Revista Iberoamericana De Micologia最新文献_第8页

Tratamiento antifúngico individualizado en el paciente crítico con infección fúngica invasora 侵袭性真菌感染危重患者个体化抗真菌治疗

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-04-01 DOI: 10.1016/j.riam.2021.04.006

Rafael Zaragoza , Emilio Maseda , Javier Pemán

{"title":"Tratamiento antifúngico individualizado en el paciente crítico con infección fúngica invasora","authors":"Rafael Zaragoza , Emilio Maseda , Javier Pemán","doi":"10.1016/j.riam.2021.04.006","DOIUrl":"https://doi.org/10.1016/j.riam.2021.04.006","url":null,"abstract":"<div><p>Invasive candidiasis (IC) is the most common invasive fungal infection (IFI) affecting critically ill patients, followed by invasive pulmonary aspergillosis (IPA). International guidelines provide different recommendations for a first-line antifungal therapy and, in most of them, echinocandins are considered the first-line treatment for IC, and triazoles are so for the treatment of IPA. However, liposomal amphotericinB (L-AmB) is still considered a second-line therapy for both clinical entities. Although in the last decade the management of IFI has improved, several controversies persist. The antifungal drugs currently available may have a suboptimal activity, or be wrongly used in certain IFI involving critically ill patients. The aim of this review is to analyze when to provide individualized antifungal therapy to critically ill patients suffering from IFI, emphasizing the role of L-AmB. Drug-drug interactions, the clinical status, infectious foci (peritoneal candidiasis is discussed), the fungal species involved, and the need of monitoring the concentration of the antifungal drug in the patient are considered.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 2","pages":"Pages 68-74"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2021.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91621748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Evolución de la infección fúngica invasora en los últimos 30 años 过去30年侵袭性真菌感染的演变

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-04-01 DOI: 10.1016/j.riam.2021.03.003

José Tiago Silva , Isabel Ruiz-Camps , José María Aguado

引用次数: 2

Antifúngicos de uso sistémico 全身使用的抗真菌药物

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-04-01 DOI: 10.1016/j.riam.2021.04.004

Inmaculada Quiles-Melero, Julio García-Rodríguez

{"title":"Antifúngicos de uso sistémico","authors":"Inmaculada Quiles-Melero, Julio García-Rodríguez","doi":"10.1016/j.riam.2021.04.004","DOIUrl":"10.1016/j.riam.2021.04.004","url":null,"abstract":"<div><p>Las infecciones fúngicas invasivas han aumentado en las últimas décadas y las opciones terapéuticas para combatirlas son limitadas. Los agentes antifúngicos empleados son útiles y tienen óptima actividad <em>in vitro</em>, pero pierden eficacia debido al desarrollo de resistencias por parte de los hongos. El incremento de especies con resistencia primaria o secundaria a algunos fármacos antifúngicos ha generado la necesidad de desarrollar nuevas formulaciones o recurrir a alternativas como la combinación de fármacos. En este artículo se revisará el espectro de actividad de las principales familias de antifúngicos, polienos, azoles, equinocandinas, 5-fluorocitosina y nuevos fármacos antifúngicos, así como los mecanismos de resistencia descritos contra los mismos.</p></div><div><p>Invasive fungal infections have increased over the last decades and the therapeutic choices to treat them are limited. The antifungal agents currently available are useful and have optimal in vitro activity; however, their activity can be lowered due to the development of fungal resistance. The increase in primary or secondary resistance to some antifungal drugs has led to the search of alternatives such as the combination of drugs or the development of new antifungals. In this paper, the activity of the main families of antifungal drugs, polyenes, azoles, echinocandins, 5-fluorocytosine and other new antifungal drugs, are reviewed. The main resistance mechanisms developed by fungi are also described.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 2","pages":"Pages 42-46"},"PeriodicalIF":1.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2021.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39209636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Seguridad clínica de la anfotericina B liposomal 脂质体两性霉素B的临床安全性

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-04-01 DOI: 10.1016/j.riam.2021.02.001

Borja Suberviola

引用次数: 3

Exophiala dermatitidis as a cause of central line associated bloodstream infection in an infant: Case report and literature review 外表皮皮炎是婴儿中央线相关血流感染的原因:病例报告和文献回顾

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.09.004

Anil Kumar , Aswathy Nandakumar , Sajitha Nair , Ashutosh Singh , Nandita Shashindran , Swathy Thulasidharan , Kiran Subhash , Arya Ramachandran , Anuradha Chowdhary

{"title":"Exophiala dermatitidis as a cause of central line associated bloodstream infection in an infant: Case report and literature review","authors":"Anil Kumar , Aswathy Nandakumar , Sajitha Nair , Ashutosh Singh , Nandita Shashindran , Swathy Thulasidharan , Kiran Subhash , Arya Ramachandran , Anuradha Chowdhary","doi":"10.1016/j.riam.2020.09.004","DOIUrl":"10.1016/j.riam.2020.09.004","url":null,"abstract":"<div><h3>Background</h3><p><span><em>Exophiala</em><em> dermatitidis</em></span><span> is a dematiaceous fungus known to cause superficial, subcutaneous, cutaneous and deep seated infections, and rarely central line associated bloodstream infection (CLABSI). A case of CLABSI due to </span><em>E. dermatitidis</em> in an infant is described.</p></div><div><h3>Case report</h3><p>Clinical and laboratory data were extracted from patient's chart and laboratory records. The isolate was identified as <em>E. dermatitidis</em><span><span> by phenotypic characterization and sequencing of the ITS and </span>LSU regions of the ribosomal DNA. Medline search was done to review all cases of CLABSI due to </span><em>E. dermatitidis</em><span>. Among the azoles tested, posaconazole (0.06</span>    <!-->mg/l)</p></div><div><h3>Conclusions</h3><p>As we did not found in the literature any case of CLABSI due to <em>E. dermatitidis</em> in an infant, we report the first one. Sequencing is a mandatory method for accurately identifying this species. Prompt removal of the central line, followed by a treatment with amphotericin B or an azole, seems to be the most effective treatment.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 1","pages":"Pages 12-15"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38339676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Problemas clínicos en Micología Médica: problema número 55 医学真菌学的临床问题:第55期

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.10.004

Mercedes Romero , Fernando Messina , Roxana Depardo , Emmanuel Marín , Alicia Arechavala , Nicolás Lista , Alejandra Rodríguez , Gabriela Santiso

引用次数: 1

Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report 与获得性免疫缺陷综合征相关的巴西副球虫S1引起的副球虫菌病:1例报告

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.09.003

Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves

{"title":"Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report","authors":"Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves","doi":"10.1016/j.riam.2020.09.003","DOIUrl":"10.1016/j.riam.2020.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms.</p></div><div><h3>Case report</h3><p>We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as <span><em>Paracoccidioides</em><em> brasiliensis</em></span> S1 by species-specific PCR using primers for protein-coding gene <em>GP43</em> (exon 2) followed by PCR-RFLP of the alpha-tubulin gene.</p></div><div><h3>Conclusions</h3><p>There are few data in literature reporting species-specific molecular identification of <em>Paracoccidioides</em> in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 1","pages":"Pages 5-8"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38371663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Tongue lesion due to Cryptococcus neoformans as the first finding in an HIV-positive patient 在hiv阳性患者中首次发现由新型隐球菌引起的舌损

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.10.003

Gabriela María Santiso , Fernando Messina , Andrea Gallo , Emmanuel Marín , Roxana Depardo , Alicia Arechavala , Laura Walker , Ricardo Negroni , María Mercedes Romero

{"title":"Tongue lesion due to Cryptococcus neoformans as the first finding in an HIV-positive patient","authors":"Gabriela María Santiso , Fernando Messina , Andrea Gallo , Emmanuel Marín , Roxana Depardo , Alicia Arechavala , Laura Walker , Ricardo Negroni , María Mercedes Romero","doi":"10.1016/j.riam.2020.10.003","DOIUrl":"10.1016/j.riam.2020.10.003","url":null,"abstract":"<div><h3>Background</h3><p>Cryptococcosis is a severe universally distributed mycosis which mainly affects immunocompromised hosts. This mycosis is caused by yeasts of two species complex of the genus <span><em>Cryptococcus</em></span>: <span><em>Cryptococcus neoformans</em></span> and <span><em>Cryptococcus gattii</em></span>. Meningeal cryptococcosis is the most frequent clinical presentation of this disseminated mycosis. The oral mucosa involvement is extremely unusual.</p></div><div><h3>Case report</h3><p>We present a case of cryptococcosis with an unusual clinical form. The patient was assisted because she had an ulcerated lesion on the lingual mucosa. Encapsulated yeasts compatible with <em>Cryptococcus</em> were found in microscopic exams of wet preparations from lingual ulcer clinical samples obtained for cytodiagnosis and mycological studies. <em>Cryptococcus neoformans</em> (<em>C. neoformans</em> var. <em>grubii</em> VNI) was isolated in culture. This patient did not know her condition of HIV seropositive before the appearance of the tongue lesion.</p></div><div><h3>Conclusions</h3><p>The involvement of the oral mucosa is uncommon in this fungal infection, but is important to include it in the differential diagnosis in HIV positive patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 1","pages":"Pages 19-22"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38772770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ringworm in cats and dogs: New guidelines 猫和狗的癣:新指南

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.02.003

F. Javier Cabañes

引用次数: 0

Lack of relationship between genotype and virulence in Candida species 念珠菌的基因型与毒力之间缺乏相关性

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.10.002

Judith Díaz-García , Maiken C. Arendrup , Rafael Cantón , Julio García-Rodríguez , Elia Gómez García de la Pedrosa , Gabriella Parisi , Javier Pemán , Brunella Posteraro , Maurizio Sanguinetti , Daniel Archimedes Da Matta , Arnaldo L. Colombo , Patricia Muñoz , Carlos Sánchez-Carrillo , Jesús Guinea , Pilar Escribano

{"title":"Lack of relationship between genotype and virulence in Candida species","authors":"Judith Díaz-García , Maiken C. Arendrup , Rafael Cantón , Julio García-Rodríguez , Elia Gómez García de la Pedrosa , Gabriella Parisi , Javier Pemán , Brunella Posteraro , Maurizio Sanguinetti , Daniel Archimedes Da Matta , Arnaldo L. Colombo , Patricia Muñoz , Carlos Sánchez-Carrillo , Jesús Guinea , Pilar Escribano","doi":"10.1016/j.riam.2020.10.002","DOIUrl":"10.1016/j.riam.2020.10.002","url":null,"abstract":"<div><h3>Background</h3><p>The virulence of isolates among different <em>Candida</em><span> species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.</span></p></div><div><h3>Aims</h3><p>We aim to assess the relationship between genotype and virulence in <em>Candida</em> species using a <span><em>Galleria mellonella</em></span> larvae infection model.</p></div><div><h3>Methods</h3><p>One hundred and ninety-four isolates from 68 clusters (<span><em>Candida albicans</em></span>, 114/41; <span><em>Candida parapsilosis</em></span>, 74/24; <span><em>Candida tropicalis</em></span>, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of <em>G. mellonella</em> larvae.</p></div><div><h3>Results</h3><p>The median of survival and the IQR ranges of clusters and singleton were as follows: <em>C. albicans</em> (2 days, IQR 1.5–2 <em>vs.</em> 2 days, IQR 1–2.25), <em>C. parapsilosis</em> (2 days, IQR 1.5–2.6 <em>vs.</em> 2 days, IQR 2–3.3), and <em>C. tropicalis</em> (1 day, IQR 1–3.5 <em>vs.</em> 2 days, IQR 2–3.5; <em>p</em>  <!-->0.05). High intra-cluster variability in terms of median of survival was found regardless the species.</p></div><div><h3>Conclusions</h3><p>No relationship between genotype and virulence in <em>Candida</em> was observed with the <em>G. mellonella</em> model.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 1","pages":"Pages 9-11"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38747337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0