Revista Iberoamericana De Micologia最新文献

{"title":"Mixed candidemia in a pediatric patient with Hirschsprung's disease","authors":"Bryan Ortiz , Kateryn Aguilar , Marco Luque , Kevin Díaz , Celeste Galindo , Daniel Rivera , Roque López , Gustavo Fontecha","doi":"10.1016/j.riam.2022.12.003","DOIUrl":"10.1016/j.riam.2022.12.003","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 1","pages":"Pages 15-16"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9246905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A promising candidate vaccine for coccidioidomycosis","authors":"F. Javier Cabañes","doi":"10.1016/j.riam.2022.03.002","DOIUrl":"10.1016/j.riam.2022.03.002","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 1","pages":"Pages 1-2"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances and challenges in the management of feline sporotrichosis","authors":"Isabella Dib Ferreira Gremião ,&nbsp;Luisa Helena Monteiro de Miranda ,&nbsp;Gabriela Reis Pereira-Oliveira ,&nbsp;Rodrigo Caldas Menezes ,&nbsp;Ana Caroline de Sá Machado ,&nbsp;Anderson Messias Rodrigues ,&nbsp;Sandro Antonio Pereira","doi":"10.1016/j.riam.2022.05.002","DOIUrl":"10.1016/j.riam.2022.05.002","url":null,"abstract":"<div><p>The domestic cat is the most susceptible host to <span><em>Sporothrix</em></span> infection, developing severe clinical forms. Few effective antifungal agents are available for treating feline sporotrichosis, and cases of treatment failure are common. Treatment success depends on cat health status, therapy-related factors, as well as social/economic issues, but it is mainly contingent upon the host–fungus interaction. The owner's adherence is critical and should be reinforced throughout the treatment to increase the chances of a successful outcome. The antifungal agents described for feline sporotrichosis are most often used in monotherapy regimens. Due to cases in which the treatment with itraconazole failed, the use of antifungal agents in combination should be considered to achieve synergy. The combination of itraconazole and potassium iodide represents an important option for the treatment of <em>naïve</em> cats presenting multiple cutaneous lesions, nasal mucosal lesions and/or respiratory signs, as well as for refractory cases. However, the therapeutic options for unsuccessfully treated cases are scarce. Therefore new options are needed, even more taking into account that there are many <em>in vitro</em> potential molecules not available for use in cats yet. More studies are necessary to correlate <em>in vitro</em> antifungal susceptibility tests results and the outcome of cats treated due to sporotrichosis. This review will briefly discuss both the antifungal drugs and treatment protocols used in cats with sporotrichosis, as well as the determinants of treatment failure.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 3","pages":"Pages 61-67"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10379857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversal of itraconazole resistance in Sporothrix brasiliensis and Sporothrix schenckii by nonsteroidal anti-inflammatory drugs","authors":"Gabriela Seibert ,&nbsp;Ana Luisa Reetz Poletto ,&nbsp;Jennifer Veppo Prade ,&nbsp;Débora Nunes Mario ,&nbsp;Cheila Denise Ottonelli Stopiglia","doi":"10.1016/j.riam.2022.01.003","DOIUrl":"10.1016/j.riam.2022.01.003","url":null,"abstract":"<div><h3>Background</h3><p>The emergence of resistant isolates has brought challenges to the treatment of sporotrichosis, prompting the search for new therapeutic strategies. Previous studies reported that nonsteroidal anti-inflammatory drugs (NSAIDs) show in vitro activity against several pathogenic fungi, including species of <em>Candida</em>, <span><em>Cryptococcus</em></span>, and <span><em>Trichosporon</em></span>.</p></div><div><h3>Aims</h3><p>This study aimed to investigate the in vitro efficacy of three NSAIDs (acetylsalicylic acid, diclofenac sodium, and ibuprofen), alone and in combination with itraconazole, against eleven clinical isolates of <em>Sporothrix brasiliensis</em> and <span><em>Sporothrix schenckii</em></span>.</p></div><div><h3>Methods</h3><p>Minimal inhibitory concentrations were determined by the broth microdilution method. Drug interactions and the fractional inhibitory concentration index of NSAIDs and itraconazole were assessed by the checkerboard method.</p></div><div><h3>Results</h3><p>When used alone, ibuprofen was the most active NSAID, followed by acetylsalicylic acid. Combinations of NSAIDs with itraconazole showed synergistic antifungal activity against nine isolates. It was also found that itraconazole combined with acetylsalicylic acid, diclofenac sodium, or ibuprofen, led to resistance reversal in two, three, and five of the six drug-resistant isolates, respectively.</p></div><div><h3>Conclusions</h3><p>The results indicate that the combination of itraconazole and the evaluated NSAIDs are a promising strategy for the treatment of sporotrichosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 3","pages":"Pages 68-71"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manuel Pereiro Miguens (1921-2022)","authors":"","doi":"10.1016/j.riam.2022.11.001","DOIUrl":"10.1016/j.riam.2022.11.001","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 3","pages":"Pages 57-58"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S113014062200033X/pdfft?md5=bf479bc8f29d280fe7e8ba767c87ec01&pid=1-s2.0-S113014062200033X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123639681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lobomycosis and paracoccidioidomycosis meet again","authors":"F. Javier Cabañes","doi":"10.1016/j.riam.2022.01.002","DOIUrl":"10.1016/j.riam.2022.01.002","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 3","pages":"Pages 59-60"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1130140622000043/pdfft?md5=10bf07b6d545ad2ea6f3810bb403e9d9&pid=1-s2.0-S1130140622000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10811673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeohyphomycosis caused by Neoscytalidium dimidiatum in a COVID-19 patient","authors":"Somayeh Dolatabadi ,&nbsp;Sara Nasirharandi ,&nbsp;Morteza Pourahmad ,&nbsp;Kazem Ahmadikia ,&nbsp;Mojgan Mokhtari ,&nbsp;Mohammad Javad Najafzadeh ,&nbsp;Rasoul Mohammadi","doi":"10.1016/j.riam.2022.07.002","DOIUrl":"10.1016/j.riam.2022.07.002","url":null,"abstract":"<div><h3>Background</h3><p><em>Neoscytalidium</em> <em>dimidiatum</em><span> is an opportunistic dematiaceous fungus belonging to the class Dothideomycetes.</span></p></div><div><h3>Case report</h3><p>We report a case of <em>N. dimidiatum</em> cerebral phaeohyphomycosis post COVID-19 infection in a 32-year-old male from Iran. The causative agent was identified by cytopathology, routine mycological methods, and DNA sequencing of the internal transcribed spacer (ITS) region of rDNA. Apart from COVID-19 complications and the corticosteroid therapy, no underlying condition was diagnosed. The symptoms suggesting the fungal infection were shown two weeks after being discharged from COVID-19 hospital stay. Magnetic resonance of the brain showed a multi-focal central nervous system infection. The delayed identification of the fungus and, thus, a late starting of the antifungal treatment with amphotericin B, might have affected the patient outcome as he finally died.</p></div><div><h3>Conclusions</h3><p>Considering the rare incidence of <em>N. dimidiatum</em> infections, this case should aware us about them, leading to a timely antifungal management.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 3","pages":"Pages 72-76"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Candida albicans and Staphylococcus aureus polymicrobial biofilm on different surfaces","authors":"Eduardo Hernandez-Cuellar ,&nbsp;Alma Lilián Guerrero-Barrera ,&nbsp;Francisco Javier Avelar-Gonzalez ,&nbsp;Juan Manuel Díaz ,&nbsp;Alfredo Salazar de Santiago ,&nbsp;Jesús Chávez-Reyes ,&nbsp;Emanuel Poblano-Sánchez","doi":"10.1016/j.riam.2022.04.001","DOIUrl":"10.1016/j.riam.2022.04.001","url":null,"abstract":"<div><h3>Background</h3><p><em>Staphylococcus aureus</em> and <em>Candida albicans</em> have been co-isolated from biofilm-associated diseases such as denture stomatitis, periodontitis, and burn wound infections, as well as from medical devices. However, the polymicrobial biofilm of both microorganisms has not been fully characterized.</p></div><div><h3>Aims</h3><p>To characterize the polymicrobial biofilm of <em>C. albicans</em> and <em>S. aureus</em> in terms of microbial density, synergy, composition, structure, and stability against antimicrobials and chemical agents.</p></div><div><h3>Methods</h3><p>Crystal violet assay was used to measure the biofilm formation. Scanning electron microscopy and confocal microscopy were used to analyze the structure and chemical composition of the biofilms, respectively.</p></div><div><h3>Results</h3><p>Supplemented media with fetal bovine serum (FBS) decreased the biofilm formation of <em>S. aureus</em> and the polymicrobial biofilm. For <em>C. albicans</em>, depending on the culture media, the addition of glucose or FBS had a positive effect in biofilm formation. FBS decreased the adhesion to polystyrene wells for both microorganisms. Supplementing the media with glucose and FBS enhanced the growth of <em>C. albicans</em> and <em>S. aureus</em>, respectively. It seems that <em>C. albicans</em> contributes the most to the adhesion process and to the general structure of the biofilms on all the surfaces tested, including a catheter model. Interestingly, <em>S. aureus</em> showed a great adhesion capacity to the surface of <em>C. albicans</em> in the biofilms. Proteins and β-1,6-linked polysaccharides seem to be the most important molecules in the polymicrobial biofilm.</p></div><div><h3>Conclusions</h3><p>The polymicrobial biofilm had a complex structure, with <em>C. albicans</em> serving as a scaffold where <em>S. aureus</em> adheres, preferentially to the hyphal form of the fungus. Detection of polymicrobial infections and characterization of biofilms will be necessary in the future to provide a better treatment.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 2","pages":"Pages 36-43"},"PeriodicalIF":1.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1130140622000171/pdfft?md5=247b42127876dfcc26fdbcfb5390128f&pid=1-s2.0-S1130140622000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40333691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saprolegniosis: A reemerging disease","authors":"F. Javier Cabañes","doi":"10.1016/j.riam.2021.12.001","DOIUrl":"10.1016/j.riam.2021.12.001","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 2","pages":"Pages 29-30"},"PeriodicalIF":1.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillosis by cryptic Aspergillus species: A case series and review of the literature","authors":"Mariana Fernandez-Pittol ,&nbsp;Izaskun Alejo-Cancho ,&nbsp;Elisa Rubio-García ,&nbsp;Celia Cardozo ,&nbsp;Pedro Puerta-Alcalde ,&nbsp;Estela Moreno-García ,&nbsp;Nicole Garcia-Pouton ,&nbsp;Miriam Garrido ,&nbsp;Miriam Villanueva ,&nbsp;Ana Alastruey-Izquierdo ,&nbsp;Cristina Pitart ,&nbsp;Carolina Garcia-Vidal ,&nbsp;Francesc Marco","doi":"10.1016/j.riam.2022.04.002","DOIUrl":"10.1016/j.riam.2022.04.002","url":null,"abstract":"<div><h3>Background</h3><p>The cryptic <em>Aspegillus</em> species are rare, these microorganisms are usually more resistant to common antifungal therapies. Therefore, a correct identification is important when evaluating the impact of such species in aspergillosis.</p></div><div><h3>Aims</h3><p>We aimed to describe the frequency, clinical and microbiological characteristics, and the outcomes of those cases of aspergillosis caused by cryptic species in a tertiary hospital.</p></div><div><h3>Methods</h3><p>We retrospectively identified all microbiologically documented cases of aspergillosis between January 2013 and December 2018. Definitive species identification of clinically significant isolates was achieved via sequencing methods. The polymerase chain reaction (PCR) products were sequenced, and the results obtained were compared to sequences deposited in GenBank. Antifungal susceptibility testing was performed using the Sensititre® YeastOne® panel.</p></div><div><h3>Results</h3><p>A total of 679 <span><em>Aspergillus</em></span> isolates were recovered from 489 patients, of which 109 were clinically relevant. Ten (9.2%) isolates were identified as cryptic species: <em>Aspergillus arcoverdensis</em> (2), <em>Aspergillus lentulus</em> (2), <em>Aspergillus ellipticus</em> (2), <em>Aspergillus alliaceus</em> (1), <em>Aspergillus nomius</em> (1), <em>Aspergillus tubingensis</em> (1) and <em>Aspergillus montevidensis</em> (1). Most patients already suffered some type of immunosuppression. Half of these patients had required intensive care before the infection showed up, and most of them had a pulmonary infection. Mortality at the 100-day follow-up was 40%. Antifungal susceptibility testing was performed on three of the isolates (<em>A. arcoverdensis</em>, <em>A. tubingensis</em> and <em>A. nomius</em><span>), which showed high minimum inhibitory concentrations (MIC) for azoles and amphotericin B.</span></p></div><div><h3>Conclusions</h3><p>The frequency of cryptic species in our centre was 9.2%. Most patients had some degree of immunosuppression, and the mortality rate was 40%.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"39 2","pages":"Pages 44-49"},"PeriodicalIF":1.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40398060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}