Baclofen Toxicity in a Patient with End-stage Renal Disease on Maintenance Dialysis.

IF 0.5 Q4 UROLOGY & NEPHROLOGY

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-01-01 Epub Date: 2023-12-12 DOI:10.4103/1319-2442.391005

Samar Ahmed, Mahmoud Kharrat, Hesham Salah, Fouad Shearyia, Reem Alrimawi, Azizah Makhsoom, Sahal Al Sharif, Rozana Alyami, Faissal Shaheen

引用次数: 0

Abstract

Baclofen is a β-(p-chlorophenyl) derivative of the neurotransmitter y-aminobutyrio acid (GABA). This centrally-acting GABA agonist is prescribed as therapy for spasticity in the spinal cord region. The drug is predominantly excreted by the kidney, thus making patients with kidney disease susceptible to side effects. We report on a patient with end-stage renal disease who developed baclofen toxicity, which was successfully treated with intense hemodialysis.

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一名接受维持性透析的终末期肾病患者的巴氯芬毒性。

巴氯芬是神经递质y-氨基丁酸（GABA）的β-（对氯苯基）衍生物。这种中枢作用的 GABA 激动剂是治疗脊髓痉挛的处方药。这种药物主要通过肾脏排泄，因此肾病患者很容易出现副作用。我们报告了一名终末期肾病患者出现巴氯芬中毒的病例，该患者通过强烈的血液透析获得了成功的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Journal of Kidney Diseases and Transplantation UROLOGY & NEPHROLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

53 weeks

期刊介绍： Saudi Journal of Kidney Diseases and Transplantation (SJKDT, ISSN 1319-2442) is the official publication of the Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia. It is published six times a year. SJKDT publishes peer-reviewed original research work and review papers related to kidney diseases, urinary tract, renal replacement therapies, and transplantation. The journal publishes original papers and reviews on cell therapy and islet transplantation, clinical transplantation, experimental transplantation, immunobiology and genomics and xenotransplantation related to the kidney. The journal also publishes short communications, case studies, letters to the editors, an annotated bibliography and a column on news and views.