Revista Iberoamericana De Micologia最新文献

{"title":"Candida and candidiasis in Portugal: Past situation, current trends and future challenges","authors":"Raquel Sabino","doi":"10.1016/j.riam.2026.04.002","DOIUrl":"10.1016/j.riam.2026.04.002","url":null,"abstract":"<div><div><em>Candida</em> infections are among the most common fungal diseases globally, with candidemia posing a serious threat in hospitalized and immunocompromised patients. In Portugal, though <em>Candida albicans</em> is the predominant species identified, other species such as <em>Candida parapsilosis</em> and <em>Nakaseomyces glabratus</em> (formerly <em>Candida glabrata</em>) are increasingly detected, particularly in intensive care units and patients with invasive devices. Emerging multidrug-resistant strains, notably <em>Candidozyma auris</em> (formerly <em>Candida auris</em>), have raised significant concern, with the first Portuguese cases reported recently. Surveillance studies suggest that antifungal resistance rates are generally low, though fluconazole resistance in <em>C. parapsilosis</em> is a concern, since <em>ERG11</em> mutations were recently detected in several isolates. Echinocandins are recommended as first-line therapy, yet availability is uneven across healthcare centers. Beyond candidemia, superficial infections like vulvovaginal candidiasis and onychomycosis remain highly frequent. Different research groups in Portugal have been conducting active research into <em>Candida</em> biology, virulence and novel therapies. Strengthening surveillance, rapid diagnostics, molecular identification, and infection control measures, alongside mandatory notification of <em>C. auris</em>, are critical for effective management. Integrated strategies under a “One Health” framework are essential to mitigate morbidity, mortality, and resistance trends associated with <em>Candida</em> infections.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 3","pages":"Pages 84-87"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clade-dependent antifungal resistance and susceptibility in Candidozyma auris: A global scoping review","authors":"Lucero A. Martinez Delgado,&nbsp;Christopher G. Pierce,&nbsp;Giselle D. Carnaby,&nbsp;Jose L. López-Ribot","doi":"10.1016/j.riam.2026.04.003","DOIUrl":"10.1016/j.riam.2026.04.003","url":null,"abstract":"<div><h3>Background</h3><div><em>Candidozyma auris</em> (formerly <em>Candida auris</em>) is an emerging multidrug-resistant fungal pathogen that has spread globally since its first identification in 2009 and is now classified as a critical-priority pathogen by the World Health Organization. Distinct genetic clades are associated with variations in geographic distribution, antifungal susceptibility, and resistance mechanisms; however, clade-specific evidence remains fragmented.</div></div><div><h3>Aims</h3><div>To systematically map global evidence on clade diversity, antifungal susceptibility patterns, resistance mechanisms, and clinical implications of <em>C. auris</em>.</div></div><div><h3>Methods</h3><div>A scoping review was conducted following PRISMA-ScR guidelines. Peer-reviewed primary studies published between 2009 and September 2025 were included if they reported clade attribution and antifungal susceptibility or resistance data. PubMed/MEDLINE, Scopus, and Web of Science were searched. Two reviewers independently screened studies and extracted data using a standardized form.</div></div><div><h3>Results</h3><div>Of 2050 records identified, 105 studies met inclusion criteria, representing 29 countries and diverse study designs. Whole-genome sequencing was the most common typing method. Antifungal susceptibility varied substantially across clades. High fluconazole resistance was consistently reported (MIC 4 to &gt;256<!--> <!-->μg/mL). Echinocandins generally retained activity, although reduced susceptibility associated with FKS1 mutations was observed. Resistance mechanisms primarily involved mutations in ERG11, FKS1, and efflux-related genes. Studies also reported challenges in healthcare-associated transmission, environmental persistence, and diagnostic misidentification.</div></div><div><h3>Conclusions</h3><div><em>C. auris</em> exhibits marked clade-dependent variability in antifungal susceptibility and resistance mechanisms. These findings support the need for clade-informed interpretation of susceptibility data, standardized surveillance, improved diagnostics, and development of novel antifungal therapies.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 3","pages":"Pages 75-83"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problemas clínicos en Micología Médica: problema número 58","authors":"Fernando Messina,&nbsp;Emmanuel Marín,&nbsp;Roxana Depardo,&nbsp;Alicia Arechavala,&nbsp;Graciana Cárdenas,&nbsp;Mercedes Romero,&nbsp;Ricardo Negroni,&nbsp;Gabriela María Santiso","doi":"10.1016/j.riam.2026.04.004","DOIUrl":"10.1016/j.riam.2026.04.004","url":null,"abstract":"<div><div>We hereby present the case of a 53-year-old HIV-positive man who had poor adherence to antiretroviral treatment for 15 years. He was referred to the hospital due to weight loss, skin lesions suggestive of Kaposi's sarcoma, poor general health, and confusion. After a lumbar puncture, treatment for meningeal tuberculosis was initiated on an empirical basis. A few days later he developed fever and, due to several risk factors, fungemia was suspected. After the fungus was isolated in blood culture, special tests were performed for definitive identification. Despite treatment, the patient died of fungemia due to a non–<em>Candida</em> yeast–like fungus, which has a high mortality rate in this patient group.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 3","pages":"Pages 116-119"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and treatment patterns of isavuconazole in real-world use in Mexico: A retrospective study of 25 patients","authors":"Monserrat Massó-Páez,&nbsp;Sandra Guzmán-Tepetla,&nbsp;Aitana Valencia-Sánchez,&nbsp;Itaivet Toledo-Vigueras,&nbsp;María del Rosario Ordaz-Cuéllar,&nbsp;Armando Barragán-Reyes,&nbsp;Daniel Aguilar-Zapata","doi":"10.1016/j.riam.2026.03.002","DOIUrl":"10.1016/j.riam.2026.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Isavuconazole is a broad-spectrum antifungal used for the treatment of critical fungal infections like invasive aspergillosis and mucormycosis. In 2019, isavuconazole was approved as an orphan drug in Mexico.</div></div><div><h3>Aims</h3><div>Médica Sur Hospital is a tertiary-level hospital in Mexico City where we have had access to isavuconazole since its approval. Five years after approval, we decided to study its clinical outcomes in real-world settings.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study of a cohort of adult patients treated with isavuconazole in our hospital from 2019 to 2024.</div></div><div><h3>Results</h3><div>We included data from 25 patients meeting the inclusion criteria, with a mean age of 57 years. Eight patients had hematologic disease, eleven presented with COVID-19-associated pulmonary aspergillosis (CAPA), and six patients had an invasive fungal infection in the intensive care unit (according to FUNDICU). The mean duration of isavuconazole use was 12.3 days (± 10.3 days). The main reasons for using isavuconazole were the ease of prescription (ten patients), as primary therapy in aspergillosis (six patients), after withdrawal of other triazole because of adverse events (three patients), a need to change to oral antifungal after an intravenous antifungal therapy (four patients), and as prophylaxis in stem cell transplantation (two patients).</div></div><div><h3>Conclusions</h3><div>Results on the use of isavuconazole in real-world clinical practice have shown that it is both well-tolerated and effective in a hospital setting in Mexico.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 3","pages":"Pages 88-95"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental continuum of Candidozyma auris: From sapronotic ecology to outbreak prediction and control with a One Health perspective","authors":"Victor Garcia-Bustos","doi":"10.1016/j.riam.2026.01.001","DOIUrl":"10.1016/j.riam.2026.01.001","url":null,"abstract":"<div><div><em>Candidozyma auris</em> (formerly <em>Candida auris</em>) has emerged within just over a decade as one of the most relevant multidrug-resistant fungal pathogens affecting human health worldwide. Its pathogenicity, capacity for skin colonization, environmental persistence, and resistance to antifungal drugs and disinfectants have all contributed to its consolidation as a leading cause of healthcare-associated outbreaks. Nevertheless, increasing evidence indicates that <em>C. auris</em> should not be viewed solely as a nosocomial yeast, but rather as part of a broader environmental continuum encompassing natural habitats, anthropogenic niches, and multiple host species. Environmental isolates have been documented in coastal wetlands, wastewater systems, agricultural products, as well as in diverse animals – including companion animals, reptiles, amphibians, and insects – supporting its classification as a sapronotic pathogen. The near-simultaneous emergence of distinct clades across continents strongly suggests that climate change, agricultural azole exposure, and ecological adaptation have collectively selected strains exhibiting thermotolerance, antifungal resistance, and cross-kingdom persistence, thereby enabling recurrent spillover into human populations. Recent advances in wastewater-based epidemiology demonstrate that <em>C. auris</em> can be detected at the community level, often preceding clinical recognition, while animal colonization underscores its overlooked role in pathogen maintenance and transmission networks. This review synthesizes current evidence on the ecological, evolutionary, and epidemiological determinants of <em>C. auris</em>, positioning outbreaks as amplification phenomena within interconnected ecological systems rather than isolated nosocomial events. Adoption of a One Health framework, integrating environmental, veterinary, and human health surveillance, will be essential for predictive outbreak modeling, early detection, and the development of sustainable strategies to mitigate the ongoing and future threats posed by this emerging fungal pathogen.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 40-45"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro effects of IFN-γ, IL-4 and IL-27 on human bronchial epithelial cells infected with Cryptococcus neoformans sensu stricto","authors":"João Batista Camargo Neto ,&nbsp;Maiara Medeiros Cunha ,&nbsp;Wanessa Maria dos Santos ,&nbsp;Leonardo Euripedes Andrade Silva ,&nbsp;Paulo Roberto da Silva ,&nbsp;David Nascimento Silva Teixeira ,&nbsp;Mario Leon Silva-Vergara ,&nbsp;Alexandre Paula Rogerio","doi":"10.1016/j.riam.2026.01.002","DOIUrl":"10.1016/j.riam.2026.01.002","url":null,"abstract":"<div><h3>Background</h3><div>The innate immune response and cytokine milieu in airway mucosa, mediated by bronchial epithelial cells, are critical in determining susceptibility or protection against cryptococcosis. In experimental models, Th2 and Th1 responses are linked to susceptibility and protection, respectively, while the roles of other cytokines remain less understood.</div></div><div><h3>Aims</h3><div>To evaluate the in vitro effects of IL-4, IFN-γ, and IL-27 (100<!--> <!-->ng/mL) on human bronchial epithelial cells (BEAS-2B) infected with a strain of <em>Cryptococcus neoformans sensu stricto</em> (multiplicities of infection [MOI] 1–100).</div></div><div><h3>Methods</h3><div>Cells were stimulated with each cytokine, followed by <em>C. neoformans</em> infection (MOI 100). After 24<!--> <!-->h, supernatants were collected to measure CCL2, IL-6, and IL-8 production. STAT1 and STAT6 activation was analyzed by flow cytometry. Phagocytosis and colony-forming unit assays assessed fungal internalization and growth.</div></div><div><h3>Results</h3><div>Cytokine-stimulated, infected cells displayed reduced IL-6 and/or CCL2 production and decreased STAT6 activation (IL-4) or STAT1 activation (IL-27, IFN-γ) compared with cells stimulated with <em>C. neoformans sensu stricto</em> or cytokines alone. IL-27 reduced fungal internalization, while IL-4 and IFN-γ increased it. All cytokines promoted higher fungal growth.</div></div><div><h3>Conclusions</h3><div>The interaction of bronchial epithelial cells stimulated with IL-4, IFN-γ, or IL-27, with yeasts of <em>C. neoformans</em> induced an anti-inflammatory profile in the cells that impaired STAT activation and favored fungal proliferation. These findings suggest that certain cytokine environments within the airway epithelium may create conditions conducive to <em>C. neoformans</em> persistence, potentially influencing the progression of the infection.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 27-35"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filamentous fungi, and their antifungal susceptibilities, isolated from patients at an oncology hospital in Turkey","authors":"Ayşe Semra Güreser ,&nbsp;Nilgün Karabıçak ,&nbsp;Serap Süzük Yıldız ,&nbsp;Mert Emre Ölmez ,&nbsp;İpek Mumcuoğlu ,&nbsp;Neşe İnan ,&nbsp;Turgay Ulaş ,&nbsp;Mehmet Sinan Dal ,&nbsp;Gülşen İskender ,&nbsp;Tuba Dal","doi":"10.1016/j.riam.2026.01.003","DOIUrl":"10.1016/j.riam.2026.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Fungal infections affect especially to patients with cancer and those who are immunocompromised.</div></div><div><h3>Aims</h3><div>We analyzed the prevalence of filamentous fungi in patients at Ankara Oncology Education and Research Hospital from 2022 to 2024; antifungal susceptibility tests were also carried out.</div></div><div><h3>Methods</h3><div>Filamentous fungi were analyzed by MALDI-TOF (matrix-assisted laser desorption ionization-time of flight), and antifungal susceptibility was tested by the broth microdilution method.</div></div><div><h3>Results</h3><div>Filamentous fungi were recovered from 66 (6.5%) of 1020 samples: 31(47%) deep tracheal aspirates, 13 (19.7%) sputum, 10 (15.2%) ear swabs, nine (13.6%) biopsies, and three (4.5%) bronchoalveolar lavage samples. Filamentous fungi other than <em>Aspergillus</em> grew from 10 (15.2%) samples, while <em>Aspergillus</em> species were recovered in 56 (84.8%). Of the 56 <em>Aspergillus</em>, 21 (31.8%) were <em>Aspergillus fumigatus</em>, 15 (22.7%) were <em>Aspergillus flavus</em>, 14 (21.2%) were <em>Aspergillus niger</em>, three (4.5%) were <em>Aspergillus terreus</em>, and one strain (1.5%) each of the following species were identified: <em>Aspergillus tamarii</em>, <em>Aspergillus nidulans</em>, and <em>Aspergillus calidoustus.</em> Of 66 patients from whom a fungal isolate was recovered, 50 (75.8%) had cancer.</div><div>Minimum inhibitory concentrations (MICs) were determined in 45 (80.4%) <em>Aspergillus</em> isolates. Eight (8/19) <em>A. fumigatus,</em> seven (7/13) <em>A. flavus</em>, and three (3/11) <em>A. niger</em> were non-wild type (WT) according to amphotericin B MIC values. Four (4/13) <em>A. flavus</em> and two (2/19) <em>A. fumigatus</em> were non-WT according to itraconazole MIC values. One (1/13) <em>A. flavus</em> was non-WT according to voriconazole MIC value.</div></div><div><h3>Conclusions</h3><div>The filamentous fungi recovered from the patients showed high antifungal MIC/MEC values, and some isolates had high amphotericin B MICs. Voriconazole was effective in vitro against <em>A. fumigatus</em>.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 36-39"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of Sporothrix brasiliensis in a Southern Giant Petrel (Macronectes giganteus): Implications for One Health","authors":"Vanice Rodrigues Poester ,&nbsp;Mariana Rodrigues Trápaga ,&nbsp;Jessica E. Dávila Hidalgo ,&nbsp;Lívia Silveira Munhoz ,&nbsp;Aryse Martins Melo ,&nbsp;Emanoel Bartz Tapi ,&nbsp;Paula Lima Canabarro ,&nbsp;Theun de Groot ,&nbsp;Bram Spruijtenburg ,&nbsp;Eelco F.J. Meijer ,&nbsp;Melissa Orzechowski Xavier","doi":"10.1016/j.riam.2026.03.001","DOIUrl":"10.1016/j.riam.2026.03.001","url":null,"abstract":"<div><h3>Background</h3><div><em>Sporothrix brasiliensis</em> is an emerging fungal pathogen whose environmental reservoirs remain unclear. There are hypothesized reservoirs involving seabirds.</div></div><div><h3>Case report</h3><div>We report the first detection of <em>S. brasiliensis</em> in a <em>Macronectes giganteus</em> specimen rescued in southern Brazil. The fungus was isolated from the cloaca and identified by polymerase chain reaction (PCR) and sequencing. Short tandem repeat (STR) genotyping revealed a distinct profile of the isolate compared to previously described strains. The results revealed that the isolate possessed a wild-type susceptibility profile to amphotericin B and itraconazole, and a non-wild-type susceptibility profile to terbinafine.</div></div><div><h3>Conclusions</h3><div>Findings suggest that migratory seabirds and marine environments may influence <em>S. brasiliensis</em> dissemination, underscoring the need for broader One Health surveillance at a global level.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 71-74"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of ELISA in sporotrichosis: A systematic review and meta-analysis","authors":"Débora Matilde de Almeida ,&nbsp;Gabriel Peres Messenburger ,&nbsp;Eduarda Santos Bierhals ,&nbsp;Sérgio Jorge ,&nbsp;Márcia de Oliveira Nobre","doi":"10.1016/j.riam.2025.11.002","DOIUrl":"10.1016/j.riam.2025.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Sporotrichosis is a subcutaneous mycosis caused by the traumatic inoculation of dimorphic fungi from the genus <em>Sporothrix</em>. Traditional diagnostic methods, including direct microscopy and fungal culture, are time-consuming, require specialized expertise, and may yield false-negative results.</div></div><div><h3>Aims</h3><div>This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of the enzyme-linked immunosorbent assay (ELISA) technique in detecting sporotrichosis in humans and animals.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across PubMed, LILACS, EMBASE, Scopus, Web of Science, ScienceDirect, CAPES Periodicals, and the Cochrane Library using both free-text terms and MeSH descriptors. The methodological quality of the studies included was assessed using the QUADAS-2 tool. Pooled sensitivity and specificity were estimated using a random-effects model. Secondary outcomes included the positive and negative likelihood ratios and the diagnostic odds ratio (DOR).</div></div><div><h3>Results</h3><div>Twelve studies met the inclusion criteria, comprising 1612 samples (1350 human and 262 feline). ELISA demonstrated a pooled sensitivity of 91% (95% CI: 85–94) and specificity of 90% (95% CI: 86–93), with a DOR of 94.2 (95% CI: 46.9–189.1). Subgroup analysis revealed higher diagnostic performance in feline samples, particularly when crude antigen extracts and combined fungal forms were used.</div></div><div><h3>Conclusions</h3><div>ELISA exhibits high diagnostic accuracy for sporotrichosis in both human and veterinary contexts. Its performance, especially in feline hosts, supports its potential role as a reliable diagnostic alternative to conventional methods.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 46-54"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal activity of rezafungin in invasive candidiasis: From bench to bed","authors":"Guillermo Quindós ,&nbsp;Carolina Garcia-Vidal ,&nbsp;Xabier Martin-Martitegui ,&nbsp;Rafael Zaragoza","doi":"10.1016/j.riam.2026.02.001","DOIUrl":"10.1016/j.riam.2026.02.001","url":null,"abstract":"<div><div>Invasive mycoses present significant medical challenges, with new populations at risk and the emergence of antifungal resistance. Therapeutic options for antifungal treatment are limited and further complicated by drug–drug interactions, toxicity, and constraints in administration routes. Despite the urgent need for more antifungal drugs, few new antifungal drugs have been introduced over the past decades. Nevertheless, there is hope on the horizon, with new antifungal drugs approved or in late-stage clinical trials.</div><div>In this review, we critically examine the antifungal activity of rezafungin, a new-generation echinocandin with distinctive PK/PD properties, including high stability that enables once-weekly dosing, as well as elevated peak concentrations (<em>C</em>_max) and area under the curve (AUC) values, and its therapeutic utility in the treatment of invasive candidiasis. We focus on its mechanism of action, as well as on its broad spectrum of activity against emergent species of <em>Candida</em> and other pathogenic fungi. Additionally, we highlight its utility in the treatment of candidemia and other forms of invasive candidiasis in various medical settings, and the potential future roles of rezafungin and the unmet needs in this field.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"43 2","pages":"Pages 55-70"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}