Qiting Zhan, Ke Gao, Yonglin Qiu, Yonghui Chen, Hongxing Guo
{"title":"Rare case of spontaneous duodeno-colic fistula.","authors":"Qiting Zhan, Ke Gao, Yonglin Qiu, Yonghui Chen, Hongxing Guo","doi":"10.17235/reed.2024.10754/2024","DOIUrl":"10.17235/reed.2024.10754/2024","url":null,"abstract":"<p><p>A 48-year-old woman presented to the outpatient clinic with a 4-month history of alternating diarrhea and constipation with bloating. Physical examination revealed a body mass index of 22.89 kg/m², normal development, and no tenderness or rebound tenderness in the abdomen. The patient has maintained a stable body size since birth, with a previously healthy status and no history of abdominal surgery or trauma. Endoscopic examination revealed an abnormal channel between the posterior wall of the duodenal bulb to the hepatic flexure of the colon. The patient was managed with conservative treatment, including acid suppression and modulation of the gut microbiota, and was closely monitored. Surgical intervention would only be considered in the event of severe symptoms or complications. Over a five-month follow-up period, the patient's symptoms improved.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"649-650"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agustín Albillos Martínez, Julia López Cardona, Javier Crespo García, Fernando Carballo Álvarez
{"title":"Population screening for colorectal cancer in Spain - A public health success with remaining challenges.","authors":"Agustín Albillos Martínez, Julia López Cardona, Javier Crespo García, Fernando Carballo Álvarez","doi":"10.17235/reed.2024.10774/2024","DOIUrl":"10.17235/reed.2024.10774/2024","url":null,"abstract":"<p><p>The development of organized colorectal cancer screening programs in developed countries has led to a reduction in the incidence and mortality of this cancer. The implementation of the national screening program in Spain represents a major achievement in public health, aligning us with other European countries, but it still faces ongoing challenges. One of the main issues is the low participation rate of the eligible population, averaging 45%, with significant variation between autonomous communities. This requires allocating specific resources to overcome barriers that hinder participation. Another key aspect to improving the screening program is extending the screening age up to 74 years, in line with the recommendations of the European Union, as many member states are already doing.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":"116 ","pages":"585-589"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A whole new challenge: endoscopic ultrasound-guided transhepatic antegrade stone removal (TASR) for the treatment of multiple choledocholithiasis after total gastrectomy.","authors":"Wei Zhang, Sen-Lin Hou, Yan-Kun Hou, Jiao Tian, Li-Chao Zhang","doi":"10.17235/reed.2023.10117/2023","DOIUrl":"10.17235/reed.2023.10117/2023","url":null,"abstract":"<p><p>EUS-TASR is a derivative of EUS-BD and serves as a remedy when ERCP fails. EUS-BD technology is commonly used in the diagnosis and treatment of biliary tract and pancreatic diseases with anatomical changes of the digestive tract. This article provides an experience of EUS-TASR and a new challenge in the treatment of common bile duct stones after total gastrectomy.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"633-634"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Gómez Otero, Eduardo Valdivielso Cortázar, Carmen Cabezal Iglesias, Lucía Pérez Vior, Laura Pardeiro Mariño, Roque Nogueira Fariña, Sara Gamundi Barros, Pedro Alonso Aguirre
{"title":"Jejunal gastrointestinal stromal tumor: a diagnostic challenge.","authors":"Maria Gómez Otero, Eduardo Valdivielso Cortázar, Carmen Cabezal Iglesias, Lucía Pérez Vior, Laura Pardeiro Mariño, Roque Nogueira Fariña, Sara Gamundi Barros, Pedro Alonso Aguirre","doi":"10.17235/reed.2024.10108/2023","DOIUrl":"10.17235/reed.2024.10108/2023","url":null,"abstract":"<p><p>Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract and a rare cause of gastrointestinal bleeding. These tumors usually affect people over 50 years of age and they exhibit a wide range of clinical manifestations, including asymptomatic patients, nonspecific symptoms, obstruction or bleeding, which may delay diagnosis. Early diagnosis and treatment are crucial because GISTs can be aggressive and metastasize. This case highlights the importance of considering GISTs in the differential diagnosis of obscure gastrointestinal bleeding.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"636-637"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Belén Agudo Castillo, Miguel Mascarenhas, Miguel Martins, Francisco Mendes, Daniel de la Iglesia, Antonio Miguel Martins Pinto da Costa, Carlos Esteban Fernández-Zarza, Mariano González-Haba Ruiz
{"title":"Advancements in biliopancreatic endoscopy - A comprehensive review of artificial intelligence in EUS and ERCP.","authors":"Belén Agudo Castillo, Miguel Mascarenhas, Miguel Martins, Francisco Mendes, Daniel de la Iglesia, Antonio Miguel Martins Pinto da Costa, Carlos Esteban Fernández-Zarza, Mariano González-Haba Ruiz","doi":"10.17235/reed.2024.10456/2024","DOIUrl":"10.17235/reed.2024.10456/2024","url":null,"abstract":"<p><p>The development and implementation of artificial intelligence (AI), particularly deep learning (DL) models, has generated significant interest across various fields of gastroenterology. While research in luminal endoscopy has seen rapid translation to clinical practice with approved AI devices, its potential extends far beyond, offering promising benefits for biliopancreatic endoscopy like optical characterization of strictures during cholangioscopy or detection and classification of pancreatic lesions during diagnostic endoscopic ultrasound (EUS). This narrative review provides an up-to-date of the latest literature and available studies in this field. Serving as a comprehensive guide to the current landscape of AI in biliopancreatic endoscopy, emphasizing technological advancements, main applications, ethical considerations, and future directions for research and clinical implementation.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"613-622"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Íñigo Jon Garaizabal Azkue, Agustín Castiella, Leire Aburruza Ucar, Silvia Torrente Iranzo, Eva Zapata Morcillo
{"title":"Turmeric associated liver injury (DILI) with susceptible HLA.","authors":"Íñigo Jon Garaizabal Azkue, Agustín Castiella, Leire Aburruza Ucar, Silvia Torrente Iranzo, Eva Zapata Morcillo","doi":"10.17235/reed.2024.10763/2024","DOIUrl":"10.17235/reed.2024.10763/2024","url":null,"abstract":"<p><p>We present a 35-year-old Caucasian woman that was sent to the Hepatology clinics of our hospital in December 2023 for new onset jaundice. Without significant past medical history, the patient presented with bloating and dyspepsia for a week. No neurological abnormalities were found. She reported occasional alcohol intake, denying other drug consumption. No recent vaccination. She reported taking an over-the-counter supplement containing turmeric (tablet with 60 mg of curcumin and 10mg of black pepper) twice daily for 2 months with the aim of speedy recovery after CrossFit. Blood analysis was remarkable for alanine transaminase (ALT) 2230 U/L, aspartate transaminase (AST) 916U/L, total bilirubin 10.5 mg/dl, and direct bilirubin 8.0mg/dl. Coagulation within range. Computed tomography revealed hepatic hemangiomas and cysts without biliary tract dilatation. Further laboratory workup including acute hepatitis serologies (VHA, VHB, VHC, VHE, HSV, VVZ, EBV, CMV and Parvovirus) and autoimmune profile were unremarkable, except for being carrier of HLA DRB1*04 and HLA B35:01*in genetical studies. Due to probable DILI diagnose, 8 points in CIOM/RUCAM scale, she was advised to stop Turmeric. She was followed up in our Hepatology clinics and observed how liver enzymes progressively down-trended. Our patient remained asymptomatic with normal liver enzymes three months after stopping the supplement intake.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"650-651"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ze-Han Chen, Li-Liangzi Guo, Li-Sheng Wang, De-Feng Li, Jun Yao
{"title":"A case of achalasia associated with early esophageal cancer.","authors":"Ze-Han Chen, Li-Liangzi Guo, Li-Sheng Wang, De-Feng Li, Jun Yao","doi":"10.17235/reed.2024.10177/2023","DOIUrl":"10.17235/reed.2024.10177/2023","url":null,"abstract":"<p><p>A 65-year-old man was admitted to our hospital complaining of reflux for more than 20 years. After endoscopy and barium-swallow examination, he was diagnosed with achalasia as well as a squamous cell carcinoma. Therefore, peroral endoscopic myotomy (POEM) combined with endoscopic submucosal dissection (ESD) was performed simultaneously. During the procedure, a mucosal erosion with a clear boundary was shown in the middle segment of the esophagus. ESD was first performed and the lesion was removed en-bloc. Subsequent POEM therapy was performed after marking the left esophageal wall 10cm above the cardia. After submucosal injection, the submucosal plane was created through a length 2cm longitudinal incision, then the muscle was cut a length of 10 cm into the esophagus and 2 cm below the cardia, and finally the incision was closed by clips. Pathological examination revealed high-grade intraepithelial neoplasia of squamous epithelium (carcinoma in situ) with a negative margin. The patient was recovered without complication four days after the procedure. The endoscopy showed perfect healing of the esophageal lesions during two-months follow-up , and the reflux symptom was resolved.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"653-654"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Ramón Lorente, José María Paredes, Pilar Llopis, Tomás Ripollés, Alba Voces, Ángela Algarra, Carmina Asencio, Patricia Latorre, Nadia Moreno, Antonio López-Serrano, Eduardo Moreno-Osset
{"title":"Ultrasound transmural healing correlates with higher adalimumab drug concentration in Crohn's disease only in the short-term.","authors":"José Ramón Lorente, José María Paredes, Pilar Llopis, Tomás Ripollés, Alba Voces, Ángela Algarra, Carmina Asencio, Patricia Latorre, Nadia Moreno, Antonio López-Serrano, Eduardo Moreno-Osset","doi":"10.17235/reed.2024.10489/2024","DOIUrl":"10.17235/reed.2024.10489/2024","url":null,"abstract":"<p><strong>Background: </strong>anti-TNF drugs have revolutionized the treatment of Crohn's disease (CD) and have set new therapeutic targets. A direct correlation between anti-TNF trough levels and endoscopic healing in inflammatory bowel disease (IBD) patients has been established, but the association between drug levels and transmural healing assessed by ultrasound is not yet clearly defined.</p><p><strong>Aims: </strong>to evaluate the correlation between the serum concentration of adalimumab (ADA) and sonographic transmural healing in CD patients at different times during follow-up.</p><p><strong>Methods: </strong>in this retrospective, cross-sectional study, all patients with CD who were undergoing treatment with ADA in our center were included. Intestinal ultrasound (IUS) was performed before the initiation of the drug and for response monitoring. ADA serum-trough levels were compared between patients with and without transmural healing at different periods of time.</p><p><strong>Results: </strong>ninety-two patients were included, and all patients showed signs of inflammatory activity in the baseline IUS. During IUS monitoring of the response to ADA, 34 (34.8 %) patients presented transmural healing. Among patients in the first year of treatment, those with sonographic healing showed higher median levels than patients without transmural healing (12.0 µg/ml vs 9.3 µg/ml, respectively; p = 0.007). There was no correlation between ADA levels and sonographic healing in patients undergoing treatment for over a year.</p><p><strong>Conclusions: </strong>higher ADA trough levels correlated with transmural healing with ultrasound during the first year of treatment. This correlation was not found after one year of treatment.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"606-612"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Castellote, Marta García Guix, Alberto Amador Navarrete, Rosa Rota Roca, Carme Baliellas Comellas
{"title":"Fatal HBV-liver failure after withdrawal of antiviral treatment.","authors":"José Castellote, Marta García Guix, Alberto Amador Navarrete, Rosa Rota Roca, Carme Baliellas Comellas","doi":"10.17235/reed.2024.10115/2023","DOIUrl":"10.17235/reed.2024.10115/2023","url":null,"abstract":"<p><p>We report a case of fatal HBV reactivation in a patient with chronic hepatitis B infection HBeAg-, who was withdrawn from antiviral therapy.. We think that it may be a warning of risks that this clinical decision may entail.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"651-652"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sucong Lyu, Guoqiang Zhong, Yangda Song, Yan Sun, Jin Li, Xiujing Fan, Qing Qing, Mingsong Li
{"title":"A novel nomogram for predicting endoscopic remission in refractory Crohn's disease with ustekinumab administration.","authors":"Sucong Lyu, Guoqiang Zhong, Yangda Song, Yan Sun, Jin Li, Xiujing Fan, Qing Qing, Mingsong Li","doi":"10.17235/reed.2024.10212/2023","DOIUrl":"10.17235/reed.2024.10212/2023","url":null,"abstract":"<p><p>Ustekinumab (UST) is a human IgG1 monoclonal antibody that targets to the share p40 subunit of interleukin-12(IL-12) and IL-23. Evidence has shown that UST therapy is well tolerated and effective in inducing clinical response in refractory CD(Crohn's disease) and dose escalation is effective in recapturing response in over half of the patients. However, no predictive factor has been reported to be helpful for UST treatment in clinical practice. Additionally, there were few reports about therapeutic drug monitoring (TDM) of UST administration in China due to its late launch time in Chinese market and lack of experience in clinical use. Herein, we establish and validate the first UST-trough concentrations (TCs) -related nomogram in China for predicting endoscopic remission in refractory CD to facilitate clinical decision making.</p>","PeriodicalId":21342,"journal":{"name":"Revista Espanola De Enfermedades Digestivas","volume":" ","pages":"644-645"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}