Rheumatology International最新文献

筛选
英文 中文
Comparable area under the curve for three risk scores to detect interstitial lung disease in patients with rheumatoid arthritis: an external validation. 三种风险评分检测类风湿关节炎患者间质性肺疾病的曲线下可比面积:外部验证
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-15 DOI: 10.1007/s00296-025-06005-z
Elin Blomberg, Bengt Wahlin, Anna Södergren
{"title":"Comparable area under the curve for three risk scores to detect interstitial lung disease in patients with rheumatoid arthritis: an external validation.","authors":"Elin Blomberg, Bengt Wahlin, Anna Södergren","doi":"10.1007/s00296-025-06005-z","DOIUrl":"https://doi.org/10.1007/s00296-025-06005-z","url":null,"abstract":"<p><p>Rheumatoid Arthritis associated Interstitial Lung Disease (RA-ILD) is an extraarticular manifestation of rheumatoid arthritis (RA) associated with increased morbidity and mortality. Several risk factors for RA-ILD have been identified, one is the promotor variant of mucin 5 B gene (MUC5B). Juge et al., Wheeler et al. and Koduri et al. have developed risk scores for identifying patients with RA at risk of RA-ILD. We aimed to externally validate the three risk scores and further investigate the frequency of MUC5B promotor variant and its association with subclinical lung changes in patients with RA in northern Sweden. Our cohort consisted of 54 patients with RA. The risk score variables were evaluated in binary logistic regression and validated using area under the receiver operating characteristics curve (AUC ROC). The genetic material was purified and genotyped for MUC5B. The Juge et al. risk score performed an AUC ROC of 0.71 (95% CI 0.57;0.86), the Wheeler et al. risk score an AUC ROC of 0.75 (95% CI 0.59;0.90) and Koduri et al. risk score an AUC ROC of 0.70 ((95% CI 0.55;0.85) in our cohort. The differences in AUC were not statistically significant. The MUC5B promotor variant frequency was 26% (n = 14). In our cohort, MUC5B was not significantly associated with subclinical lung changes. The three externally validated risk scores for RA-ILD performed well in this cohort and could be used clinically. In patients with RA in northern Sweden, MUC5B was not found to be independently associated with subclinical RA-ILD.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"252"},"PeriodicalIF":2.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic delay and cardiovascular complications in Takayasu arteritis: a case-based review. 高须动脉炎的诊断延迟和心血管并发症:一项基于病例的回顾。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-13 DOI: 10.1007/s00296-025-06001-3
Gulmira Seitzhanova, Darkhan Suigenbayev, Akerke Auanassova
{"title":"Diagnostic delay and cardiovascular complications in Takayasu arteritis: a case-based review.","authors":"Gulmira Seitzhanova, Darkhan Suigenbayev, Akerke Auanassova","doi":"10.1007/s00296-025-06001-3","DOIUrl":"https://doi.org/10.1007/s00296-025-06001-3","url":null,"abstract":"<p><p>Takayasu arteritis (TA) is a rare systemic inflammatory disease affecting medium and large arteries, mainly in young Asian women, with a frequency of 1-3 cases per million inhabitants. Diagnosing this disease is challenging due to nonspecific early symptoms, leading to gradual clinical progression until vascular complications appear. A 21-year-old pregnant woman, experiencing progressive mild fatigue, referred for clinical examination. Over the past 3-4 years, she had reported weakness, headache, sweating, and dizziness. Imaging revealed significant vascular damage, including an ascending aortic aneurysm, aortic valve annuloaortic ectasia, aortic, mitral, tricuspid, and pulmonary regurgitation, as well as dilation of the left atrium and left ventricle. While available treatments alleviated symptoms and slowed the progression, late diagnosis resulted in lifelong illness. The diagnostic challenges associated with nonspecific early symptoms and the risk of serious vascular complications underscore the importance of early detection of TA in young women with symptoms of systemic inflammation. Women with TA are more likely to have an unfavourable pregnancy outcomes than the general population. Therefore, such patients need careful monitoring and a collaborative approach to achieve the best possible delivery results. This report aims to compile information on pregnancy in women with TA and how the disease impacts pregnancy progression.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"251"},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New versus old: comparison of the 2022 ACR/EULAR versus the 1990 ACR classification criteria for giant cell arteritis in a real-world cohort. 新与旧:2022年ACR/EULAR与1990年ACR巨细胞动脉炎分类标准在现实世界队列中的比较
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-13 DOI: 10.1007/s00296-025-05965-6
Raoul Bergner, C Löffler, P Schulz, D Klank, J Friedrich
{"title":"New versus old: comparison of the 2022 ACR/EULAR versus the 1990 ACR classification criteria for giant cell arteritis in a real-world cohort.","authors":"Raoul Bergner, C Löffler, P Schulz, D Klank, J Friedrich","doi":"10.1007/s00296-025-05965-6","DOIUrl":"https://doi.org/10.1007/s00296-025-05965-6","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"248"},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gout disease-related years lived with disability in the North Africa and Middle East countries: a systematic analysis of the GBD study 1990-2019. 北非和中东国家痛风疾病相关的残疾生活年数:对1990-2019年GBD研究的系统分析
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-13 DOI: 10.1007/s00296-025-06006-y
Moloud Payab, Sahar Saeedi Moghaddam, Yasaman Sharifi, Farshad Sharifi, Mahbube Ebrahimpur, Alireza Hadizadeh, Zahra Esfahani, Pouya Ebrahimi, Pedram Ramezani, Zahra Hoseini Tavassol, Ali Ghanbari, Parnian Shobeiri, Zeinab Shirzad Moghaddam, Rosa Haghshenas, Elham Abdolhamidi, Ameneh Kazemi, Arezou Dilmaghani-Marand, Bagher Larijani
{"title":"Gout disease-related years lived with disability in the North Africa and Middle East countries: a systematic analysis of the GBD study 1990-2019.","authors":"Moloud Payab, Sahar Saeedi Moghaddam, Yasaman Sharifi, Farshad Sharifi, Mahbube Ebrahimpur, Alireza Hadizadeh, Zahra Esfahani, Pouya Ebrahimi, Pedram Ramezani, Zahra Hoseini Tavassol, Ali Ghanbari, Parnian Shobeiri, Zeinab Shirzad Moghaddam, Rosa Haghshenas, Elham Abdolhamidi, Ameneh Kazemi, Arezou Dilmaghani-Marand, Bagher Larijani","doi":"10.1007/s00296-025-06006-y","DOIUrl":"https://doi.org/10.1007/s00296-025-06006-y","url":null,"abstract":"<p><p>The purpose of this study is to describe the changes in the age-standardized prevalence rate, incidence rate, and years lived with disability (YLDs) rate for gout disease and the associated risk factors in 21 North Africa and Middle East (NAME) countries from 1990 to 2019 based on age, gender, and socio-demographic index (SDI). From 1990 to 2019, the Global Burden of Disease (GBD) team performed a comprehensive systematic review of databases and disease-modeled analysis in the NAME countries. Age-standardized prevalence, incidence, and YLD rates, as well as the attributed burden to risk factors (high body mass index (BMI) and kidney dysfunction), were reported with 95% uncertainty intervals (UIs). The age-standardized YLDs estimated in 2019 and 1990 were 14.2 (95% UI 8.9-20.4) and 15.8 (10.0-22.7) per 100,000 populations, respectively, with an increase of 11.7% (7.1-16.4%) from 1990. The health indicators were all reported to be higher among males. The three countries with higher SDI that had the highest age-standardized YLDs rate in 2019 were Qatar (22.5 [14.5-32.7]), the United Arab Emirates (20.5 [12.9-29.9]), and Kuwait (19.0 [11.7-27.6]), while YLDs in 2019 attributable to high BMI and kidney dysfunction were estimated to be 7.2 (3.8-12.2) and 3.7 (2.3-5.5) per 100,000, respectively. According to our findings, the burden of gout in the NAME is higher than the reported global average and has risen from 1990 to 2019. Despite advances in gout treatment, NAME countries should prioritize preventive interventions to manage the disease's burden. Gout is the most common type of inflammatory arthropathy, and there have been no specific reports of this disease burden in the NAME countries, which account for nearly 8% of the global population. This report estimated that age-standardized YLDs increased by 11.7% (7.1%-16.4%) from 1990 to 2019 in this region. Consequently, these countries have to prioritize preventive interventions to manage the disease's burden.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"250"},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of central sensitization and associated factors in systemic lupus erythematosus: a cross-sectional study. 评价系统性红斑狼疮的中枢致敏和相关因素:一项横断面研究。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-13 DOI: 10.1007/s00296-025-05997-y
Ayşegül Yetişir, Elif Altunel Kılınç, Gülin Hüda Gedik, Volkan Deniz, İpek Türk, Gülşah Yaşa Öztürk
{"title":"Evaluation of central sensitization and associated factors in systemic lupus erythematosus: a cross-sectional study.","authors":"Ayşegül Yetişir, Elif Altunel Kılınç, Gülin Hüda Gedik, Volkan Deniz, İpek Türk, Gülşah Yaşa Öztürk","doi":"10.1007/s00296-025-05997-y","DOIUrl":"https://doi.org/10.1007/s00296-025-05997-y","url":null,"abstract":"<p><p>To examine the central sensitization and its determinants in systemic lupus erythematosus (SLE) and compare it with psoriatic arthritis (PsA) and healthy controls (HC). We evaluated the sociodemographic and disease-related parameters, and administered to the study groups the Brief Illness Perception Questionnaire (B-IPQ), the Fatigue Severity Scale (FSS), the Jenkins Sleep Evaluation Scale (JSS), the Health Assessment Questionnaire-Disability Index (HAQ-DI), and the Central Sensitization Inventory (CSI). We also measured pain using the visual analog scale (VAS) (0-10 cm). This study included age- and gender-matched SLE (n = 74), PsA (n = 74), and HC (n = 80) groups. The JSS, FSS, and CSI scores were higher in SLE than in HC. Although tender joint count, swollen joint count, VAS, and HAQ-DI scores were statistically higher in the PsA group compared to the SLE group, the central sensitization rates in the two groups were similar (56.7% for SLE and 55.4% for PsA, p = 0.868). CSI was significantly correlated with the number of tender joints, VAS, HAQ-DI, B-IPQ, JSS, and FSS (Spearman's rho ranged from 0.501 to 0.646) in SLE. FSS, JSS, and tender joint count were the most important predictors of CSI. Age, the number of swollen and tender joints, FSS, B-IPQ, and JSS accounted for 74% of the variation in CSI scores in SLE. Psychosocial variables influence central sensitization, which occurs frequently in SLE. SLE and PsA exhibited similar CSI scores but higher than HC. It is beneficial to evaluate and manage central sensitization in SLE patients with fatigue and sleep disorders.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"249"},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"My world has shrunk": a mixed-methods exploration of the impact of systemic autoimmune rheumatic diseases on patients' lives. “我的世界缩小了”:对系统性自身免疫性风湿病对患者生活影响的混合方法探索。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-10 DOI: 10.1007/s00296-025-05993-2
Martha A Piper, Alice Tunks, Sean Humfrey, Lucy Calderwood, Shaista Tayabali, Sydnae Taylor, Arvind Kaul, Ellie Dalby, Shihab Ahmed, Sue Farrington, Thomas A Pollak, Melanie Sloan
{"title":"\"My world has shrunk\": a mixed-methods exploration of the impact of systemic autoimmune rheumatic diseases on patients' lives.","authors":"Martha A Piper, Alice Tunks, Sean Humfrey, Lucy Calderwood, Shaista Tayabali, Sydnae Taylor, Arvind Kaul, Ellie Dalby, Shihab Ahmed, Sue Farrington, Thomas A Pollak, Melanie Sloan","doi":"10.1007/s00296-025-05993-2","DOIUrl":"10.1007/s00296-025-05993-2","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 11","pages":"247"},"PeriodicalIF":2.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjuvant-induced autoimmune syndrome (ASIA syndrome) and the role of sonography in its diagnosis: a case-based review. 佐剂诱导的自身免疫综合征(ASIA综合征)和超声在其诊断中的作用:一项基于病例的回顾。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-08 DOI: 10.1007/s00296-025-05954-9
Lyatif Masar Kodzhaahmed, Elis Korudova, Konstantin Batalov, Dimitrina Petrova, Zguro Batalov
{"title":"Adjuvant-induced autoimmune syndrome (ASIA syndrome) and the role of sonography in its diagnosis: a case-based review.","authors":"Lyatif Masar Kodzhaahmed, Elis Korudova, Konstantin Batalov, Dimitrina Petrova, Zguro Batalov","doi":"10.1007/s00296-025-05954-9","DOIUrl":"https://doi.org/10.1007/s00296-025-05954-9","url":null,"abstract":"<p><p>Adjuvant-induced autoimmune/ autoinflammatory syndrome (ASIA) is a group of symptoms that are often found in other systemic, autoimmune diseases, which makes its recognition and diagnosis a growing problem in modern clinical practice. Although not completely clear, the genesis is associated with adjuvants - substances found in implants, vaccines, substances external to the body that lead to an exaggerated immune response. Key points of the clinical and paraclinical specificity of the disease are arthralgias, myalgias, cognitive disorders, and positivity of various autoimmune and inflammatory markers. The objectives of this report are to summarize current information about the disease, discuss diagnostic criteria, and review therapeutic options, placing special interest on the ultrasound findings. The presented case outlines the diagnostic difficulty even with the various clinical, imaging, and laboratory findings. Directing clinical thought towards this syndrome is of utmost importance for its easier recognition in practice and achieving favorable outcomes in the treatment of affected patients.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 10","pages":"246"},"PeriodicalIF":2.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatoid arthritis is independently associated with metabolic Dysfunction-Associated steatotic liver disease: evidence from the paracelsus 10,000 Population-Based cohort study. 类风湿关节炎与代谢功能障碍相关的脂肪变性肝病独立相关:来自paracelsus 10,000人群队列研究的证据
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-06 DOI: 10.1007/s00296-025-06002-2
Mathias Ausserwinkler, Axel J Hueber, Sophie Gensluckner, Bernhard Paulweber, Eugen Trinka, Patrick Langthaler, Christian Datz, Andreas Voelkerer, Franz Singhartinger, Bernhard Iglseder, Maria Flamm, Elmar Aigner, Bernhard Wernly
{"title":"Rheumatoid arthritis is independently associated with metabolic Dysfunction-Associated steatotic liver disease: evidence from the paracelsus 10,000 Population-Based cohort study.","authors":"Mathias Ausserwinkler, Axel J Hueber, Sophie Gensluckner, Bernhard Paulweber, Eugen Trinka, Patrick Langthaler, Christian Datz, Andreas Voelkerer, Franz Singhartinger, Bernhard Iglseder, Maria Flamm, Elmar Aigner, Bernhard Wernly","doi":"10.1007/s00296-025-06002-2","DOIUrl":"10.1007/s00296-025-06002-2","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is associated with systemic inflammation and increased risk of cardiovascular and metabolic comorbidities. The relationship between RA and metabolic dysfunction-associated steatotic liver disease (MASLD) has not been established in population-based studies.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of 6638 participants from the population-based Paracelsus 10,000 cohort in Austria, including 187 individuals with physician-diagnosed RA meeting ACR/EULAR classification criteria. MASLD was defined using the Fatty Liver Index (≥ 60) combined with cardiometabolic risk factors according to 2024 EASL guidelines. We used Poisson regression models with sequential adjustment for demographic factors, metabolic syndrome, lifestyle factors, NSAID use, and cardiovascular risk (SCORE2). Liver fibrosis risk was assessed using the Fibrosis-4 Index (FIB-4).</p><p><strong>Results: </strong>MASLD prevalence was higher in RA patients than controls (41.2% vs. 28.5%, P < 0.001). In sequential regression models, the association between RA and MASLD persisted after adjustment for demographics (IRR, 1.55; 95% CI 1.33-1.82), metabolic and lifestyle factors (IRR, 1.20; 95% CI 1.03-1.40), and cardiovascular risk factors (IRR, 1.35; 95% CI 1.14-1.60; P < 0.001). In addition, RA patients showed elevated liver fibrosis markers (median FIB-4: 1.21 vs. 1.08; P < 0.001).</p><p><strong>Conclusions: </strong>In this population-based cohort, RA was independently associated with a 35% increased risk of MASLD and elevated liver fibrosis markers. These findings suggest that systematic liver assessment should be considered in the routine care of RA patients.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 10","pages":"243"},"PeriodicalIF":2.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Biopsychosocial model-based exercise improves muscle strength, proprioception, pain, function, and quality of life in rheumatoid arthritis patients with knee involvement: a randomized controlled clinical trial. 修正:一项随机对照临床试验:基于生物心理社会模型的运动改善膝关节受累的类风湿关节炎患者的肌肉力量、本体感觉、疼痛、功能和生活质量。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-06 DOI: 10.1007/s00296-025-05999-w
Ayşen Akgöz, Yavuz Yakut, Orkun Tüfekçi, Batuhan E Aktaş, Erkin O Sari, Aysima Barlak, Kezban Bayramlar, Şule Apraş Bilgen, Feza Korkusuz, Edibe Ünal
{"title":"Correction: Biopsychosocial model-based exercise improves muscle strength, proprioception, pain, function, and quality of life in rheumatoid arthritis patients with knee involvement: a randomized controlled clinical trial.","authors":"Ayşen Akgöz, Yavuz Yakut, Orkun Tüfekçi, Batuhan E Aktaş, Erkin O Sari, Aysima Barlak, Kezban Bayramlar, Şule Apraş Bilgen, Feza Korkusuz, Edibe Ünal","doi":"10.1007/s00296-025-05999-w","DOIUrl":"https://doi.org/10.1007/s00296-025-05999-w","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 10","pages":"245"},"PeriodicalIF":2.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring fracture risk during antiosteoporotic therapy: a retrospective cohort study. 在抗骨质疏松治疗期间监测骨折风险:一项回顾性队列研究。
IF 2.9 3区 医学
Rheumatology International Pub Date : 2025-10-06 DOI: 10.1007/s00296-025-05995-0
Mariya Nedkova, Tsvetanka Petranova, Rositsa Karalilova, Zguro Batalov
{"title":"Monitoring fracture risk during antiosteoporotic therapy: a retrospective cohort study.","authors":"Mariya Nedkova, Tsvetanka Petranova, Rositsa Karalilova, Zguro Batalov","doi":"10.1007/s00296-025-05995-0","DOIUrl":"https://doi.org/10.1007/s00296-025-05995-0","url":null,"abstract":"<p><p>Osteoporosis is among the leading socially significant diseases, with potential for early diagnosis and effective treatment. Appropriate selection of therapy, particularly after reassessment of ongoing antiosteoporotic therapy, can reduce both fracture risk and healthcare system costs. To evaluate strategies for reassessing antiosteoporotic therapy on the grounds of changes in fracture risk among women in the Bulgarian population. We conducted a retrospective observational cohort study including 300 participants women with postmenopausal, senile osteoporosis or low-energy fractures undergoing antiresorptive therapy. Data were collected at the time of discharge and during a 1-year follow-up period, covering a total monitoring period of 3 years. The FRAX score based on hip fracture (HF), proved to be a more sensitive predictor of future fractures ( HF > 4.5% in 65.22% with postmenopausal osteoporosis and in 100% with senile). In the bisphosphonate treatment group, total bone mineral density (BMD) of the lumbar spine (VL) and BMD оf the femoral neck (FN) demonstrated a clearer trend of BMD improvement (month 36: 0.838 g/cm<sup>2</sup> ± 0.01 SD and 0.622 g/cm<sup>2</sup> ± 0.04 SD ) compared to T-scores. BMD -particularly of the FN-and FN T-scores in patients at very high fracture risk were significant indicators for therapy reassessment. BMD of the FN consistently predicted changes in fracture risk across all monitoring periods. Implementing national strategies for the reassessment of antiosteoporotic therapy, on the grounds of evolving fracture risk, could enhance clinical decision-making and address existing gaps in the treatment of high-risk patients.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 10","pages":"244"},"PeriodicalIF":2.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信