Revista Iberoamericana De Micologia最新文献_第9页

Problemas clínicos en micología médica: problema número 54 医学真菌学的临床问题:第54期

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.04.001

Fernando Messina , Ricardo Negroni , Elena Maiolo , Alicia Arechavala , María Mercedes Romero , Silvia Paz , Hugo Fainboim , Gabriela María Santiso

引用次数: 0

Trichophyton erinacei: an emergent pathogen of pediatric dermatophytosis 毛癣菌:儿童皮肤真菌病的一种新兴病原体

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.06.001

Belén Rivaya , Gema Fernández-Rivas , Francisco Javier Cabañes , Isabel Bielsa , Gemma Castellá , Jun Hao Wang , Lurdes Matas

{"title":"Trichophyton erinacei: an emergent pathogen of pediatric dermatophytosis","authors":"Belén Rivaya , Gema Fernández-Rivas , Francisco Javier Cabañes , Isabel Bielsa , Gemma Castellá , Jun Hao Wang , Lurdes Matas","doi":"10.1016/j.riam.2020.06.001","DOIUrl":"10.1016/j.riam.2020.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Dermatophytoses in children are common pathologies worldwide caused mainly by <span><span>Trichophyton rubrum</span></span>. However, due to the globalization and the atypical pets that people nowadays own, some zoonotic species are also involved in these lesions.</p></div><div><h3>Case report</h3><p>We present two cases of <em>tinea faciei</em> caused by the zoonotic mould <em>Trichophyton erinacei</em> in two children that owned a guinea pig and a hedgehog, respectively<em>.</em> Mycological diagnosis was performed inoculating skin scales on Sabouraud-glucose agar plates supplemented with chloramphenicol, with and without gentamicin, and on Sabouraud-glucose agar tubes, with and without cycloheximide. Microscopical examination in both cases and ITS region sequencing to confirm the identification (performed in one of them) were compatible with <em>T. erinacei.</em> Multiple treatments like corticosteroids and antibiotics were prescribed prior to the accurate diagnosis. Finally, both patients received topical and oral terbinafine, respectively, the lesions being resolved entirely.</p></div><div><h3>Conclusions</h3><p>Zoonotic fungi must be considered in the diagnosis of skin lesions. An accurate medical record, with a guided anamnesis about possible risk factors and an ongoing and open dialogue between health professionals, are essential to improve both the management of these exotic and zoophilic dermatophytoses.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38433689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Disseminated sporotrichosis with immune reconstitution inflammatory syndrome in an HIV patient: Case report and review of the literature 1例HIV患者播散性孢子菌病伴免疫重建炎症综合征:病例报告及文献复习

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.09.001

Vanice Rodrigues Poester , Lívia Silveira Munhoz , Rossana Patricia Basso , Beatriz Mendes Roca , Mariana Umpiérrez Vieira , Aryse Martins Melo , Gabriel Baracy Klafke , Karine Ortiz Sanchotene , Jussara Maria Silveira , David Stevens , Vanessa Brito de Souza Rabello , Rosely Maria Zancope-Oliveira , Melissa Orzechowski Xavier

引用次数: 9

Sporotrichosis in Brazil: Animals + humans = one health 巴西的孢子虫病:动物+人类=一个健康

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.01.001

F. Javier Cabañes

引用次数: 7

Identification of Mucor circinelloides antigens recognized by sera from immunocompromised infected mice 免疫功能低下感染小鼠血清中环状毛霉抗原的鉴定

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.07.002

Maialen Areitio , Adela Martin-Vicente , Aitana Arbizu , Aitziber Antoran , Leire Aparicio-Fernandez , Idoia Buldain , Leire Martin-Souto , Aitor Rementeria , Javier Capilla , Fernando L. Hernando , Andoni Ramirez-Garcia

{"title":"Identification of Mucor circinelloides antigens recognized by sera from immunocompromised infected mice","authors":"Maialen Areitio , Adela Martin-Vicente , Aitana Arbizu , Aitziber Antoran , Leire Aparicio-Fernandez , Idoia Buldain , Leire Martin-Souto , Aitor Rementeria , Javier Capilla , Fernando L. Hernando , Andoni Ramirez-Garcia","doi":"10.1016/j.riam.2020.07.002","DOIUrl":"10.1016/j.riam.2020.07.002","url":null,"abstract":"<div><h3>Background</h3><p><span><em>Mucor circinelloides</em></span> is an opportunistic fungus capable of causing mucormycosis, a highly aggressive infection of quick spreading. Besides, it also has a high mortality rate due to late diagnosis and difficult treatment.</p></div><div><h3>Aims</h3><p>In this study we have identified the most immunoreactive proteins of the secretome and the total protein extract of <em>M. circinelloides</em> using sera from immunocompromised infected mice.</p></div><div><h3>Methods</h3><p><span>The proteins of the secretome and the total extract were analyzed by two-dimensional electrophoresis and the most immunoreactive antigens were detected by Western Blot, facing the sera of immunocompromised infected mice to the proteins obtained in both extracts of </span><em>M. circinelloides</em>.</p></div><div><h3>Results</h3><p>Seven antigens were detected in the secretome extract, and two in the total extract, all of them corresponding only to three proteins. The enzyme enolase was detected in both extracts, while triosephosphate isomerase was detected in the secretome, and heat shock protein HSS1 in the total extract.</p></div><div><h3>Conclusions</h3><p>In this work the most immunoreactive antigens of the secretome and the total extract of <em>M. circinelloides</em> were identified. The identified proteins are well known fungal antigens and, therefore, these findings can be useful for future research into alternatives for the diagnosis and treatment of mucormycosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38679094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Infección del torrente sanguíneo por Candida glabrata en una unidad de cuidados intensivos neonatales con prescripción de profilaxis con fluconazol 新生儿重症监护病房使用氟康唑预防的光滑念珠菌血流感染

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.06.002

Juan Carlos Lona-Reyes , Larissa María Gómez-Ruiz , Araceli Cordero-Zamora , Mariana Chávez-Rodríguez , Juan Antonio Gallegos-Marín , Denisse Sinaí Jiménez-Hernández

{"title":"Infección del torrente sanguíneo por Candida glabrata en una unidad de cuidados intensivos neonatales con prescripción de profilaxis con fluconazol","authors":"Juan Carlos Lona-Reyes , Larissa María Gómez-Ruiz , Araceli Cordero-Zamora , Mariana Chávez-Rodríguez , Juan Antonio Gallegos-Marín , Denisse Sinaí Jiménez-Hernández","doi":"10.1016/j.riam.2020.06.002","DOIUrl":"https://doi.org/10.1016/j.riam.2020.06.002","url":null,"abstract":"<div><h3>Background</h3><p><em>Candida glabrata</em> is an emerging pathogen with the ability to develop tolerance and resistance to azole antifungals, which creates uncertainty about the usefulness of antifungal prophylaxis in newborns.</p></div><div><h3>Aims</h3><p>The aim of this study was to describe the factors associated with <em>C. glabrata</em> infection in a NICU that uses prophylaxis with fluconazole.</p></div><div><h3>Methods</h3><p>A case-control study paired by gestational age was designed and conducted at the Civil Hospital of Guadalajara Dr. Juan I. Menchaca. Newborns with <em>C. glabrata</em> infection were studied and for each one a matched control was selected by gestational age. Odds ratios (OR) were estimated with 95% confidence intervals (95% CI) and McNemar test for contrast of hypothesis was applied.</p></div><div><h3>Results</h3><p>Twenty-one infected patients were identified, from whom 66.7% were male; the median gestational age was 31.5 weeks. Increased risk of infection with <em>C. glabrata</em> was observed when there was a prescription of more than one antimicrobial scheme (OR 21, 95% CI, 1.23 - 358.3; <em>p</em>  =0.04). During the study period, exposure to fluconazole showed no difference in the risk of infection.</p></div><div><h3>Conclusions</h3><p>Neonates with more than one antimicrobial regimen and those with surgical comorbidities had a higher risk of <em>C. glabrata</em> infection.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92027428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Guttural pouch mycosis, sympathy for Aspergillus nidulans 咽喉袋真菌病，与细曲霉同感

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.01.002

F. Javier Cabañes

引用次数: 1

Synergistic interactions between β-lapachone and fluconazole in the inhibition of CaCdr2p and CaMdr1p in Candida albicans β-拉帕酮与氟康唑对白色念珠菌CaCdr2p和CaMdr1p抑制的协同作用

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.09.002

Daniel Clemente Moraes , Leandro Figueira Reis de Sá , Levy Tenorio Sousa Domingos , Maria do Carmo Freire Ribeiro Pinto , Rosangela Maria de Araújo Soares , Antônio Ferreira-Pereira

{"title":"Synergistic interactions between β-lapachone and fluconazole in the inhibition of CaCdr2p and CaMdr1p in Candida albicans","authors":"Daniel Clemente Moraes , Leandro Figueira Reis de Sá , Levy Tenorio Sousa Domingos , Maria do Carmo Freire Ribeiro Pinto , Rosangela Maria de Araújo Soares , Antônio Ferreira-Pereira","doi":"10.1016/j.riam.2020.09.002","DOIUrl":"10.1016/j.riam.2020.09.002","url":null,"abstract":"<div><h3>Background</h3><p>Mortality rate of invasive <em>Candida</em> infections is raising mainly amongst immunocompromised patients. These infections are hard-to-treat mainly due to the increasing incidence of resistance. The overexpression of ATP-binding cassette and major facilitator superfamily transporters is the main responsible for the failure of antifungal therapies. In a <span><em>Saccharomyces cerevisiae</em></span> model, β-lapachone inhibited Pdr5p, a transporter homologous to those found in <span><em>Candida albicans</em></span>.</p></div><div><h3>Aims</h3><p>To determine whether β-lapachone reverses the resistance phenotype mediated by efflux transporters in <em>C</em>. <em>albicans</em> clinical isolates.</p></div><div><h3>Methods</h3><p>The antifungal activity of β-lapachone combined with fluconazole was measured by agarose chemosensitization and microdilution assays. CaCdr2p and CaMdr1p activities were evaluated through fluorescent dyes accumulation. ATPase activity was assessed using transporter-enriched plasma membranes.</p></div><div><h3>Results</h3><p>β-lapachone reverted antifungal resistance of <em>S. cerevisiae</em> and <em>C. albicans</em> strains overexpressing CaCdr2p and CaMdr1p transporters by inhibiting these proteins activities. CaCdr2p ATPase activity was not impaired by the compound.</p></div><div><h3>Conclusions</h3><p><span>β-lapachone is a promising drug candidate to be used as an adjuvant in the treatment of candidiasis caused by fluconazole-resistant </span><em>C. albicans</em> strains.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40455514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Bat white-nose syndrome: A devastating epizootic in North America 蝙蝠白鼻综合征:北美一种毁灭性的动物流行病

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.01.003

F. Javier Cabañes

引用次数: 0

Recent changes in candidemia trends in a tertiary hospital (2011–2018) 某三级医院念珠菌流行趋势近期变化(2011-2018年)

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.09.005

Ana I. Piqueras , Thomas Rubio , Eva M. Lopez-Medina , Ana Gimeno , Vicent Modesto , Emilia Cantón , Javier Pemán

{"title":"Recent changes in candidemia trends in a tertiary hospital (2011–2018)","authors":"Ana I. Piqueras , Thomas Rubio , Eva M. Lopez-Medina , Ana Gimeno , Vicent Modesto , Emilia Cantón , Javier Pemán","doi":"10.1016/j.riam.2020.09.005","DOIUrl":"10.1016/j.riam.2020.09.005","url":null,"abstract":"<div><h3>Background</h3><p>The epidemiology of candidemia has changed over the last decades and varies widely among geographic areas.</p></div><div><h3>Aims</h3><p>We examined in children (aged 0–14) with candidemia the trends in the incidence rate of this infection, as well as the clinical characteristics of the patients, in order to optimize the prognosis and the control measures of this serious disease.</p></div><div><h3>Methods</h3><p>A retrospective cohort study of candidemia in the period 2011–2018 in the neonatal intensive care unit (NICU), pediatric ICU (PICU) and pediatric wards of a tertiary hospital, was conducted. The clinical course, <em>Candida</em> species isolated, antifungal susceptibility, outcome and incidence rates were analyzed and compared.</p></div><div><h3>Results</h3><p>We diagnosed 68 episodes of candidemia in 62 children, 48% occurred in the NICU, 31% in the PICU and 21% in pediatric wards. <span><em>Candida albicans</em></span> was the most frequent species isolated in NICU infants (53%), and <span><em>Candida parapsilosis</em></span><span> predominated among PICU patients (59%) and pediatric wards (50%). One third of NICU infants had invasive candidiasis (IC), most of them having extremely low birth weight (ELBW) (35%). All isolates were susceptible to the antifungal administered. Over time, the incidence of candidemia decreased in the PICU (from 2.2 to 0.3 episodes/1000 patient-days, OR</span>  <!-->0.6; 95%CI 0.5–0.8), whereas in the NICU and in the wards remained stable. Mortality occurred mostly in NICU patients (26%), predominated in ELBW infants and did not change over time.</p></div><div><h3>Conclusions</h3><p>The higher incidence and mortality of candidemia and IC observed in preterm infants requires a continuous evaluation of practices and diagnostic methods which will allow improving the prognosis of this most vulnerable population.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38339678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3