{"title":"An uncommon case of hematochezia.","authors":"Yimin Ma, Youhong Cao, Ping Ma","doi":"10.17235/reed.2026.11973/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11973/2026","url":null,"abstract":"<p><p>Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder, primarily associated with mutations in the SMAD4 and BMPR1A genes[1]. It is characterized by the development of multiple juvenile polyps throughout the gastrointestinal tract, most commonly located in the rectum and sigmoid colon. Cases of JPS with ossification are exceedingly uncommon, and the underlying pathogenesis remains unclearly. Several mechanisms have been implicated in ectopic ossification, including sensory neuron activation, lymphocytic infiltration, mast cell degranulation, skeletal muscle cell necrosis, and endothelial-to-mesenchymal transition.The presence of ossification may indicate an increased risk of disease progression, underscoring the importance of regular endoscopic surveillance in affected patients.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rut Fernández Bezanilla, Iñaki Casado Morentin, César Ibarra Ponce de León, Miguel Durá Gil, Nerea Gendive Martín, Emma Martínez Moneo
{"title":"Intraductal papillary neoplasm of the bile duct: diagnostic challenges in a tertiary center.","authors":"Rut Fernández Bezanilla, Iñaki Casado Morentin, César Ibarra Ponce de León, Miguel Durá Gil, Nerea Gendive Martín, Emma Martínez Moneo","doi":"10.17235/reed.2026.11974/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11974/2026","url":null,"abstract":"<p><p>Intraductal papillary neoplasm of the bile duct (IPNB) is an uncommon biliary tumor with recognized malignant potential and a broad clinicopathological spectrum. Its diagnosis remains challenging, particularly in extrahepatic disease, due to limitations of cross-sectional imaging. We report a consecutive series of five patients diagnosed with IPNB in a tertiary hepatobiliary center, highlighting their clinical, radiologic, endoscopic, and pathological features. Most patients presented with obstructive jaundice or cholangitis, and lesions were predominantly located in the distal bile duct. Cross-sectional imaging showed bile duct dilatation but often yielded inconclusive findings or underestimated intraductal disease, frequently leading to suspicion of cholangiocarcinoma or indeterminate strictures. Cholangioscopy provided additional diagnostic value by enabling direct visualization of characteristic villous or papillary lesions and facilitating targeted biopsies, contributing variably to diagnostic clarification. Histopathology demonstrated high-grade dysplasia in most cases, with one patient harboring invasive carcinoma. All patients required biliary drainage, and most underwent or were considered for surgical resection. These findings highlight the diagnostic discordance between preoperative assessment and definitive pathological diagnosis in IPNB and underscore the limitations of conventional imaging. Cholangioscopy represents a valuable complementary tool in the evaluation of indeterminate biliary strictures, although its findings should be interpreted within a multimodal diagnostic approach.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leire Parapar Álvarez, María Ojeda Remizova, Carlos Diz Calderón, Sol Pereiro Morillo, Pedro Luna Rojas, Daniel Pérez Corte, Carlos Andrés Vargas González
{"title":"Staged endoscopic management of esophageal anastomotic dehiscence using vacuum therapy: experience from two cases.","authors":"Leire Parapar Álvarez, María Ojeda Remizova, Carlos Diz Calderón, Sol Pereiro Morillo, Pedro Luna Rojas, Daniel Pérez Corte, Carlos Andrés Vargas González","doi":"10.17235/reed.2026.11872/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11872/2026","url":null,"abstract":"<p><p>Esophageal anastomotic dehiscence is one of the most serious complications after esophageal surgery. In recent years, endoscopic vacuum therapy (EVT) has become established as an effective alternative to surgical management, as it promotes local infection control and progressive defect closure. However, in clinical practice, uncertainty remains regarding which device should be used at each stage and when the strategy should be modified. Our contribution is to describe a pragmatic two-step, staged approach: initial use of EsoSponge® when the main priority is active drainage of the cavity and local septic control, followed by VACStent® when a small or partially collapsed residual cavity persists and it is desirable to maintain the vacuum effect while also achieving luminal sealing and progression to oral intake. We believe that this sequence may be particularly useful in leaks not completely resolved with conventional EVT, once initial clinical control has been achieved and cavity reduction has been observed.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucía Pérez Vior, Camila Espinosa Martínez, Sofía Delgado Roel, Carlos Miñones Ginarte, Lucía Pablo Martínez, Antonio Manuel Platas Cousillas, María Pérez Vior, Luis Ecenarro Del Río
{"title":"Transgastric retrograde endoscopic disimpaction in advanced achalasia.","authors":"Lucía Pérez Vior, Camila Espinosa Martínez, Sofía Delgado Roel, Carlos Miñones Ginarte, Lucía Pablo Martínez, Antonio Manuel Platas Cousillas, María Pérez Vior, Luis Ecenarro Del Río","doi":"10.17235/reed.2026.11983/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11983/2026","url":null,"abstract":"<p><p>Achalasia is an esophageal motility disorder that may lead to severe esophageal dilation and food impaction in advanced stages. We report a 54-year-old man with known achalasia who presented with massive esophageal food impaction. Initial endoscopic management failed to achieve complete disimpaction despite prolonged attempts. A multidisciplinary approach was undertaken, performing a transgastric retrograde endoscopic access combined with pneumatic dilation of the lower esophageal sphincter. This strategy enabled complete removal of the impacted material and subsequent esophageal clearance. The patient had a favorable clinical outcome and was scheduled for definitive surgical treatment. Massive food impaction in advanced achalasia is rare and may be refractory to conventional endoscopic techniques. Combined endoscopic-surgical approaches may offer an effective alternative in selected cases.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clara Navarro Peiró, Carlos Boix Clemente, Mercedes Jaén Revuelta, Gloria Alemany Pérez, Paloma Villar Espinal, Lara González González, Beatriz Moreno Torres, Carlos Alventosa Mateu
{"title":"Intestinal amoebiasis: a cause of colonic ulceration.","authors":"Clara Navarro Peiró, Carlos Boix Clemente, Mercedes Jaén Revuelta, Gloria Alemany Pérez, Paloma Villar Espinal, Lara González González, Beatriz Moreno Torres, Carlos Alventosa Mateu","doi":"10.17235/reed.2026.11942/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11942/2026","url":null,"abstract":"<p><p>We present two clinical cases of intestinal amoebiasis. The first case was asymptomatic, with colonic ulcers incidentally detected during colonoscopy. The second case presented with diarrhea and a hepatic abscess, also associated with colonic ulcers. Both patients showed a favorable clinical outcome following treatment. Amoebiasis is caused by the parasite Entamoeba histolytica. It is transmitted via the fecal-oral route and is more common among travelers, immunocompromised individuals, and men who have sex with men. Clinically, it can range from asymptomatic infection to severe colitis and hepatic abscess formation. Diagnosis is established through stool microbiological tests, serology, and intestinal biopsies. In invasive cases, treatment consists of metronidazole or tinidazole, followed by a luminal amoebicide such as paromomycin. In cases of large abscesses, drainage may be required.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Espinosa-Pascual, Ana María Pedraza-Flechas, Maunel Durán-Poveda, Diego Rodríguez-Villar, Yudan Zhu, Gil Rodríguez-Caravaca, Pilar Cárdenas-Soriano
{"title":"Surgical site infection in laparoscopic colon surgery: a cohort study.","authors":"Ricardo Espinosa-Pascual, Ana María Pedraza-Flechas, Maunel Durán-Poveda, Diego Rodríguez-Villar, Yudan Zhu, Gil Rodríguez-Caravaca, Pilar Cárdenas-Soriano","doi":"10.17235/reed.2026.11880/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11880/2026","url":null,"abstract":"<p><strong>Background: </strong>Colon surgery is among the procedures with the highest rates of surgical site infection (SSI). The aim of this study was to assess the incidence of SSI in laparoscopic colon surgery and to identify potential associated risk factors.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted from July 2012 to July 2024. Patients undergoing laparoscopic colon surgery at Hospital Universitario Fundación Alcorcón were consecutively included. The incidence of SSI in laparoscopic surgery was evaluated, along with its potential association with preoperative preparation, adequacy of antibiotic prophylaxis, and other risk factors related to surgical wound infection. Explanatory binary logistic regression models with backward stepwise selection were fitted. Potential interactions between the risk factors identified in laparoscopic procedures and type of surgical approach (laparoscopic vs. non-laparoscopic) were also assessed.</p><p><strong>Results: </strong>The study included 491 patients who underwent laparoscopic surgery and 1,209 who underwent non-laparoscopic surgery. The incidence of SSI was 6.1% (95% CI: 4.3-8.6) in laparoscopic procedures and 14.6% (95% CI: 12.8-16.7) in non-laparoscopic procedures. Inadequate preoperative preparation was associated with the occurrence of SSI (OR: 4.3; 95% CI: 1.85-10.1; p-value: 0.001), independently of patient age and NHNS index. This association between preoperative preparation and SSI was not observed in non-laparoscopic surgeries.</p><p><strong>Conclusions: </strong>A high level of compliance with preoperative preparation may provide an additional benefit in laparoscopic colon surgery compared with open surgery.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuling Xiong, Chao Peng, Yue Tian, Yuxia Gao, Jie Sun, Qiao Li
{"title":"Collagenous gastritis: a rare case in young adult with iron deficiency anemia.","authors":"Yuling Xiong, Chao Peng, Yue Tian, Yuxia Gao, Jie Sun, Qiao Li","doi":"10.17235/reed.2026.11993/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11993/2026","url":null,"abstract":"<p><p>Collagenous gastritis (CG) is an extremely rare chronic inflammatory gastropathy with non-specific symptoms and high misdiagnosis rate. We report a 21-year-old female with 6-month postprandial epigastric discomfort, anorexia, dizziness, fatigue, and severe iron deficiency anemia. Endoscopy showed diffuse erythema, erosions, and typical nodular elevation-depression lesions in the gastric corpus. Histopathology and Masson's trichrome staining verified subepithelial collagen band thickening (>10 μm), confirming CG. After 8-week oral iron and proton pump inhibitor treatment, clinical symptoms resolved and hematological parameters improved markedly, but histological changes persisted. This case indicates that CG should be considered in young adults with unexplained iron deficiency anemia and atypical endoscopic features, and nodule-depression pattern serves as a key diagnostic clue.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical outcomes and survival following percutaneous endoscopic gastrostomy: a longitudinal cohort study.","authors":"Eduardo Segovia-Vergara, Álvaro Arredondo-Barría, Marisol Traimante-Ruiz, Rodrigo Mansilla-Vivar","doi":"10.17235/reed.2026.11929/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11929/2026","url":null,"abstract":"<p><strong>Introduction: </strong>Percutaneous endoscopic gastrostomy (PEG) is a procedure indicated for prolonged enteral nutritional support. Compared with the surgical approach, it is associated with lower morbidity and mortality and improved nutritional recovery. However, local evidence on its clinical outcomes and prognosis remains limited.</p><p><strong>Objective: </strong>To describe the clinical characteristics, complications, and survival of patients undergoing PEG between 2008 and 2020 at the Hospital of Puerto Montt.</p><p><strong>Materials and methods: </strong>Longitudinal observational cohort study including 748 adult patients who underwent PEG between 2008 and 2020 at the Hospital of Puerto Montt. The etiology of the indication, complications, and survival were analyzed using Kaplan-Meier and Cox proportional hazards models.</p><p><strong>Results: </strong>The most frequent indication was neurological (77.4%), followed by neoplastic causes (17.9%). The overall complication rate was 8.3%. Median overall survival was 491 days, lower in patients with neoplastic indications (249 days) compared to those with neurological indications (545 days). Advanced age and a neoplastic indication were the only factors associated with increased mortality.</p><p><strong>Conclusion: </strong>Survival after PEG placement depends on multiple factors, particularly the clinical indication, which should be supported by appropriate evaluation and staging of the underlying disease. In this cohort, PEG placement was associated with no procedure-related mortality and a low rate of complications, which may be underestimated due to the hospital-based nature of the data registry. Survival outcomes were comparable to those reported in the literature.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Staged endoscopic submucosal dissection of synchronous multiple early esophageal cancers for stricture prevention.","authors":"Shiji Zhang, Tao Dong, Jun Xiao","doi":"10.17235/reed.2026.11999/2026","DOIUrl":"https://doi.org/10.17235/reed.2026.11999/2026","url":null,"abstract":"<p><p>Synchronous multiple lesions are not uncommon in patients with early esophageal cancer. Endoscopic submucosal dissection (ESD) provides an effective and safe treatment while preserving esophageal integrity. Single session ESD is generally performed for synchronous multiple early esophageal cancers, offering the advantage of reduced medical costs. However, when the lesions are adjacent, extensive mucosal defect after ESD increases the risk of refractory stricture. In this case, we described a strategy-staged ESD for the prevention of stricture following extensive resection of synchronous multiple early esophageal cancers.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raúl Honrubia Lopez, Sergio Casabona-Francés, Cristina Fernández de Castro, Carolina Gutiérrez-Junquera, Elena Grueso-Navarro, Emilio José Laserna-Mendieta, Isabel Pérez-Martínez, Alfredo J Lucendo
{"title":"Eosinophilic esophagitis - Risk factors, pathophysiological mechanisms, and practical aspects for diagnosis and treatment in children and adults.","authors":"Raúl Honrubia Lopez, Sergio Casabona-Francés, Cristina Fernández de Castro, Carolina Gutiérrez-Junquera, Elena Grueso-Navarro, Emilio José Laserna-Mendieta, Isabel Pérez-Martínez, Alfredo J Lucendo","doi":"10.17235/reed.2026.11574/2025","DOIUrl":"https://doi.org/10.17235/reed.2026.11574/2025","url":null,"abstract":"<p><p>Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease characterized by eosinophilic infiltration and symptoms of esophageal dysfunction with rapidly increasing epidemiology. EoE represents the main cause of dysphagia and food impaction in children and young adults, with symptoms varying according to patient age. Diagnosis requires endoscopy with the taking of esophageal biopsy samples in sufficient numbers and from multiple locations, since endoscopic findings, graded according to the EREFS (edema, rings, exudates, furrows, stenosis) score, are nonspecific. Different studies have identified potential non-invasive biomarkers and methods of obtaining esophageal samples that allow dispensing with endoscopy and biopsies in both initial diagnosis and the monitoring of response to treatment. Their implementation might reduce the diagnostic delay and healthcare costs associated with EoE. First-line anti-inflammatory treatments include empirical elimination diets, proton pump inhibitors, and topical corticosteroids. Dupilumab has recently been incorporated for refractory patients. Esophageal dilation is a safe and effective option to relieve symptoms in case of stenosis. Adherence to long-term treatment and the transition from pediatric to adult services remain challenging. The efficacy of current therapies allows achieving and maintaining remission in a large proportion of patients with EoE. However, there are gaps in non-invasive diagnostic methods and long-term control. Thus, the aim of this review is to synthesize the pathophysiological bases and summarize the main advances in the diagnosis and treatment of EoE, as well as to highlight some current limitations in the care process.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":"118 ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}