing the need for specialized care. Thi study explores the prevalence, characteristics, and clinical implications of OD in a specialized Smell & Taste Clinic established at the ENT-HNS department of the University Hospitals Leuven (UZ Leuven) in 2021.Methodology: We included consecutive patients with OD in the observational longitudinal ProspeRoâ€™Scent registry at UZ Leuven between September 2021 and April 2024. Chemosensory assessment was done with psychophysical tests (Sniffinâ€™ Sticks TDI and Taste sprays) and questionnaires.Results: Of the 203 unique, consecutive patients, COVID-19-associated OD (C19OD) was the predominant etiology (50.2%), followed by idiopathic (25.1%), and post-traumatic (8.9%) OD. Parosmia was present in 60.2% of patients, with the highest prevalence in C19OD cases (80.9%). Sniffinâ€™ Sticks TDI testing indicated that patients with parosmia had better olfactory thresholds and discrimination scores than patients without. During follow-up (n=116; average 7.7 months), 31% of C19OD patients exhibited clinically relevant improvement in TDI scores, compared to 13% for the other etiologies. Quality of life, as assessed by sQOD-NS, was not significantly different between etiologies but correlated with higher parosmia scores.Conclusions: C19OD patients suffered more from parosmia, correlating with worse quality of life, but had better baseline TDI scores and demonstrated a higher likelihood of clinically relevant improvement over time compared to other etiologies.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"163-171"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Budesonide nasal irrigation for chronic rhinosinusitis: a meta-analysis of therapeutic outcomes and safety profile. 布地奈德鼻腔冲洗治疗慢性鼻窦炎：治疗结果和安全性的荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.349

N Magboul, A F Alharbi, A T Alqutub, S Almatrafi, A Alroqi, S H Aldousary, S R Alromaih, A S Alrasheed, S A Alsaleh

{"title":"Budesonide nasal irrigation for chronic rhinosinusitis: a meta-analysis of therapeutic outcomes and safety profile.","authors":"N Magboul, A F Alharbi, A T Alqutub, S Almatrafi, A Alroqi, S H Aldousary, S R Alromaih, A S Alrasheed, S A Alsaleh","doi":"10.4193/Rhin24.349","DOIUrl":"10.4193/Rhin24.349","url":null,"abstract":"Background: Corticosteroids are used in managing Chronic Rhinosinusitis (CRS) through several formulations, including oral steroids and nasal sprays. More recently, incorporating concentrated budesonide respules into high-volume saline irrigations has been proposed to enhance the penetration of topical steroids into the paranasal sinuses. We aim to evaluate the safety and efficacy of budesonide nasal irrigation (BNI) in managing CRS.Methodology: A systematic review with meta-analysis was performed following PRISMA guidelines. Data were extracted independently from the eligible studies. In double-arm and single-arm meta-analyses, continuous outcomes were pooled using mean difference (MD) with a 95% confidence interval (CI).Results: Twenty-six studies were reviewed, comprising 1464 patients. BNI had better outcomes than saline nasal irrigation (SNI) regarding Sino-Nasal Outcome Test score (SNOT-22). Lund-Kennedy Endoscopy scores (LKES) changed from baseline. Regarding safety, there was no significant difference between BNI and SNI regarding Intraocular Pressure (IOP). Single-arm analysis showed a pooled mean serum cortisol level within the normal range after BNI.Conclusions: BNI demonstrated improved SNOT-22 and LKES scores, with normal post-treatment IOP and cortisol levels, indicating a beneficial impact on CRS while maintaining safety.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"130-144"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery. 运动分析对内窥镜鼻窦手术精神运动技能的客观评价。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin22.320

K Miyaji, M Suzuki, R Watanabe, K Matoba, A Nakazono, Y Nakamaru, K Ebina, T Abe, D Hinder, A J Psaltis, P J Wormald, A Homma, A Konno

{"title":"Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery.","authors":"K Miyaji, M Suzuki, R Watanabe, K Matoba, A Nakazono, Y Nakamaru, K Ebina, T Abe, D Hinder, A J Psaltis, P J Wormald, A Homma, A Konno","doi":"10.4193/Rhin22.320","DOIUrl":"10.4193/Rhin22.320","url":null,"abstract":"Background: This study aims to digitalize surgical maneuvers in ESS using a motion capture system under standardized conditions provided by 3D printed-sinus models.Methodology: Forty-seven otolaryngologists performed ESS on 3D printed models manufactured from computed tomography (CT) images of actual patients. Participants were classified to 3 groups according to the objective structured technical skills assessment score. All surgical maneuverers performed during ESS were captured by a motion capture system. The path length, velocity, acceleration, and jerk were calculated for each surgical instrument and compared among the groups. Principle Component Analysis (PCA) was utilized to identify which metrics reflected surgical skill level. In addition, ten registrars repeated the surgical dissection. Their motion metrics were also compared between first training and the repeated training and then subjected to the PCA.Results: Several metrics such as the angular acceleration and jerk of the cutting forceps were identified by PCA as possible indicators distinguishing the different skill levels for the ESS maneuvers. PCA analysis in the repetitive training also found the angular metrics of the upturned-cutting forceps correlating to their skill improvement.Conclusions: Combined with the validated 3D-printed sinus models, the motion capture system provided the objective evaluation of the surgical performances of ESS.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"190-199"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the Sino-Nasal Outcome Test-25 (SNOT-25) measure for patients with nasal septal perforation. 鼻中隔穿孔患者的鼻结果测试-25 （SNOT-25）测量的验证。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.443

S P Williams, S C Leong

引用次数: 0