Saudi Journal of Kidney Diseases and Transplantation最新文献_第10页

A Cross-sectional Study on Fibroblast Growth Factor 23 and Other Markers of Mineral Metabolism in Healthy Children in India. 关于印度健康儿童成纤维细胞生长因子 23 及其他矿物质代谢标志物的横断面研究。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-03-01 Epub Date: 2023-12-25 DOI: 10.4103/1319-2442.391893

Swasti Chaturvedi, Theophilus S Vijayakumar, Victoria Job, N V Mahendri, Isidro Salusky, Indira Agarwal

{"title":"A Cross-sectional Study on Fibroblast Growth Factor 23 and Other Markers of Mineral Metabolism in Healthy Children in India.","authors":"Swasti Chaturvedi, Theophilus S Vijayakumar, Victoria Job, N V Mahendri, Isidro Salusky, Indira Agarwal","doi":"10.4103/1319-2442.391893","DOIUrl":"10.4103/1319-2442.391893","url":null,"abstract":"Fibroblast growth factor 23 (FGF23) plays a significant role in phosphate homeostasis but data on children are limited. We aimed to detect FGF23 levels in 107 healthy children aged 6-16 years and evaluate its correlation with markers of phosphate and calcium metabolism, and the dietary intake of calcium, phosphate, and proteins. Height, weight, and Tanner stages were measured, and dietary intake was calculated. Biochemical analyses of hemoglobin, serum calcium, phosphate, creatinine, Vitamin D, and plasma parathyroid hormone (PTH) and FGF23 levels were performed, alongside their associations with FGF23. Of the children, 65.4% were males. Their mean body mass index was 15.79 ± 2.96 for males and 16.5 ± SD 2.72 for females. The mean Vitamin D and PTH levels were 29.7 ± 1.1 ng/mL and 29.2 ± 1.2 pg/mL, respectively. The mean FGF23 levels were 159 ± 15.2 reference units (RU)/mL. The mean FGF23 levels were significantly higher in females (209.3 ± 31 RU/mL) than in males (132.3 ± 15.1 RU/mL). All biochemical parameters were within the normal range. FGF23 correlated with age, weight, and height, but not Vitamin D, PTH, or dietary calcium and phosphate. FGF23 showed a negative correlation with hemoglobin levels (r = -0.23). Since most children had a nonvegetarian diet, the FGF23 levels were not assessed in vegetarians. These observations were attributed to the rural lifestyle favoring adequate exposure to sunlight and physical activity. The increased FGF23 levels in females, the trends in urban settings, and the levels in strictly vegetarian diets need further study.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Increased Blood Flow Rate and Oral Activated Charcoal on the Severity of Uremic Pruritus: A Randomized Crossover Clinical Trial. 增加血流量和口服活性炭对尿毒症瘙痒严重程度的影响：随机交叉临床试验。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-03-01 Epub Date: 2023-12-25 DOI: 10.4103/1319-2442.391890

Mahmoud Zanganeh, Ali Abbasi, Ahmad Khosravi, Monireh Amerian, Hossein Ebrahimi

引用次数: 0

Topical Henna Application Causing Acute Kidney Injury and Acute Hemolytic Anemia. 局部涂抹指甲花导致急性肾损伤和急性溶血性贫血。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-03-01 Epub Date: 2023-12-25 DOI: 10.4103/1319-2442.391897

Hany Tobia Michael, Dhanya Mohan, Hind Aljaghber, Fakhriya Alalawi, Mohammed Railey, Amna Alhadari

引用次数: 0

Baclofen Toxicity in a Patient with End-stage Renal Disease on Maintenance Dialysis. 一名接受维持性透析的终末期肾病患者的巴氯芬毒性。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391005

Samar Ahmed, Mahmoud Kharrat, Hesham Salah, Fouad Shearyia, Reem Alrimawi, Azizah Makhsoom, Sahal Al Sharif, Rozana Alyami, Faissal Shaheen

引用次数: 0

Comparison of P300 Cognitive-evoked Potentials and Visual and Auditory Reaction Time in Stage 5 Chronic Kidney Disease Patients on Different Treatment Modalities. 不同治疗模式下慢性肾脏病 5 期患者 P300 认知诱发电位与视听反应时间的比较

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391001

Manoharan Renugasundari, Subramaniyam Velkumary, Sreejith Parameswaran, Nivedita Nanda, Jean Fredrick

{"title":"Comparison of P300 Cognitive-evoked Potentials and Visual and Auditory Reaction Time in Stage 5 Chronic Kidney Disease Patients on Different Treatment Modalities.","authors":"Manoharan Renugasundari, Subramaniyam Velkumary, Sreejith Parameswaran, Nivedita Nanda, Jean Fredrick","doi":"10.4103/1319-2442.391001","DOIUrl":"https://doi.org/10.4103/1319-2442.391001","url":null,"abstract":"Patients with chronic kidney disease (CKD) are at a higher risk of cognitive impairment. Poor quality of life and decreased compliance are frequently observed with cognitive decline among CKD patients. Cognitive impairment among Stage 5 CKD patients varies with different modalities of treatment, and contradicting results have been reported. Fifty-four medically stable Stage 5 CKD patients undergoing different modalities of treatment were recruited: Patients with Stage 5 CKD on maintenance hemodialysis (HD) (n = 18), continuous ambulatory peritoneal dialysis (CAPD) (n = 18), and conservative management (CM) (n = 18). Eighteen apparently healthy participants were recruited as a control group. The cognitive functions assessed were P300 event- related potential, auditory and visual reaction times (VRTs). Kidney function was assessed by serum creatinine and estimated glomerular filtration rate. Creatinine levels were significantly higher in all three treatment groups compared with the control group. Multivariate analysis revealed a significant association between the CKD groups (n = 54) and the parameters of cognitive function. P300 latency was prolonged in all treatment groups compared with the control group and was significantly prolonged in patients on CM compared with HD and CAPD patients. The VRT of CM patients was found to be significantly higher compared with the control group. The auditory reaction time was significantly prolonged in all treatment groups compared with the control group and in the CM group compared with the CAPD group. Cognitive function was more affected in Stage 5 CKD patients on CM compared with patients undergoing HD or CAPD.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spot Urinary Citrate Normograms in Children. 儿童点滴尿柠檬酸盐正常值图。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391007

Majid Malaki, Seyed Abolhassan Seyedzadeh

引用次数: 0

De novo Donor-specific Anti-human Leukocyte Antigen Antibody and Its Outcome in Pediatric Renal Transplant Recipients: A Single-center Experience in India. 小儿肾移植受者的新捐献者特异性抗人类白细胞抗原抗体及其结果：印度单中心经验。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391006

Anshuman Saha, Shahenaz F Kapadia, Kinnari B Vala, Varsha B Trivedi, Himanshu V Patel, Pankaj R Shah, Vivek B Kute

{"title":"De novo Donor-specific Anti-human Leukocyte Antigen Antibody and Its Outcome in Pediatric Renal Transplant Recipients: A Single-center Experience in India.","authors":"Anshuman Saha, Shahenaz F Kapadia, Kinnari B Vala, Varsha B Trivedi, Himanshu V Patel, Pankaj R Shah, Vivek B Kute","doi":"10.4103/1319-2442.391006","DOIUrl":"https://doi.org/10.4103/1319-2442.391006","url":null,"abstract":"Development of de novo donor-specific anti-HLA antibody (dnDSA) is associated with poor graft survival in adults. However, there is a paucity of data about its prevalence and outcome in Indian children. We retrospectively assessed the proportion and spectrum of dnDSA and its outcome on antibody-mediated rejection (ABMR) and graft function. Children ≤18 years who were transplanted between November 2016 and October 2019 were included in this study. Pretransplant donor-specific antibody (DSA) was screened by complement-dependent cytotoxicity, flow cytometry crossmatch, and single antigen bead (SAB) class I and II by Luminex platform. Either antithymocyte globulin or basiliximab was used as induction. Tacrolimus, mycophenolate, and prednisolone were used for the maintenance of immunosuppression. SAB screening was done at 1, 3, 6 months, and yearly in seven children and at the time of acute graft dysfunction in eight. Mean fluorescence intensity ≥1000 was considered positive. Protocol biopsies were done at 3, 6, and 12 months and annually thereafter in seven children. Fifteen children, all males with a median age (interquartile range) of 13 years (11; 15.5) were analyzed. Only one child had pretransplant DSA who developed dnDSA posttransplant. Overall, 8 (53%) developed dnDSA over a median follow-up of 18 months. Seven (87%) had Class II, one Class I and 3 (37%) both Class I and II. Six had dQ and two had DR. All children with dnDSA had ABMR, of these two had subclinical rejection. DSAs persisted despite treatment, though graft function improved. Children with DSA and ABMR had lower graft function than those without DSA. The proportion of dnDSA was high in our study, majority against DQ. The detection of dnDSA prompted early diagnosis and treatment of ABMR.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Maintenance Peritoneal Dialysis in Children: A State Hospital Experience from Southeastern Turkey. 儿童维持性腹膜透析的结果：土耳其东南部一家州立医院的经验。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391002

Mehtap Akbalik Kara, Ayse Seda Pinarbasi

{"title":"Outcomes of Maintenance Peritoneal Dialysis in Children: A State Hospital Experience from Southeastern Turkey.","authors":"Mehtap Akbalik Kara, Ayse Seda Pinarbasi","doi":"10.4103/1319-2442.391002","DOIUrl":"https://doi.org/10.4103/1319-2442.391002","url":null,"abstract":"This study aimed to evaluate the clinical features, laboratory features, and outcomes of pediatric patients on peritoneal dialysis (PD) and compare the factors affecting mortality. The demographic, clinical, and laboratory data of 50 patients on maintenance PD followed up for more than 3 months were retrospectively analyzed for non-survivors and survivors to evaluate all factors affecting mortality. The patients (26 boys and 24 girls) had a mean age of 85.4 ± 58.7 months (range: 1-194 months) at the initiation of PD. The mean duration of dialysis at follow-up was 27.8 ± 21.7 months (range: 3-115 months). The rate of peritonitis was one episode per 27.27 patient months. PD was discontinued because of transplantation in eight patients, death in eight patients, and shifting to hemodialysis in three patients. In the Kaplan-Meier analysis, the 1-year patient survival rate at 1 year, 2 years, and 5 years was 81.8%, 51.7%, and 12.3%, respectively. Non-survivors were significantly younger at the start of kidney replacement therapy, had a final younger age at dialysis, and had lower albumin levels than survivors. We excluded four patients with a follow-up period of <6 months. Cox regression analysis revealed a low albumin status (P = 0.014, hazard ratio: 0.230) and a high level of ferritin (P = 0.002, hazard ratio: 1.002) to be risk factors for mortality. This study showed a high mortality rate. Hypoalbuminemia, a younger age at the start of kidney replacement therapy, and a younger final age at dialysis had a significant association with mortality.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sporotrichosis in a Renal Transplant Patient: A Rare Case Report with a Review of the Literature. 肾移植患者的孢子丝菌病：罕见病例报告及文献综述。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.391004

Suman Sethi, Sudhir Mehta, Vikas Makkar

引用次数: 0

Urinary Apolipoprotein A1 and Neutrophil Gelatinase-associated Lipocalin in Children with Idiopathic Nephrotic Syndrome. 特发性肾病综合征患儿尿液中的载脂蛋白 A1 和中性粒细胞明胶酶相关脂质体。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI: 10.4103/1319-2442.390998

Suresh Murugesan, Abhijeet Saha, Bobbity Deepthi, Manpreet Kaur, Trayambak Basak, Shantanu Sengupta, Vineeta Batra, Ashish Dutt Upadhyay

{"title":"Urinary Apolipoprotein A1 and Neutrophil Gelatinase-associated Lipocalin in Children with Idiopathic Nephrotic Syndrome.","authors":"Suresh Murugesan, Abhijeet Saha, Bobbity Deepthi, Manpreet Kaur, Trayambak Basak, Shantanu Sengupta, Vineeta Batra, Ashish Dutt Upadhyay","doi":"10.4103/1319-2442.390998","DOIUrl":"https://doi.org/10.4103/1319-2442.390998","url":null,"abstract":"Urinary biomarkers are a promising diagnostic modality whose role was explored in nephrotic syndrome (NS). We estimated urinary apolipoprotein A1 (Apo A1) and neutrophil gelatinase-associated lipocalin (NGAL) in children with first-episode NS (FENS) and controls with a longitudinal follow-up to see the serial changes during remission. The study groups comprised 35 children with FENS and an equal number of age- and sex-matched controls. Patients were followed up at regular intervals, and 32 patients were classified as having steroid-sensitive NS (SSNS) and 3 as having steroid-resistant NS (SRNS). The mean follow-up period was 8.7 ± 4.2 months. Three patients in the SSNS group were labeled as having frequent relapses or steroid-dependent disease during follow-up. Of the three children with SRNS, two had minimal changes in the disease and one had idiopathic membranous nephropathy. The levels of Apo A1:creatinine, NGAL:creatinine, and spot urinary protein:urinary creatinine ratios were significantly higher in children with FENS compared with controls. The levels of the urine biomarkers decreased significantly at subsequent follow-up with remission. The Apo A1 and NGAL levels in SSNS patients were significantly high compared with both the controls and FENS patients. Urinary Apo A1 levels in SRNS patients were lower at initial presentation. This longitudinal study revealed changes in the urinary Apo A1 and NGAL in NS over the course of the disease.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0