Saudi Journal of Kidney Diseases and Transplantation最新文献

Is galectin-3 a novel marker of reflux nephropathy in children? 半凝集素-3是儿童反流肾病的新标志物吗？

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_231_21

Safiye Ulku Ozcetin, Ibrahim Gokce, Neslihan Cicek, Pınar Vatansever, Harika Alpay

{"title":"Is galectin-3 a novel marker of reflux nephropathy in children?","authors":"Safiye Ulku Ozcetin, Ibrahim Gokce, Neslihan Cicek, Pınar Vatansever, Harika Alpay","doi":"10.4103/sjkdt.sjkdt_231_21","DOIUrl":"10.4103/sjkdt.sjkdt_231_21","url":null,"abstract":"Background: Vesicoureteral reflux may lead to renal parenchymal scarring (RPS) by causing recurrent pyelonephritis. Galectin-3 (Gal-3) is considered to be a new marker for fibrosis, which plays a role in the pathogenesis of RPS. Serum Gal-3 levels in patients with RPS were examined in our study, and it was attempted to elucidate the role of serum Gal-3 levels in the diagnosis and pathophysiology of RPS.Methods: The study included 154 patients with RPS between 4 and 18 years of age. Serum creatinine levels and estimated glomerular filtration rates of all patients were normal. Patients were divided into three groups according to findings on dimercaptosuccinic acid scintigraphy. Group-1 consisted of 19 patients with one scar. Group-2 consisted of nine patients with multiple scars without loss of renal function. Group-3 consisted of 126 patients with renal hypodysplasia and/or multiple scars and with separate (split) renal function below 40%. Moreover, 41 age-matched healthy children without chronic disease constituted the control group (Group-4). Serum Gal-3 levels were measured in blood samples of all children.Results: The mean serum Gal-3 level was higher in patients with RPS than healthy controls (10.9 ± 7.1 ng/ml and 6.9 ± 4.6 ng/ml) (P: 0.01), and it was also assessed separately for each scar group. There was a significant difference between Gal-3 levels and scar groups. The mean serum Gal-3 levels were increased as the degree of RPS increased.Conclusion: Serum Gal-3 levels are higher in patients with RPS and are thought to be useful in diagnosing RPS and in elucidating its pathophysiology.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"1-7"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Taurolock solution with heparin as lock solution of tunneled catheters. 牛头锁液与肝素作为隧道导管锁液的比较。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_23_24

Hamad Jeelani, Manzoor Ahmad Parry, Amer Said Alameri, Dalia Moussa, Surabhi Gupta, Arasu Mohan, Ahmed Jalal, Ahmed Hassan, Peter William, Said Qader, Ibrahim Hamdi, Mohammed Shaban, Sally Samy, Gada Ibrahim, Pola Fikry

{"title":"Comparison of Taurolock solution with heparin as lock solution of tunneled catheters.","authors":"Hamad Jeelani, Manzoor Ahmad Parry, Amer Said Alameri, Dalia Moussa, Surabhi Gupta, Arasu Mohan, Ahmed Jalal, Ahmed Hassan, Peter William, Said Qader, Ibrahim Hamdi, Mohammed Shaban, Sally Samy, Gada Ibrahim, Pola Fikry","doi":"10.4103/sjkdt.sjkdt_23_24","DOIUrl":"10.4103/sjkdt.sjkdt_23_24","url":null,"abstract":"Introduction: The employment of dialysis catheters can result in catheter-related blood stream infections (CRBSI), leads to hospitalization, morbidity, and mortality. Citrate-taurolidine lock solution can lower the occurrence of CRBSI. This study was done to evaluate Citrate-taurolidine lock solution for decreasing CRBSI.Materials and methods: This retrospective study included 89 patients who received hemodialysis for at least 6 months via a tunneled catheter. A comparison was made between patients who were administered TauroLock-Hep500™ (taurolidine, citrate, and heparin) or heparin lock solution for catheter-related infection and catheter dysfunction.Results: In this study, 47 patients received heparin lock-solution and 42 patients received Taurolock lock-solution. During a total of 7560 catheter days, the Taurolock group experienced CRBSI in 3 patients. In contrast, the heparin group had 15 patients with CRBSI over a span of 8140 catheter days. This corresponds to an incidence rate of 0.39 episodes of CRBSI per 1000 catheter days in the Taurolock group and 1.84 episodes per 1000 catheter days in the heparin group. Catheter dysfunction rates were similar in the Taurolock group compared to the heparin lock solution. In addition, in the Heparin group, two patients necessitated catheter removal, whereas no patients in the Taurolock group required catheter removal.Conclusion: Our study demonstrates a higher incidence of CRBSI in the Heparin group compared to the Taurolock solution and a similar effectiveness of the Taurolock solution in preventing catheter dysfunction over Heparin.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"48-52"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red cell distribution width predicts chronic kidney disease in elderly uncontrolled type 2 diabetic patients. 红细胞分布宽度预测老年未控制的2型糖尿病患者的慢性肾脏疾病。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_641_20

Amin R Soliman, Khaled Marzouk Sadek, Haytham Soliman, Hoda Abdelhamid Maamoun

{"title":"Red cell distribution width predicts chronic kidney disease in elderly uncontrolled type 2 diabetic patients.","authors":"Amin R Soliman, Khaled Marzouk Sadek, Haytham Soliman, Hoda Abdelhamid Maamoun","doi":"10.4103/sjkdt.sjkdt_641_20","DOIUrl":"10.4103/sjkdt.sjkdt_641_20","url":null,"abstract":"Background: Red cell distribution width (RDW) is a hematological parameter routinely obtained as part of the complete blood count. RDW has emerged as a potential independent predictor of clinical outcome in patients with established cardiovascular disease. RDW is associated with inflammation, ineffective erythropoiesis, undernutrition, iron deficiency, and impaired renal function in patients with heart failure. It is also associated with increased morbidity and mortality risk. No published data are available regarding the use of RDW as a predictor of kidney disease in type 2 diabetic patients.Patients and methods: We collected sociodemographic parameters, medical and diabetes history, and laboratory data at baseline from 650 elderly type 2 diabetics. RDW was measured as part of a standard complete blood count measurement. To assess if RDW predicts nephropathy risk, we used Cox proportional hazards regression.Results: During 34-month follow-up, 105 patients developed diabetic kidney disease as evident with either micro/macro albuminuria or a rise in serum creatinine. Mean age was 53 ± 11 years, 66.6% of the patients were males, 33% were smokers. Mortality was significantly higher in patients with high versus low (above vs. below median) RDW at baseline. RDW was a significant predictor of renal morbidity both in an univariate model (HR1 increase = 1.611: 95% confidence interval [CI]: 1.292-1.926) and also in a multivariate model (HR1increase = 1.526; 95% CI: 1.285-1.905) adjusting for several variables (gender, eGFR, HbA1c, CRP, and albumin). RDW was also found to be an independent predictor of kidney affection in elderly diabetics with higher HbA1c.Conclusions: RDW independently predicts kidney disease in elderly patients with type 2 diabetes mellitus.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"21-25"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical, biochemical, and molecular spectrum of nephropathic cystinosis: Two novel CTNS mutations. 肾病胱氨酸病的临床、生化和分子谱：两种新的CTNS突变。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_376_21

Zeinab Youssef Abdallah, Rasha Helmy, Walaa S Nazim, Marwa M Nabhan, Hanan Abdelaziz, Hala N Soliman, Ahmed K Saad, Mona Ibrahim, Amr Sobhi Gouda, Ekram Fateen, Neveen A Soliman

{"title":"Clinical, biochemical, and molecular spectrum of nephropathic cystinosis: Two novel CTNS mutations.","authors":"Zeinab Youssef Abdallah, Rasha Helmy, Walaa S Nazim, Marwa M Nabhan, Hanan Abdelaziz, Hala N Soliman, Ahmed K Saad, Mona Ibrahim, Amr Sobhi Gouda, Ekram Fateen, Neveen A Soliman","doi":"10.4103/sjkdt.sjkdt_376_21","DOIUrl":"10.4103/sjkdt.sjkdt_376_21","url":null,"abstract":"Background: Nephropathic cystinosis (NC) is an autosomal recessive disease. Mutations in the CTNS gene encoding the lysosomal membrane cystine transporter cystinosin are identified as the molecular basis of cystinosis.Aim: To evaluate the clinical phenotype, biochemical profile, and screen for mutations in CTNS genes in NC patients.Methods: Thirteen patients from 11 unrelated families were clinically suspected, for whom biochemical evaluation and screening of pathogenic CTNS gene mutations were performed.Results: Polymorphonuclear leukocyte cells leucocytes cystine assay range 4-13 nmol ½ cystine/mg proteins and median 5.5 nmol ½ cystine/mg proteins at follow up. Eight patients (66.6%) had high activity of chitotriosidase (101-417 umol/l/h, median 139.5), compared with normal subjects (4-80 nmol/l/h, mean 23 nmol/l/h). Value range was reduced to (56-175 umol/l/h, median 89) on treatment. Furthermore, two patients had high thyroid stimulating hormone level (36.1, 79. UI/ml), that normalized to (8.5, 6.4 UI/ml) during follow up. Nine pathogenic variants were identified in thirteen patients; two novel variants in two separate families, P111Rfs*7 and K335R, in exons 7 and 12, respectively, and seven known pathogenic variants.Conclusion: Our study highlights the importance of close follow up of NC patients and expands the mutational spectrum of CTNS gene, as two novel mutations are identified in two unrelated families.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"34-41"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stent versus no stent in ureteroneocystostomy in live-related renal transplant: A randomized controlled trial. 活体肾移植输尿管膀胱造口术中的支架与无支架：一项随机对照试验。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_228_21

Souvik Dey, Krishna Asuri, Seenu Vuthaluru, Om Prakash Prajapati, Seema Sood, Sandeep Mahajan, Virinder Bansal

{"title":"Stent versus no stent in ureteroneocystostomy in live-related renal transplant: A randomized controlled trial.","authors":"Souvik Dey, Krishna Asuri, Seenu Vuthaluru, Om Prakash Prajapati, Seema Sood, Sandeep Mahajan, Virinder Bansal","doi":"10.4103/sjkdt.sjkdt_228_21","DOIUrl":"10.4103/sjkdt.sjkdt_228_21","url":null,"abstract":"Background: Ureteric stent decreases urological complications postrenal transplantation, but increases the risk of urinary tract infection (UTI). There is no consensus for the placement of a routine ureteric stent following a living donor kidney transplant in adults.Methods: Between January 2018 and October 2019, 100 living donor renal transplant recipients were randomized to a stented or nonstented group. Incidence of UTIs, hematuria, pyuria or asymptomatic bacteriuria and urological complications were compared over a follow-up period of 3 months.Results: A total of 93 patients were considered for final analysis, 48 in stented and 45 in nonstented group. Both groups were comparable in terms of incidence of UTI (11/48 [22.9%] vs. 7/45 [15.6%] P = 0.4), pyuria (25/48 [52.1%] vs. 21/45 [46.7%] P = 0.6), and ureteric anastomotic leak (0/45 vs. 1/45 [1.1%] P = 0.48). Incidence of hematuria was significantly higher in stented group (46/48 [95.8%] vs. 35/45 [77.8%] P = 0.01].Conclusion: Stent placement does not increase UTI rates but increases the incidence of hematuria and necessitates a second procedure for stent removal. However, a larger sample size is required to comment on the ureteric complications.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"8-15"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome of marginal donors and recipients in living donor renal transplantation: A single-center study. 活体肾移植中边缘供体和受体的预后：一项单中心研究。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_635_20

Anil Sharma, Gaurav Sindwani, Ankit Bhardwaj, Rajan Mathur

{"title":"Outcome of marginal donors and recipients in living donor renal transplantation: A single-center study.","authors":"Anil Sharma, Gaurav Sindwani, Ankit Bhardwaj, Rajan Mathur","doi":"10.4103/sjkdt.sjkdt_635_20","DOIUrl":"10.4103/sjkdt.sjkdt_635_20","url":null,"abstract":"Objective: The primary objective of this study was to identify the donors who were marginal or complex living donors, and the secondary objective was to compare the donor and recipient outcomes in renal transplants involving marginal versus nonmarginal donors.Patients and methods: A retrospective analysis of the records of the voluntary kidney donors and patients with chronic kidney disease who underwent living donor renal transplantation from January 2012 to September 2020 was conducted. A total of 205 adult renal transplants were included in the study. The donors were categorized as marginal or complex living donors based on the presence of one or more of the following criteria: Age 60 years or more, body mass index (BMI) more than 30, glomerular filtration rate (GFR) <80 ml/min/1.73 m2, hypertension, proteinuria, impaired glucose tolerance, renal calculi, renal cysts, and history of tuberculosis.Results: The mean age of the donors was 45.23 years. 35 (17.1%) donors were male and 170 (82.9%) were female. The mean BMI of the donors was 25.29. The mean duration of hospitalization for donor nephrectomy was 4.39 days. A total of 73 (35.60%) donors were found to be marginal. The most common cause for being a marginal donor was a BMI of more than 30. The mean estimated GFR of recipients was lower in the marginal (54.68) group than in the nonmarginal group (60.71), but the difference was not statistically significant (P - 0.083).Conclusions: Marginal kidney donors have similar short-term outcomes as optimal donors, and the graft function at 2 years' follow-up was also comparable in the marginal and nonmarginal groups.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"16-20"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin-converting enzyme insertion/deletion gene polymorphism in children with nephrotic syndrome: Genotype-phenotype correlations. 肾病综合征患儿血管紧张素转换酶插入/缺失基因多态性：基因型-表型相关性

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_726_20

Ayman M Hammad, Sohier Yahia, Amany Shouma, Wafaa Laimon, Sahar Hamed, Riham Eid

{"title":"Angiotensin-converting enzyme insertion/deletion gene polymorphism in children with nephrotic syndrome: Genotype-phenotype correlations.","authors":"Ayman M Hammad, Sohier Yahia, Amany Shouma, Wafaa Laimon, Sahar Hamed, Riham Eid","doi":"10.4103/sjkdt.sjkdt_726_20","DOIUrl":"10.4103/sjkdt.sjkdt_726_20","url":null,"abstract":"Purpose: Detecting the genetic etiology of idiopathic nephrotic syndrome (INS) in different ethnic groups, especially in steroid-resistant subjects, is currently essential for individualized management, predicting prognosis, and family counseling. The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism has been studied for its possible role in INS in different ethnic groups with conflicting results reported. This study was carried out to explore the possible role of ACE I/D polymorphism in disease susceptibility, steroid response, and outcome in Egyptian children with INS.Subjects and methods: ACE gene I/D polymorphism genotypes and allele frequencies were explored in 86 children with INS versus 140 healthy controls using polymerase chain reaction and examined in different disease phenotypes and pathological variants.Results: Thirty-sex patients were steroid resistant, and 20 had focal segmental glomerulosclerosis (FSGS). The DD genotype and D allele were significantly more frequent in patients compared to controls (P < 0.001 for both) and in steroid-resistant compared to steroid-sensitive subjects (P = 0.004 and 0.003, respectively). Furthermore, patients with FSGS displayed a higher rate of DD genotype (P = 0.04) compared to other pathological variants. DD genotype was also more frequent in patients with hypertension compared to non-hypertensive subjects (P = 0.03) and also in patients who progressed to renal impairment (P = 0.04).Conclusion: The ACE gene DD genotype and D allele can be considered as risk factors for INS susceptibility and significant phenotype modifiers regarding the presentation, pathology, response to steroids, and renal survival in Egyptian children.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"26-33"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent hyperparathyroidism in the 1st year postrenal transplantation. 肾移植后1年持续性甲状旁腺功能亢进。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/sjkdt.sjkdt_26_24

Ahmad Alflaiw, Khalid Alotaibi, Ziad Arabi

{"title":"Persistent hyperparathyroidism in the 1st year postrenal transplantation.","authors":"Ahmad Alflaiw, Khalid Alotaibi, Ziad Arabi","doi":"10.4103/sjkdt.sjkdt_26_24","DOIUrl":"10.4103/sjkdt.sjkdt_26_24","url":null,"abstract":"Background: Hyperparathyroidism (HPT) is a frequent complication in chronic kidney disease and may persist in 20%-50% of cases 1 year after kidney transplantation (KT). HPT contributes to long-term allograft dysfunction and increased risk of fractures. There is scant data on the prevalence of HPT in kidney transplant recipients (KTRs) in Saudi Arabia. The aim of this study is to evaluate the prevalence of this complication and to identify its risk factors in a single center in Saudi Arabia.Subjects and methods: In a retrospective study, data of 204 KTRs who underwent KT between January 2017 and May 2020 were collected. Data included patient's demographic characteristics, history of hypertension, diabetes mellitus (DM), coronary artery disease, duration of dialysis therapy, dialysis modality, and type of vascular access. Serum intact parathyroid hormone (iPTH) was measured prior to transplant, then every 6 months posttransplant for 2 years.Results: Two hundred four KTRs were included in our study. The average age was 42.9 ± 15 years. 111 (54.4%) were males, 161 (78.9%) had received living-donor KT, and 43 (21.1%) had deceased donor KT. 83 (40.7%) were diabetic, and 30 (14.7%) had coronary artery disease. Mean serum iPTH was 67.8 ± 54.7 pmol/L before KT, then 30.6 ± 32.7 pmol/L, 24.7 ± 22.3 pmol/L, 21.9 ± 25.2 pmol/L,1-6 months, 6-12 months, and 12-24 months, respectively, post-KT. Forty-seven (23%) patients were found to have persistent HPT (pHPT) at 1-year post-KT, and they showed a higher incidence of DM, longer duration of dialysis, and greater likelihood of receiving deceased donor KT. In multivariate analysis, pre-KT PTH value was an important risk factor of pHPT post-KT. Whereas age, gender, DM, type of transplant, dialysis duration, and serum creatinine were not.Conclusion: In a single-center experience, (23%) of KTRs had pHPT, and baseline PTH value was an important risk factor in its development.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"37 1","pages":"42-47"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubulointerstitial Nephritis - A Histopathological Study of Renal Biopsies. 肾小管间质性肾炎-肾活检的组织病理学研究。

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2025-01-01 Epub Date: 2025-12-23 DOI: 10.4103/sjkdt.sjkdt_526_20

Anitha Padmanabhan, Amrita Neelakantan, Nitin Gadgil

{"title":"Tubulointerstitial Nephritis - A Histopathological Study of Renal Biopsies.","authors":"Anitha Padmanabhan, Amrita Neelakantan, Nitin Gadgil","doi":"10.4103/sjkdt.sjkdt_526_20","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_526_20","url":null,"abstract":"Tubulointerstitial nephritis (TIN) is a frequent cause of acute kidney injury. TIN has a reported incidence ranging from 1% to 10% of all renal biopsies. Among patients with chronic renal failure, the incidence ranges from about 22% to 33.5%. We studied the histological features of renal biopsies with TIN, evaluated its etiology and correlated TIN with clinical features and investigations. Our study extended over a period of seven years, with 50 cases. The slides were stained with hematoxylin and eosin and special stains like periodic acid-Schiff, Jones methenamine silver and Masson's trichrome. All adequate renal biopsies showing features of acute and chronic TIN were included in our study. Renal biopsies showing features of only primary glomerular pathology and inadequate biopsies were excluded from the study. TIN accounted for 14.84% of all the renal biopsies received in our histopathology section within this period, with 74% cases presenting as acute renal failure. The mean age of our study group was 39 years, with the male-female ratio being 1:1.63. Drug-induced TIN accounted for 42% of the cases, making it the most common cause; 48% of the cases of drug-induced TIN were attributed to the use of nonsteroidal anti-inflammatory drugs. The other causes were immunological, infectious, metabolic, vascular, plasma cell dyscrasias, T-cell mediated and idiopathic. TIN is an important cause of acute renal failure, with drug-induced TIN constituting almost half the cases. These cases can be reversed if caught early, making renal biopsy a valuable modality in diagnosing TIN in cases of acute renal failure.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"36 1-6","pages":"48-57"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-PLA2R Antibody-Positive Membranous Nephropathy Superimposed by Pleural Tuberculosis a Year Later: Mere Association or Actual Cause? 抗pla2r抗体阳性膜性肾病一年后合并胸膜结核：单纯关联还是实际原因？

IF 0.3

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2025-01-01 Epub Date: 2025-12-23 DOI: 10.4103/sjkdt.sjkdt_364_21

Priyanka Tolani, Amit S Pasari, Amol Bhawane, Anshul Patodia, Manish R Balwani

引用次数: 0