Rheumatology International最新文献

{"title":"Transient elastography measurements of the liver and transplanted kidney in patients with AA amyloidosis: a cross-sectional comparative study.","authors":"Murat Bektaş, Bilger Çavuş, Besim Fazıl Ağargün, İbrahim Volkan Şenkal, Nevzat Koca, Burak İnce, Selma Sarı, Ahmet Burak Dirim, Metban Güzel Mastanzade, Gizem Dağcı, Pelin Karaca Özer, Mehmet Aydoğan, Melek Büyük, Yasemin Yalçınkaya, Bahar Artım-Esen, Murat İnanç, Mine Güllüoğlu, Halil Yazıcı, Sevgi Kalayoğlu Beşışık, Selman Fatih Beşışık, Ahmet Gül","doi":"10.1007/s00296-025-05906-3","DOIUrl":"https://doi.org/10.1007/s00296-025-05906-3","url":null,"abstract":"<p><p>To evaluate the utility of elasticity imaging techniques, such as transient elastography (FibroScan), in assessing the liver and transplanted kidney in patients with AA amyloidosis (AA-A). This study was conducted in patients with AA-A, while patients with immunoglobulin light chain amyloidosis (AL-A), Familial Mediterranean Fever (FMF) without amyloidosis, and healthy controls (HC) were included as comparison groups for liver stiffness (LS) measurements. Additionally, kidney stiffness (KS) was measured in renal transplant recipients (RTRs) with transplants due to AA-A or other causes of chronic renal failure. LS evaluations were performed in 65 patients with AA-A, 14 with AL-A, 20 with FMF, and 27 with HC. LS (kPa) was significantly higher [median (IQR)] in patients with AA-A [6.4 (5.4)] and AL-A [9.8 (11)] compared to HC [4.7 (1.7)] (p < 0.001). However, the difference between AL-A and AA-A was not statistically significant. LS values were comparable in FMF-AA patients with [6.8 (6.6)] and without [5.7 (3.6)] liver involvement, and FMF patients without amyloidosis [7.15 (4.6)]. The median KS values were comparable in 19 AA-A and 16 disease controls. However, KS values were significantly higher in patients with recurrent amyloidosis in the transplanted kidney [29.3 (18.9)] compared to those without recurrence [10.9 (7.7)] (p = 0.003). In our study, increased liver stiffness measurements were observed in patients with AA-A, AL-A, and FMF compared to HC. Transient elastography using FibroScan appears to be a promising non-invasive tool for assessing liver involvement in AA-A and may aid in detecting recurrence of amyloidosis in transplanted kidneys. Further studies are needed to validate the utility of FibroScan in evaluating the involvement of the liver and kidneys in patients with AA-A.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"162"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migratory and intermittent polyarthritis as an atypical presentation of carnitine palmitoyltransferase II deficiency with positive response to treatment with Interleukin-1 receptor antagonist: a case presentation and case-based review.","authors":"Savvas Psarelis, Zacharias Raptopoulos, Konstantinos Parperis","doi":"10.1007/s00296-025-05917-0","DOIUrl":"10.1007/s00296-025-05917-0","url":null,"abstract":"<p><p>Carnitine palmitoyltransferase 2 (CPT2) deficiency is an autosomal recessive disorder affecting fatty-acid metabolism that manifests in three phenotypes: lethal neonatal, infantile and adult. In the adult population, CPT2 deficiency is characterized as the commonest cause of recurrent episodes of rhabdomyolysis. Although inflammatory arthritis has not been previously associated with CPT2 deficiency, existing literature suggests a potential mechanism involving synovial inflammation secondary to the accumulation of fatty acids and acylcarnitine. Attacks are most commonly triggered by infections, strenuous exercise, fasting and consumption of a fat-rich meal. Management in typically conservative, involving dietary modification (high-carbohydrate, low-fat diet) and personalized exercise regimens. The following article describes the case of 43-year old male patient with chronic, intermittent arthritis who was diagnosed with CPT2 deficiency and is currently receiving treatment with interleukin 1 receptor antagonist (IL-1Ra). In addition, a case-based review was conducted to evaluate the possible, underlying mechanisms of inflammatory arthritis in patients with CPT2 deficiency, along with any nuances in the treatment strategy. The presented case, along with the associated case-based literature review, highlight the inflammatory changes taking place in the synovial cells upon accumulation of fatty acids and acylcarnitine molecules that release IL-1β. Finally, the report explores potential future therapeutic strategies.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"161"},"PeriodicalIF":3.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and gender-related differences in systemic lupus erythematosus: a scoping review.","authors":"Katinka Albrecht, Wiebke Troll, Johanna Callhoff, Anja Strangfeld, Sarah Ohrndorf, Johanna Mucke","doi":"10.1007/s00296-025-05910-7","DOIUrl":"10.1007/s00296-025-05910-7","url":null,"abstract":"<p><p>A scoping review was conducted to compile evidence on sex-specific differences in systemic lupus erythematosus (SLE) with focus on autoantibodies, organ manifestation, damage, treatment and patient-reported outcomes (PROs). Systematic searches in PubMed and Cochrane were performed including meta-analyses, observational studies and clinical trials from 01/2015 to 11/2024. Studies of adults with SLE reporting outcomes by sex were eligible. The research protocol is registered in the Registry for Scoping Reviews (OSF, https://osf.io/gfbs9 ). From 373 screened articles, 81 publications were included. Studies comprised differences in autoantibodies (n = 13), damage (n = 40), organ involvement (n = 27), treatment (n = 14), and PROs (n = 6). Twenty studies compared proportions of outcomes by sex with patient numbers ranging from 98 to 11,943. The female/male ratio was between 4:1 and 11:1. The review found a higher age at onset in men and a higher proportion of positive lupus anticoagulant, nephritis, serositis, antiphospholipid syndrome, greater renal and cardiovascular damage and severe infections. SLE in women more often presented with Ro/SSA autoantibodies, alopecia, photosensitivity, Raynaud, and osteoporosis. Some studies showed more frequent cyclophosphamide and less frequent antimalarials in men. Little evidence indicated more frequent non-adherence with azathioprine and mycophenolate in women. Limited evidence was available for PROs. This review confirms significant sex differences in SLE, with men showing later onset, more severe organ damage, and distinct autoantibody and treatment patterns, while women more often present with Ro/SSA autoantibodies, photosensitivity, and osteoporosis. Evidence on patient-reported outcomes remains limited, highlighting the need for further research to guide sex-specific management.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"160"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary arteritis in the course of granulomatosis with polyangiitis.","authors":"Sobuń Aleksandra, Madej Marta, Mroczek Ewa, Guziński Maciej, Wiland Piotr, Sebastian Agata","doi":"10.1007/s00296-025-05896-2","DOIUrl":"10.1007/s00296-025-05896-2","url":null,"abstract":"<p><p>Granulomatosis with polyangiitis (GPA) is a rare disease that belongs to the group of necrotizing systemic vasculitis, which is characterized by the involvement of small and medium-sized blood vessels, the formation of granulomas, and the presence of proteinase 3-anti-neutrophil cytoplasmic antibodies (PR3-ANCA). The disease typically involves the upper and lower respiratory tract and kidneys, but other organs and systems may also be involved. A rare manifestation of the disease is the involvement of large vessels, which may occur in the form of aneurysms, dissection and stenosis. We present the case of a 39-year-old male patient who was diagnosed with GPA several years ago, with the involvement of lungs, kidneys, skin and inflammation of the ascending aorta. The patient currently reported fever, cough and dyspnea. The imaging studies showed stenosis of the right and left pulmonary arteries. The treatment included glucocorticosteroids and rituximab. A review of the literature on pulmonary artery involvement in granulomatosis with polyangiitis was performed, seven case reports meeting such criteria were found.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"159"},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low adherence to cardiovascular risk assessment guidelines in patients with rheumatoid arthritis: a retrospective chart review of routine clinical practice.","authors":"Louise Murphy, Grainne Murphy, Nicola Cornally, Sheena McHugh, Mohamad M Saab, Patrick Cotter","doi":"10.1007/s00296-025-05916-1","DOIUrl":"10.1007/s00296-025-05916-1","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with rheumatoid arthritis (RA) have an elevated risk of developing cardiovascular disease (CVD). Despite European guidelines recommending routine CVD risk assessment, implementation in clinical practice is challenging. The objectives of this review were to determine if patients attending an Irish tertiary rheumatology centre received CVD risk assessments in line with European guidelines and assess the extent of CVD risk factor screening over five years of routine rheumatology care.</p><p><strong>Methods: </strong>A retrospective chart review was conducted for patients newly diagnosed with RA in 2018, with five-year follow-up. Data were extracted to determine if CVD risk assessments were performed, and where absent, risk was retrospectively calculated. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist for cohort studies was used to guide the reporting of this study.</p><p><strong>Results: </strong>Among 21 patients, no documented CVD risk assessments were identified. CVD risk factor screening was consistently insufficient. There was a lack of documented clinical data necessary to conduct a CVD risk assessment on more than half of patients at study entry, and one quarter of patients at five-year follow up. Of those with data available (n = 10), retrospective calculations showed 80% had an undetected moderate or higher CVD risk at diagnosis. There was no documented referral to primary care for CVD risk assessment.</p><p><strong>Conclusion: </strong>Implementation of CVD risk management guidelines in the routine care of patients with RA is challenging. The interpretation and operationalisation of guideline recommendations by rheumatology healthcare professionals in relation to implementation barriers needs to be explored.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"158"},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity of older patients with rheumatoid arthritis.","authors":"Yuliya Fedorchenko, Olena Zimba, Ainur B Qumar, Marlen Yessirkepov, Burhan Fatih Kocyigit","doi":"10.1007/s00296-025-05901-8","DOIUrl":"10.1007/s00296-025-05901-8","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) in older adults presents a complex clinical challenge, exacerbated by age-related comorbidities, musculoskeletal degeneration, and psychosocial factors, all contributing to significant mobility limitations and reduced quality of life. This narrative review synthesizes current evidence on rehabilitation interventions to enhance physical function in RA patients, focusing on walking, aquatic therapy, sauna and massage therapies, and yoga. A comprehensive search of Medline/PubMed, Scopus, Web of Science, and DOAJ (up to May 2025) identified studies highlighting the efficacy of structured physical activity (PA) in reducing disease activity, fatigue, and pain, while improving functional capacity and mental health. Walking interventions, including high-intensity interval protocols, demonstrate immunomodulatory and cardiometabolic benefits, with significant reductions in Disease Activity Score (DAS28) and inflammatory markers. Aquatic therapy, leveraging water's buoyancy, improves functional outcomes and reduces depressive symptoms, while sauna and massage therapies offer pain relief and enhanced flexibility. Yoga, as a mind-body practice, significantly lowers disease activity and enhances physical function and psychological well-being. Wearable technologies, such as actigraphy and pedometry, support personalized exercise regimens by providing real-time data for dynamic goal-setting. The European Alliance of Associations for Rheumatology (EULAR) and American College of Rheumatology (ACR) guidelines advocate for tailored exercise integration into RA management. Despite these benefits, adherence remains challenging due to pain, fatigue, and psychological barriers, necessitating individualized, biopsychosocial approaches. This review provides practical recommendations for rheumatology specialists to implement evidence-based rehabilitation strategies, emphasizing multidisciplinary care to optimize mobility and quality of life in older adults with RA.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"157"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term changes in Sjögren's disease: a 9-year prospective follow-up study from the SJOGRENSER Registry.","authors":"Mónica Fernández-Castro, Zulema Plaza-Almuedo, Jose Rosas, Victor Martínez-Taboada, Alejandro Olivé, Raúl Menor-Almagro, Belen Serrano-Benavente, Judit Font-Urgelles, Angel García-Aparicio, Sara Manrique-Arija, Jesus Alberto García-Vadillo, Ruth López-González, Javier Narváez, Beatriz Rodriguez-Lozano, Carlos Galisteo, Jorge González-Martín, Paloma Vela-Casasempere, Cristina Bohórquez, Celia Erausquin, Beatriz Paredes-Romero, Leyre Riancho-Zarrabeitia, Sheila Melchor-Diaz, Jose Maria Pego-Reigosa, Sergi Heredia, Clara Moriano, Maria Angeles Blazquez-Cañamero, Paula Estrada, Enrique Júdez, Joaquín María Belzunegui, Consuelo Ramos, Fernando Sánchez-Alonso, Jose Luis Andreu","doi":"10.1007/s00296-025-05909-0","DOIUrl":"10.1007/s00296-025-05909-0","url":null,"abstract":"<p><p>The objective of SjögrenSER Prospective (SjD-PROS) was to evaluate the improvement, stability or progression of SjD in clinical practice. SjD-PROS is an observational, longitudinal, multicenter study of SjD in Spain. Participants from the prior transversal phase were invited to a follow-up visit after 9.5 years. Data were collected via interviews and medical records. Variables were analyzed using means, medians and frequencies. Statistical associations were assessed using T student test, Kruskal-Wallis and the Chi-square test. We included 314 patients, 95% women (mean age of 66 years; mean disease duration of 17 years). At follow-up visit, the most frequent systemic manifestations were arthralgias (54%) and hematological involvement (49%), with arthralgias being significantly less frequent than at baseline visit (p < 0.001); the most affected organs were the lung (15.6%) and the kidney (11.5%). Half of the patients in SjD-PROS, had positive rheumatoid factor, 16% less than at baseline visit; β2-microglobulin was significantly elevated compared to baseline visit (62.5%, p < 0.001). Articular, pulmonary, hematological and biological domains of ESSDAI index showed the greatest changes, both in improvement and worsening, and the greatest activity. Systemic treatments use was significantly higher in patients showing activity in ESSDAI. This study offers valuable insights into the most variable clinical and serological manifestations throughout the course of SjD. ESSDAI domains showing the greatest changes reflected the greatest treatments needs. These findings allow for patient stratification based on phenotype, a crucial step in designing follow-up protocols.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"156"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and psychometric characteristics of the psoriatic arthritis quality of life (PSAQoL) questionnaire in the Turkish population.","authors":"Mehmet Tuncay Duruöz, Kemal Nas, Sevtap Acer Kasman, Emre Uzun, Halise Hande Gezer","doi":"10.1007/s00296-025-05911-6","DOIUrl":"10.1007/s00296-025-05911-6","url":null,"abstract":"<p><p>The aim of this study was to translate and culturally validate the Psoriatic Arthritis Quality of Life Questionnaire (PsAQoL) into Turkish and to evaluate its reliability and validity in patients with psoriatic arthritis (PsA). A total of 162 PsA patients diagnosed according to CASPAR criteria were recruited from two rheumatology clinics. The PsAQoL was translated and culturally adapted into Turkish using a standardized forward-backward translation method. Internal consistency was assessed using Cronbach's alpha. Construct validity was evaluated by correlating PsAQoL scores with quality of life (SF-36), functional (HAQ), emotional (HADS), and clinical disease activity indices (DAPSA, BASDAI, DAS28). The Turkish version of the PsAQoL was found to be clear, concise, and well understood by patients. The average time to complete the questionnaire was 3.3 ± 0.9 min. Internal consistency was good (Cronbach's α = 0.930). Strong correlations were found with SF-36 physical (r = - 0.744) and mental components (r = - 0.731), indicating convergent validity. Moderate correlations were observed with HAQ (r = 0.533), VAS pain (r = 0.408), HADS-Anxiety (r = 0.535), and HADS-Depression (r = 0.517), while correlations with unrelated clinical parameters such as age and PASI were weak or insignificant, indicating divergent validity. No floor or ceiling effects were detected, and there were no missing responses. The Turkish version of the PsAQoL is a valid, reliable, and practical tool for assessing disease-specific quality of life in PsA. Its ease of use and psychometric strength support its application in both clinical practice and researchs.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"155"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating pain visual analogue scale from health assessment questionnaire for rheumatoid arthritis with beta mixture models.","authors":"Sean P Gavan, Sainan Chang, Felice Rivellese, Zoë Ide, Michael Stadler, Katherine Payne, Darren Plant, Anne Barton, Costantino Pitzalis","doi":"10.1007/s00296-025-05897-1","DOIUrl":"10.1007/s00296-025-05897-1","url":null,"abstract":"<p><p>To map from the health assessment questionnaire disability index (HAQ) to the pain visual analogue scale (VAS) for people with rheumatoid arthritis. The estimation sample comprised adults with rheumatoid arthritis and inadequate response to tumour necrosis factor-α inhibitors in a multicentre phase 4 randomised controlled trial. Beta mixture models were estimated with combinations of HAQ and its square, age and sex as independent variables. Bayesian Information Criteria informed the number of components. Model performance (root mean squared error; mean absolute error; pseudo-R²) was estimated by k-fold cross validation. Graphs illustrated mean observed and predicted pain VAS, and cumulative distribution of observed and simulated pain VAS values. For face validity, a probabilistic analysis simulated 5000 pain VAS values at four HAQ scores. For external validation, the performance of the preferred specification was assessed using the Rheumatoid Arthritis Medication Study cohort. There were 1055 observations from 158 participants in the estimation sample (mean age: 55.8; 81% female; mean HAQ: 1.72). The preferred specification was a two-component beta mixture model (probability variables: HAQ, age, sex; main regression variable: HAQ). Visual plots illustrated good fit across the HAQ distribution, and a similar cumulative distribution of observed and predicted pain VAS values. Probabilistic analysis demonstrated that the preferred specification handled uncertainty appropriately. External validation demonstrated that the preferred specification performed well in an independent dataset. Beta mixture models provide accurate non-linear estimates of pain VAS from HAQ scores to support evidence synthesis and resource allocation decision-making for people with rheumatoid arthritis.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"154"},"PeriodicalIF":3.2,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-compassion, emotion regulation, and resilience as predictors of psychological well-being in fibromyalgia patients: a cross-sectional study.","authors":"İbrahim Hakkı Karakuş, Erdoğdu Akça, Mehmet Tuncay Duruöz, Kemal Sayar","doi":"10.1007/s00296-025-05905-4","DOIUrl":"10.1007/s00296-025-05905-4","url":null,"abstract":"<p><p>While the roles of self-compassion and cognitive emotion regulation in mental health are increasingly acknowledged, their specific impact on fibromyalgia (FM) remains understudied. Given the substantial psychological burden associated with FM, this study aimed to examine these constructs in relation to emotional distress and resilience. Specifically, we sought to: (1) compare self-compassion and emotion regulation strategies between FM patients and healthy controls; (2) explore their associations with depression, anxiety, pain intensity, and resilience; and (3) identify predictors of psychological distress, focusing on self-compassion and emotion regulation. The study included 160 participants (80 FM patients and 80 age- and gender-matched healthy controls) who completed validated instruments, including the Self-Compassion Scale (SCS), Cognitive Emotion Regulation Questionnaire (CERQ), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Toronto Alexithymia Scale (TAS-20), Brief Resilience Scale (BRS), and Visual Analog Scale (VAS). Group comparisons were conducted using Student's t tests. Pearson correlations assessed associations among psychological variables. Mediation analyses, performed using PROCESS macro with 5000 bootstrap resamples, tested whether resilience mediated the relationships between self-compassion and clinical outcomes. FM patients reported significantly lower self-compassion and greater use of maladaptive emotion regulation strategies-particularly rumination and catastrophizing-compared to healthy controls (p < 0.001). Self-compassion was negatively correlated with depression and anxiety, while resilience was positively associated with self-compassion and inversely related to psychological distress. Regression analyses showed that self-compassion, rumination, catastrophizing, resilience, and pain intensity significantly predicted depression and anxiety. Resilience mediated the relationship between self-compassion and  both depressive and anxiety symptoms, though no significant mediation was observed for pain intensity. FM patients experience heightened psychological distress, characterized by reduced self-compassion and increased use of maladaptive emotion regulation strategies. Self-compassion and emotion regulation emerged as key predictors of depression and anxiety, with resilience playing a mediating role in depressive symptoms. These findings underscore the potential of interventions that cultivate self-compassion and strengthen adaptive emotion regulation to improve psychological well-being in individuals with FM and support a more integrative approach to treatment.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 7","pages":"153"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}