Rheumatology International最新文献

{"title":"Cardiovascular vasculopathy in gout and rheumatoid arthritis: a shared perspective.","authors":"Enrique Calvo-Aranda, Marta Novella-Navarro","doi":"10.1007/s00296-025-05936-x","DOIUrl":"https://doi.org/10.1007/s00296-025-05936-x","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"179"},"PeriodicalIF":2.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher uric acid associated with elevated IL‑6 and IL‑1β levels in older inpatients: a cross‑sectional study.","authors":"Jakub Husejko, Mariusz Kozakiewicz, Marcin Gackowski, Katarzyna Mądra-Gackowska, Jakub Wojtasik, Dominika Strzała, Maciej Pesta, Justyna Ciesielska, Dorota Ratajczak, Kornelia Kędziora-Kornatowska","doi":"10.1007/s00296-025-05931-2","DOIUrl":"https://doi.org/10.1007/s00296-025-05931-2","url":null,"abstract":"<p><p>Previous studies have shown the role of uric acid in triggering inflammatory reactions through its influence on a large group of cytokines. Therefore, searching for possible relationships between treating hyperuricemia and the course of inflammatory processes may provide valuable knowledge for clinical practice. The study was designed to determine the relationship between uric acid levels and interleukin-6 (IL-6) and interleukin-1-beta (IL-1 beta) levels determined in older adults during hospitalization. Patients were assigned to different study groups based on the uric acid levels and effectiveness, lack of treatment, or recognition of hyperuricemia. Classical variance analysis methods or nonparametric Kruskal-Wallis tests were used for statistical analysis. The analysis showed different correlations between the concentration of uric acid and the mentioned interleukins and designated study groups. In the case of properly treated hyperuricemia, a weak negative correlation is observed between the level of uric acid and interleukin IL-1β. There is a statistically significant positive correlation between the value of uric acid and interleukins IL-6 and IL-1β in people with untreated hyperuricemia and, to a lesser extent, in people with normal uric acid levels. The study's results suggest that effective treatment may be associated with appropriate control of uric acid concentration and modulation of the inflammatory response. However, due to several measurement limitations, further research is warranted to better elucidate these associations.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"177"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of face-to-face and remote Tai Chi in stable axial spondyloarthritis: a pilot randomised controlled trial.","authors":"Françoise Fayet, Angélique Fan, Bruno Pereira, Céline Lambert, Laurent Perron, Malory Rodere, Martine Duclos, Martin Soubrier","doi":"10.1007/s00296-025-05912-5","DOIUrl":"https://doi.org/10.1007/s00296-025-05912-5","url":null,"abstract":"<p><p>To investigate the effects of a Tai Chi (TC) programme (hospital-based or remote) on total physical activity (PA) time in patients with axial spondyloarthritis (axSpA ). Between January 2019 and July 2021, patients with stable AS (BASDAI ≤ 40/100 or symptoms at an acceptable level, within the last six months) were enrolled in a four-month parallel, two-arm pilot study. Participants were randomised to either the immediate Tai Chi group (ITG), starting face-to-face TC immediately after enrolment for a duration of 4 months, or to the waiting list control group (WLCG), which started a 2 month face-to-face TC programme 2 months after enrolment. Due to COVID-19 pandemic, courses were delivered remotely using the same protocol after a lockdown period. Total enrolment was 40, including 20 in the hospital-based TC and 20 in the remote TC sub-study. Intention-to-treat analysis of all population demonstrated a significantly higher level of PA at month 2 in the ITG compared to the WLCG including hospital-based and remote TC (effect size: 0.19, 95% CI: 0.01 to 0.37, p = 0.04). These results were maintained at month 4. Patient Global Assessment (PGA) was improved at month 2 in both ITG (p < 0.05). There were no significant between-group differences in physical, psychological, and clinical outcomes. However, within-group analyses showed that TC had beneficial effects on endurance, lower limb strength, leg balance, shoulder and wrist mobility, PGA, and coping. There was no significant difference in total PA between remote and hospital-based TC at month 2. Both remote and hospital-based TC increased total PA in patients with axSpA.Trial registration: The study was registered on ClinicalTrials.gov ( https://clinicaltrials.gov/study/NCT04700150 ) prior to starting enrolment.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"178"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication adherence and health empowerment in gout: a cross-sectional survey of patients.","authors":"Haixia Wang, Yuan Yao, Xiaobing Lv, Meng Yu, Shoumeng Geng, Chunming Yong","doi":"10.1007/s00296-025-05915-2","DOIUrl":"https://doi.org/10.1007/s00296-025-05915-2","url":null,"abstract":"<p><p>Gout is a prevalent chronic metabolic disorder that significantly impairs the quality of life of affected individuals. Enhancing medication adherence among gout patients is crucial for optimizing clinical outcomes. The present study aims to investigate the levels of health empowerment and medication adherence among gout patients and to identify the factors influencing these outcomes. This study recruited gout patients who presented to our hospital between April 2024 and January 2025. Medication adherence and health empowerment were assessed using validated scales. Logistic regression analysis was employed to identify independent risk factors associated with poor medication adherence. A total of 364 gout patients were included in the study. The mean health empowerment score among gout patients was 24.06 ± 5.22. Correlation analysis revealed significant associations between medication adherence and several variables, including residence, per capita monthly income, duration of gout, number of gout flares in the past year, and health empowerment level. Residence (OR = 2.812, 95% CI: 2.180 ~ 3.445), per capita monthly income (OR = 1.935, 95% CI: 1.006 ~ 2.482), duration of gout (OR = 1.823, 95% CI: 1.311 ~ 2.246), number of gout flares in the past year (OR = 2.412, 95% CI: 1.856 ~ 3.205), and health empowerment level (OR = 3.547, 95% CI: 2.664 ~ 4.862) were significant influencing factors of medication adherence in gout patients. The findings indicate that both medication adherence and health empowerment levels are suboptimal among gout patients. These results highlight the importance of prioritizing health empowerment education and improving medication adherence in clinical practice.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"176"},"PeriodicalIF":3.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal inflammatory markers in giant cell arteritis: a diagnostic blind spot.","authors":"Cara E Currier, A M Bays, J L Thomason","doi":"10.1007/s00296-025-05930-3","DOIUrl":"https://doi.org/10.1007/s00296-025-05930-3","url":null,"abstract":"<p><strong>Objective: </strong>Giant cell arteritis (GCA) is a vasculitis requiring urgent diagnosis. Although Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) are important for making the diagnosis, some GCA patients have normal inflammatory markers. We retrospectively analyzed GCA patients with normal versus elevated inflammatory markers to evaluate for differences in clinical presentation and vascular ultrasound to aid in the diagnosis of GCA patients with normal ESR and CRP.</p><p><strong>Methods: </strong>We conducted a retrospective study with patients diagnosed with GCA through a Fast Track Clinic (FTC). Clinical presentation and ultrasound results were compared in 23 GCA patients with normal ESR and CRP to 107 GCA patients with elevated ESR and/or CRP. We incorporated an additional 159 patients without GCA to calculate the sensitivity and specificity of ESR and CRP for detecting GCA. Data were analyzed using Pearson Chi-square, Fisher's exact test and ROC curves.</p><p><strong>Results: </strong>CRP is 74% sensitive and 49% specific (AUC = 0.675) compared to ESR with 48% sensitivity and 72% specificity (AUC = 0.644) for detecting GCA. Patients with a longer period between onset of symptoms and measurement of markers (mean of 35 versus 20 days) were more likely to have normal markers (p = 0.03).</p><p><strong>Conclusion: </strong>GCA patients present similarly regardless of inflammatory markers. Patients with normal inflammatory markers had a significantly longer time between symptom onset and inflammatory marker measurement. ESR and CRP have some diagnostic accuracy, low inflammatory markers should not preclude a GCA work-up.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"175"},"PeriodicalIF":3.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid hand massage therapy to mitigate sarcopenia and improve patients' quality of life: a hypothesis.","authors":"Burhan Fatih Kocyigit, Olena Zimba, Marlen Yessirkepov, Umida Khojakulova","doi":"10.1007/s00296-025-05927-y","DOIUrl":"https://doi.org/10.1007/s00296-025-05927-y","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a systemic inflammatory disorder frequently associated with sarcopenia, a gradual decline in skeletal muscle mass and strength. Hand sarcopenia in RA leads to functional deterioration and diminished quality of life. Although conventional methods, such as exercise and nutrition, are typically used, current evidence suggests that massage therapy may offer advantages through anti-inflammatory, circulatory, and anabolic pathways. This hypothesis-driven article proposes that targeted hand massage may alleviate sarcopenia in RA by enhancing local perfusion, modulating immunological responses, mitigating oxidative stress, and stimulating muscle-regenerative pathways. Experimental investigations in animals and humans have demonstrated that massage can activate mechanotransduction signaling, enhance muscle protein synthesis, stimulate satellite cell activity, and reduce inflammatory mediators, including tumor necrosis factor-alpha and interleukin-6. Moreover, enhancements in handgrip strength and muscle oxygenation have been documented after mechanical interventions. Small sample sizes, diverse methodologies, and the absence of standardized massage procedures limit the clinical validity of the data. Randomized controlled trials involving RA patients with compromised hand function and sarcopenia are necessary to explore this hypothesis. Standardized outcome measures, such as handgrip strength, disease activity scores, muscle tissue imaging, and inflammatory biomarkers, are required to assess efficacy. If verified, massage therapy may provide a non-invasive, low-risk complement to established care, potentially enhancing muscle function and quality of life in RA patients with sarcopenia.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"173"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-citrullinated protein antibodies may be prognostic factor for vascularization of the synovial membrane in patients with high activity of RA.","authors":"Michal Jakubaszek, Brygida Kwiatkowska, Mateusz Płaza, Maria Maślińska","doi":"10.1007/s00296-025-05920-5","DOIUrl":"10.1007/s00296-025-05920-5","url":null,"abstract":"<p><p>This single-center study aimed to evaluate relationship between the concentration of anti-citrullinated protein antibodies (ACPA) and the degree of synovial perfusion in patients with high disease activity of rheumatoid arthritis (RA). The study enrolled 60 patients diagnosed with RA and group of 20 patients with psoriasis arthritis (PsA). Different laboratory variables were assessed and particularly ACPA (U/ML), disease activity was calculated by DAS 28(ESR) and simplified disease activity score (SDAI). The degree of the synovial membrane vascularization was assessed using power doppler US (PDUS) and additionally vascularity index was measured by PDUS index (INDEX%) in the ROI (region of interest). Correlation between the concentration of ACPA and INDEX% in RA group was confirmed as week positivity indicating that ACPA may be a prognostic factor for vascularization of the synovial membrane in patients with RA.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"172"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal seasonal variation in disease parameters of axial spondyloarthritis: a register-based study.","authors":"Emma Onkamo, Björn Sundström, Bengt Wahlin","doi":"10.1007/s00296-025-05913-4","DOIUrl":"10.1007/s00296-025-05913-4","url":null,"abstract":"<p><strong>Objectives: </strong>Axial spondyloarthritis (axSpA) displays varying disease activity over time. However, few studies have examined the association between disease activity and seasonal differences, and consequently, evidence of a seasonality in disease activity in axSpA is limited. We therefore aimed to study the variation in measures of disease activity, perceived well-being, and functional ability, including both patient-reported and objective measures throughout the year, and their relationship with seasons.</p><p><strong>Methods: </strong>Objective and patient-reported disease parameters from 44 987 assessments on 5197 individuals were retrieved from the Swedish Rheumatology Quality register. The variation in different measures of disease activity over the year was examined using generalized additive models with cyclic cubic splines.</p><p><strong>Results: </strong>Patient reported and objective measures of disease were found to vary congruently over the year, with a trend of decreased disease parameters in the spring. Mean CRP values showed a statistically significant variation throughout the year, with highest in July (7.35 mg/L) and lowest in March (6.88 mg/L). Significant seasonal variation was also seen in BASDAI (range of mean values 3.67-3.72), BASFI (2.79-2.87) and BASMI (3.26-3.31), with highest values in late summer, beginning of fall, or in the fall, respectively. In subgroup analysis, significant variation was only seen in subjects with a disease duration of more than 10 years.</p><p><strong>Conclusion: </strong>Although a statistically significant seasonal variation in disease parameters was found, the absolute variation was close to none and may therefore be clinically irrelevant.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"174"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum ferritin as a specific biomarker of anti-MDA5-interstitial lung disease: a multicenter, case-control study in observational and validation datasets.","authors":"Edoardo Conticini, Latika Gupta, Marco Fornaro, Chiara Rizzo, Vikas Agarwal, Anamika Kumari Anuja, Federica Camarda, Paolo Cameli, Miriana d'Alessandro, Lidia La Barbera, Lekshmi Minikumari Rahulan, Silvia Grazzini, Stefano Stano, Giuliana Guggino, Florenzo Iannone, Elena Bargagli, Luca Cantarini, Bruno Frediani","doi":"10.1007/s00296-025-05918-z","DOIUrl":"https://doi.org/10.1007/s00296-025-05918-z","url":null,"abstract":"<p><strong>Background: </strong>Serum ferritin has been proposed as biomarker of interstitial lung disease (ILD) in anti-MDA5 dermatomyositis (DM). Nevertheless, no data exist for serum ferritin in other idiopathic inflammatory myopathies (IIM)-ILD nor in IIM without ILD. Aim of this case-control study was to assess whether serum ferritin may be considered a specific and sensitive biomarker for IIM-ILD, as well as to assess whether it correlates with clinical and immunological findings.</p><p><strong>Patients and methods: </strong>All patients affected by IIM and followed at Siena (Italy), Palermo (Italy), Bari (Italy) and Lucknow, (India) IIM referral centers were retrospectively included. They had diagnosis of DM and ASS, with and without ILD. Myositis specific or myositis associated antibodies were tested through line immunoassay (Euroimmune, Lubeck, Germany). Serum ferritin concentrations at the first assessment (T0) were detected by ChemiLuminescent Enzyme Immunoassay technology.</p><p><strong>Results: </strong>A total of 139 IIM patients (study cohort n = 51 and validation cohort n = 88; mean age and standard deviation 44.3 ± 17.75) were included. The most common subtype was DM (n = 70, 50.3%), followed by ASS (n = 50, 35.9%). The three most common MSAs were MDA5 (n = 25, 18%), Jo1 (n = 25, 18%) and Mi2 (n = 10, 7%). ILD was assessed in 69 subjects. Ferritin values were higher in DM-MDA5 than DM-non-MDA5 (p = 0.0073) and ASS (p = 0.0006). All 69 patients affected by ILD were subsequently divided showing statistically significant difference for ferritin (p = 0.0013).</p><p><strong>Conclusion: </strong>Our study included a huge number of patients from multicenter datasets, comprising patients of different ethnicities. Ferritin values lower than 303.5 ng/ml evaluated for the first time in a patient with suspected IIM and ILD, waiting for autoimmunity tests, allowed to exclude MDA5-DM. The strength of our findings was corroborated by binomial logistic regression, which proved the independence of ferritin from CPK and CRP to identify DM-MDA5-ILD. Such evidence allows to exclude that ferritin values are influenced by systemic inflammation.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"171"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid vasculitis presenting in the absence of rheumatoid arthritis: a case-based review.","authors":"David A J Cromie, Sarah K Stewart, Gary D Wright, Estelle G Healy","doi":"10.1007/s00296-025-05926-z","DOIUrl":"10.1007/s00296-025-05926-z","url":null,"abstract":"<p><p>Rheumatoid vasculitis (RV) is an extra-articular manifestation (EAM) of rheumatoid arthritis (RA), which is typically observed in long-standing, severe disease. The skin and peripheral nerves are most commonly affected, although the clinical presentation can be highly variable. We report an unusual case of a 58-year-old male who presented with peripheral neuropathy, constitutional symptoms, and Raynaud's phenomenon and was subsequently diagnosed with RV despite having no history of RA. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies were strongly positive, and a sural nerve biopsy demonstrated vasculitis. The patient also developed nodular lesions over his forearms consistent with rheumatoid nodules that regressed following treatment. Currently, the patient has not developed any clinical synovitis. In addition, a search of Pubmed/Medline, Embase, Web of Science, ScienceDirect, the Directory of Open Access Journals (DOAJ), and Google Scholar identified 18 full-text case reports describing patients who developed RV in the absence of a diagnosis of RA at the time of onset. Further analysis of these cases revealed a wide range of clinical manifestations. RV preceded RA onset in 5 of these patients, with durations ranging from 6 months to 6 years. In addition to our patient, 3 patients with RV who did not develop evidence of articular involvement were identified. The development of subcutaneous nodules in our patient appeared to be a unique finding among the identified patients. We highlight that RV can precede RA and suggest that this presentation be considered in any future diagnostic criteria for RV.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 8","pages":"168"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}