Rhinology最新文献_第2页

Radial intralesional linear calcifications and focal hyperostosis: key points for diagnosis, extension and point of origin identification of sinonasal inverted papilloma. 鼻窦内翻性乳头状瘤的诊断、扩展及起源点鉴别要点：病灶内线状钙化及局灶性骨质增生。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.379

E Granell, A Cardesin, D Pallares, R Sanchez, J R Gras

引用次数: 0

Pocket guide: biologics in upper and lower airways in adults. 袖珍指南：成人上下气道生物制剂。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.510

W J Fokkens, V Backer, V J Lund, P J Barnes, M Bernal-Sprekelsen, L Bjermer, E de Corso, D M Conti, M E Cornet, Z Diamant, R Djukanovic, M Gaga, P Gevaert, J K Han, C Hopkins, G Joos, B N Landis, S Lau, S E Lee, J Mullol, A T Peters, G K Scadding, S Schneider, B Senior, I D Pavord, S Quirce, D Ryan, M E Wechsler, P W Hellings

引用次数: 0

Analysis of clinical characteristics of fungus ball based on the number of involved sinuses. 基于受累窦数的真菌球临床特征分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin23.501

T Yang, C Liu, Y Wang, J Zhou, Y Li, H Wei

{"title":"Analysis of clinical characteristics of fungus ball based on the number of involved sinuses.","authors":"T Yang, C Liu, Y Wang, J Zhou, Y Li, H Wei","doi":"10.4193/Rhin23.501","DOIUrl":"10.4193/Rhin23.501","url":null,"abstract":"Background: Fungus ball (FB) typically presents unilaterally, with the maxillary sinus being the most commonly affected site.Multi-sinus FB cases are seldom discussed.Methodology: A retrospective study involving 1709 FB patients categorized them into single sinus fungus ball (SSFB), double sinus fungus balls (DSFB), and multiple sinus fungus balls (MSFB) groups for clinical analysis.Results: The SSFB group comprised 1596 patients (93.39%), the DSFB group 111 patients (6.50%), and the MSFB group two patients (0.12%). The prevalence of diabetes mellitus in the DSFB group was higher than that in the SSFB group. A female prevalence was noticed and there was no difference in the sex ratio by age group. On computed tomography (CT), maxillary sinus FB group had higher intralesional hyperdensity than sphenoid sinus FB group. Oppositely, sphenoid sinus FB group had higher lateral sinus wall sclerosis than maxillary sinus FB group.Conclusions: DSFB occurs in a minority of cases but needs to be investigated especially in diabetics given the link between diabetes mellitus and increased DSFB risk. A female predominance is seen in both pre- and postmenopausal women. On CT, the presence of intralesional hyperdensity and lateral sinus wall sclerosis correlates with the location of the FB.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"230-236"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of eosinophilic otitis media in the era of biological therapy: systematic review and proportion meta-analysis. 生物治疗时代嗜酸性中耳炎的治疗：系统回顾和比例荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.421

M Lazzeroni, H Elzinga, P Merkus, E van Spronsen, W J Fokkens, S Reitsma

{"title":"Management of eosinophilic otitis media in the era of biological therapy: systematic review and proportion meta-analysis.","authors":"M Lazzeroni, H Elzinga, P Merkus, E van Spronsen, W J Fokkens, S Reitsma","doi":"10.4193/Rhin24.421","DOIUrl":"10.4193/Rhin24.421","url":null,"abstract":"Background: Eosinophilic otitis media (EOM) is a recently recognised type 2 inflammatory disease, strongly associated with asthma and chronic rhinosinusitis with nasal polyps. Known as a difficult-to-treat condition, EOM is often refractory to traditional therapies for (chronic) otitis media. This review aims to assess the success rates of the different interventions for patients with EOM including newly available biological therapy.Methodology: In March 2024 we systematically searched PubMed, Embase, Scopus and Web of Science for studies on more than 5 EOM patients undergoing any medical or surgical intervention with a reported success rate. Proportion meta-analysis on a random effect model was used to synthesize results effectively. Risk of bias was assessed through the Risk Of Bias In Non randomized Studies of Interventions tool (ROBINS-I).Results: From 1103 potential articles, 14 studies with 361 patients were included. 62% were females and 85% had bilateral presentation. Otorrhoea was present in 68% of patients, tympanic membrane perforation in 50%. The overall success rate was 61.3. However, interventions comprising biological agents targeting type 2 inflammatory cascade showed higher success rates compared to non-biological treatments.Conclusions: A shift towards biologic-based therapies could be beneficial for managing the challenging condition EOM.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"145-152"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligation of anterior ethmoidal artery nasal branch: anatomical-based management of recalcitrant epistaxis. 乙状动脉鼻前支结扎术：根据解剖学治疗顽固性鼻衄。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.317

A Vinciguerra, A Daloiso, I Dohin, F Boaria, M Marc, M Ferrari, B Verillaud, F Chatelet, P Herman

{"title":"Ligation of anterior ethmoidal artery nasal branch: anatomical-based management of recalcitrant epistaxis.","authors":"A Vinciguerra, A Daloiso, I Dohin, F Boaria, M Marc, M Ferrari, B Verillaud, F Chatelet, P Herman","doi":"10.4193/Rhin24.317","DOIUrl":"10.4193/Rhin24.317","url":null,"abstract":"Recurrent epistaxis, despite conservative therapies (i.e. nasal packing or direct vessel coagulation), is generally treated with ligation of the sphenopalatine artery (SPA). Indeed, the rationale behind SPA ligation lies in its ability to disrupt arterial blood supply to the nasal mucosa, thereby reducing the likelihood of recurrent bleeding episodes (1). Nevertheless, in some cases, nosebleeds persist despite appropriate SPA ligation, opening discussion of the anterior ethmoidal artery (AEA) contribution in recalcitrant epistaxis that, for some authors, is up to 28.8% (2). From an anatomical point of view, the AEA leaves the orbital cavity and passes the ethmoidal roof through the ethmoidal canal, before entering inside the anterior cranial fossa via the lateral lamella (3). Endocranially, the AEA gives posterior branches which vascularize the anterior cribriform plate, whereas its many trunk continues anteriorly and divides into two branches: the anterior meningeal branch, and a second vessel that enters inside the nasal fossa through the cribroethmoidal foramen located 2.86 Â± 1.93 mm (range, 1-7 mm) (4) anteriorly to the first olfactory phylum, giving rise to the so-called nasal branch (NbAEA) (5).","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"253-255"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of primary chronic rhinosinusitis in young adults from a Swedish birth cohort. 瑞典出生队列中年轻成人原发性慢性鼻窦炎的患病率。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.048

K Aberg, A Asarnoj, S K Georen, L O Cardell, I Kull, A Bergstrom, E Melén, M Holmstrom, M van Hage, M Westman

{"title":"The prevalence of primary chronic rhinosinusitis in young adults from a Swedish birth cohort.","authors":"K Aberg, A Asarnoj, S K Georen, L O Cardell, I Kull, A Bergstrom, E Melén, M Holmstrom, M van Hage, M Westman","doi":"10.4193/Rhin24.048","DOIUrl":"10.4193/Rhin24.048","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is common worldwide but scarcely studied among young adults. The aim was to investigate prevalence, clinical features, comorbidity, and mucosal inflammatory patterns of CRS among 24-year-olds in a populationbased study.Method: 3037 subjects from the birth cohort BAMSE (Barn/children Allergy Milieu Stockholm Epidemiology) had complete questionnaire answers on CRS at the 24-year-follow-up. Subjects fulfilling the European Position Paper on Rhinosinusitis (EPOS) criteria of CRS at 16 and/or 24 years (n=141), were invited to a clinical examination. We examined 81 subjects. Sixty-eight subjects were included, of whom 40 had CRSsNP, 2 CRSwNP and 26 CRS symptoms only. Twenty-three controls without CRS from BAMSE were included. Nasal endoscopy was performed, IgE against airborne allergens and cytokine gene expression in nasal lavage (NAL) were analyzed.Results: The questionnaire-based CRS prevalence was 4.1%, of which 2.2% was endoscopically verified. Sensitization to airborne allergens was more often seen among CRSsNP and \"CRS symptoms only\", compared to controls. Among CRS subjects overall, the proportion of asthma, AR, atopic eczema, and sensitization to airborne allergens was significantly higher compared to the rest of the cohort. The gene expression of IL-1b and IL-8 in NAL was elevated among CRSsNP and \"CRS symptoms only\" compared to controls, with a trend for TNF-a and MPO.Conclusions: The prevalence of primary CRS was estimated to 2-4%. There was a significant association between CRS and atopic diseases in this age group. The NAL profile showed signs of type-1 inflammation.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"180-189"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is nasal closure an effective treatment for severe refractory epistaxis in HHT? A scoping review and narrative synthesis. 鼻塞是治疗HHT患者严重难治性鼻出血的有效方法吗？范围审查和叙事综合。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.448

R Bickerton, R Gera, T Ross, C Rennie

{"title":"Is nasal closure an effective treatment for severe refractory epistaxis in HHT? A scoping review and narrative synthesis.","authors":"R Bickerton, R Gera, T Ross, C Rennie","doi":"10.4193/Rhin24.448","DOIUrl":"10.4193/Rhin24.448","url":null,"abstract":"Introduction: Hereditary haemorrhagic telangiectasia (HHT) is an uncommon genetic disorder characterised by recurrent, severe epistaxis which poses significant management challenges. Nasal closure has emerged as a treatment for refractory cases, however there is limited research on its outcomes. We aim to consolidate existing evidence to assess its efficacy and safety.Methods: We conducted a systematic search of the Cochrane library, EMBASE, PubMed and non-indexed publications from the past 30 years. Two independent reviewers extracted data and assessed bias from included studies. Findings were summarised via narrative synthesis due to heterogeneity of included studies.Results: 192 patients from ten studies underwent nasal closure. Frequently used outcome measures were validated epistaxis severity scores, Glasgow Benefit Inventory and haemoglobin trends. Surgery improved quality of life and reduced epistaxis severity post-operatively. Partial dehiscence is a frequently reported complication which is usually successfully treated with revision surgery.Conclusions: Nasal closure reduces epistaxis severity, improving quality of life in patients with severe, refractory HHT-related epistaxis, providing a valuable treatment option for the most challenging cases. The strength of our conclusions is limited by the heterogeneity of outcome measures. To our knowledge, this is the largest pooled database of patients who have undergone nasal closure.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"153-162"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydration alters viscosity of nasal secretions in postnasal drip. 水合作用改变鼻后滴注时鼻分泌物的黏度。

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.459

S Bucher, T M L Friederici, Y Stanossek, M B Soyka

引用次数: 0

Association between psychophysically measured olfactory dysfunction and mental health status in long COVID patients. 长期COVID患者心理物理测量的嗅觉功能障碍与心理健康状况的关系

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.295

P Boscolo-Rizzo, R Zandonella Callegher, E Cancellieri, L Pellegrini, G Tirelli, U Albert

{"title":"Association between psychophysically measured olfactory dysfunction and mental health status in long COVID patients.","authors":"P Boscolo-Rizzo, R Zandonella Callegher, E Cancellieri, L Pellegrini, G Tirelli, U Albert","doi":"10.4193/Rhin24.295","DOIUrl":"10.4193/Rhin24.295","url":null,"abstract":"Background: Long COVID frequently presents with persistent olfactory dysfunction (OD), affecting both physical and psychological well-being. This study aims to evaluate the mental health consequences of OD in long COVID patients.Methodology: A cross-sectional study involved 86 adult patients. Participants presented OD for at least three months post-COVID- 19 and were evaluated using the extended battery of Sniffin' Sticks test (SST). Psychological assessments included the Impact of Event Scale-Revised (IES-R), Beck Hopelessness Scale (BHS), Depression, Anxiety, and Stress Scale-21 (DASS-21), and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q).Results: Significant differences in mental health factors were observed between patients with and without OD: in comparison to normosmic patients, hyposmic patients showed higher IES-R Total, Avoidance, and Hyperarousal scores, along with increased DASS-21 Anxiety scores and BHS total scores.Conclusions: OD in long COVID patients were significantly associated with increased post-traumatic stress symptoms, anxiety symptoms and hopelessness, and with lower quality of life. Limited sample size, inability to determine causation and exploratory nature of the study may limit the generalizability of results. Comprehensive management addressing both physical and mental health should be assessed in long COVID patients.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"221-229"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world treatment of chronic rhinosinusitis with dupilumab and omalizumab: results from the Korean National Health Insurance Service database. 使用dupilumab和omalizumab治疗慢性鼻窦炎的现实世界：来自韩国国民健康保险服务数据库的结果

IF 4.8 2区医学

Rhinology Pub Date : 2025-04-01 DOI: 10.4193/Rhin24.209

S A Han, J Yoon, B H Kim, J H Park, Y-S Lim, Y B Kim, C G Cho, S-W Park, J Y Kim

{"title":"Real-world treatment of chronic rhinosinusitis with dupilumab and omalizumab: results from the Korean National Health Insurance Service database.","authors":"S A Han, J Yoon, B H Kim, J H Park, Y-S Lim, Y B Kim, C G Cho, S-W Park, J Y Kim","doi":"10.4193/Rhin24.209","DOIUrl":"10.4193/Rhin24.209","url":null,"abstract":"Background: Biological treatment has proven effective for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and is increasingly prescribed. However, in the real-world, strict adherence to the recommended dose may not be feasible and studies on the actual administration patterns of biologics are limited. This study aimed to evaluate the patterns of real-world use of biologics for CRS in Korea, through the National Health Insurance Service (NHIS).Methods: We analysed data from the NHIS database from January 2010 to March 2024. Patients with CRS or nasal polyp defined by the ICD-10 codes, who had undergone computed tomography, and had a history of being prescribed dupilumab or omalizumab were identified. A total of 808 patients were analysed for their administration patterns and systemic corticosteroid use.Results: Twelve weeks after initiation of therapy, 46.2% of patients received dupilumab at 2-weekly intervals and 53.9% of patients on omalizumab patients were receiving treatment at 2- or 4-week intervals. The annual expense of CRS patients treated with biologics was greater than for those receiving other treatments. The average annual usage of systemic steroids was decreased from 33.0 days to 12.7 days after using biologics.Conclusions: The results of this study which analysed real-world data in a large population, suggest a discrepancy between the recommended dose and real-world administration of biologics. Further studies are warranted on feasible administration schedules that reflect various patient factors and healthcare costs.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"172-179"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0