Saudi Journal of Kidney Diseases and Transplantation最新文献

{"title":"Spinal Epidural Lipomatosis, a Steroid-associated Side Effect Seen in a Case of Adult Minimal Change Disease.","authors":"Prakash Ghogale, Avishkar Kadhao, Dattatray Kale, Prabhakar Yadav, Zaid Nafe, Saurabh Pathak","doi":"10.4103/sjkdt.sjkdt_374_21","DOIUrl":"10.4103/sjkdt.sjkdt_374_21","url":null,"abstract":"<p><p>Minimal change disease is a significant cause of primary nephrotic syndrome in adults of all ages, accounting for approximately 10-15% of cases. Prednisolone is commonly taken for a minimum of 4 weeks and a maximum of 16 weeks in adult patients with minimal change disease at a dose of 1.0 mg/kg/day (with a maximum of 80 mg/day). Long-term use of high-dose steroids increases the chance of developing a variety of steroid-related toxicities, the most common of which are diabetes mellitus, gastrointestinal problems, infections, osteoporosis and steroid-induced psychiatric syndrome, all of which can impair quality of life. Here, we report a case of spinal epidural lipomatosis, which is an uncommon side effect of steroid medications encountered by us in an adult patient who presented with nephrotic syndrome and had a kidney biopsy that revealed minimal change disease and was treated with steroids.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"36 1-6","pages":"89-94"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audiological Findings in Hemodialysis Patients.","authors":"S Azria, S S Elkhayat, K Chaaoun, G Medkouri, B Ramdani, R Laababsi, Z Elkrimi, B Abdulhakeem","doi":"10.4103/sjkdt.sjkdt_504_20","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_504_20","url":null,"abstract":"<p><p>Hearing loss in end-stage chronic renal failure is more common than in the general population. The etiopathogenetic mechanisms reported included the use of ototoxic drugs, hypertension, fluid and electrolyte disorders associated with kidney failure, and factors related to hemodialysis itself, such as acute hypotension, reduced blood osmotic pressure, acute urea clearance, and the immunological reaction caused by dialyzer membranes. The aim of our study was to evaluate auditory function in patients with end-stage chronic renal failure, to study the prevalence of hearing loss and the factors that may influence its occurrence in these patients, and to evaluate the effects of a single session of hemodialysis on the parameters of hearing. A descriptive and analytical cross-sectional study was conducted in hemodialysis patients attending the hemodialysis center of the university hospital Ibn Rochd of Casablanca. The inclusion criteria were age less than 65 years, patient consent, the absence of otologic pathology, and the absence of a documented history of drug ototoxicity. We collected demographic, clinical and laboratory data. All patients underwent a complete otologic examination. Tone audiometry was performed in all patients one hour before the hemodialysis session; a subgroup of patients received a second audiogram after the dialysis session. Thirty patients were enrolled. The average age was 47.37 ± 10.17 years; the sex ratio was 1, and 13.3% had hearing loss at all tested frequencies. Severe hearing loss was only found at the high frequencies (4000 and 8000 Hz); it was around 10%. Low frequencies (125 and 200 Hz) were affected in 61.67% of cases. Higher frequencies (4000 and 8000 Hz) were affected in 63.33% of cases. The prevalence of hearing loss in speech frequencies (500, 1000, 2000 and 4000 Hz) was about 33.3% (10 patients). It was mild in 20% of cases and moderate in 13.33% of cases. Sensorineural hearing loss was found in 16.6% of cases, conductive hearing loss in 10% and mixed hearing loss in 6.67%. No statistically significant correlation was found between hearing impairment in these patients and their age, gender, duration of hemodialysis, body mass index, history of ototoxic drugs, hypertension, hypotension during dialysis and biochemical parameters. There was a statistically significant correlation between hearing loss and the presence of peridialytic cramps. The comparison of hearing thresholds before and after hemodialysis did not find any statistically significant difference. The prevalence of hearing impairment in patients undergoing hemodialysis remains high. We have not been able to demonstrate the effect of hemodialysis on hearing. Hearing loss can negatively affect patients' quality of life. A hearing evaluation of patients treated for chronic renal failure may be necessary to enable appropriate and early care for possible impairment and thus avoid the social impact of deafness.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"36 1-6","pages":"18-25"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Study of Immunoglobulin M Nephropathy in Northern Areas of Pakistan.","authors":"Humaira Nasir, Naima Tariq, Nadira Mamoon, Zafar Ali, Fariha Khalil, Imran N Ahmad, Asim Qureshi","doi":"10.4103/sjkdt.sjkdt_423_20","DOIUrl":"10.4103/sjkdt.sjkdt_423_20","url":null,"abstract":"<p><p>Immunoglobulin M IgM nephropathy (IgMN) is a controversial entity first described in 1970. Since its inception, the disease remains underdiagnosed because of its diverse clinical as well as morphological presentations and its lack of recognition as a separate distinct entity. We undertook this study, which includes a large number of cases, to better characterize and understand the natural history of this disease. The objective of the study was to determine the clinico-pathological features of patients diagnosed with IgMN. This cross-sectional study was conducted from 1 January 2013 to 28 February 2020 at the Department of Histopathology, Shifa International Hospital, Islamabad. All renal biopsies diagnosed as IgMN were included in the study. A comparative analysis was performed to see the associations of the clinicopathological features with the histological patterns. Univariate analysis was conducted to determine predictors of end-stage renal disease (ESRD). During the study period, 175 (2.80%) cases were diagnosed as having IgMN. The male to female ratio was 1.65:1. The mean age was 28.68 ± 16.19 years. Minimal change disease was the most common histological pattern, seen in 44% (n = 77) of the cases. Of our cases, 89% presented with nephrotic syndrome (NS) and 37.5% of the patients developed ESRD. Mean blood pressure, serum creatinine, treatment type, and response were found to be significantly associated with ESRD. IgMN in our population was frequently seen to present with NS, with variable morphological patterns. It has a poor prognosis with increased resistance to steroids and the frequent development of ESRD.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"2-12"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Chapter for Saudi Journal of Kidney Disease and Transplantation: Strengthening Excellence and Expanding Impact.","authors":"Tej K Mattoo, Khalid Alhasan","doi":"10.4103/sjkdt.sjkdt_2024351-6_ED1","DOIUrl":"10.4103/sjkdt.sjkdt_2024351-6_ED1","url":null,"abstract":"","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"1"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus Nephritis with Crescents: Clinicopathological Profile and Predictors of Poor Outcomes.","authors":"Asif Sadiq Wani, Anupma Kaul, Zafirah Zahir, Niraj Kumari, Sandeep Kansurkar","doi":"10.4103/sjkdt.sjkdt_568_20","DOIUrl":"10.4103/sjkdt.sjkdt_568_20","url":null,"abstract":"<p><p>Lupus nephritis occurs in 10-40% of patients with systemic lupus erythematosus. Although crescents involving >50% of the glomeruli portend a poor prognosis, little is known about outcomes with fewer crescents. We compared the clinicopathological profiles of different percentages of crescents, treatment outcomes, the type of immunosuppression used, the characteristics of anti-neutrophil cytoplasmic antibody-positive cases, and predictors of poor outcomes in cases of lupus nephritis with crescents. This was a 14-year retrospective single-center cohort study of patients with lupus nephritis who had cellular and/or fibrocellular crescents. In total, 8515 native biopsies were evaluated. Lupus nephritis was observed in 457 patients, and crescents were found in 110 patients. The patients were predominantly young females with nephritic syndrome. The remission rate was higher in those with ≤25% of crescentic glomeruli (Cr1) [complete remission (CR): 33.3%, partial remission (PR):17.6%] and those with 25-50% (Cr2) (CR: 24.1%, PR: 10.3%) than in those with >50% (Cr3) (CR: 13.0% PR: 3.3%). Chronic kidney disease (CKD) and end-stage renal disease (ESRD) rates were higher in Cr3 (CKD: 43.3%; ESRD: 10.0%) than in Cr1 (CKD: 21.5%; ESRD: 6.8%) and Cr2 (CKD: 34.4%; ESRD: 13.8%). Serum creatinine at biopsy, estimated glomerular filtration rate at the time of biopsy, rapidly progressive glomerulonephritis clinical presentation, the percentage of global glomerulosclerosis, the percentage of tubular atrophy, and >50% crescents predicted poor outcomes. Lupus nephritis with a higher proportion of crescents has an aggressive clinical presentation, the progression of the disease is rapid, and it has a poor response to treatment, warranting intensive immunosuppression.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"48-57"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endrin Poisoning Complicated by Rhabdomyolysis-associated Acute Kidney Injury: Two Rare Case Reports.","authors":"Suman Sethi, Sudhir Mehta","doi":"10.4103/sjkdt.sjkdt_186_21","DOIUrl":"10.4103/sjkdt.sjkdt_186_21","url":null,"abstract":"<p><p>Acute kidney injury (AKI) caused by rhabdomyolysis following a single episode of seizure is a rare entity. We report a rare case of food poisoning contaminated with pesticides, complicated by a seizure episode. This was followed by rhabdomyolysis and AKI in two members of the same family. The diagnosis of rhabdomyolysis was supported by a markedly elevated level of serum creatinine phosphokinase. Both patients underwent hemodialysis and subsequently made a rapid and complete recovery. Under further investigations, the contaminated source of food was identified. Toxicological screening led to the identification of the pesticide endrin as the cause of the seizure and rhabdomyolysis-associated AKI. The cause of AKI in both cases was attributed to acute rhabdomyolysis. Endrin is known to cause renal insufficiency by various mechanisms, including direct acute tubular injury, interstitial edema, and impaired autoregulation of renal blood flow. The temporal relationship between ingestion of the endrin-contaminated food and the development of seizures preceding acute rhabdomyolysis supported this fact. As endrin is known to cause seizures, especially in the absence of other etiologies for rhabdomyolysis, our cases supported the occurrence of endrin-induced rhabdomyolysis following seizures.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"98-103"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Report of the Durability of the Antibody Response in Maintenance Hemodialysis Patients and Kidney Transplant Recipients Vaccinated with Two Doses of the ChAdOx1 nCoV-19 Vaccine: A Prospective, Comparative, Multicenter, Observational Study.","authors":"Hari Shankar Meshram, S P Ashwin, Pritam Khomane, Sanshriti Chauhan, Sushil P Chauhan, Sandeep Deshmukh, Deepak Kumar, Mayur Patil, Vineet Mishra, Priyash Tambi, Nauka Shah, Ruchir Dave, Akash Shah, Vivek B Kute, Subho Banerjee","doi":"10.4103/sjkdt.sjkdt_187_22","DOIUrl":"10.4103/sjkdt.sjkdt_187_22","url":null,"abstract":"<p><p>The immunogenicity of COVID-19 vaccines in maintenance hemodialysis (MHD) and kidney transplant recipients (KTR) are suboptimal. However, there are no data on the durability of the humoral response with the ChAdOx1 nCoV-19 vaccine in these groups. This was a multicenter, prospective cohort study of MHD patients (n = 73), KTR (n = 62), and controls (n = 22) who received the ChAdOx1 nCoV-19 vaccine between February 2021 and April 2022. The vaccine response was measured at 1 and 6 months after the second dose. The antibody response in the MHD group compared with the controls was statistically lower at both 1 and 6 months. However, only six (8.2%) cases showed negative seroresponses at 1 month, and five (6.84%) had negative responses at 6 months. For the KTR group, overall, 26 (35.61%) cases had no seroresponse, and 36 (64.39%) seroconverted at6 months. In this group, antibody levels were lower at 6 months; however, there was no significant difference compared with 1 month. In a comparison of the MHD group and KTR, the antibody levels were significantly lower in the KTR group. The risk factors for no response at 6 months in the KTR group were a greater age, a recent history of antirejection, and being in the early transplant period, whereas only age was linked with a low response in the MHD group. Our report highlights the consistent and durable response of the COVID-19 vaccine in both groups of patients, despite them having an attenuated response compared with the controls.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"39-47"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapsing Hepatitis B-associated Vasculitis with Features of Polyarteritis Nodosa and c-Antineutrophilic Cytoplasmic Antibodies-associated Vasculitis.","authors":"Sardar Hassan Ijaz, Usman Khan, Areeba Shahnawaz, Aemen Shams Khakwani, Yusra Irshad, Mahum Nadeem, Varda Choudhry, Joseph Ghata","doi":"10.4103/sjkdt.sjkdt_255_21","DOIUrl":"10.4103/sjkdt.sjkdt_255_21","url":null,"abstract":"<p><p>Hepatitis B virus (HBV)-associated vasculitis manifests as vasculitis of the medium vessel and polyarteritis nodosa (PAN). HBV-associated PAN (HBV-PAN) is negative for antineutrophilic cytoplasmic antibodies (ANCA), without glomerulonephritis (GN) or pulmonary involvement; relapse does not occur after successful HBV seroconversion. We describe a case of HBV-associated vasculitis characterized by small and medium overlapping vasculitis and an atypical long-term course in a 60-year-old male with hypertension and HBV who initially presented with abdominal pain and scrotal swelling. The abdominal angiogram revealed a beaded morphology and aneurysms involving the mesenteric, hepatic, and intraparenchymal renal arteries. Tests for the HBV core antibody, cANCA, PR3, and rheumatoid factor were positive. He received pulse steroids and cytoxan for PAN and entecavir for HBV, which resolved the symptoms. Serum creatinine (SCr) rose and then remained stable. Multiple urinalysis measurements were negative. Two years later, the patient developed abdominal pain, orchitis, hemoptysis, and acute kidney injury (SCr = 11 mg/dL). The viral load of HBV was negative. Urinalysis showed 3+ blood and 3+ protein. The renal biopsy displayed pauci-immune crescentic GN with active crescents involving ~50% of the glomeruli. Two arteries had evidence of past arteritis with elastic lamina disruption. Acute necrotizing arteritis was absent. The patient recovered renal function after receiving pulse steroids, plasma exchange, rituximab, and cytoxan. Although the initial trigger may have been HBV, the vasculitis became self-perpetuating, as it recurred without HBV viremia. Patients with HBV-PAN who are ANCA+ should be closely followed because they could be at a higher risk of relapsing vasculitis.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"104-109"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Campylobacter fetus Peritonitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis.","authors":"Nourelhouda Ben Ayed, Hanen Chaker, Salma Toumi, Faouzia Mahjoubi, Mohamed Ben Hmida, Adnene Hammami","doi":"10.4103/sjkdt.sjkdt_145_21","DOIUrl":"10.4103/sjkdt.sjkdt_145_21","url":null,"abstract":"<p><p>Peritonitis is one of the most serious complications of peritoneal dialysis (PD). The most common microbial causes of PD-associated peritonitis are Gram-positive pathogens. However, unusual microorganisms may be involved in this type of infection, such as Campylobacter fetus. Here, we report a case of C. fetus peritonitis in a 60-year-old woman undergoing continuous ambulatory PD. This patient was admitted to the nephrology department with a history of fatigue, abdominal pain, diarrhea, vomiting, and fever. A bacteriological examination of the PD effluent revealed a cloudy liquid containing 900 leukocytes/mm3 with 75% polymorphonuclear neutrophils. C. fetus was obtained in a pure culture. Antibiotic susceptibility testing was performed. A favorable outcome was noted after treatment with amoxicillin or clavulanic acid and amikacin. Thus, an accurate bacteriological diagnosis of PD-associated peritonitis requires optimal culture methods to improve the isolation of fastidious microorganisms such as Campylobacter and therefore guide appropriate antibiotic therapy.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"133-136"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Bartonellosis in a Kidney Transplant Recipient Complicated by Infection-associated Glomerulonephritis: A Case Report and Literature Review.","authors":"Bojana Šimunov, Goran Radulović, Bojana Maksimović, Branislav Čingel, Dinko Škegro, Danica Galešić Ljubanović, Željka Jureković","doi":"10.4103/sjkdt.sjkdt_510_21","DOIUrl":"10.4103/sjkdt.sjkdt_510_21","url":null,"abstract":"<p><p>Bartonella henselae is the causative agent of cat-scratch disease, which is characterized by self-limited regional lymphadenopathy with fever. However, visceral manifestations are possible, especially in immunocompromised patients. Here, we report a case of bartonellosis in a kidney transplant (KT) recipient complicated by glomerulonephritis (GN) associated with the infection. A 52-year-old male who received a deceased-donor KT a year earlier presented to the emergency department with fever, malaise, and abdominal pain. Maintenance immunosuppression consisted of tacrolimus, mycophenolate mofetil, and prednisone. Inguinal lymphadenopathy was found, along with generalized intra-abdominal lymphadenopathy was found. A microscopic examination of the inguinal node demonstrated necrotizing granulomas. His kidney function deteriorated, and an allograft biopsy was performed. The finding was diffuse endocapillary proliferative GN with immune complexes. The B. henselae serology results came back positive, and doxycycline and rifampin were initiated. Given the severity of the kidney injury and the imminent loss of the graft, it was decided that the patient should be treated with steroid pulses. On completion of the antibiotic therapy, his lymphadenopathy resolved. His kidney function gradually recovered, and the patient was no longer dependent on dialysis. Bartonellosis is rare in KT recipients. To our knowledge, there are no other reports of infection-associated GN caused by bartonellosis in KT recipients. Nevertheless, numerous parainfectious immune disorders have been reported in association with Bartonella infections. B. henselae infections should be considered in KT recipients presenting with fever and lymphadenopathy, and also in those presenting with cryptogenic parainfectious manifestations like GN.</p>","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"35 1-6","pages":"127-132"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}