Macarena Torres-Larrubia, Sergio Casiano-Manzano, Zulianni Andreina Jiménez-Colmenárez, Joaquín Domínguez-Humanes, Alberto Masa-Caballero, María Herrador-Paredes, Pilar Mata-Romero, Pablo Solís-Muñoz
{"title":"Isolated colonic amyloidosis: a rare condition mimicking malignancy.","authors":"Macarena Torres-Larrubia, Sergio Casiano-Manzano, Zulianni Andreina Jiménez-Colmenárez, Joaquín Domínguez-Humanes, Alberto Masa-Caballero, María Herrador-Paredes, Pilar Mata-Romero, Pablo Solís-Muñoz","doi":"10.17235/reed.2025.11100/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11100/2025","url":null,"abstract":"<p><p>We report the case of a 54-year-old male with localized colonic amyloidosis presenting as rectal bleeding. Initial colonoscopy revealed a neoplastic-appearing lesion in the descending colon, but histopathology identified amyloid deposits, confirmed by Congo Red staining. Further assessment ruled out systemic involvement and primary (AL) amyloidosis, establishing the diagnosis as isolated colonic amyloidosis. This case highlights the importance of biopsy and histopathological evaluation in patients with atypical findings, especially when confounding factors such as monoclonal gammopathy of undetermined significance (MGUS) are present. Comprehensive pathological and molecular assessment are important to differentiate between localized and systemic amyloidosis and guide appropriate management.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andres Castañeda Agredo, Sergio Farrais Villalba, David S Sanders
{"title":"Follow-up in coeliac disease: evidence and future challenges.","authors":"Andres Castañeda Agredo, Sergio Farrais Villalba, David S Sanders","doi":"10.17235/reed.2025.11168/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11168/2025","url":null,"abstract":"<p><p>It is estimated that Coeliac Disease has a prevalence of 1% of the global population, and many cases remain undiagnosed, either because patients do not have proper health monitoring or, conversely, due to the asymptomatic nature of the disease in some cases. Furthermore, there is no population wide screening program, although suspicion of the disease has significantly improved. Consequently, it is expected that the incidence will continue to rise in the upcoming years. With this letter, we aim to raise awareness of the imminent challenge for gastroenterologists with expertise in Coeliac Disease and the need to strengthen knowledge and follow-up of the disease in primary care for uncomplicated cases, as well as the necessity of a nutritionist.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miriam Celada-Sendino, Margarita Fernández-de la Varga, Carlos Ordieres-Díaz, Pedro Amor-Martín, Marta Álvarez-Posadilla, Adrián Huergo-Fernández
{"title":"Challenges in the management of chronic hepatitis E in immunocompromised patients: reactivation after treatment with ribavirin.","authors":"Miriam Celada-Sendino, Margarita Fernández-de la Varga, Carlos Ordieres-Díaz, Pedro Amor-Martín, Marta Álvarez-Posadilla, Adrián Huergo-Fernández","doi":"10.17235/reed.2025.11177/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11177/2025","url":null,"abstract":"<p><p>Chronic HEV infection is a significant cause of morbidity and mortality in immunocompromised patients, with rapid progression to advanced fibrosis. We present the case of a 71-year-old immunocompromised male with chronic liver disease due to hepatitis E, who experienced several episodes of HEV reactivation despite treatment with ribavirin. Thus, the treatment of the infection involves a challenge due to the lack of validated therapeutic options and the risk of viral reactivation after stopping treatment.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hugo Uchima, Leticia Moreira-Ruiz, Glòria Fernández Esparrach
{"title":"Low risk, high cost: challenging the role of gastric cancer screening in low-prevalence countries.","authors":"Hugo Uchima, Leticia Moreira-Ruiz, Glòria Fernández Esparrach","doi":"10.17235/reed.2025.11087/2024","DOIUrl":"https://doi.org/10.17235/reed.2025.11087/2024","url":null,"abstract":"<p><p>Gastric cancer is the second commonest gastrointestinal (GI) neoplasm, with a high mortality rate and highly variable regional incidence data associated with factors such as diet, genetics, and infection with Helicobacter pylori. In high-risk countries as Japan and South Korea endoscopic screening has shown its potential to reduce this cancer's mortality. However, in low-risk countries such as Spain, where population screening is not cost-effective, a selective approach is advised focused on high-risk groups, including patients with a family history of gastric cancer, or in the form of opportunistic screening during gastroscopy for other clinical indications. High-quality gastroscopy is key for the identification of early lesions. This includes using high-definition endoscopes with chromoendoscopy, pursuing optimal mucosal visibility with washes or premedication, systematically inspecting all of the mucosa, investing adequate observation times, and using risk stratification tools such as EGGIM or OLGIM. Endoscopic surveillance is particularly advisable for high-risk precursor lesions, with intervals adjusted for patient profile. Further research is crucial for optimizing these interventions and reducing the condition's mortality rate.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":"117 ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The EUS-guided rendezvous technique was performed for stent implantation.","authors":"Yongzhan Zhao, Longwei Fang, Yuxi Zhang, Tingting Yu, Lichao Zhang, Senlin Hou","doi":"10.17235/reed.2025.11060/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11060/2025","url":null,"abstract":"<p><p>When Endoscopic retrograde cholangiopancreatography (ERCP) fails in patients with obstructive jaundice, EUS-guided rendezvous technique (EUS-RV) becomes an alternative treatment. For the EUS-RV, we can puncture the intrahepatic bile duct (IHBD) and the extrahepatic bile duct (EHBD). Puncturing the EHBD needs through duodenum, the puncture site can be divided into via the proximal duodenum (D1) and via the second portion of the duodenum (D2). Puncturing the IHBD will difficult to perform at the patients whose IHBD is not dilated. For these patients, puncturing EHBD becomes an unavoidable choice. Generally, the closer the puncture point is to the duodenal papilla, the more difficult it is to implant the stent. Therefore, we innovatively adopted the method that concomitantly withdrawing the guidewire during stent deployment.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia de Miguel, Amaia Arrubla, Juan Carrascosa, Juan J Vila
{"title":"Resolution of pancreatic ductal disruption through endoscopic ultrasound (EUS)-guided Rendez-vous in a patient with pancreas divisum.","authors":"Patricia de Miguel, Amaia Arrubla, Juan Carrascosa, Juan J Vila","doi":"10.17235/reed.2025.11124/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11124/2025","url":null,"abstract":"<p><p>A 73-year-old woman presented with a pancreas divisum was admitted for acute pancreatitis. Abdominal CT was performed due to a torpid evolution with fever and oral intolerance, demonstrating necrosis and ductal disruption in the pancreatic neck. An ERCP was attempted, however, the minor papilla (MP) could not be identified because of the presence of edematous duodenal folds. EUS revealed ductal disruption and the pancreatic duct was punctured using a 22G needle at the level of the body-tail junction (<2 mm). Then, rendez-vous was completed by cannulating the MP with a rail technique and a pancreatic stent was placed. Given the persistence of oral intolerance secondary to the duodenal parietal inflammatory component, EUS-guided gastrojejunostomy was performed with a 20 mm luminal apposition stent. The patient exhibited progressive clinical improvement and was discharged following a control ERCP, which confirmed resolution of the ductal disruption and significant improvement of the duodenal inflammatory changes. Consequently, the endoscopic gastrojejunostomy was reversed.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yessica Domínguez-Novoa, Enrique Domínguez-Muñoz, Xurxo Martínez-Seara, José Lariño-Noia, Julio Iglesias-García
{"title":"Evaluation of pancreatic microvascularization in chronic pancreatitis by EUS-guided detective flow imaging (DFI): a prospective, single-centre, observational study.","authors":"Yessica Domínguez-Novoa, Enrique Domínguez-Muñoz, Xurxo Martínez-Seara, José Lariño-Noia, Julio Iglesias-García","doi":"10.17235/reed.2025.11054/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11054/2025","url":null,"abstract":"<p><strong>Introduction: </strong>Early diagnosis of chronic pancreatitis (CP) is a clinical challenge. Endoscopic ultrasound-guided detective flow imaging (EUS-DFI) can evaluate pancreatic microvascularization, which may be altered in chronic inflammation. Our study aimed to evaluate EUS-DFI findings in patients with CP.</p><p><strong>Methods: </strong>Prospective, single-centre, observational study including patients undergoing EUS for known or clinically suspected CP. EUS criteria for CP were evaluated according to the Rosemont classification. EUS-DFI findings were analysed and classified into three grades: grade 0 - absence of microvasculature, grade 1 - Reticular pattern with mild microvascularization, and grade 2 - reticular pattern with marked microvascularization. The correlation between EUS-DFI and Rosemont classification was analysed.</p><p><strong>Results: </strong>205 patients (mean age 53 years, range 21-85, 107 males) were included. 34 patients (16.6%) had a normal pancreas, 55 (26.7%) indeterminate findings of CP, 108 (52.7%) suggestive changes of CP and 8 (4.0%) consistent with CP. An EUS-DFI grade 0 was only seen in subjects with a normal pancreas, whereas an EUS-DFI grade 1 was usually associated with indeterminate and suggestive findings of CP (97.6% of cases). A grade 2 was observed in some patients with suggestive CP and in all patients with definite findings of CP (p<0.001). EUS-DFI was significantly different between groups according to Rosemont classification (p<0.001).</p><p><strong>Conclusion: </strong>EUS-DFI allows the assessment of pancreatic microvascularization in CP, which correlates with the severity of morphological changes of the disease.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anabella Cuestas, Miriam Cuatrecasas, María Glòria Fernández Esparrach, Leticia Moreira-Ruiz
{"title":"Gastric siderosis: an endoscopic diagnosis challenge.","authors":"Anabella Cuestas, Miriam Cuatrecasas, María Glòria Fernández Esparrach, Leticia Moreira-Ruiz","doi":"10.17235/reed.2025.11148/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11148/2025","url":null,"abstract":"<p><p>A 71-year-old man presented for a routine physical examination with multiple comorbidities, including severe panvascular disease and valvulopathy, requiring anticoagulation therapy. He had a history of chronic hemolytic anemia and had been taking oral ferrous sulfate for two years. Upper gastrointestinal endoscopy (UGE) was performed, as part of the study of the persist anemia, revealing an extensive nodular area with multiple brownish deposits and spontaneous hemorrhage. Biopsy showed mild inflammation in the lamina propria and ferric pigment confirmed by positive Perl's iron stain, suggesting drug-induced injury. After diagnosis of GS, iron supplements were discontinued and a UGE nine months later showed no remaining lesions.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intestinal polyps and chronic schistosomiasis.","authors":"Vitorino M Santos, Andressa Plaça Tedeschi","doi":"10.17235/reed.2025.11154/2025","DOIUrl":"https://doi.org/10.17235/reed.2025.11154/2025","url":null,"abstract":"<p><p>Intestinal polyps have been described in association with chronic schistosomiasis, and must be differentiated from malignant tumors and appropriately managed. This uncommon condition may be very rarely detected in people from non-endemic areas of this zoonosis, who were occasionally infected during some travel period. The lesions are more frequently described in men, and predominating in the colon. The diagnosis is confirmed by histopathological evaluations and finding eggs of Schistosoma in biopsy samples. The use of Praziquantel has been a very effective treatment. The authors emphasize the diagnosis confirmation as early as possible, avoiding mistakes with cancer.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haiya Ou, Zhiming Lai, Xiaopeng Ye, Xiaotong Wang, Haixiong Lin
{"title":"Irritable bowel syndrome and structural brain changes - A two-sample Mendelian randomization study of cortical thickness and surface area.","authors":"Haiya Ou, Zhiming Lai, Xiaopeng Ye, Xiaotong Wang, Haixiong Lin","doi":"10.17235/reed.2025.10983/2024","DOIUrl":"https://doi.org/10.17235/reed.2025.10983/2024","url":null,"abstract":"<p><strong>Background and aims: </strong>The relationship between irritable bowel syndrome (IBS) and structural changes in various regional cortical areas remains unclear. Mendelian randomization (MR) was used to explore the potential association between IBS and Structural Brain Changes.</p><p><strong>Methods: </strong>Genetically independent loci associated with IBS in individuals of European ancestry were selected as instrumental variants (IVs) in the large-scale genome-wide association studies (GWAS). Outcome data were obtained from 34 subregions of the cerebral cortex in a population of 51,665 individuals. MR analysis was performed to explore the potential association between IBS and cerebral cortex structure (surface area (SA) and thickness (TH)). Cochran's Q test, MR-Egger intercept test was used to examined heterogeneity and horizontal pleiotropy of single nucleotide polymorphisms (SNPs). \"Leave-one-out\" sensitivity analysis was conducted to assess the influence of individual SNPs.</p><p><strong>Results: </strong>Five relationships were obtained from a total of 68 phenotypes in 34 subregional structures of the cerebral cortex. IVW analysis showed that IBS was associated with increased SA in the inferior temporal and rostral anterior cingulate regions (βSA=22.810 mm2, PSA=0.040; βSA=11.133 mm2, PSA=0.006). Additionally, IBS was associated with increased TH in the isthmus cingulate and pars opercularis regions (βTH=0.013 mm, PTH=0.043; βTH=0.010 mm, PTH=0.010), and decreased TH in the rostral anterior cingulate region (βTH=-0.009 mm², PTH=0.017).</p><p><strong>Conclusions: </strong>There is a potential association between IBS and the cerebral cortex structure. These findings provide important support for the association between diseases related to neurological damage and psychiatric abnormalities in IBS patients.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}