Saudi Journal of Kidney Diseases and Transplantation最新文献_第5页

A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study. 比较点滴尿蛋白-肌酐比值与 24 小时尿蛋白对蛋白尿定量的影响：一项医院横断面研究

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-11-01 Epub Date: 2024-05-09 DOI: 10.4103/sjkdt.sjkdt_261_22

Aditya Mahaseth, Bishnu Pahari, Madhav Ghimire, Sushil Rayamajhi

{"title":"A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study.","authors":"Aditya Mahaseth, Bishnu Pahari, Madhav Ghimire, Sushil Rayamajhi","doi":"10.4103/sjkdt.sjkdt_261_22","DOIUrl":"https://doi.org/10.4103/sjkdt.sjkdt_261_22","url":null,"abstract":"Quantifying the amount of proteinuria is mandatory in various disease conditions. The aim of this study was to study whether the spot urine protein-creatinine ratio (P-CR) correlates well with 24-h urinary total protein (UTP). The research hypothesis was that spot urine P-CR would correlate well with 24-h UTP. This was a cross-sectional, single-center study conducted in a tertiary care hospital. The spot urinary P-CR and 24-h urinary protein were determined from 70 patients with persistent glomerular proteinuria. This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (>3.5 g/day). Random spot urine P-CR correlated well with the 24-h UTP, particularly at lower levels of protein excretion.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualization of the Dosage Regimen of Erythropoietin is Crucial in End-stage Renal Disease Patients. 促红细胞生成素剂量方案的个体化对终末期肾病患者至关重要

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397212

M K Krishnapriya, S Karthika, Anisha Babu, Antriya Annie Tom

引用次数: 0

The Relationship between Serum TWEAK Levels and Carotid Intima-media Thickness in Patients with Fabry Disease. 法布里病患者血清 TWEAK 水平与颈动脉内膜中层厚度之间的关系

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397202

Kultigin Turkmen, Ismail Baloglu, Talat Aykut, Salih Demir, Ebru Altın, Zeynep Aybike Akguzel, Muhammet Kocabas, Fatma Humeyra Yerlikaya

{"title":"The Relationship between Serum TWEAK Levels and Carotid Intima-media Thickness in Patients with Fabry Disease.","authors":"Kultigin Turkmen, Ismail Baloglu, Talat Aykut, Salih Demir, Ebru Altın, Zeynep Aybike Akguzel, Muhammet Kocabas, Fatma Humeyra Yerlikaya","doi":"10.4103/1319-2442.397202","DOIUrl":"10.4103/1319-2442.397202","url":null,"abstract":"Fabry disease (FD) is associated with inflammation, proteinuria, and chronic kidney disease. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) plays an important role in inflammation in diabetic nephropathy and lupus nephritis. Since there is a close relationship linking serum TWEAK (sTWEAK), inflammation, and carotid intima-media thickness (CIMT) in various kidney diseases, we aimed to determine the relationship between sTWEAK levels and CIMT in subjects with and without proteinuria in a cross-sectional study involving 15 FD patients (seven females, eight males) and seven healthy controls (four females, three males). There were no differences in age, sex, estimated glomerular filtration rate, and biochemical parameters (serum glucose, albumin, creatinine, uric acid, C-reactive protein (CRP), low-density lipoprotein, and high-density lipoprotein) between FD patients and healthy controls. The spot urine protein-creatinine ratios of healthy controls and FD patients were 90 mg/g and 185 mg/g, respectively (P = 0.022). STWEAK levels were higher in FD patients than in healthy controls (P = 0.007). The CIMT of FD patients and healthy controls was 0.55 ± 0.14 mm and 0.42 ± 0.04 mm, respectively (P = 0.007). STWEAK was positively correlated with CRP and CIMT, and negatively with proteinuria (P = 0.005, P = 0.013, and P = 0.018, respectively). In the multivariate analysis, only sTWEAK was an independent variable of increased CIMT. We demonstrated that sTWEAK and CIMT were increased in FD patients. STWEAK might have a role in the pathogenesis of subclinical atherosclerosis in FD.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors of Anxiety among Hemodialyzed Patients in Ténès, Algeria: A Cross-Sectional Study. 阿尔及利亚泰内斯血液透析患者焦虑的风险因素：一项横断面研究

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397205

Amina Bekara, Mohammed El Amine Bekara, Lallia Amara, Nassima Amamra

引用次数: 0

IF 0.5

Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397207

Illyoung Seo, Youri Kim

引用次数: 0

Improved Arterial Stiffness Indices 3 and 6 Months after Living-donor Renal Transplantation. 活体肾移植术后 3 个月和 6 个月动脉僵硬度指数有所改善

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397199

Bhanu Pratap Singh, Vijoy Kumar Jha, Harshit Khurana, Debasish Mahapatra, Shashibhusan

{"title":"Improved Arterial Stiffness Indices 3 and 6 Months after Living-donor Renal Transplantation.","authors":"Bhanu Pratap Singh, Vijoy Kumar Jha, Harshit Khurana, Debasish Mahapatra, Shashibhusan","doi":"10.4103/1319-2442.397199","DOIUrl":"https://doi.org/10.4103/1319-2442.397199","url":null,"abstract":"Arterial stiffness is a non-traditional risk factor of cardiovascular disease and may explain part of the excess cardiovascular risk in chronic kidney disease patients. Successful renal transplantation (RT) may restore renal function and improve several metabolic abnormalities involved in arterial stiffness. This prospective study conducted non-invasive assessments of arterial stiffness indices [the augmentation index (AI) and pulse wave velocity (PWV)] in end-stage kidney disease (ESKD) patients before RT and 3 and 6 months after living-donor RT, alongside the effects of age and calcineurin inhibitors on arterial stiffness. The study included 26 ESKD patients (22 males and 4 females; mean age, 34.07 years; median duration of dialysis, 10 months) scheduled for RT and followed up for three visits (within 1 week before transplantation, and 3 and 6 months after transplantation). Six months after successful RT, the patients had nearly normal serum creatinine and significantly improved serum phosphate and intact parathyroid hormone levels. The pretransplant AI was 21.53% ± 13.61% which reduced significantly 6 months after RT to 16.19% ± 10.74% (P <0.05). Although there was a reduction in PWV 6 months after RT from the pre-transplant PWV, it was not significant. A significant correlation between age and the augmentation index was noted 3 and 6 months after RT. Patients on tacrolimus-based immunosuppression after RT showed significant improvements in the AI compared with patients on a cyclosporine-based regimen. RT helped to improve arterial stiffness indices, resulting in reduced cardiovascular risk.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Supramaximal Angiotensin-converting Enzyme Inhibition in Controlling Proteinuria in Congenital Nephrotic Syndrome with Cytomegalovirus Infection and an NPHS1 Mutation. 超大剂量血管紧张素转换酶抑制剂对巨细胞病毒感染和 NPHS1 基因突变的先天性肾病综合征患者控制蛋白尿的有效性

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397210

Nimisha Dange, Kiran P Sathe, Alpana Kondekar, Vishal Sawant

{"title":"Effectiveness of Supramaximal Angiotensin-converting Enzyme Inhibition in Controlling Proteinuria in Congenital Nephrotic Syndrome with Cytomegalovirus Infection and an NPHS1 Mutation.","authors":"Nimisha Dange, Kiran P Sathe, Alpana Kondekar, Vishal Sawant","doi":"10.4103/1319-2442.397210","DOIUrl":"https://doi.org/10.4103/1319-2442.397210","url":null,"abstract":"Congenital nephrotic syndrome (NS) is characterized by early-onset heavy proteinuria. Most cases of congenital NS are associated with genetic mutations in the podocyte proteins. The causal relationship of perinatal infections with congenital NS has not yet been proven. Inadequate response to the treatment of such infections should prompt us to conduct genetic testing for congenital NS. The heavy proteinuria associated with congenital NS is usually difficult to control with conventional treatment. It often results in progressive kidney disease with a high risk of mortality in early life. Here, we describe an infant who developed congenital NS and was found to have a coexisting Cytomegalovirus infection and an underlying NPSH1 mutation. Proteinuria did not respond to a standard dose of enalapril. A supramaximal dose of enalapril was tried and was effective and safe in controlling the proteinuria. It was associated with improved growth, complete resolution of edema, normal serum albumin, and normal renal function beyond 2 years of age.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Depression and Its Correlation with Serum Levels of Interleukin-6 in Patients on Maintenance Hemodialysis. 评估维持性血液透析患者的抑郁及其与血清白细胞介素-6水平的相关性。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397201

Shabana Nazneen, Manjusha Yadla, Prabhakar Reddy

{"title":"Assessment of Depression and Its Correlation with Serum Levels of Interleukin-6 in Patients on Maintenance Hemodialysis.","authors":"Shabana Nazneen, Manjusha Yadla, Prabhakar Reddy","doi":"10.4103/1319-2442.397201","DOIUrl":"https://doi.org/10.4103/1319-2442.397201","url":null,"abstract":"Depression is the most common psychiatric disorder in patients on hemodialysis. An imbalance between proinflammatory and anti-inflammatory cytokines is thought to play a role in the pathogenesis of depression in patients on dialysis. We undertook this study to assess the correlations of the proinflammatory cytokine interleukin 6 (IL-6) and the anti-inflammatory cytokine IL-10 with depression in patients on maintenance hemodialysis. This cross-sectional observational study was carried out at our hospital, a tertiary care referral government teaching hospital, over 2 years. Depression was assessed using the Becks Depression Inventory score. A higher cutoff of >16 was taken for a diagnosis of depression. Clinical, demographic, and laboratory parameters were analyzed. Cytokines were assessed using enzyme-linked immunosorbent assays. Eighty patients satisfied the inclusion criteria. The prevalence of depression in our study was 41.5%. Depression was more common in those who were unemployed and/or illiterate. Mild depression was found in patients from the upper-lower and lower-middle classes, but severe depression was seen in lower-economic classes. Serum levels of IL-6 showed a positive correlation with the severity of depression. Depression was common in patients on maintenance hemodialysis. High levels of serum IL-6 were observed in those with depression. Depression in patients on maintenance hemodialysis is associated with a considerable risk of mortality.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypernatremia Masking a Case of Primary Sjögren Syndrome-induced Distal Renal Tubular Acidosis. 高钠血症掩盖原发性斯约格伦综合征诱发的远端肾小管酸中毒病例

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397208

Chinmaye Sapre, Abhishek Prajapati, Rohan Parikh

引用次数: 0

A Case Report of Fibrillary Glomerulonephritis with Mild Albuminuria: A Viewpoint on Proteomics. 纤维性肾小球肾炎伴轻度白蛋白尿的病例报告：蛋白质组学视角

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-09-01 Epub Date: 2024-03-11 DOI: 10.4103/1319-2442.397209

Xavier Enrique Guerra-Torres

引用次数: 0