Rhinology最新文献

{"title":"Dupilumab in chronic rhinosinusitis without nasal polyps: randomized phase 2 trial (ORION).","authors":"S E Lee, A T Peters, P Gevaert, J K Han, C Bachert, F Moreira da Silva, A Rosenbluut, C C Hu, J Maloney, P Caferra, A Michalak, A P Fontenot, L B Robinson, N A Phadke","doi":"10.4193/Rhin25.660","DOIUrl":"10.4193/Rhin25.660","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is often driven by type 2 inflammation and is characterized by nasal obstruction/ discharge, facial pain/pressure, and/or reduced smell, either with or without nasal polyps (CRSwNP or CRSsNP).</p><p><strong>Objective: </strong>To test whether dupilumab improves radiographic features in CRSsNP.</p><p><strong>Methods: </strong>ORION (NCT04678856), a phase 2, randomized, multicenter, double blind, placebo-controlled study, assessed dupilumab efficacy and safety in adults with uncontrolled CRSsNP. Patients were randomized 1:1 to dupilumab or placebo for 24 to 52 weeks. Endpoints included changes from baseline at week 24 in Lund-Mackay computed tomography (LMK-CT) score (dupilumab only [primary] and vs placebo [secondary]), sinus Total Symptom Score (sTSS), University of Pennsylvania Smell Identification Test (UPSIT) score, and 22-item Sino-Nasal Outcome Test(SNOT-22) score. Primary analysis was conducted in the intention-to-treat population with screening blood eosinophil count (sBEC) ≥300 cells/uL. Safety data were evaluated in all patients.</p><p><strong>Results: </strong>Seventy-one patients were randomized (dupilumab, n = 38; placebo, n = 33). In the dupilumab group with sBEC≥300 cells/uL (n = 16), mean (95% CI) week 24 change from baseline in LMK-CT was -6.63 (-8.71 to -4.54); week 24 mean differences vs placebo (95% CI) for LMK-CT, sTSS, UPSIT, and SNOT-22 were -5.95 (-8.38 to -3.51), -1.43 ( 3.28 to 0.41), 5.91 (-1.56 to 13.38), and -14.71 (-34.35 to 4.94). Treatment-emergent adverse events were balanced between treatment groups.</p><p><strong>Conclusion: </strong>Dupilumab was associated with improvement in LMK-CT score and a trend toward improvement in sinonasal symptoms at week 24 in adults with severe, uncontrolled CRSsNP with sBEC ≥300 cells/uL.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"599-608"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper airway disease in Jeju Haenyeo: the aging and resilience cohort (JH-ARC) study.","authors":"S W Chang, M Kang, J Lee, M J Suh, J H Kim, E Park, S Ji, E Lee, C Yang, A Ha, J K Rhim, J Cho, J D Joo","doi":"10.4193/Rhin26.196","DOIUrl":"10.4193/Rhin26.196","url":null,"abstract":"<p><p>Jeju Haenyeo are traditional female breath-hold divers from Jeju Island, the southernmost and largest island of the Republic of Korea, who harvest marine products without modern diving equipment. During diving, they are repeatedly exposed to cold seawater, breath-holding, and pressure changes. The upper airway may be particularly vulnerable, as it is the first anatomical region directly exposed to seawater and pressure-related stimuli.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"710-712"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhinology starts collaboration with Wiley.","authors":"W J Fokkens","doi":"10.4193/Rhin26.905","DOIUrl":"https://doi.org/10.4193/Rhin26.905","url":null,"abstract":"<p><p>Rhinology has been produced for over 60 years in-house but with the increasing complexities of publishing scientific journals we felt it was the right moment to form an external partnership and after a rigorous search, and in close collaboration with the editoril board, choose Wiley, whose expertise in the field and modus operandi are the most compatible with Rhinology.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":"64 5","pages":"577"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The qualitative exploration of work productivity among chronic rhinitis patients.","authors":"S N Sharudin, F D Zahedi, H M Yusoff, S Husain, A K W Hamizan, R Hod","doi":"10.4193/Rhin25.032","DOIUrl":"https://doi.org/10.4193/Rhin25.032","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinitis is a global public health concern affecting sleep, cognitive function, mood, quality of life, and work performance. It contributes to socioeconomic costs through decreased productivity, including absenteeism and presenteeism. This study explores the impact of chronic rhinitis on work productivity and employee performance to inform better management strategies.</p><p><strong>Method: </strong>A literature review and semi-structured interviews were conducted with 19 chronic rhinitis patients from Hospital Canselor Tuanku Muhriz and Hospital Ampang. Data saturation was reached, and thematic analysis was performed using Atlas.ti.</p><p><strong>Result: </strong>Eight themes were identified: absence during working hours, work limitations, disruption of social interactions, reduced work efficiency, emotional disturbances, weaknesses in compliance with work procedures, sleepiness at work, and negative perceptions from colleagues.</p><p><strong>Conclusion: </strong>Chronic rhinitis significantly affects work productivity, leading to absenteeism, reduced efficiency, and workplace stigma. These findings highlight the need for targeted management strategies to improve work performance and reduce the negative impact of chronic rhinitis on affected individuals.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":"64 5","pages":"647-657"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metropolitan air pollution and the upper and lower airway: chronic rhinosinusitis and asthma outpatient burden.","authors":"H H Yang, E Velasquez, P H Hwang","doi":"10.4193/Rhin26.072","DOIUrl":"10.4193/Rhin26.072","url":null,"abstract":"<p><strong>Background: </strong>Although evidence has implicated air pollution in both upper and lower airway inflammation, regulatory efforts have primarily emphasized lower-airway outcomes. We characterize the association between ambient pollutant levels and outpatient burden of chronic rhinosinusitis (CRS) and asthma across the US.</p><p><strong>Methodology: </strong>We conducted an ecological cohort study of US metropolitan statistical areas (MSAs) between 2007 and 2020. Annual outpatient claims were obtained from the MarketScan database and linked with data from the Environmental Protection Agency (EPA) monitoring network. For each MSA, annual outpatient visits for CRS and asthma were normalized to the number of wellness check visits (CRS-OV, asthma-OV). Daily 365-day rolling averages were calculated for each EPA-monitored pollutants. Mixed-effects models estimated associations with CRS-OV and asthma-OV, and additive pollutant interactions.</p><p><strong>Results: </strong>Controlling for community health indicators, higher levels of all EPA monitored pollutants predicted increased CRS-OV and asthma-OV. Adjusting for co-pollutant levels, PM2.5 (particles ≤ 2.5um in diameter) and SO2 (gas from fossil fuel combustion) remained independently predictive. Each standard deviation increase in PM2.5 corresponded to 15% and 6% increases in CRS-OV and asthma-OV, while each standard deviation increase in SO2, corresponded to 12% and 10%, respectively. Positive additive interaction between PM2.5 and SO2 was observed for both CRS-OV and asthma-OV.</p><p><strong>Conclusions: </strong>While EPA-monitored pollutants were broadly associated with outpatient burden, PM2.5 and SO2 emerged as independent and synergistic predictors after co-pollutant adjustment, with stronger associations for CRS compared to asthma. Regulatory focus should extend beyond lower-airway outcomes and include upper-airway morbidity as a critical indicator of pollution-related burden.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"588-598"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal biopsy in ANCA-associated vasculitis: a game changer or a false friend?","authors":"L Gazzini, I Girolami, S Niederbacher, L Calabrese, M Bond","doi":"10.4193/Rhin26.217","DOIUrl":"10.4193/Rhin26.217","url":null,"abstract":"<p><p>Earâ€\"noseâ€\"throat (ENT) involvement is common in ANCA associated vasculitis, particularly in granulomatosis with polyangiitis (GPA) and EGPA eosinophilic granulomatosis with polyangiitis (EGPA), with sinonasal manifestations frequently representing the earliest clinical features of disease.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"716-717"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic outcomes of biologic switching in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.","authors":"H J Aljubran, M R Alabdulaal, L A Aldhaif, D M Motabagani, R M Alhussain, Z S AlWusaybie, F O Aldhafeeri, A Almomen","doi":"10.4193/Rhin25.623","DOIUrl":"10.4193/Rhin25.623","url":null,"abstract":"<p><strong>Background: </strong>Biological therapy is a newer line of treatment that has been utilized in practice for patients with chronic rhinosinusitis with nasal polyps, showing excellent results. However, some patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) do not respond to this therapy. Hence, this study aims to evaluate the efficacy and safety of biological switching in these patients.</p><p><strong>Methodology: </strong>Using the Web of Science, Cochrane, MEDLINE, and Embase databases, we analyzed studies involving biological switching in CRSwNP patients published up to June 2025. The studies were extracted, and data were pooled for meta-analysis.</p><p><strong>Results: </strong>Of 3,367 studies identified, eight studies (involving 470 patients) were included in the systematic review, four of which were included in the meta-analysis. The results showed that the most common reason for switching was insufficient CRS symptom control (59.7%), followed by undesirable side effects (10.8%). The findings demonstrated dramatic effects of biological switching in terms of the SNOT-22 score, with a mean improvement of 71.4%. In addition, studies that switched patients to dupilumab showed significant improvement after switching in both SNOT-22 and nasal polyp scores. Overall, the success rate of biological switching ranged from 59.6% to 100%, with an average success rate of 79.2%.</p><p><strong>Conclusions: </strong>This review demonstrated the effect of biological switching as an option for patients with refractory CRSwNP or those experiencing biological side effects. These findings highlight a new therapeutic alternative that can serve as a fundamental choice when managing CRSwNP patients.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"578-587"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological silencing of nasal TRPV1+ nociceptors ameliorates eosinophilic infiltration but exacerbates neutrophilic infiltration in murine models of allergic rhinitis.","authors":"F Ye, Y Tao, J Chen, R Wang, Y Li, Z Shi, Q Yang","doi":"10.4193/Rhin25.667","DOIUrl":"10.4193/Rhin25.667","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of allergic rhinitis (AR) involves hyperreactivity of both the immune and neural systems. While sensory nerves detect allergens and release neuropeptides that directly participate in immune regulation, their precise role within the AR inflammatory network remains incompletely elucidated.</p><p><strong>Methodology: </strong>Using house dust mite (HDM) and ovalbumin (OVA)-induced murine AR models, we selectively silenced nasal TRPV1-expressing sensory nerves pharmacologically with QX-314 (co-administered with capsaicin) and Resiniferatoxin (RTX). The effects of neuronal silencing on animal behavior, allergen-specific IgE levels, inflammatory cell nfiltration, and immune cell populations were systematically evaluated via immunofluorescence, histological staining, ELISA, and flow cytometry.</p><p><strong>Results: </strong>Both QX-314 and RTX effectively silenced TRPV1+ sensory neurons in the trigeminal ganglia and significantly downregulated the expression of neuropeptides CGRP and SP. Silencing nasal TRPV1+ sensory nerves markedly reduced eosinophilic infiltration and levels of the associated marker ECP in the nasal mucosa of AR model mice. Unexpectedly, it also led to a significant increase in neutrophilic infiltration and MPO-positive cells. RTX-mediated ablation further compromised epithelial barrier integrity and aggravated the local inflammatory burden. Flow cytometric analysis further confirmed that RTX-mediated ablation of TRPV1+ neurons significantly decreased the proportions of infiltrating eosinophils and B cells, but increased the proportion of neutrophils in the OVA model.</p><p><strong>Conclusions: </strong>Silencing nasal TRPV1+ sensory nerves exerts a dual immunomodulatory effect in AR, attenuating eosinophilic inflammation while promoting neutrophilic infiltration. This reveals a critical neuro-immune balance in the nasal mucosa and suggests that precisely targeted neuromodulation strategies are required to suppress allergic inflammation.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"678-690"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucus transport in the olfactory cleft is significantly slower than in the nasal respiratory mucosa.","authors":"A K Hernandez, S Biguerdi, K Schindowski, T Hummel","doi":"10.4193/Rhin26.082","DOIUrl":"10.4193/Rhin26.082","url":null,"abstract":"<p><p>Intranasal mucociliary transport has been conventionally described as moving, essentially, in an anterior-to-posterior direction along the ciliated respiratory mucosa (RM). This mechanism is essential for clearing inhaled particles and pathogens and may be impaired in individuals with certain genetic conditions or infections.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"718-720"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of mepolizumab in eosinophilic asthma and chronic rhinosinusitis with nasal polyps.","authors":"E Chiner, I Boira, J L Lafuente, M Anton, M A Bernabeu, P Fernandez, V Esteban, M Llombart","doi":"10.4193/Rhin26.207","DOIUrl":"10.4193/Rhin26.207","url":null,"abstract":"<p><p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease affecting 2â€\"4% of the population which has a significant impact on quality of life. Approximately 40% to 60% of people with CRSwNP also have eosinophilic asthma, reflecting the unified airway concept characterised by type 2 inflammation driven by interleukin (IL)-4, IL-5 and IL-13.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"713-715"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}