Rheumatology International最新文献

{"title":"Development of a fibromyalgia-specific quality of life instrument: the Fibromyalgia Quality of Life Scale (FM-QoLS).","authors":"Ilke Coskun Benlidayi, Ceren Ornek, Aylin Sariyildiz, Yasar Sertdemir","doi":"10.1007/s00296-025-05895-3","DOIUrl":"10.1007/s00296-025-05895-3","url":null,"abstract":"<p><p>The study aimed to develop a quality of life (QoL) scale specific to patients with fibromyalgia. The scale development involved four steps: (1) Issue collection, (2) Face validity and selection of the most relevant items, (3) Formation of the preliminary scale and pilot testing, and (4) Psychometric evaluation. For psychometric evaluation, the scale was administered to a sample of fibromyalgia patients. Suitability for exploratory factor analysis (EFA) was assessed using the Kaiser-Meyer-Olkin (KMO) test and Bartlett's Test of Sphericity. Reliability was assessed with Cronbach's alpha, Guttman split-half test, and test-retest correlations. Construct validity was determined via EFA using Principal Axis Factoring. The correlation of the developed scale with established measures of QoL, fibromyalgia impact, fatigue, sleep, and mood was tested to assess convergent validity. Floor and ceiling effects were also examined. The initial item list included 25 issues related to QoL in fibromyalgia. Following the assessments and rating of the initial issue list through cognitive interviews, 10 issues were removed. The remaining questions were administered to 60 patients with fibromyalgia. The final version of the Fibromyalgia Quality of Life Scale (FM-QoLS) contained 14 items and two domains: symptomatology-functionality and psychosocial. Moderate-strong correlations between most items indicated that the scale has a homogeneous structure and measures the same construct. The FM-QoLS showed moderate-strong correlations with pain, anxiety, depression, sleep, fatigue, and established measures of QoL. Regarding the test-retest reliability of FM-QoLS items, the gamma values ranged from 0.923 to 0.995. The FM-QoLS is a 14-item QOL scale specific to patients with fibromyalgia. The scale has high validity and reliability, with no floor and ceiling effects. The FM-QoLS could help physicians address the multifaceted QoL challenges in fibromyalgia patients. Future research could refine the scale by exploring its use in different populations.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 6","pages":"142"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment and management of midfoot osteoarthritis by podiatrists in Australia: a cross-sectional survey of current practice.","authors":"Polly Q X Lim, Hylton B Menz, Karl B Landorf, Michelle R Kaminski, Kade L Paterson, Shannon E Munteanu","doi":"10.1007/s00296-025-05881-9","DOIUrl":"10.1007/s00296-025-05881-9","url":null,"abstract":"<p><p>Midfoot osteoarthritis (OA) is a common and disabling condition, yet lacks clinical guidelines for its assessment and management. This study aimed to investigate strategies used by Australian podiatrists to assess and manage midfoot OA. An exploratory cross-sectional survey of podiatrists working in Australia was conducted. Respondents were invited through professional organisations to complete an online questionnaire on their usual assessment and management practices for midfoot OA, based on a vignette. Between November 2022 and July 2023, 103 participants (52% women, mean age 40 years) with an average of 15 years of clinical experience responded. Physical assessments (including history taking and musculoskeletal assessments) (96%) and medical imaging (90%) were commonly used diagnostic methods, with palpation (96%), passive movement testing (95%) and x-ray imaging (62%) frequently reported. Associated impairments were assessed with range of motion testing of the midfoot (96%), gait analysis (95%), functional tests (83%), muscle strength (72%), and observation of static alignment (71%), including foot posture (69%). Most participants assessed comorbidities (93%), body composition (66%) and cognitive/psychosocial impairments (62%). Treatment approaches included footwear advice (97%), orthotic therapy (85%), strapping/taping (81%), education (79%), and exercise therapy (75%). One-third (34%) expected a 'satisfactory' treatment response within two months, and 36% would refer to another healthcare practitioner for co-management between two and three months if treatment was ineffective. A wide range of approaches are used to assess and manage midfoot OA. These findings have potential to inform the design of future studies in developing valid assessment approaches and effective interventions for this condition.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 6","pages":"141"},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of HLA-B51 and ocular involvement in Behçet's disease: a multicenter cross-sectional study.","authors":"Shamma Ahmad Al Nokhatha, Najla Aljaberi, Jawaher Al Zeyoudi, Ahlam Almarzooqi, Farah Soukieh, Mumtaz Khan","doi":"10.1007/s00296-025-05892-6","DOIUrl":"https://doi.org/10.1007/s00296-025-05892-6","url":null,"abstract":"<p><p>Behçet's disease (BD) is a rare multisystem vasculitis. Globally, BD exhibits a unique geographic distribution, with the highest prevalence along the historic Silk Road. To study the demographics, clinical characteristics, and outcomes of BD in the United Arab Emirates (UAE). A multicenter retrospective chart review study was conducted at hospitals in the UAE from 2008 to 2024. All adult and pediatric patients who were diagnosed with BD by a rheumatologist and treated within the timeframe were included in the study while those who received any alternative final diagnosis were excluded. The results were analyzed using descriptive and inferential statistics. One hundred and twenty-three patients were treated and monitored for BD. Most were female (n = 70, 57%). Their median age was 32 years (24-41), and approximately two-thirds were Emirati (n = 82, 67%). Twelve patients (10%) had a family history of BD, including 7 (6%) with first-degree BD. The time from the initial symptoms to diagnosis was 11.9 months (2.3-31.0). The most common clinical manifestations were oral ulcers (n = 99, 81%), arthralgia (n = 63, 51%), genital ulcers (n = 62, 50%), and ocular involvement (n = 37, 30%). Most of the patients were HLA-B51 positive (n = 92, 84%). At diagnosis, 36 (29%) met the ISG criteria, 73 (59%) met the ICBD criteria, and 50 (41%) met neither criteria. The male patients exhibited more major organ involvement (ocular, neurological, vascular, and cardiac), greater use of corticosteroids and anti-TNFa medications, and greater disease activity than the female patients. Among the patients with isolated ocular manifestations (n = 9) who met neither classification criteria, most were female (56%), with a median age of 37 years (26.5-3.5). None had a family history of autoimmune conditions, and all were HLA-B51 positive. Most of these patients (n = 8, 89%) received corticosteroids, 5 (56%) received azathioprine, and 2 (22%) received anti-TNFa therapies. These findings provide insights into the clinical profile of BD in the UAE. Notably, we found a high proportion of patients with positive HLA-B51 and ocular manifestation. Further research with larger sample sizes is needed to better understand these associations.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 6","pages":"140"},"PeriodicalIF":3.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach to cardiovascular events in patients with systemic lupus erythematosus: risk factor assessment and treatment analysis.","authors":"Dorota Suszek, Magdalena Popławska, Jakub Prośniak, Katarzyna Siemieniec, Karolina Przeniosło, Weronika Wallach, Monika Żybowska-Męczyńska, Klaudia Ostrowicz, Anna Rzewuska-Fijałkowska, Bożena Targońska-Stępniak","doi":"10.1007/s00296-025-05894-4","DOIUrl":"https://doi.org/10.1007/s00296-025-05894-4","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) patients have a significantly increased risk of developing cardiovascular disease (CVD). Despite the implementation of preventive measures and treatment of lipid disorders, as well as reduced use of glucocorticoids, CVD remains one of the leading causes of death in this patient group. It is crucial to develop an appropriate CVD risk assessment strategy that considers the distinctive characteristics of this patient population. This paper provides a comprehensive analysis of the methods used to assess CVD risk in SLE patients. It also presents effective strategies for the reduction of the effects of traditional and non-traditional risk factors for atherosclerosis.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 6","pages":"139"},"PeriodicalIF":3.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a novel patient reported experience measure (PREM) in rheumatology: a cross-sectional online survey of Australian rheumatology outpatients.","authors":"Madeleine J Bryant, Susan Lester, Oscar Russell, Samuel Whittle, Vidya Limaye, Susanna Proudman, Rachel J Black, Catherine L Hill","doi":"10.1007/s00296-025-05882-8","DOIUrl":"https://doi.org/10.1007/s00296-025-05882-8","url":null,"abstract":"<p><p>To determine rheumatology patient care experience using the novel Commissioning for Quality in Rheumatoid Arthritis-PREM-Australian version (CQRA-PREM-AU). Patients attending Central Adelaide Local Health Network rheumatology outpatient clinics were invited to complete a cross-sectional web-based survey, comprising CQRA-PREM-AU (22 items, 8 domains, scored 1-5), demographics, Patient Global Assessment (PGA) and Patient Reported Disease Activity (PRDA) Visual Analogue Scales (VAS) (scored 0-100), Single Item Literacy Screener (SILS). Analysed were multivariable linear regression analysis of CQRA-PREM-AU overall score with patient-related covariates (diagnosis, age, sex, SILS, PGA, PRDA), and univariate regression analysis with clinic-related covariates (site, nurse contact, type/number of consultations). Response rate was 1408/4591(31%). 214 incomplete records were excluded; 1194 records were analysed. Respondent characteristics: 68% female, median age 64 years (IQR 54, 73), 29% rural, 7% non-English language at home. PGA median score 50 (IQR 27, 63) and PRDA median score 50 (IQR 26, 69). CQRA-PREM-AU Domain 1 (regarding patient Needs and Preferences) had the best overall mean score (4.1, SD 0.86). Scored poorly were Domain 3 (Information about care, 3.5, SD 0.89), Domain 4 (Daily living, 3.5, SD 1.06) and Domain 5 (Emotional care, 3.6, SD 1.04). Worse PGA, and diagnoses of systemic lupus erythematosus, \"other\", or \"unknown\" were all associated with significantly lower CQRA-PREM-AU score (p < 0.01). Older age, and rheumatology nurse contact were associated with better experience score (p < 0.01). Use of CQRA-PREM-AU highlights the association between contact with a rheumatology nurse and better care experience, and identifies other targets for improving healthcare delivery.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 6","pages":"138"},"PeriodicalIF":3.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Damage accrual and predictors of mortality in ANCA-associated vasculitis: a retrospective observational study.","authors":"Murat Bektaş, Burak Ince, Sibel Zaralı, Übeyde Ayşe Gülseren, Ece Ük, Besim Fazıl Ağargün, Damla Yenersu Güzey, Yasemin Yalçınkaya, Bahar Artım-Esen, Ahmet Gul, Murat İnanç","doi":"10.1007/s00296-025-05883-7","DOIUrl":"https://doi.org/10.1007/s00296-025-05883-7","url":null,"abstract":"<p><p>In this study, we aimed to evaluate the factors affecting the development of damage and mortality in patients with AAV treated at our tertiary referral center. This retrospective study included data on patients with AAV who fulfilled the Chapel Hill Consensus Conference (CHCC) criteria. Patients were divided into c-ANCA/PR3( +) and p-ANCA/MPO ( +) groups based on ANCA immunofluorescence and/or ELISA results, and relapse, damage, and mortality data were compared across the groups. Data from 254 patients (n = 136, 53.5% female) were included in the analysis. Clinical diagnosis was GPA in 186 (73.2%) and MPA in 68 (26.8%) patients. During the follow-up, 217 of 242 (89.7%) patients developed damage, and the median VDI score of the cohort was 2 (IQR: 2). VDI scores were higher in the first period (1997-2011) than in the second period (2011-2021) in the entire cohort (p = 0.012) and in patients with GPA compared with MPA (p = 0.034). Five-year and overall survival rates were 88.1% and 80.3% in the entire cohort; 87.8% and 81% in c-ANCA/PR3 ( +); 86.2% and 76% in p-ANCA/MPO ( +) (Log-Rank: p = 0.35); 91% and 84.5% in GPA; 81% and 67.2% in MPA patients (Log-Rank: p < 0.001). Development of malignancy, severe infection, and active/persistent disease after the induction phase were associated with higher mortality in patients with AAV. In our AAV cohort, permanent organ damage was detected in the majority of the patients. Although the median VDI score decreased over time, mortality did not change.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 5","pages":"137"},"PeriodicalIF":3.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful infliximab therapy in systemic sarcoidosis presenting with giant leg ulcers: a case based review.","authors":"Nabil Belfeki, Nadia Ghariani Fetoui, Nour El Imene Ouni, Juliette Avci, Renaud Guedec-Ghelfi, Sonia Kammoun, Nouha Ghriss","doi":"10.1007/s00296-025-05887-3","DOIUrl":"https://doi.org/10.1007/s00296-025-05887-3","url":null,"abstract":"<p><p>Sarcoidosis is a chronic granulomatous inflammatory disease that primarily affects the lungs and skin. Cutaneous involvement occurs in approximately 30% of cases. We report herewith a rare case of a 55-year-old man with chronic, non-healing bilateral leg ulcers, ultimately diagnosed as ulcerative cutaneous sarcoidosis through histopathological confirmation. Giant leg ulcers complicating systemic sarcoidosis is rare and its management is challenging because there are no specific recommendation. In our case, a 24-month course of intravenous infliximab associated with oral prednisone induced sustained clinical remission. The current decline is three years. The aim of our work is to review the clinical presentation and management of ulcerative cutaneous sarcoidosis and compare them to reported cases in literature.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 5","pages":"136"},"PeriodicalIF":3.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The broad range of self-management strategies that people with rheumatic and musculoskeletal conditions apply: an online survey using a citizen science approach.","authors":"E Te Braake, R Schriemer, C Grünloh, S Ahoud, T Asselberghs, V Bodelier, D Hansen, C Ophuis, R Wolkorte","doi":"10.1007/s00296-025-05842-2","DOIUrl":"https://doi.org/10.1007/s00296-025-05842-2","url":null,"abstract":"<p><p>Rheumatic and musculoskeletal diseases (RMDs) cause several restrictions in daily living. Self-management is an important aspect of managing RMDs. However, little is known about the self-management strategies that are currently applied in daily life. This study aimed to identify the current self-management strategies that people with RMDs apply through a citizen science approach. An online survey was iteratively developed together with people with RMDs. The survey was distributed among people with all types of RMDs. Survey responses were collected within Qualtrics, and once anonymized, analysed using Atlas.ti. General self-management strategies and motivations to start performing a strategy were deductively coded by two reviewers, after consultations with patient partners. 250 complete surveys were collected. 91.2% of the respondents were female. 1305 self-management strategies were mentioned, and 669 elaborations were given. Most participants applied self-management strategies within the 'physical activity' category in their daily lives (e.g., walking, biking). Motivations to start performing a certain self-management strategy mostly originated from the bodily functioning dimension (e.g., reducing pain). 1275 facilitators to start a self-management strategy were mentioned, which were mostly related to the 'support' category. Barriers (N = 480) were most frequent in the 'condition-related' category. Self-management is an important aspect of managing a person's condition in daily life. People choose one or several strategies based on the challenge they are facing, depending on their feasibility and preferences in line with their personal context. The comprehensive overview of strategies informs both patients and healthcare professionals to support a personalized self-management journey.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 5","pages":"135"},"PeriodicalIF":3.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral patterns, influencing factors, and satisfaction related to referrals of patients with rheumatic diseases to other healthcare professionals: an online survey of rheumatologists.","authors":"Khalid A Alnaqbi, Mohammed Alaswad, Amr A A Mahmoud, Suad Hannawi","doi":"10.1007/s00296-025-05889-1","DOIUrl":"https://doi.org/10.1007/s00296-025-05889-1","url":null,"abstract":"<p><p>Managing rheumatic diseases requires teamwork, but referral patterns and challenges remain poorly understood. This study explored rheumatologists' perspectives on referral patterns in the Gulf countries. We conducted a web-based, 21-question cross-sectional survey between November and December 2024, collecting data on rheumatologists' demographics, referral patterns, influencing factors, and satisfaction. Participants were recruited through email invitations, WhatsApp groups and snowball sampling. Statistical analyses included descriptive and inferential methods, such as subgroup comparisons and logistic regression, to identify predictors of referral frequency and satisfaction. A total of 149 rheumatologists participated, with 58.4% being consultants. Approximately 55% had up to 10 years of post-training experience. The primary referral method was electronic health records (EHR) (84.8%). In the three months preceding the survey, 36.3% made 0-10 referrals, while 35.6% made over 20. Dermatology (85.5%) and physiotherapy (79.5%) were the most referred specialties, aligning with psoriatic arthritis and systemic lupus erythematosus as the most referred diseases. Most rheumatologists (78%) often or always followed up on referrals, and 37.4% reported moderate changes in their referral decision-making over time. Key influences on referral decisions included patient-, practice-, and diagnostic-related factors. Patient gender preference had no impact. Multidisciplinary meetings (78.2%), access to updated clinical guidelines (76.5%), attending multidisciplinary continuing medical education or training programs (67.2%), and improved EHR referral systems (64.7%) were the top resources for improving referrals. Satisfaction post-referral was affected by various factors such as patients' experiences post-referral (61.5%), and healthcare professionals' responsiveness to their questions (54.2%). Logistic regression analysis showed that age, employment status, practice setting, and geographical location were associated with referral decisions. This study is the first to provide valuable insights into referral practices among Gulf rheumatologists, identifying key influencing factors and areas for improvement. Findings suggest that enhancing EHR systems, multidisciplinary meetings, and clinical guidelines can optimize referrals and interdisciplinary care.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 5","pages":"134"},"PeriodicalIF":3.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease activity score is associated with vertebral fragility fractures in patients with rheumatoid arthritis: a cross-sectional multidisciplinary study.","authors":"Chiara Lopez, Simone Parisi, Mirko Parasiliti-Caprino, Guglielmo Beccuti, Francesco Ghellere, Maria Chiara Ditto, Ezio Ghigo, Fabio Broglio, Enrico Fusaro","doi":"10.1007/s00296-025-05877-5","DOIUrl":"https://doi.org/10.1007/s00296-025-05877-5","url":null,"abstract":"<p><p>Rheumatoid Arthritis (RA) is associated with osteometabolic alterations. This study aims to estimate the prevalence of osteometabolic complications and to explore the potential association with disease parameters in patients with RA. This cross-sectional study enrolled consecutive patients with diagnosis of RA, admitted to Rheumatology Unit of our Hospital and referred to the Endocrinology Unit for the assessment of osteometabolic health. Anamnestic, anthropometric, biochemical and instrumental data were collected for each subject. The prevalence of osteometabolic alterations was 35% for sarcopenia, 41% for osteoporosis and 28% for vertebral fragility fractures in a population of 110 RA patients. At multivariable analysis, copeptin showed direct association (β-coeff 0.006; p = 0.015) with lower lumbar bone mineral density (BMD) values on dual-energy X-ray absorptiometry (DXA). Disease Activity Score for 28 joints with C-Reactive Protein (DAS28-CRP) (OR 1.632; p = 0.031) proved to be associated with vertebral fragility fractures, correcting for age, sex, body mass index (BMI) and disease parameters. Furthermore, DAS28-CRP (β-coeff 0.584; p = 0.001), steroid therapy (β-coeff 0.993; p = 0.013), and old age (β-coeff 0.040; p = 0.013) were directly associated with sarcopenia score (SARC-F), while male sex showed indirect association (β-coeff - 1.027; p = 0.036), correcting for autoantibody positivity and BMI. In the last model, copeptin resulted indirectly associated with fat mass index on DXA (β-coeff - 0.236, p = 0.049), using age and disease parameters, as covariates. RA is characterized by a high prevalence of osteometabolic complications, caused by a complex interplay between autoimmune and metabolic pathways. Management of osteometabolic health in RA patients should be a shared decision making between rheumatologist and endocrinologist.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 5","pages":"133"},"PeriodicalIF":3.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}