Revista Espanola De Enfermedades Digestivas最新文献

{"title":"Primary gastric rhabdomyosarcoma. A rare cause of an upper gastrointestinal bleeding.","authors":"Eduany Hernández, Javier Tejedor-Tejada, Laura Sánchez Sanmamed, Cristina Camblor, Ana Villar Caamaño, Samuel Robles Gaitero, Esmeralda Groba","doi":"10.17235/reed.2024.10538/2024","DOIUrl":"10.17235/reed.2024.10538/2024","url":null,"abstract":"<p><p>Adenocarcinoma accounts for 90% of malignant gastric tumours. Lymphomas, gastrointestinal stromal tumours (GIST) and other less frequent tumours account for 10%. However, rhabdomyosarcoma (RMS) remains a rare cause within the broad differential diagnosis of gastric lesions. Most cases of gastrointestinal RMS in adults are metastatic disease so primary RMS is extremely rare. A few cases reports of esophageal and gastric RMS have been published. This is a 76-year-old patient with a history of oncological oncology of poorly differentiated lung adenocarcinoma T2N1M0 in 2008 treated with surgery with no signs of recurrence. She presented to emergency with occasional episodes of melena and iron deficiency anemia for the last 3 months. The laboratory findings showed moderated anemia. Gastroscopy was performed and a prominent submucosal and ulcerated bulge was observed at the posterior wall of the gastric body and fundus. A histologic examination reveled tissue fragments composed of small round spindle-shaped cells. Tumor cells had atypical nuclei showing dense chromatin ad pale to eosinophilic cytoplasm. Immunohistochemically, the tumor was positive for AE1/3, desmin, myogenin and CD56. Patient was diagnosed with primary gastric RMS. Thoraco-abdominopelvic CT showed a locally advanced stage (T2 N1M0).</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"476-477"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmablastic lymphoma in a HIV positive patient: colonic disease as an unusual presentation.","authors":"Ana López-Mourelle, Miriam Rubiera, Pablo Argüelles-Estrada, Sara Lamas-Álvarez, Fernando Fernández Cadenas","doi":"10.17235/reed.2024.10784/2024","DOIUrl":"10.17235/reed.2024.10784/2024","url":null,"abstract":"<p><p>Plasmablastic lymphoma (PBL) is an aggressive and rare variant of diffuse large B-cell lymphoma associated with human immunodeficiency virus (HIV) infection. Here, we describe a case of PBL of the ascending colon in an HIV positive patient.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"483-484"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and evolution of newly diagnosed autoimmune gastritis in a large Spanish retrospective cohort.","authors":"Esteban Fuentes-Valenzuela, Sergio Escribano Cruz, Javier Parra Villanueva, Almudena Calvache Rodríguez, Ariadna Gil Díaz, María Del Carmen López-Martín, Itziar Rubio de la Plaza, Santiago Blanco, Irene Chivato Martín-Falquina, Beatriz Rodríguez-Batllori Aran, Raquel Latorre Martinez, Luis Alonso Castillo Herrera, Rafael Olvera, Daniel Alcalde Rodríguez, Karina Guzmán López, Alicia Bejerano Domínguez","doi":"10.17235/reed.2025.11101/2025","DOIUrl":"10.17235/reed.2025.11101/2025","url":null,"abstract":"<p><strong>Introduction: </strong>There is growing interest in autoimmune gastritis (AIG), particularly regarding its prevalence and natural history.</p><p><strong>Methods: </strong>A retrospective observational study was performed, including all patients with positive parietal cell antibodies who underwent gastroscopy between 2013 and 2023. The first subsequent gastroscopy was defined as follow-up endoscopy and considered for histological comparison. Categorization of histological stages was as follows; stage 0 (potential), stage I (non-atrophic gastritis), stage II (atrophic gastritis) and stage III (dysplasia, neuroendocrine tumor or adenocarcinoma).</p><p><strong>Results: </strong>A total of 426 patients were included, 316 were female with a median of 54.4 years (IQR 45.3-63.2). During this period, a total of 26798 patients underwent at least one upper endoscopy, so the prevalence of AIG was 1.6% (95% CI 1.4-1.7%). Histologically, 105 patients were classified as potential AIG (24.7%), 99 patients as stage I (23,2%), 215 patients as stage II (50.5%) and 7 patients as stage III (1.6%). 153 patients had a follow-up endoscopy. A significant increase of advanced stage disease was observed at follow-up (difference 18.7% 95% CI 7.6%-29%; p=0.001) and a decrease of potential GAI (difference 20.2% 95% CI 11.8% -28.7%; p<0.001). At baseline, 39 patients exhibited hyperplastic polyps (9.2%), 8 patients fundic gland polyps (1.9%), 3 adenomas with low-grade dysplasia (0.7%) and 3 patients presented G1 neuroendocrine tumors (0.7%). Only one patient (0.2%) was diagnosed with signet-ring cell gastric carcinoma.</p><p><strong>Conclusions: </strong>AIG has a low prevalence among patients undergoing gastroscopy. Biopsies in patients with positive parietal cell antibodies showed that around half of the population exhibit significant atrophy and a notable progressive disease.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"441-446"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small intestine bacterial overgrowth breath test does not predict symptom severity in gut-brain interaction disorders: role of anxiety, depression and inflammatory biomarkers.","authors":"Sandra Izquierdo Santervás, Carlos Maroto Martín, Aida Fiz-López, José Antonio Garrote Adrados, Sara Cuesta Sancho, David Bernardo Ordiz, Eduardo Arranz Sanz, Luis Fernández-Salazar","doi":"10.17235/reed.2025.11157/2025","DOIUrl":"10.17235/reed.2025.11157/2025","url":null,"abstract":"<p><strong>Background: </strong>the high prevalence of disorders of the gut-brain interaction (DGBI), the availability of breath tests for the diagnosis of small intestine bacterial overgrowth (SIBO) together with some confusion about the concept of SIBO have led to an increase in the number of SIBO diagnoses.</p><p><strong>Objective: </strong>this study aimed to analyze factors associated with the severity of gastrointestinal symptoms in patients undergoing a SIBO breath test.</p><p><strong>Methods: </strong>a cross-sectional observational study including 70 patients who underwent a SIBO test with lactitol and completed questionnaires including the ROME IV criteria for irritable bowel syndrome (IBS), the Irritable Bowel Syndrome Severity Score (IBSSS), and HAD anxiety and depression scales. Additionally, blood levels of histamine, citrulline, ghrelin, intestinal-fatty acid binding protein (I-FABP) and transient receptor potential cation channel subfamily V, member 1 (TRPV-1) were measured.</p><p><strong>Results: </strong>the mean age of the cohort was 45 ± 16 years and 70 % were female. Abdominal pain and/or abdominal distension were present in 85 % of patients and 44 % met IBS Rome IV criteria. IBSSS total score correlated with age (-0.354, p < 0.001), HAD-A (0.391, p < 0.001) and HAD-D (0.409, p < 0.001) scores, and histamine levels (0.279, p = 0.019). Abdominal pain correlated with levels of histamine (0.320, p < 0.05; 0.282, p < 0.05) and ghrelin (0.252, p < 0.05, 0.347, p < 0.05), while abdominal distension correlated with I-FABP levels (0.314, p < 0.05). The SIBO test was positive in 75 % but did not correlate with symptom severity.</p><p><strong>Conclusion: </strong>this study unveiled some factors associated with the severity of abdominal pain and distension such as age, auto-perceived anxiety and depression and some biomarkers but not the SIBO test result.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"433-440"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare early gastric mixed neuroendocrine-non-neuroendocrine neoplasm misdiagnosed as early gastric cancer.","authors":"Pengwei Liu, Yan Zhang","doi":"10.17235/reed.2024.10933/2024","DOIUrl":"10.17235/reed.2024.10933/2024","url":null,"abstract":"<p><p>Recently, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) have attracted more attention. However, early gastric MiNEN is uncommon, and there are rare reports on the characteristics of it. As its clinical and endoscopic features are resemble to early gastric cancer (EGC), it can be easily misdiagnosed. The purpose of this article is to elaborate the endoscopic and pathological characteristics of early gastric MiNEN, which is of great significance for distinguishing it from EGC. A 67-year-old male patient underwent EGD revealing a 0-IIc+IIa lesion on the lesser curvature of the lower stomach body. The biopsy pathology indicated the lesion was an EGC. Endoscopic submucosal dissection (ESD) was subsequently applied to remove the lesion. According to postoperative pathological, the lesion was diagnosed as early MiNEN (tubular adenocarcinoma 50%, neuroendocrine carcinoma 50%), pT1b (submucosa 600 μm), pUL (1), Ly (0), v (1), pHM0, pVM0. And after that, surgical resection were added. A follow-up CT scan and endoscopy performed six months later revealed no metastasis or recurrence. This case highlights that early gastric MiNEN could mimic ECG. We deemed that ME-NBI combined with pathological biopsy could contribute to the identification of early gastric MiNEN.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"479-481"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable bowel syndrome and structural brain changes - A two-sample Mendelian randomization study of cortical thickness and surface area.","authors":"Haiya Ou, Zhiming Lai, Xiaopeng Ye, Xiaotong Wang, Haixiong Lin","doi":"10.17235/reed.2025.10983/2024","DOIUrl":"10.17235/reed.2025.10983/2024","url":null,"abstract":"<p><strong>Background and aims: </strong>the relationship between irritable bowel syndrome (IBS) and structural changes in various regional cortical areas remains unclear. Mendelian randomization (MR) was used to explore the potential association between IBS and structural brain changes.</p><p><strong>Methods: </strong>genetically independent loci associated with IBS in individuals of European ancestry were selected as instrumental variants (IVs) from large-scale genome-wide association studies (GWAS). Outcome data were obtained from 34 subregions of the cerebral cortex in a population of 51,665 individuals. MR analysis was performed to explore the potential association between IBS and cerebral cortex structure (surface area [SA] and thickness [TH]). Cochran's Q test and MR-Egger intercept test were used to examined heterogeneity and horizontal pleiotropy of single nucleotide polymorphisms (SNPs). \"Leave-one-out\" sensitivity analysis was conducted to assess the influence of individual SNPs.</p><p><strong>Results: </strong>five relationships were obtained from a total of 68 phenotypes in 34 subregional structures of the cerebral cortex. IVW analysis showed that IBS was associated with increased SA in the inferior temporal and rostral anterior cingulate regions (βSA = 22.810 mm2, PSA = 0.040; βSA = 11.133 mm2, PSA = 0.006). Additionally, IBS was associated with increased TH in the isthmus cingulate and pars opercularis regions (βTH = 0.013 mm, PTH = 0.043; βTH = 0.010 mm, PTH = 0.010), and decreased TH in the rostral anterior cingulate region (βTH = -0.009 mm², PTH = 0.017).</p><p><strong>Conclusions: </strong>there is a potential association between IBS and the cerebral cortex structure. These findings provide important support for the association between diseases related to neurological damage and psychiatric abnormalities in IBS patients.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"426-432"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic abscess due to Salmonella enterica infection successfully treated with percutaneous drainage.","authors":"Alan Rafael Jiménez Rodríguez, Carlos Eugenio González Martínez, Diego García-Compeán, Héctor Jesús Maldonado Garza","doi":"10.17235/reed.2024.10536/2024","DOIUrl":"10.17235/reed.2024.10536/2024","url":null,"abstract":"<p><p>A 66-year-old female presented to our hospital with diffuse abdominal pain and diarrhea. An abdominal CT showed a splenic abscess of 9.9 x 6.1 x 6.5 cm. A conservative approach with US-guided percutaneous drainage and antibiotic treatment was performed successfully. Splenic abscess is a rare complication of Salmonella spp infection. In selected cases, percutaneous drainage can be performed safely with good efficacy.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"477-478"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel three traction rings device with endoscopic submucosal dissection (ESD) for the removal of a large superficial duodenal adenoma.","authors":"De-Feng Li, Yan-Hui Tian, Rui-Yue Shi, Ding-Guo Zhang","doi":"10.17235/reed.2024.10652/2024","DOIUrl":"10.17235/reed.2024.10652/2024","url":null,"abstract":"<p><p>Endoscopic treatment is generally recommended for the duodenal epithelial adenoma. Although underwater endoscopic mucosal resection (UEMR) has become established as an effective modality for the superficial duodenal adenoma. However, it is difficult to completely remove a large superficial duodenal adenoma with en bloc resection. Endoscopic submucosal dissection (ESD) is commonly performed to remove a large superficial duodenal adenoma, whereas which is technically challenged with severe adverse events. It has reported that entire traction using clip-and-nylon ring with ESD was effective and safe in the removal of a large rectal sessile serrated adenoma (SSA). Herein, we shared our experience of the novel three traction rings device in the treatment of a large superficial duodenal adenoma.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"464-466"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of biliary brush cytology via endoscopic retrograde cholangiopancreatography: a 7-year tertiary center experience.","authors":"Beatriz Gros, Paloma Elma Alañón Martínez, Marina Orti Cuerva, Ana Aparicio-Serrano, Elma Gallego Jiménez, Ana Santos Lucio, María Pleguezuelo Navarro, Antonio Hervás Molina, Francisco Javier Serrano Ruiz","doi":"10.17235/reed.2025.11158/2025","DOIUrl":"10.17235/reed.2025.11158/2025","url":null,"abstract":"<p><strong>Background: </strong>biliary brushing cytology during endoscopic retrograde cholangiopancreatography (ERCP) was used to assess the nature of a biliary stricture. Its low sensitivity challenges the exclusion of malignancy through this technique. The aim of this study was to evaluate the diagnostic yield of brush cytology in biliary strictures and to identify predictive factors associated with a positive diagnosis of malignancy.</p><p><strong>Methods: </strong>an observational retrospective study was performed in a tertiary center. All adult patients undergoing a biliary brushing during ERPC from 2016 to 2022 were included. Logistic regression analyses were performed to identify predictive factors for positive brush cytology.</p><p><strong>Results: </strong>a total of 5,309 patients underwent ERCP within the evaluated period. Out of these, biliary brushing was performed in 518 patients, including 568 cytology samples; 57.7 % (299) were male, with a median of 74 (64-84) years of age. Within the cohort, 24 % (126) had benign strictures and 76 % (392) had malignancy, of which the most common etiologies were pancreatic cancer 42.5 % (220/518), followed by cholangiocarcinoma 22.6 % (117/518). The sensitivity, specificity, positive predictive value, and negative predictive value were 48 %, 98 %, 98 % and 37 %, respectively. Sensitivity was 45 % and 52 % in pancreatic adenocarcinoma and cholangiocarcinoma, respectively. Older age (OR 1.02, 95 % CI: 1.01-1.03, p = 0.01) and higher bilirubin levels (OR 1.05, 95 % CI: 1.03-1.08, p < 0.001) were independent predictors for brush cytology positivity. The post-ERCP complication rate was 9.7 % (45/518).</p><p><strong>Conclusions: </strong>biliary brushing cytology during ERCP is a safe procedure with a low sensitivity and high specificity. Older age and higher bilirubin levels are associated with positive biliary cytology.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"447-454"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic treatment of postoperative intestinal stenosis combined with bilioenteric anastomotic stenosis.","authors":"Zheng Li, Sen-Lin Hou, Lichao Zhang, Haiming Du","doi":"10.17235/reed.2024.10741/2024","DOIUrl":"10.17235/reed.2024.10741/2024","url":null,"abstract":"<p><p>Postoperative anastomotic stenosis is a common complication after biliary, pancreatic and gastrointestinal surgery, which may be caused by multiple factors such as tissue proliferation and cancer recurrence. Endoscopic therapy is often hampered when the lens is difficult to pass through. A patient with intestinal stricture complicated by bilioenterostomy stenosis was treated by superselection of guide wire and stent.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"485-486"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}