Saudi Journal of Kidney Diseases and Transplantation最新文献_第2页

Integration of Urinary Neutrophil Gelatinase-associated Lipocalin with the Renal Angina Index to Predict Subsequent Severe Acute Kidney Injury in Critically Ill Children: A Diagnostic Accuracy Study. 将尿液中性粒细胞明胶酶相关脂质体蛋白与肾绞痛指数相结合，预测重症儿童的后续严重急性肾损伤：诊断准确性研究》。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_407_22

Ngilyang Sunya, Shalu Gupta, Abhijeet Saha

{"title":"Integration of Urinary Neutrophil Gelatinase-associated Lipocalin with the Renal Angina Index to Predict Subsequent Severe Acute Kidney Injury in Critically Ill Children: A Diagnostic Accuracy Study.","authors":"Ngilyang Sunya, Shalu Gupta, Abhijeet Saha","doi":"10.4103/sjkdt.sjkdt_407_22","DOIUrl":"10.4103/sjkdt.sjkdt_407_22","url":null,"abstract":"The primary objective of this study was to determine the performance of the renal angina index (RAI) in predicting subsequent severe acute kidney injury (AKI) on day 3 of admission and whether integrating urinary neutrophil gelatinase-associated lipocalin (NGAL) with RAI would lead to improved prediction of AKI. This was a prospective observational study conducted in the pediatric intensive care unit (PICU) of a tertiary care hospital involving 170 children meeting the inclusion criteria. The RAI was assessed within 24 h of admission to the PICU. Positivity for renal angina was considered RAI ≥8. Urine samples were collected for all enrolled patients within the first 24 h and on day 3 of the PICU stay. NGAL was assayed using human-specific enzyme-linked immunosorbent assay. The overall incidence of AKI was 18.2%. Out of 170 children, 31 (18.2%) were RAI-positive on day 0. A higher proportion of patients in the RAI-positive group developed AKI on day 3 compared with the RAI-negative group (83.9% vs. 3.6%, P <0.001). Those who were RAI-positive on day 0 had a sensitivity, specificity, positive predictive value (PPV), and negative predictive value of 83.8%, 96.4%, 83.8%, and 96.4%, respectively, for predicting severe AKI on day 3. Incorporating urinary NGAL improved the specificity and PPV to 97.8% and 85.7%, respectively. Assessing the RAI is simple and useful for predicting severe AKI in critically ill children. The addition of urinary NGAL to the RAI optimizes its use for identifying patients at risk of subsequent severe AKI.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S79-S85"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Renal Function before and after Autologous Stem Cell Transplantation in Egyptian Patients with Multiple Myeloma and Renal Insufficiency: A Retrospective Study. 埃及多发性骨髓瘤合并肾功能不全患者自体干细胞移植前后肾功能的比较：回顾性研究

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_333_22

Mohamed Abdelkader Morad, Omar Fahmy, Mohamed A Marie, Eman Samir, Reham Emad Eldin Abdullah

{"title":"Comparison of Renal Function before and after Autologous Stem Cell Transplantation in Egyptian Patients with Multiple Myeloma and Renal Insufficiency: A Retrospective Study.","authors":"Mohamed Abdelkader Morad, Omar Fahmy, Mohamed A Marie, Eman Samir, Reham Emad Eldin Abdullah","doi":"10.4103/sjkdt.sjkdt_333_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_333_22","url":null,"abstract":"Renal failure is a common feature of multiple myeloma (MM) that occurs in 20%-40% of newly diagnosed patients with MM and is the result of monoclonal immunoglobulin light chains. Many studies have examined the effect of autologous stem cell transplantation (ASCT) in MM patients with renal impairment and the safety of performing the transplantation in patients with renal failure. This study aimed to compare renal function before and after ASCT in Egyptian MM patients with renal insufficiency to evaluate the effect of ASCT on renal recovery. Our study included 31 MM patients with renal impairment out of 400 patients who met the criteria of the International Myeloma Working Group for symptomatic MM. The estimated glomerular filtration rate (eGFR) calculated by the Modification of Diet in Renal Disease formula was compared before and after the transplant. Only four patients (12.9%) were dependent on dialysis. Six of those with a history of hemodialysis (HD) who were either dependent on dialysis or dialyzed according to need achieved independence from HD. There was no significant correlation between the degree of renal impairment and the disease's status at the time of transplantation (P = 0.86). The study showed significant improvements in serum creatinine levels compared with its value before the transplant (P = 0.016) and in eGFR (P = 0.004). In total, 45% of patients achieved renal improvement, shown by a 25% increase in GFR above the baseline. There was a significant improvement of renal function after ASCT in MM patients with renal impairment.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S14-S23"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Health-related Quality of Life in Children with Chronic Kidney Disease in Indonesia: A Single Tertiary Hospital Study. 印度尼西亚慢性肾病患儿健康相关生活质量评估：单一三级医院研究

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_231_22

Retno Palupi-Baroto, Braghmandita W Indraswari, Asal Wahyuni Erlin Mulyadi, Siti N Rusdhy, Kharisma N Prabowo, Kristia Hermawan

{"title":"Assessing Health-related Quality of Life in Children with Chronic Kidney Disease in Indonesia: A Single Tertiary Hospital Study.","authors":"Retno Palupi-Baroto, Braghmandita W Indraswari, Asal Wahyuni Erlin Mulyadi, Siti N Rusdhy, Kharisma N Prabowo, Kristia Hermawan","doi":"10.4103/sjkdt.sjkdt_231_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_231_22","url":null,"abstract":"Health-related quality of life (HRQOL) is an important patient-reported outcome. However, HRQOL research in pediatric patients with chronic kidney disease (CKD) in developing countries is limited. This cross-sectional study involved children with CKD who attended Dr. Sardjito General Hospital between January 2017 and September 2018. In total, 82 child-parent pairs were enrolled. Total HRQOL scores were significantly lower in children with Stages 3a-5 CKD than in children with Stages 1-2 CKD in the child (69.89 vs. 82.12, P = 0.004) and parent questionnaires (72.26 vs. 81.20, P = 0.02). The scores for the physical, school, and social function domains were significantly decreased. This study showed that children with Stages 3a-5 CKD had significantly lower HRQOL scores compared with children in the Stages 1-2 CKD group. Multidisciplinary teams can provide patient-centered and comprehensive management to optimize HRQOL scores during childhood and in future adult life.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S66-S78"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Serum Visfatin as a Biomarker of Lupus Nephritis in Egyptian Patients with Systemic Lupus Erythematosus. 评估血清 Visfatin 作为埃及系统性红斑狼疮患者狼疮肾炎生物标志物的作用

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_176_22

Amr Shaker, Ahmed Fayed, Mohamed Abdelkader Morad, Safa Labib, Riem M Elmessiery, Karem Mohamed Salem, Hend A ElSheimy, Hany Hammad, Ahmed Fathy

{"title":"Evaluation of Serum Visfatin as a Biomarker of Lupus Nephritis in Egyptian Patients with Systemic Lupus Erythematosus.","authors":"Amr Shaker, Ahmed Fayed, Mohamed Abdelkader Morad, Safa Labib, Riem M Elmessiery, Karem Mohamed Salem, Hend A ElSheimy, Hany Hammad, Ahmed Fathy","doi":"10.4103/sjkdt.sjkdt_176_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_176_22","url":null,"abstract":"One of the most significant consequences of systemic lupus erythematosus (SLE) is lupus nephritis (LN). Visfatin, an adipokine that is significantly expressed in visceral fat and is a marker of endothelial dysfunction in chronic kidney disease, has multiple proinflammatory actions. We aimed to evaluate the state of serum visfatin in SLE patients and to detect its possible correlation with the disease's activity and effects on the kidney affection. Fifty patients with active LN, 50 patients with inactive lupus, and 50 healthy people had their serum visfatin levels tested. Chemical and immunological markers of SLE and LN were measured. The SLE Disease Activity Index (SLEDAI) was used to measure the disease's activity. Renal biopsies from the LN subgroup were collected and classified using the modified classification of the World Health Organization. The serum visfatin of patients with active LN was significantly greater than that of inactive lupus patients and the healthy controls (20.56 ± 1.07 ng/mL, 16.77 ± 1.02 ng/mL, and 9.96 ± 1.46 ng/mL, P <0.001). SLEDAI and serum visfatin levels were shown to be significantly correlated (P = 0.000057). Serum visfatin levels were likewise significantly correlated with the index of histological activity in the active group (P <0.00001). Serum visfatin was raised in individuals with active LN and was related to the SLEDAI and disease severity scores. Serum visfatin could be utilized as a noninvasive biomarker for evaluating the severity of LN and risk stratification of the risk.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S170-S176"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life among Hemodialysis Patients: Role of the Dialysis Shift. 血液透析患者的生活质量：透析班的作用。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_370_22

Safa Nowrooz, Turki Alanazi, Abdulmohsen Al-Ghamdi, Abdulaziz Alzahrani, Abdulrahman Alshammari, Neda AlYaqoot, Mana Almutraid, Ahmed Jaradat, Amgad El-Agroudy

{"title":"Quality of Life among Hemodialysis Patients: Role of the Dialysis Shift.","authors":"Safa Nowrooz, Turki Alanazi, Abdulmohsen Al-Ghamdi, Abdulaziz Alzahrani, Abdulrahman Alshammari, Neda AlYaqoot, Mana Almutraid, Ahmed Jaradat, Amgad El-Agroudy","doi":"10.4103/sjkdt.sjkdt_370_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_370_22","url":null,"abstract":"This study examined the effects of the time of hemodialysis (HD) on patients' quality of life (QOL). This study included 175 HD patients (116 males, 59 females), aged 18-80 years (mean = 58.1 ± 11.3 years). Shift 1 was 7:00-11:00 AM, Shift 2 was 12:00-4:00 PM, Shift 3 was 5:00-9:00 PM, and Shift 4 was 10:00-2:00 AM (38, 38, 43, and 56 patients, respectively). Those on Shift 4 had a higher mean age compared with the other shifts, with a higher number of widowed people (8.6%). The proportions of males and females showed no significant differences among the shifts. The mean duration on dialysis was 42.1 ± 39.3 months, with a shorter duration for Shift 4. We observed the highest QOL score for the psychological and spiritual subscale, followed by the family subscale. Half the patients were dissatisfied with their jobs and had less satisfaction with their sexual life, their education, and getting a kidney transplant. We found a significant difference in overall QOL among shifts, with the greatest difference between Shifts 3 and 4. Health and functioning, psychological and spiritual, and social and economic scores were lowest in Shift 4, which was significantly different from Shift 1 and Shift 3. We found significant associations between overall QOL and general health, and the scores from different domains. Satisfaction was moderate in all groups. The study revealed poor QOL among Shift 4 patients; hence, they need more support in clinical practice guidelines.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S122-S132"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Nonadherence to Dietary Prescriptions among Hemodialysis Patients, Makkah, Saudi Arabia. 沙特阿拉伯麦加血液透析患者不遵守饮食处方的相关因素。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_249_23

Ghanim Hamid Al-Khattabi

{"title":"Factors Associated with Nonadherence to Dietary Prescriptions among Hemodialysis Patients, Makkah, Saudi Arabia.","authors":"Ghanim Hamid Al-Khattabi","doi":"10.4103/sjkdt.sjkdt_249_23","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_249_23","url":null,"abstract":"The nonadherence of hemodialysis (HD) patients correlates with morbidity and mortality. Despite severe consequences, noncompliance with their medical regimen is the norm for HD patients rather than the exception. Factors associated with nonadherence to dietary restrictions among HD patients have been explored in many studies; however, most were in Western countries and there is a remarkable paucity of studies in Saudi Arabia. HD patients have several features that put them at an increased risk of nonadherence to dietary restrictions, including prolonged, intensive treatment, and their medical regimens are easily determined with objective measures. This crosssectional study aimed to determine factors related to nonadherence to dietary restrictions among 361 HD patients randomly selected from HD centers in Makkah, Saudi Arabia. Individuals were assessed for adherence using the End-Stage Renal Disease - Adherence Questionnaire in addition to clinical examinations and laboratory investigations. Female patients were more likely to be nonadherent to dietary restrictions. Adherence to dietary restrictions was relatively higher among non-Saudi patients, older people, those who are married, those with university qualifications, those who are employed, and those with higher monthly incomes; nevertheless, these differences were not statistically significant. Despite the relatively higher frequency of adherence to dietary restrictions among patients with a duration of dialysis of <60 months, hypertensive patients, patients with a previous kidney transplant, and those with a previous history of psychiatric illnesses, these differences were not statistically significant. Patients with factors associated with nonadherence to dietary restrictions deserve special attention and support to improve their adherence.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S44-S65"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Values of Immature Granulocytes Detected by the Sysmex XN 9000 Hematology Analyzer in Children with Urinary Tract Infections. 用 Sysmex XN 9000 血液分析仪检测尿路感染儿童体内未成熟粒细胞的诊断价值。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_33_22

Nuran Cetin, Evin Kocaturk, Asli Kavaz Tufan, Zeynep Kusku Kiraz, Ozkan Alatas

{"title":"Diagnostic Values of Immature Granulocytes Detected by the Sysmex XN 9000 Hematology Analyzer in Children with Urinary Tract Infections.","authors":"Nuran Cetin, Evin Kocaturk, Asli Kavaz Tufan, Zeynep Kusku Kiraz, Ozkan Alatas","doi":"10.4103/sjkdt.sjkdt_33_22","DOIUrl":"10.4103/sjkdt.sjkdt_33_22","url":null,"abstract":"Immature granulocytes (IGs) are used as markers of infection and systemic inflammation. We aimed to investigate the diagnostic value of IGs in children with urinary tract infections (UTIs). Children with their first UTIs were included in this observational study. Blood samples were obtained before antibiotic therapy. The blood analysis was repeated 2 weeks after the treatment ended. In total, 194 children (95 with febrile UTI, 58 with cystitis, and 41 controls) were included. The percentage of IGs (IG%) and IG count (IGC) measured at the time of admission were higher in the patients with febrile UTI than in the patients with cystitis and the controls (P = 0.000). The IGC and IG% after treatment were higher in patients with renal scarring than in those without scarring (P = 0.012 and P = 0.021, respectively). Cox's regression analysis showed the significant associations of renal scarring with both IGC and IG% (hazard ratio: 8.181, P = 0.002; hazard ratio: 5.106, P = 0.033, respectively). Both IGC and IG% were positively associated with severe vesicoureteral reflux (VUR) [odds ratio (OR): 22.235, P = 0.025; OR: 15.597, P = 0.038, respectively]. In conclusion, the IG% and IGC, which can be easily measured in a routine complete blood count without the need for additional effort, could be used as biomarkers for predicting febrile UTI, renal scarring, and severe VUR in children.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S133-S141"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Postcoronavirus Disease 2019 Antineutrophil Cytoplasmic Antibody-associated Vasculitis Successfully Treated with Rituximab. 一例使用利妥昔单抗成功治疗的 2019 年冠状病毒病后抗中性粒细胞胞浆抗体相关性血管炎病例。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_317_22

Mahmoud M Mohamed, Atif Ibrahim, Zareen Razaq, Waleed Hassan

{"title":"A Case of Postcoronavirus Disease 2019 Antineutrophil Cytoplasmic Antibody-associated Vasculitis Successfully Treated with Rituximab.","authors":"Mahmoud M Mohamed, Atif Ibrahim, Zareen Razaq, Waleed Hassan","doi":"10.4103/sjkdt.sjkdt_317_22","DOIUrl":"10.4103/sjkdt.sjkdt_317_22","url":null,"abstract":"We report a case of a 69-year-old Caucasian male with a history of hypertension, Type 2 diabetes, and Stage IIIa chronic kidney disease (CKD), who presented to the emergency department with positional dizziness, generalized weakness, weight loss, and suppressed appetite. Two months earlier, the patient was diagnosed with coronavirus disease 2019 (COVID-19). The patient had non-oliguric acute kidney injury alongside preexisting CKD. The urinalysis showed hematuria and significant non-nephrotic proteinuria. His serological markers were positive for antineutrophil cytoplasmic antibodies with high titers. A kidney biopsy showed focal crescentic glomerulonephritis of the pauci-immune type. Initially, treatment with immunosuppressive medication was deferred because the biopsy findings suggested a poor renal outcome, as the cortical sample showed tubular atrophy and interstitial fibrosis of more than 50%. The patient was discharged but was later readmitted with worsening renal function, deep venous thrombosis in the lower extremities, and patchy lung consolidation suggesting possible pneumonia, which was ruled out. He required dialysis and brief empiric antibiotics for pneumonia, and anticoagulation for deep venous thrombosis, and was treated with intravenous (IV) pulsed steroids, followed by gradually tapering oral steroids and rituximab induction therapy. He continued dialysis three times a week. Three months after discharge, his renal function improved to near-baseline level, and he no longer required hemodialysis. He continues to be on maintenance IV rituximab therapy and low-dose oral steroids and is followed closely by a rheumatologist. Our case reflects the evolving state of understanding how COVID-19 impacts the immune system, its varying manifestations, and its management.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S219-S225"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Interleukin-18, Kidney Injury Molecule-1, and the Renal Resistive Index for Predicating Acute Kidney Injury in Critically Ill Patients with Sepsis. 血清白细胞介素-18、肾损伤分子-1 和肾阻力指数用于预测重症脓毒症患者的急性肾损伤。

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_56_22

Amr Mohamed Shaker, Moataz F Mohamed, Karim K Thabet, Tarek Ramzy, Yasser M Abdelhamid

{"title":"Serum Interleukin-18, Kidney Injury Molecule-1, and the Renal Resistive Index for Predicating Acute Kidney Injury in Critically Ill Patients with Sepsis.","authors":"Amr Mohamed Shaker, Moataz F Mohamed, Karim K Thabet, Tarek Ramzy, Yasser M Abdelhamid","doi":"10.4103/sjkdt.sjkdt_56_22","DOIUrl":"10.4103/sjkdt.sjkdt_56_22","url":null,"abstract":"Interleukin-18 (IL-18) is a pro-inflammatory cytokine that rises approximately 24-48 h before a diagnosis of acute kidney injury (AKI). Kidney injury molecule-1 (KIM-1) is one of the most promising early biomarkers. It participates in the process of both kidney injury and healing, although the precise mechanism of the restoration of tubular integrity after injury still remains unclear. The renal resistive index (RRI) is used for evaluating changes in intrarenal perfusion occurring in renal parenchyma diseases. The study included 80 critically ill patients with sepsis, divided into 40 patients who developed AKI and 40 patients without AKI. All patients were evaluated through their history, clinical examination, laboratory investigations of serum IL-18 and KIM-1, and the RRI. Serum IL 18, serum KIM-1, and the RRI were significantly higher in critically ill patients with sepsis and AKI. Receiver operating characteristic analysis for detecting AKI 1 day after admission showed that the area under the curve (AUC) for serum IL-18 was 86.1%, the AUC for serum KIM-1 was 86%, and the AUC for the RRI was 88%, demonstrating statistical significance for the diagnosis of AKI within the next 24 h. Serum IL-18, KIM-1, and the RRI represent early predictors of AKI in critically ill septic patients.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S153-S160"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Urinary Neutrophil Gelatinase with the Histopathological Extent of Kidney Damage in Patients with Diabetic Nephropathy. 糖尿病肾病患者尿液中性粒细胞明胶酶与肾脏组织病理学损伤程度的相关性

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI: 10.4103/sjkdt.sjkdt_95_22

Priya Garg, Manjunath Shetty, Vani Krishnamurthy

{"title":"Correlation of Urinary Neutrophil Gelatinase with the Histopathological Extent of Kidney Damage in Patients with Diabetic Nephropathy.","authors":"Priya Garg, Manjunath Shetty, Vani Krishnamurthy","doi":"10.4103/sjkdt.sjkdt_95_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_95_22","url":null,"abstract":"Diabetic nephropathy (DN), a leading cause of chronic kidney disease, is known to develop in around 40% of patients with diabetes. NGAL, a biomarker expressed by the tubular epithelium, has been evaluated in both acute and chronic kidney injury. However, kidney damage revealed by the histology of renal tissue core biopsies has not been quantified by morphometry and its correlation with urinary NGAL (uNGAL) has not been studied. Our objective was to compare levels of uNGAL with the extent of kidney damage in the histopathological results of morphometry in patients with DN. This prospective analytical study was conducted in a tertiary hospital. Urine samples of 42 patients were collected and freeze-dried. uNGAL was estimated through a chemiluminescent microparticle immunoassay. Pearson's correlation coefficients between kidney damage quantified by morphometry and NGAL values were examined. The correlation of uNGAL with the percentage of acute tubular injury assessed by morphometry in the renal core was 7.35% (P = 0.64). uNGAL had the highest correlation with inflammation (r = 54.2%; P = 0.002). Another parameter with a significant correlation was glomerular sclerosis with r = 35.6% (95% confidence interval: 10%-60%) and an associated P = 0.02. UNGAL was strongly correlated with inflammatory kidney damage in patients with DN.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":"34 Suppl 1","pages":"S112-S121"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0