Rheumatology International最新文献

{"title":"Retractions in the field of pregnancy and pain: bibliometric characteristics, reasons, and trends.","authors":"Dinara Yerlanova, Olena Zimba, Umida Khojakulova, Bekaidar Nurmashev, Ainur B Qumar, Burhan Fatih Kocyigit","doi":"10.1007/s00296-026-06319-6","DOIUrl":"10.1007/s00296-026-06319-6","url":null,"abstract":"<p><p>The aim of this study is to analyze the dynamics of scientific integrity in the literature by analyzing bibliometric characteristics, temporal trends, and reasons for retractions in the field of pregnancy and pain. This cross-sectional study analyzed publications retrieved in the Scopus database using the keywords \"pregnancy\" and \"pain\" and tagged as \"retracted\". Publication year, retraction year, country, journal, subject area, keywords, citation counts, Altmetric Attention Score (AAS), and reasons for retraction were evaluated. Temporal trends were examined using linear regression, and the correlation between citation counts and AAS was analyzed using Spearman's rho test. A total of 55 retracted publications were examined. A significant upward trend over time was identified (β = 0.36; p = 0.017). These retractions originated from 17 countries, notably from Egypt (n = 19) and China (n = 14). The primary reason for retraction was data integrity issues (n = 20), followed by peer review problems (n = 13) and duplication (n = 9). The median citation count was 8 (0-80), and the median AAS score was 0 (0-659). A positive, significant correlation between citation numbers and AAS scores was reported (rho = 0.35; p = 0.008). Retractions have grown over time, mainly due to data integrity and peer review-publication processes. Citations and digital visibility of retracted studies, especially in clinical contexts, need careful monitoring. The results highlight the importance of rigorous research design, data transparency, and editorial oversight in upholding scientific integrity.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models in the diagnosis and treatment of immunosuppression-related infections in rheumatic diseases: a comparative, vignette-based study.","authors":"Edip Bayrak, Ramazan Azim Okyay, Hilmi Erdem Sumbul, Umida Khojakulova, Burhan Fatih Kocyigit","doi":"10.1007/s00296-026-06315-w","DOIUrl":"10.1007/s00296-026-06315-w","url":null,"abstract":"<p><p>This study compared the diagnostic accuracy, initial test selection, and initial treatment choices of three current-generation Large Language Models (LLMs) with those of two infectious disease specialists in managing infectious complications in patients with immunosuppressed rheumatic disease. This cross-sectional comparative study utilized 100 standardized Turkish-language clinical vignettes, developed by an expert committee, encompassing ten infection categories: viral, bone/joint, respiratory, central nervous system, gastrointestinal, genitourinary, skin and soft tissue, rare diseases, vaccination and prophylaxis, and adverse drug reactions. A prespecified reference standard, based on current clinical practice guidelines (ACR, EULAR, KLİMİK, IDSA, ATS, WHO, SANJO/EBJIS), was established prior to data collection. Three LLMs (Gemini 3.1 Pro, ChatGPT 5.5, Claude 4.7 Opus) and two blinded infectious disease specialists, operating under closed-book conditions, answered the same vignettes across three domains: diagnosis, initial diagnostic work-up, and initial treatment. Responses were evaluated dichotomously as correct or incorrect according to the reference standard. Diagnostic accuracy was 91% and 93% for the two human experts, compared to 99%, 97%, and 100% for Gemini 3.1 Pro, ChatGPT 5.5, and Claude 4.7 Opus, respectively. This pattern was consistent across all three domains (Cochran Q, all p ≤ 0.003). Human experts achieved complete case management in 83% and 90% of vignettes, while the LLMs achieved 97-100% (p < 0.001). Of 40 pairwise comparisons, 10 showed Bonferroni-corrected significance, all in human-versus-model comparisons. In this vignette-based comparison, all three LLMs answered a higher proportion of items correctly than the two participating infectious disease specialists in all three domains. As the cases were standardized written vignettes with a single prespecified correct answer, and only two human comparators were available, this reflects performance on a structured written task rather than superiority in clinical care. These findings suggest that LLMs could serve as a complementary decision-support tool, especially for identifying rare or opportunistic diagnoses, but should not replace specialists without further prospective, real-world validation.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher postoperative complication rates in patients with systemic lupus erythematosus undergoing surgical and obstetric procedures: a nationwide retrospective matched cohort study.","authors":"Francisco Eduardo Silva, Mirhelen Mendes de Abreu","doi":"10.1007/s00296-026-06316-9","DOIUrl":"10.1007/s00296-026-06316-9","url":null,"abstract":"<p><p>Population-level evidence on postoperative outcomes in systemic lupus erythematosus (SLE) remains limited. To compare postoperative outcomes between patients with SLE and matched controls and identify factors associated with complications and algorithm-defined disease reactivation. We conducted a nationwide retrospective matched cohort study using DATASUS data. Patients with SLE were matched 1:5 to controls by sex, age group, geographic macro-region, preoperative surgical risk, and surgical category. Postoperative outcomes were assessed over 180 days. Multivariable analyses assessed factors associated with outcomes within the SLE cohort. Sensitivity analyses comprised restriction to elective procedures and exclusion of patients classified with cutaneous lupus. The cohort included 1,708 patients with SLE and 8,540 controls. SLE was associated with increased risks of surgical (RR 2.20, 95% CI 1.91-2.54), clinical (RR 3.30, 95% CI 2.53-4.30), infectious (RR 3.66, 95% CI 2.88-4.64), and other procedure- or care-related complications (RR 11.33, 95% CI 6.19-20.76). Among patients undergoing obstetric procedures, SLE was associated with obstetric complications (RR 1.87, 95% CI 1.37-2.54). Within the SLE cohort, cardiovascular risk was independently associated with higher odds of clinical (adjusted OR 2.75, 95% CI 1.36-5.54) and other procedure- or care-related complications (adjusted OR 5.46, 95% CI 1.84-16.18). Associations between SLE and surgical, clinical, and infectious complications remained significant in both sensitivity analyses. Algorithm-defined SLE reactivation occurred in 3.3%. Patients with SLE had higher risks of several postoperative complications than matched controls. The contributions of disease activity and immunosuppressive treatment warrant further investigation.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrotic range proteinuria and rapid progression to end-stage kidney disease in seronegative pauci-immune necrotizing glomerulonephritis masked by cutaneous lesions: a case-based review.","authors":"Aleksandra Gałan, Filip Koszałka, Izabela Zakrocka, Amir Nour Mohammadi, Jakub Kleinrok, Agnieszka Korolczuk, Wojciech Załuska","doi":"10.1007/s00296-026-06320-z","DOIUrl":"10.1007/s00296-026-06320-z","url":null,"abstract":"<p><p>Antineutrophil cytoplasmic antibodies (ANCA)-negative pauci-immune necrotizing glomerulonephritis (PING) is a rare entity, representing a distinct subset of small-vessel vasculitis. The absence of ANCA does not exclude the diagnosis, and clinical suspicion should remain high in the presence of compatible systemic and renal findings. We present the case of a 22-year-old woman with recurrent, non-specific cutaneous manifestations since early childhood, who was hospitalized for an exacerbation of skin lesions. Laboratory results revealed nephrotic-range proteinuria of 17 g/d [N < 150 mg/d] and a reduced estimated glomerular filtration rate (eGFR) of 47 mL/min/1.73 m² [N > 90 mL/min/1.73 m²]. Renal biopsy results demonstrated cellular crescents, focal segmental tubular necrosis, intense mononuclear inflammatory infiltrates, and segmental proliferation of Bowman's capsule epithelial cells. Direct immunofluorescence yielded negative results for IgG, IgA, IgM, C3, or C1q deposits. Electron microscopy confirmed segmental podocyte foot process effacement and microvillous transformation. Serologic testing was comprehensively negative, specifically confirming the absence of PR3-ANCA, MPO-ANCA, anti-glomerular basement membrane (GBM) antibodies, and serum cryoglobulins. Based on the clinical, histologic, and immunopathologic findings, a definitive diagnosis of isolated ANCA-negative PING was established, although atypical features prompted the consideration of secondary podocytopathy. Methylprednisolone therapy was initiated, but progressive renal deterioration following a substantial loss to follow-up period necessitated renal replacement therapy. This report underscores the diagnostic challenge of ANCA-negative PING, given its absent serologic markers and overlapping features with other glomerular diseases, highlighting the crucial role of renal biopsy in reaching a timely diagnosis.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabinoids for pain management in rheumatoid arthritis: a scoping review of clinical evidence and mechanisms.","authors":"Nikolaos Zintziovas, Agathi Karakosta, Paraskevi Voulgari, Georgios Stefanakis, Eleni Arnaoutoglou, Petros Tzimas, Georgia Micha","doi":"10.1007/s00296-026-06314-x","DOIUrl":"10.1007/s00296-026-06314-x","url":null,"abstract":"<p><p>Persistent pain remains a major unmet need in rheumatoid arthritis (RA), even in patients with adequately controlled inflammatory disease. Cannabinoids have been proposed as potential modulators of pain and inflammation, but their clinical role in RA remains uncertain. To map and critically appraise the available clinical evidence on cannabinoid-related interventions or exposures for pain management in adults with RA. PubMed/MEDLINE, Scopus, the Directory of Open Access Journals, and the Cochrane Central Register of Controlled Trials were searched for studies published from January 1, 1990, to September 10, 2026. Randomized controlled trials and observational studies evaluating cannabinoid-related interventions or exposures in adults with confirmed RA and reporting pain-related outcomes were eligible. Risk of bias was assessed using Cochrane RoB 2 for randomized trials and ROBINS-I for observational studies. Of 593 records identified, three studies met the eligibility criteria: one randomized placebo-controlled trial and two observational studies. In the randomized trial of 58 patients, nabiximols reduced pain on movement by 0.95 points (p = 0.044), pain at rest by 1.04 points (p = 0.018), and improved sleep quality by 1.17 points (p = 0.027); DAS28 decreased by 0.76 points (p = 0.002), while no serious adverse events were reported. Observational studies suggested possible symptomatic benefit but were limited by heterogeneous cannabinoid exposure and serious to critical risk of bias. Current clinical evidence remains insufficient to establish the efficacy or long-term safety of cannabinoids for RA-related pain. Larger, rigorously designed trials using standardized cannabinoid formulations and pain-relevant outcomes are needed.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incomplete adjustment for cardiovascular risk factors in a capillaroscopy-based mortality analysis of Raynaud's phenomenon.","authors":"Hefziba Lorences Noguera, Esteban Cárdenas Durán","doi":"10.1007/s00296-026-06309-8","DOIUrl":"10.1007/s00296-026-06309-8","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baricitinib retention and factors associated thereof in clinical practice: a prospective, multicenter 12-month study in rheumatoid arthritis patients.","authors":"Irini Flouri, Antonios Bertsias, Konstantina Zoupidou, Christos Koutsianas, George Fragoulis, Dimitrios Nezis-Katsifis, Elena Sambatakaki, Nestor Avgoustidis, Argyro Repa, George Bertsias, Maria Tektonidou, Petros Sfikakis, Dimitrios Vassilopoulos, Dimitrios Boumpas, Prodromos Sidiropoulos","doi":"10.1007/s00296-026-06313-y","DOIUrl":"10.1007/s00296-026-06313-y","url":null,"abstract":"<p><p>Herein we report for baricitinib drug retention, predictors thereof and clinical responses in rheumatoid arthritis (RA) patients with a special focus in comorbidities. Prospective, multicenter, observational study of RA patients starting baricitinib because of active disease. Patients were followed every 3 months for 12 months. The primary endpoint was baricitinib retention at 12 months; predictors for survival and clinical responses at 6 months were secondary endpoints. Retention rate was estimated by Kaplan-Meier (K-M) while predictors of discontinuation by Cox regression. We recruited 135 patients, 93.3% females, mean (standard deviation-SD) age 56.1 (10.1) years, median (interquartile range) disease duration 57 (90) months. 18.5% started baricitinib as first line targeted therapy. 35.9% (28/88) and 44.1% (26/59) achieved DAS28 remission/low disease activity (LDA) at 6 and 12 months respectively. Baricitinib retention at 12 months was 68.9%. K-M analysis showed that hypertension (p=0.049), latent tuberculosis infection (LTBi) (p=0.007) and depression (p=0.005) were associated to lower retention, while multivariate analysis showed that depression [Hazard ratio (HR) 2.715, p=0.007] and LTBi (HR 2.519, p=0.020) predicted baricitinib discontinuation. Analysis for patients on therapy for at least 6 months showed that together with hypertension (HR 2.477, p=0.022) and LTBi (HR 3.761, p=0.023), higher DAS28 at 6 months (HR 1.434, p=0.024) predicted baricitinib discontinuation at 12 months. In established RA, 68.9% of the patients remained on baricitinib at 12 months and had an improvement of disease activity. Mostly comorbidities contributed to baricitinib persistence, supporting their importance as factors to be addressed to optimize RA clinical care.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glymphatic dysfunction as a potential mechanistic link to cognitive ımpairment in Behçet's disease: a hypothesis.","authors":"Muhammed Zahid Sahin, Saltanat K Yerkebayeva, Neslihan Gokcen","doi":"10.1007/s00296-026-06321-y","DOIUrl":"10.1007/s00296-026-06321-y","url":null,"abstract":"<p><p>Behçet's disease (BD) is a chronic multisystem inflammatory disease in which cognitive impairment is increasingly recognized but remains incompletely understood. Although cognitive dysfunction is more common in patients with Neuro-Behçet's disease (NBD), it has also been reported in patients without clinically apparent neurological involvement, suggesting that mechanisms beyond focal inflammatory lesions may contribute to cognitive impairment. The glymphatic system is a brain-wide perivascular clearance pathway that maintains cerebral homeostasis by facilitating the exchange of cerebrospinal and interstitial fluid and the removal of inflammatory mediators and metabolic waste products. Previous neuroimaging studies have demonstrated white matter microstructural abnormalities in both NBD and neurologically asymptomatic BD, with more extensive alterations in NBD. Furthermore, studies in systemic lupus erythematosus have identified an increased burden of enlarged perivascular spaces, choroid plexus enlargement, and lower diffusion tensor imaging along the perivascular space (DTI-ALPS) indices, providing preliminary imaging evidence of alterations putatively related to glymphatic function in systemic inflammation and neuropsychiatric involvement. However, the relationship between glymphatic dysfunction and cognitive impairment has not yet been directly investigated in BD. We hypothesize that chronic neuroinflammation, endothelial dysfunction, blood-brain barrier disruption, vascular inflammation, and sleep disturbance may impair glymphatic clearance in BD, leading to persistent neuroinflammation, white matter injury, and cognitive dysfunction. This proposed relationship has not yet been directly tested in BD. We further propose that glymphatic dysfunction may occur not only in patients with NBD but also in a subset of BD patients without overt neurological involvement, although it is likely to be more pronounced in NBD. If validated, this hypothesis could provide a novel mechanistic framework for cognitive impairment in BD and support the development of imaging biomarkers and adjunctive therapeutic strategies targeting glymphatic function.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of inflammatory back pain criteria in axial psoriatic arthritis compared with non-psoriatic axial spondyloarthritis and chronic low back pain: a cross-sectional study.","authors":"Salih Özgöçmen, Gamze Kılıç, Erkan Kılıç, Hatice Bodur, Kevser Orhan, Kemal Erol, Özgür Akgül, İbrahim Tekeoğlu, Gizem Cengiz, Betül Sargın, Dilek Keskin, Nihan Cüzdan Balta, Merve Baykul, Tuba Erdem Sultanoğlu, Mazlum Serdar Akaltun, Murat Toprak, Hakan Alkan, Hatice Reşorlu, Emre Uzun, Sevtap Acer Kasman, Nilay Şahin, Mehtap Kalçık Unan, Ajda Bal, Cevriye Mülkoğlu, İlknur Albayrak Gezer, Mustafa Çalış, Gamze Dilek, Mehmet Tuncay Duruöz, Nesrin Şen, Okan Küçükakkaş, Ozan Volkan Yurdakul, Sami Hizmetli, Şebnem Ataman, Ayhan Kamanlı, Erhan Çapkın, Fikriye Figen Ayhan, Gül Devrimsel, Hilal Ecesoy, İsmihan Sunar, Meltem Alkan Melikoğlu, Ömer Faruk Şendur, Öznur Kutluk, Sena Tolu, Tiraje Tuncer, Yaşar Keskin, Kemal Nas","doi":"10.1007/s00296-026-06311-0","DOIUrl":"10.1007/s00296-026-06311-0","url":null,"abstract":"<p><p>To compare the within-study discriminatory characteristics of established inflammatory back pain (IBP) criteria sets and individual items in predefined groups of patients with axial psoriatic arthritis (axPsA), non-psoriatic axial spondyloarthritis (axSpA), and chronic mechanical low back pain (cLBP). Data were drawn retrospectively from a multicentre PsA registry and a separate single-center axSpA/cLBP cohort. IBP criterion sets (Calin, ASAS, Berlin) and individual IBP items were evaluated using sensitivity, specificity, likelihood ratios, and area under the receiver operating characteristic curve (AUC). Because case and comparator groups were predefined rather than prospectively assembled from an unselected diagnostic population, the estimates represent classification-discrimination within the study sample, not real-world diagnostic accuracy. A total of 697 patients were analyzed, including 282 patients with axPsA, 292 with axSpA, and 123 with cLBP. In these selected comparisons, Calin and ASAS criteria showed high observed specificity, whereas Berlin criteria showed greater sensitivity (91.1% in axPsA and 86.7% in axSpA). Among individual IBP items, insidious onset showed the highest AUC in both comparisons (0.939, 95% CI 0.911-0.961 in axPsA and 0.913, 95% CI 0.881-0.939 in axSpA). In contrast, age at onset < 40 years and good response to NSAIDs showed little discrimination in axPsA (AUC 0.544 and 0.543, respectively). In multivariable analyses, Calin, ASAS, and Berlin criteria were associated with axPsA group membership, while Calin and ASAS criteria showed the strongest associations with axSpA group membership; conventional and Firth models yielded directionally similar estimates. Within these predefined cohorts, IBP criteria and individual items differed in their ability to discriminate group membership. IBP should be regarded as a supportive clinical feature, not a standalone screening or diagnostic tool. The high specificity and positive likelihood ratio estimates may reflect enrichment of symptom- and imaging-positive cases and use of an ASAS-negative cLBP comparator; prospective validation in unselected clinical populations is required.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ClinFIT, pain, disability, and spinal mobility in patients with chronic nonspecific low back pain: single-arm prospective pre-post cohort study.","authors":"Ivan Ljudevit Caktaš, Frane Grubišić, Porin Perić, Kristina Kovač Durmiš, Iva Žagar, Ivan Jurak, Sandra Ćulap, Filip Horvatiček, Doroteja Caktaš","doi":"10.1007/s00296-026-06304-z","DOIUrl":"10.1007/s00296-026-06304-z","url":null,"abstract":"<p><p>The aim of this study was to evaluate changes in functioning during rehabilitation using ClinFIT and to identify baseline predictors of post-treatment functional status. In this prospective single-arm pre-post study, 123 patients with cLBP (mean age 51.8 ± 9.1 years) completed a standardised 4-week physiotherapy programme. Participants were assessed at baseline, mid-treatment, and post-treatment. Functioning was measured with ClinFIT, disability with RMDQ, pain intensity with VAS, and spinal mobility with the Schober, reclination and Thomayer tests and sagittal mobility index. Changes over time were assessed with Friedman tests. Hierarchical multivariable linear regression identified independent predictors of post-treatment ClinFIT scores, controlling for age, sex, and BMI. All outcomes improved significantly during treatment (all Friedman tests p < 0.001; Kendall's W 0.18-0.52). ClinFIT correlated moderately with RMDQ (ρ = 0.54-0.62) and VAS (ρ = 0.48-0.56), and only weakly with objective spinal mobility measures (Thomayer ρ = 0.26-0.32; Schober correlations were non-significant). In the final multivariable regression model (R² =0.616, adjusted R² =0.578, p < 0.001), baseline ClinFIT was the strongest predictor of post-treatment functioning (β = 0.67, p < 0.001). Baseline RMDQ, age, sex, BMI, employment status, disease duration and objective mobility measures were not significant independent predictors. Patients with cLBP improved significantly in functioning, pain, disability, and spinal mobility over the rehabilitation period. Baseline functional status was the strongest predictor of post-treatment functioning, although this partly reflect the use of the same instrument at both time points. Objective mobility measures showed limited independent value. ClinFIT appears to be a promising tool for monitoring functioning in rehabilitation settings.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}