Ángela Suárez-Noya, Carmen Álvarez-Navascués, Mercedes Rodríguez, Valle Cadahía-Rodrigo, Lissa Franco, Andrés Castaño-García, Susana Rojo-Alba, María Varela, María Luisa González-Diéguez, Manuel Rodríguez
{"title":"The role of immigration in chronic hepatitis B and C in Asturias - Origin and characteristics of the patients. An observational, cross-sectional study.","authors":"Ángela Suárez-Noya, Carmen Álvarez-Navascués, Mercedes Rodríguez, Valle Cadahía-Rodrigo, Lissa Franco, Andrés Castaño-García, Susana Rojo-Alba, María Varela, María Luisa González-Diéguez, Manuel Rodríguez","doi":"10.17235/reed.2025.11373/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11373/2025","url":null,"abstract":"<p><strong>Objective: </strong>To understand the burden of immigration in chronic hepatitis B (CHB) and C (CHC) in our setting and the characteristics of immigrants with each infection.</p><p><strong>Materials and methods: </strong>An observational, descriptive, and cross-sectional study that included all patients attended for CHB (n=758) and CHC (n=1,673) between January 2014 and December 2023. Demographic, epidemiological, and clinical variables were analyzed.</p><p><strong>Results: </strong>The proportion of immigrants was higher in CHB than in CHC (38.8% vs. 5.6%; P<0.001), as well as among incident cases compared to prevalent ones, both in CHB (60.7% vs. 23.1%; p<0.001) and CHC (7.8% vs. 2.6%; p<0.001). The geographic area with the highest proportion of CHB was sub-Saharan Africa (33.3%), and for CHC it was Eastern Europe (40.4%). The main known mechanism of infection was vertical-familial transmission (28.2%) in CHB and injecting drug use (21.3%) in CHC. Compared with those with CHB, immigrants with CHC were older (51.6 vs. 34 years; p<0.001), consumed alcohol more frequently (16% vs. 3.7%; p<0.001), had a higher BMI (26.7 vs. 24.5 kg/m²; p=0.03), and greater liver stiffness (7.9 vs. 5.2 kPa; p<0.001) evaluated by transient elastography.</p><p><strong>Conclusions: </strong>Immigration plays a growing role in hepatitis B and C in our setting, making systematic screening in this population necessary. Although the impact of immigration is much greater in CHB than in CHC, immigrants with CHC present a more advanced stage of liver fibrosis.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yessica Domínguez Novoa, J Enrique Domínguez-Muñoz, José Lariño Noia, Julio Iglesias-García
{"title":"Cystic pancreatic lesions: when to watch and when to act?","authors":"Yessica Domínguez Novoa, J Enrique Domínguez-Muñoz, José Lariño Noia, Julio Iglesias-García","doi":"10.17235/reed.2025.11428/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11428/2025","url":null,"abstract":"<p><p>Cystic pancreatic lesions (CPL) represent a growing challenge in gastroenterology, as their detection becomes more prevalent, and their management is increasingly complex. While many CPLs are benign and require only observation, others carry a significant risk of malignant transformation. The key to effective management relies in an accurate risk stratification, which can guide decisions regarding surveillance and treatment. As we move towards more personalized, patient-centered approaches, it is crucial to balance the benefits of early detection and intervention with the risks of overtreatment and the psychological burden on patients. Advances in molecular diagnostics and imaging, combined with improved patient education and shared decision-making, will be essential in shaping the future of CPLs management. The goal is not only to improve patient outcomes but also to ensure that care is compassionate, cost-effective, and aligned with individual patient needs.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanjing Ni, Guize Li, Xuemei Wang, Xiaoning Zheng, Jun Li
{"title":"Neurogenic megacolon in an adult presenting with acute intestinal obstruction.","authors":"Yanjing Ni, Guize Li, Xuemei Wang, Xiaoning Zheng, Jun Li","doi":"10.17235/reed.2025.11401/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11401/2025","url":null,"abstract":"<p><p>A 72-year-old man presented with a 1-week history of abdominal distension and cessation of defecation. He had undergone craniotomy for a cerebral aneurysm 10 years ago, with subsequent CT scans showing extensive damage to the corresponding brain tissue. Physical examination revealed severe abdominal distension without rebound tenderness. Initial CT showed marked colonic dilation with fecal retention, suggestive of megacolon. Conservative management with enemas and fasting failed, prompting a subtotal colectomy with colostomy under general anesthesia. Histopathology revealed chronic mucosal inflammation, muscular atrophy, and neuronal degeneration, confirming neurogenic megacolon. On the third postoperative day, he developed pulmonary embolism (confirmed by CTA), managed with low-molecular-weight heparin. One month postoperatively, he developed nutritional edema. Nutritional support therapy, including intravenous fat emulsion, amino acids, and vitamins was administered, resulting in gradual resolution of the edema.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An unusual etiology of diarrhea: primary intestinal lymphangiectasia.","authors":"Cong Dai, Yu-Hong Huang","doi":"10.17235/reed.2025.11483/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11483/2025","url":null,"abstract":"<p><p>Primary intestinal lymphangiectasia (PIL) is a rare disorder characterized by malformed and dilated intestinal lymphatic vessels, resulting in impaired drainage and leakage of lymph fluid into the gastrointestinal lumen. This leads to protein-losing enteropathy, causing chronic diarrhea, peripheral edema, weight loss, and hypoalbuminemia due to loss of proteins, lymphocytes, and lipids. Diagnosis relies on endoscopic visualization of pathognomonic white mucosal plaques (representing dilated lymphatics) and histopathological confirmation of lymphatic dilation, after excluding secondary causes like malignancy, surgery, or inflammatory conditions.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fluoxetine in functional constipation with somatic symptom disorder - Efficacy and safety from a propensity score-matched cohort study.","authors":"Bin Yang, Xiangying Feng, Qinxian Huang, Xuzhao Li, Xue Jiang, Weihong Fu, Qingchuan Zhao, Zhifeng Zhao","doi":"10.17235/reed.2025.11434/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11434/2025","url":null,"abstract":"<p><strong>Introduction: </strong>Functional constipation (FC) is often accompanied by somatic symptom disorder (SSD), especially in refractory conditions. In such patients, constipation manifestations often appear to reflect heightened somatic symptoms rather than bowel dysfunction such as excessive preoccupation to defecation. We Therefore conducted a cohort study to evaluate the efficacy and safety of fluoxetine in patients with FC and comorbid SSD.</p><p><strong>Methods: </strong>We conducted a cohort study involving 316 FC patients with somatic symptoms. Among them, 161 patients received fluoxetine, while 155 treated with polyethylene glycol (PEG). Using propensity scores, patients were matched into 77 pairs for comparative analysis. The primary outcome was proportion of achieving ≥ 3 completely spontaneous bowel movements (CSBMs) per week at six-month. Secondary outcomes included assessments of bowel symptom, mental Scale, treatment satisfaction. Safety was evaluated by adverse events.</p><p><strong>Results: </strong>At six months, 40.26% of fluoxetine group achieved primary endpoint compared to 22.08% in PEG group (P = 0.009). Significant improvements were noted in secondary outcomes, including frequency of CSBMs, bowel symptom severity, GAD-9 score, and patient satisfaction. Key factors contributing to treatment effectiveness included baseline GAD-9 scores > 9 (OR=5.01; P < 0.01). Adverse events occurred in 16 cases (9.9%) of the fluoxetine group, with most being mild life-affecting.</p><p><strong>Conclusion: </strong>Fluoxetine appears to be a safe and effective therapeutic option over a 6-month period for patients with FC and SSD, exerting dual benefits in alleviating both constipation and associated psychological symptoms.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiofrequency ablation for cholangiocarcinoma - Safety and effectiveness in clinical practice.","authors":"Francisco Pérez Roldán, Pedro González Carro","doi":"10.17235/reed.2025.11257/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11257/2025","url":null,"abstract":"<p><p>Cholangiocarcinoma comprises a heterogeneous group of biliary tract neoplasms, and represents the second most common neoplasm of the liver (15 %) after hepatocellular carcinoma. Diagnosis is achieved through various imaging techniques and is generally made at an advanced stage, often rendering the tumor unresectable. Bipolar biliary radiofrequency ablation is a palliative treatment that, when applied endoscopically, is a safe and effective technique. It is indicated for inoperable cholangiocarcinomas presenting with jaundice, to recanalize the biliary tract and restore patency of obstructed metal stents, and even as a pre-stenting therapy. Its primary indication is in hilar cholangiocarcinomas, particularly extrahepatic tumors. This technique should likely be incorporated into treatment protocols for cholangiocarcinoma, as well as for the management of occluded metal stents in other types of malignancies.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":"117 ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Ramos Martínez, Andrea Gutiérrez-Villanueva, Mariano González-Haba Ruiz, Itziar Diego-Yagüe, Alberto Nieto-Fernández, Elena Muñez, Ana Fernández Cruz, Jorge Calderón Parra
{"title":"Fecal microbiota transplantation for prevention of recurrent acute cholangitis. Review of four published cases.","authors":"Antonio Ramos Martínez, Andrea Gutiérrez-Villanueva, Mariano González-Haba Ruiz, Itziar Diego-Yagüe, Alberto Nieto-Fernández, Elena Muñez, Ana Fernández Cruz, Jorge Calderón Parra","doi":"10.17235/reed.2025.11404/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11404/2025","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent acute cholangitis (RAC) constitutes a relevant clinical problem that may condition the prognosis of the patient. Chronic suppressive antibiotic therapy can be used for preventive purposes, but it is associated with adverse effects and can select resistant bacterial strains. Fecal microbiota transfer (FMT) has been shown to be effective in preventing recurrent Clostridioides difficile infection and could be a useful strategy in patients with RAC.</p><p><strong>Objective: </strong>To review the experience of the use of FMT in the prevention of episodes of RAC by reviewing published cases.</p><p><strong>Result: </strong>Four cases were identified in which FMT significantly reduced RAC episodes. The patients were characterized by lack of efficacy of conventional treatments, had different predisposing factors for RAC and frequent colonization and infection by multidrug-resistant bacteria.</p><p><strong>Conclusions: </strong>The four cases presented provide limited but encouraging evidence of the preventive effect of FMT on successive episodes in patients without biliary tract obstruction. Larger and more adequately designed studies will be necessary to deepen the knowledge of this possible preventive strategy.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Sánchez Infantes, César Lévano-Linares, Tamara Diaz Vico, María Teresa Pérez Domene, Ana Torres Alemán, Belén Manso Abajo, Manuel Durán Poveda
{"title":"Benign multicystic peritoneal mesothelioma: use of hyperthermic intraperitoneal chemotherapy (HIPEC).","authors":"Silvia Sánchez Infantes, César Lévano-Linares, Tamara Diaz Vico, María Teresa Pérez Domene, Ana Torres Alemán, Belén Manso Abajo, Manuel Durán Poveda","doi":"10.17235/reed.2025.11416/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11416/2025","url":null,"abstract":"<p><p>Benign Multicystic Peritoneal Mesothelioma (BMPM) is a rare mesothelial neoplasm, first described in 1979, with an estimated incidence of 1-2 cases per million. It primarily affects women of reproductive age and has been associated with chronic inflammatory processes such as endometriosis or previous surgeries. Due to its clinical and radiological similarity to ovarian neoplasms, it is essential to include gynecological pathology in the differential diagnosis.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josefa Mora Vallellano, Francisco Cárdenas Lafuente, Sergio Fernández Espínola, Federico Acosta González, Irene Romero García, Ana Martínez Ruiz, Pablo Sánchez González, Daniel Pineda Tenor
{"title":"Closing the care gap - Systematic identification of overlooked patients with hepatitis C.","authors":"Josefa Mora Vallellano, Francisco Cárdenas Lafuente, Sergio Fernández Espínola, Federico Acosta González, Irene Romero García, Ana Martínez Ruiz, Pablo Sánchez González, Daniel Pineda Tenor","doi":"10.17235/reed.2025.11405/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11405/2025","url":null,"abstract":"<p><p>Achieving the World Health Organization's goals for Hepatitis C Virus (HCV) elimination is challenged by patients who remain untreated or are lost to follow-up. We aimed to develop and assess a data-driven strategy to identify and re-engage these overlooked patients. From 592 candidates (20218-2023) we identified 54 untreated patients who were suitable for specialist referral.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julio Otero Figar, Laura García López, Inés Magide Yañez, Mario Álvarez Díez, Blanca Mesonero de la Cruz, Elena Granda Villanueva, Eva Barreiro Alonso
{"title":"Pancreaticocolonic fistula resolved through conservative management: a case that defies the norm.","authors":"Julio Otero Figar, Laura García López, Inés Magide Yañez, Mario Álvarez Díez, Blanca Mesonero de la Cruz, Elena Granda Villanueva, Eva Barreiro Alonso","doi":"10.17235/reed.2025.11316/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11316/2025","url":null,"abstract":"<p><p>Spontaneous fistulization of pancreatic collections into the colon is a rare complication of necrotizing acute pancreatitis, with an incidence of less than 3% and high morbidity and mortality. We present the case of a 47-year-old male with severe necrotizing acute pancreatitis who developed a 12 mm pancreaticocolonic fistula between an infrapancreatic retroperitoneal collection and the hepatic flexure of the colon. Given the patient's clinical stability, a conservative approach was adopted, consisting of broad-spectrum antibiotic therapy, parenteral nutrition, and close radiological monitoring. Within two months, imaging studies demonstrated complete resolution of the fistula without the need for surgical or endoscopic intervention. This case highlights the potential for successful conservative management in hemodynamically stable patients, offering a less invasive alternative in selected clinical scenarios.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}