Rhinology最新文献_第2页

Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial. 嗅觉训练治疗COVID-19相关嗅觉丧失：一项随机双盲对照试验

IF 4.8 2区医学

Rhinology Pub Date : 2025-06-01 DOI: 10.4193/Rhin24.081

T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano

{"title":"Olfactory training for the treatment of COVID-19 related smell loss: a randomised double-blind controlled trial.","authors":"T L I Serrano, M A Antonio, L T Giacomin, A M Morcillo, J Dirceu Ribeiro, E Sakano","doi":"10.4193/Rhin24.081","DOIUrl":"10.4193/Rhin24.081","url":null,"abstract":"Background: Olfactory training is the most widely recommended treatment for smell loss; however, there are no randomised placebo-controlled trials evaluating its effectiveness in COVID-19. We aimed to evaluate the efficacy of isolated training and factors associated to olfactory recovery.Methods: This is a prospective randomised double-blind controlled trial, using standard olfactory training (OT) and placebo (PB) in COVID-19 patients experiencing smell loss. They were followed up for 180 days and assessed with the Connecticut olfactory test (CCCRC) and with subjective methods on a monthly basis.Results: A total of 123 participants completed follow-up: 68 in the OT group and 55 in the PB group. Overall, 84.5% achieved normosmia, with full recovery (FR) significantly higher in PB. At baseline, OT had lower olfactory scores and higher corticosteroid use. Multivariate analysis showed no significant differences in outcomes between groups. Baseline olfactory test scores were the strongest predictors of recovery. Exploratory analyses stratified participants by time to treatment initiation (early < 30 days; late > 30 days), showing a 58% higher chance of FR in the early group for similar CCCRC scores, regardless of management type.Conclusions: OT is not superior to PB for treating COVID-19-related smell loss. Better results of first evaluation indicate great chance of full recovery and the use of systemic corticosteroid, in persistent olfactory loss, has not affected outcome.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"325-333"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review. 中药治疗急慢性鼻窦炎的系统综述。

IF 4.8 2区医学

Rhinology Pub Date : 2025-06-01 DOI: 10.4193/Rhin23.526

K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis

{"title":"Traditional herbal medicine in the treatment of acute and chronic rhinosinusitis: a systematic review.","authors":"K Choulakis, A Karatzanis, C Skoulakis, I M Vlastos, E Prokopakis","doi":"10.4193/Rhin23.526","DOIUrl":"10.4193/Rhin23.526","url":null,"abstract":"Background: Traditional medicine and herbal medicine are relatively commonly utilized by patients for the treatment of acute (ARS) and chronic rhinosinusitis (CRS). The aim of this study is to review the literature to evaluate scientific evidence regarding the use of herbal preparations in the treatment of rhinosinusitis.Methodology: We reviewed all published studies until February 2024 in PubMed, EMBASE, and Cochrane, using the followingkeywords: herbal medicine and nasal diseases, herbs and nasal diseases, Traditional Chinese Medicine (TCM) and nasal diseases, traditional medicine and nasal diseases, phytotherapy and nasal diseases.Results: Thirty-three clinical studies met the purpose of this review and were assessed. These studies examine the effect of eleven herbal preparations for the treatment of ARS and CRS.Conclusions: Herbal preparation BNO-1016 presents significant evidence in the literature regarding its use in the treatment of ARS, while the TCM preparation Xiangju might be a useful component in the treatment of CRS. Specific traditional herbal medicinal products, therefore, show promising results for the treatment of rhinosinusitis, and their use should be examined further. Given the relatively high demand for medicinal herbs, therapeutic use of those preparations should be explored further.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"286-305"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-HDAC7 expression related to poor prognosis in sinonasal mucosal melanoma. hdac - 7高表达与鼻黏膜黑色素瘤预后不良相关

IF 4.8 2区医学

Rhinology Pub Date : 2025-06-01 DOI: 10.4193/Rhin24.463

D Zheng, C Liu, X Pu, X Deng, Y Chen, S Li

{"title":"High-HDAC7 expression related to poor prognosis in sinonasal mucosal melanoma.","authors":"D Zheng, C Liu, X Pu, X Deng, Y Chen, S Li","doi":"10.4193/Rhin24.463","DOIUrl":"10.4193/Rhin24.463","url":null,"abstract":"Background: Sinonasal mucosal melanoma (SNMM) is a rare malignant melanoma. Histone deacetylase 7 (HDAC7) is involved in the development of various tumours, but its function in SNMM remains underexplored.Methodology: We retrospectively studied 30 patients with SNMM treated between 2013 and 2023. Immunohistochemistry was used to assess HDAC7, Β-catenin, c-Myc, and Ki-67 expression. Relationships among HDAC7 expression, clinical characteristics, prognosis,Β-catenin, c-Myc, and Ki-67 were analysed.Results: HDAC7 was overexpressed in SNMM tissues compared to normal tissues. Expression was higher in stage IV compared to stage III and in T4 grade compared to T3 grade. The median overall survival (OS) was 29 months, with 8 patients alive. High-HDAC7 expression (in 13 patients) correlated with poorer OS and disease-free survival (DFS). HDAC's carcinogenic role in SNMM may be mediated by Β-catenin/c-Myc. Univariate analysis for OS revealed high-HDAC7, high c-Myc, positive surgical margins, T4 grade, and stage IV were significant factors leading to SNMM's poor prognosis. However, HDAC7 expression was the only independent prognostic factor. Additionally, a nomogram model showed promising results but was not validated in another cohort.Conclusions: High-HDAC7 expression is associated with advanced T grade, clinical stage, and poor prognosis in SNMM. HDAC7 may influence cell proliferation, invasion and migration by activating the Β-catenin/c-Myc signalling pathway.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"373-382"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinology â€" What else? 鼻科——还有什么？

IF 4.8 2区医学

Rhinology Pub Date : 2025-06-01 DOI: 10.4193/Rhin25.903

B N Landis

引用次数: 0

Clinical features and outcomes of skull base osteoradionecrosis in nasopharyngeal carcinoma patients: a systematic review and meta-analysis. 鼻咽癌患者颅底放射性骨坏死的临床特征和预后：系统回顾和荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-30 DOI: 10.4193/Rhin25.522

S Ding, C X Y Liao, W H B Mak, H K Chan, C P L Chan, C C F Lai, S M W Chow, J Y K Chan, D C M Yeung

{"title":"Clinical features and outcomes of skull base osteoradionecrosis in nasopharyngeal carcinoma patients: a systematic review and meta-analysis.","authors":"S Ding, C X Y Liao, W H B Mak, H K Chan, C P L Chan, C C F Lai, S M W Chow, J Y K Chan, D C M Yeung","doi":"10.4193/Rhin25.522","DOIUrl":"https://doi.org/10.4193/Rhin25.522","url":null,"abstract":"Background: Skull base osteoradionecrosis following radiotherapy for nasopharyngeal carcinoma is a potentially life-threatening complication. Assessing severity, prognosis and providing appropriate treatment for the condition can be clinically challenging. This systematic review evaluates factors associated with patient outcome.Methodology: A literature search of PubMed, Embase, MEDLINE and Cochrane databases was conducted in August 2024. Data was extracted for patients with skull base osteoradionecrosis caused by nasopharyngeal carcinoma. Results were presented by narrative synthesis or with statistical analysis.Results: 359 patients from 31 papers were included. The clivus and posterior nasopharyngeal wall were the most common subsites for osteoradionecrosis. We categorized subsites into posterior, roof and lateral areas. Subsite was not associated with ICA exposure or infection. Frequent symptoms include headache, foul odour and epistaxis. Foul odour was negatively associated with infection and epistaxis was highly associated with ICA exposure. The most common direct complication was CSF leak (18.2%), whereas the most common post-treatment complication was infection (43.8%). Carotid blowout was the most common cause of mortality (45.9%).Conclusions: Foul odour and epistaxis may predict cases of skull base osteoradionecrosis complicated by ICA exposure and infection. Further research is necessary to assess the significance of ORN subsite as a prognosticator or guide to treatment.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors in patients treated with surgical drainage for rhinogenic intracranial complications: a nationwide study. 鼻源性颅内并发症手术引流治疗患者的危险因素：一项全国性研究。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-30 DOI: 10.4193/Rhin25.057

M Morita, K Tarasawa, H Hidaka, Y Yun, K Fujimori, K Fushimi, S Hamada, M Asako, R Kawachi, M Yagi, H Iwai

{"title":"Risk factors in patients treated with surgical drainage for rhinogenic intracranial complications: a nationwide study.","authors":"M Morita, K Tarasawa, H Hidaka, Y Yun, K Fujimori, K Fushimi, S Hamada, M Asako, R Kawachi, M Yagi, H Iwai","doi":"10.4193/Rhin25.057","DOIUrl":"https://doi.org/10.4193/Rhin25.057","url":null,"abstract":"Background: Data on risk factors for rhinogenic intracranial complications (RICs) including cerebral abscess have been limited. Using a nationwide database, the aim was to identify the factors related to mortality and delayed discharge.Methodology: Data of 326 patients between 2012 and 2022 were extracted from a Japanese inpatient database. The main outcome was survival at discharge. In a subgroup analysis of the 316 surviving patients, the outcome was delayed discharge.Results: The mortality rate was 3.1%. Logistic regression analyses identified intracerebral complications more than one surgical intervention and consciousness level evaluated by the Japan Coma Scale (JCS): JCS I and JCS≥ II as risk factors for mortality. Concurrent interventions of intracranial and sinonasal drainage was identified as a factor associated with decreased risk.Conclusions: Although RICs are rare, with decreasing mortality due to progress in imaging and clinical strategies, they remain the most severe complications of rhinosinusitis. Subdural and/or intracerebral abscess, consciousness level at admission, and more than one surgical intervention were found to be risk factors for mortality. Conversely, concurrent interventions, intracranial and sinonasal drainage, contributed to reducing this risk.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic rhinosinusitis in nasopharyngeal carcinoma patients post- IMRT: a meta-analysis. 鼻咽癌患者IMRT后慢性鼻窦炎：一项荟萃分析。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-23 DOI: 10.4193/Rhin25.095

N Y M Chua, W K Lau, A L Chui, C L Ng, D Y Wang

{"title":"Chronic rhinosinusitis in nasopharyngeal carcinoma patients post- IMRT: a meta-analysis.","authors":"N Y M Chua, W K Lau, A L Chui, C L Ng, D Y Wang","doi":"10.4193/Rhin25.095","DOIUrl":"https://doi.org/10.4193/Rhin25.095","url":null,"abstract":"Background: Intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC) can cause chronic rhinosinusitis (CRS), an underexplored side effect. This review aimed to determine the incidence and severity of CRS in NPC patients post-IMRT.Methods: Electronic databases (PubMed, CINAHL, Embase, Cochrane Library, Web of Science) were searched for studies published from 2000 onwards. Eligible studies assessed CRS in NPC patients post-IMRT, using validated methods per EPOS 2020 (Lund-Mackay (LM) CT scoring, Lund-Kennedy (LK) endoscopic scoring, SNOT questionnaire). Meta-analysis was conducted using SPSS and R to quantify pooled CRS incidence and severity.Results: Nine studies (n=1,478) were included, revealing distinct patterns in CRS development and severity. Patients without prior sinusitis showed significantly increased likelihood of developing CRS post-IMRT, while those with prior sinusitis had reduced odds due to a ceiling effect, as CRS was already present in 100% of these patients before IMRT. Both groups showed significant increases in CRS severity pre- and post-IMRT, with the LK and LM scoring methods showing the most substantial changes.Conclusions: This review underscores the significant increases in both the incidence and severity of CRS in NPC patients post- IMRT. Clinicians should recognise the risk of CRS post-IMRT and recommend options to reduce the likelihood of CRS development.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The extra cost of biologics as first-line treatment in uncontrolled chronic rhinosinusitis with nasal polyps with no previous sinus surgery is overwhelming: a budget impact analysis. 一项预算影响分析显示，在未做过鼻窦手术的未控制的慢性鼻窦炎合并鼻息肉患者中，生物制剂作为一线治疗的额外费用是压倒性的。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-23 DOI: 10.4193/Rhin24.418

M Fieux, J Margier, S Bartier, M Chang, F Carsuzaa, P H Hwang, Z M Patel, S Tringali, V Favier, T Savary

{"title":"The extra cost of biologics as first-line treatment in uncontrolled chronic rhinosinusitis with nasal polyps with no previous sinus surgery is overwhelming: a budget impact analysis.","authors":"M Fieux, J Margier, S Bartier, M Chang, F Carsuzaa, P H Hwang, Z M Patel, S Tringali, V Favier, T Savary","doi":"10.4193/Rhin24.418","DOIUrl":"https://doi.org/10.4193/Rhin24.418","url":null,"abstract":"Background: Both surgery and biologics offer comparable control rates for patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) but differ in terms of cost and complications. The aim was to assess the mean total direct cost per patient of biologics or surgery as first-line treatment in uncontrolled CRSwNP and to perform a budget impact analysis (BIA).Methods: An economic model was build based on pricing of March 2024, and on the theoretical French population to simulate both the 5-year mean direct cost per patient and the BIA. For the BIA, two scenarios were evaluated: in scenario 1 (the normal one), 18% of patients received biologics as first-line (vs 82% surgery) and in scenario 2 (the less likely one), 90% of patients received biologics as first-line (vs 10% surgery). Within both scenarios, two approaches were considered, the surgical one (when patients received surgery as first-line) and the biological one (when patients received biologics as first-line, no previous sinus surgery).Results: Over 5 years, the estimated mean direct cost per patient per year was significantly lower in the surgical approach compared to the biological one (60,026€). The BIA found that the estimated net overall incremental budget impact was 91,287,924€ in scenario 1 and 1,024,768,639€ in scenario 2. In both scenarios, the biological approach was the most expensive (+184% and +1048%, respectively).Conclusion: At current costs, if biologics were used as a first-line treatment (no previous sinus surgery) in patients with uncontrolled CRSwNP, the extra direct cost would be overwhelming.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant cystic fibrosis and NSAID-exacerbated respiratory disease. 伴有囊性纤维化和非甾体抗炎药加重的呼吸系统疾病。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-23 DOI: 10.4193/Rhin25.132

S D Le Bon, J Plojoux, Y Coattrenec, B N Landis

引用次数: 0

Effectiveness of Artificial Intelligence in detecting sinonasal pathology using clinical imaging modalities: a systematic review. 人工智能在使用临床成像方式检测鼻窦病理中的有效性：系统综述。

IF 4.8 2区医学

Rhinology Pub Date : 2025-05-19 DOI: 10.4193/Rhin25.044

D-P Petsiou, D Spinos, A Martinos, J Muzaffar, G Garas, C Georgalas

{"title":"Effectiveness of Artificial Intelligence in detecting sinonasal pathology using clinical imaging modalities: a systematic review.","authors":"D-P Petsiou, D Spinos, A Martinos, J Muzaffar, G Garas, C Georgalas","doi":"10.4193/Rhin25.044","DOIUrl":"https://doi.org/10.4193/Rhin25.044","url":null,"abstract":"Background: Sinonasal pathology can be complex and requires a systematic and meticulous approach. Artificial Intelligence (AI) has the potential to improve diagnostic accuracy and efficiency in sinonasal imaging, but its clinical applicability remains an area of ongoing research. This systematic review evaluates the methodologies and clinical relevance of AI in detecting sinonasal pathology through radiological imaging.Methodology: Key search terms included \"artificial intelligence,\" \"deep learning,\" \"machine learning,\" \"neural network,\" and \"paranasal sinuses,\". Abstract and full-text screening was conducted using predefined inclusion and exclusion criteria. Data were extracted on study design, AI architectures used (e.g., Convolutional Neural Networks (CNN), Machine Learning classifiers), and clinical characteristics, such as imaging modality (e.g., Computed Tomography (CT), Magnetic Resonance Imaging (MRI)).Results: A total of 53 studies were analyzed, with 85% retrospective, 68% single-center, and 92.5% using internal databases. CT was the most common imaging modality (60.4%), and chronic rhinosinusitis without nasal polyposis (CRSsNP) was the most studied condition (34.0%). Forty-one studies employed neural networks, with classification as the most frequent AI task (35.8%). Key performance metrics included Area Under the Curve (AUC), accuracy, sensitivity, specificity, precision, and F1-score. Quality assessment based on CONSORT-AI yielded a mean score of 16.0 ± 2.Conclusions: AI shows promise in improving sinonasal imaging interpretation. However, as existing research is predominantly retrospective and single-center, further studies are needed to evaluate AI's generalizability and applicability. More research is also required to explore AI's role in treatment planning and post-treatment prediction for clinical integration.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0