Revista Iberoamericana De Micologia最新文献

{"title":"Scedosporium boydii finding in an immunocompromised patient and review of the literature","authors":"Silvana Ramadán ,&nbsp;Hernán Dalmaso ,&nbsp;Alicia Luque ,&nbsp;Maximiliano Sortino ,&nbsp;María Luján Cuestas ,&nbsp;Katherine Hermida Alava ,&nbsp;Diego Bertola ,&nbsp;Lucía Bulacio","doi":"10.1016/j.riam.2023.10.001","DOIUrl":"10.1016/j.riam.2023.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Scedosporiasis is an emerging mycosis that has gained importance in recent years due to its worldwide prevalence. It is caused by species of the <span><span>Scedosporium apiospermum</span></span> complex. These species can cause opportunistic infections in immunocompromised patients and, occasionally, in immunocompetent patients as well. The high intrinsic antifungal resistance make these infections difficult to manage.</div></div><div><h3>Aims</h3><div>The objective of this study was to interpret the mycological findings in a transplant patient, together with the images obtained in the radiological studies, in order to provide an early and effective antifungal therapy.</div></div><div><h3>Methods</h3><div>The mycological analysis of samples taken from a heart transplant patient with radiological images suggesting a fungal infection was performed. Computed tomography scan of the head and thorax showed space-occupying lesions in both the frontal lobe and cerebellum, and multiple pulmonary nodules. The nodules were punctured and the samples obtained were analyzed according to the procedures for mycological analysis. The identity of the isolates was confirmed by nucleotide sequencing. Eventually, the antifungal susceptibility was studied.</div></div><div><h3>Results</h3><div>The fungal isolates obtained, whose identity was confirmed by sequencing, belonged to the species <span><span>Scedosporium boydii</span></span>. Injured tissues were surgically removed and a treatment with amphotericin B and voriconazole-minimum inhibitory concentration (MIC) 0.5<!--> <!-->μg/mL and ≥0.5<!--> <!-->μg/mL respectively – was administered.</div></div><div><h3>Conclusions</h3><div>Although the patient died due to complications of a <span><span>Klebsiella pneumoniae</span></span><span> sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.</span></div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 4","pages":"Pages 39-44"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of filamentous basidiomycetes from respiratory samples in a tertiary care Spanish hospital","authors":"Iker Falces-Romero ,&nbsp;Inmaculada Quiles-Melero ,&nbsp;Julio García-Rodríguez","doi":"10.1016/j.riam.2023.11.001","DOIUrl":"10.1016/j.riam.2023.11.001","url":null,"abstract":"<div><h3>Background</h3><div>The clinical significance of the filamentous basidiomycetes isolated from clinical samples is not always clear. Thus, these fungi have been considered environmental contaminants traditionally.</div></div><div><h3>Aims</h3><div>To review those clinical cases in which filamentous basidiomycetes from respiratory samples had been isolated.</div></div><div><h3>Methods</h3><div>The retrospective study was carried out in a single tertiary care hospital. We recovered all culture-confirmed isolations of filamentous basidiomycetes from respiratory samples (bronchial aspirate [BAS], bronchoalveolar lavage [BAL] and sputum) analyzed between the years 2020 and 2023. Isolates were identified by ITS region sequencing.</div></div><div><h3>Results</h3><div>In six patients a filamentous basidiomycete had been isolated from a respiratory sample. The species identified were all different: <span><span>Fomitopsis</span></span> sp. (BAS), <span><span>Trametes</span><em> ljubarskyi</em></span> (BAL), <em>Stereum gausapatum</em> (BAS), <em>Porostereum spadiaceum</em> (BAS), <em>Phlebia subserialis</em> (sputum) and <span><em>Inonotus</em><em> levis</em></span> (BAL). All the patients were immunosuppressed or had an underlying disease with pulmonary involvement. None of them received any specific antifungal treatment (in relation with the fungus isolated) and all six improved clinically and were discharged.</div></div><div><h3>Conclusions</h3><div>The isolation of filamentous basidiomycetes in these patients had uncertain clinical significance. However, the isolation of any filamentous basidiomycete in respiratory samples from immunosuppressed patients or patients with chronic pulmonary disease is an emerging situation that should be carefully assessed in the context of chronic allergic episodes or suspicion of invasive fungal infections.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 4","pages":"Pages 51-53"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new endophytic species of Microthecium (Melanosporales, Sordariomycetes, Pezizomycotina, Ascomycota) from Mallorca (Balearic Islands, Spain)","authors":"Alberto M. Stchigel ,&nbsp;José F. Cano-Lira ,&nbsp;Ángel Pintos-Amengual","doi":"10.1016/j.riam.2023.10.002","DOIUrl":"10.1016/j.riam.2023.10.002","url":null,"abstract":"<div><h3>Background</h3><div>The genus <em>Microthecium</em> contains 31 species worldwide distributed. Most of them are saprobic on soil and plant debris, but a few have been reported as mycoparasites on hypocrealean fungi. By contrast, this genus has never been reported as phytopathogenic, nor endophytic.</div></div><div><h3>Aims</h3><div>To isolate and identify endophytic fungi from Mediterranean herbaceous plants and trees in order to contribute to the knowledge of the hosts and their geographical location. The present work has been focused on the study of endophytic fungi of hawthorn (<em>Crataegus monogyna</em>).</div></div><div><h3>Methods</h3><div>The following steps were taken: i, isolation of the fungal strain from living stems of <em>C. monogyna</em>; ii, cultural and micro-morphological study, and iii, sequence comparison of different genetic markers by BLAST search with sequences deposited in GenBank.</div></div><div><h3>Results</h3><div>At the present work we describe a new species of the genus, <em>Microthecium pleomorphosporum</em>, isolated from living stems of <em>C. monogyna</em> in Mallorca (Balearic Islands, Spain). This fungus is characterized by the production of non-ostiolate perithecia and two sorts of ascospores (some smooth-walled, others delicately reticulated) bearing a germ pore at each end which are frequently ornamented by a surrounding donut-like structures, and a phialidic asexual morph and bulbils. The morphologically closest related species is <em>Microthecium tenuissimum</em>, which has bigger ascospores and lacks asexual reproduction. Phylogenetically, <em>M pleomorphosporum</em> is close-related to other species of the genus, although no genetic marker that discriminates this new species from other phylogenetically closer ones could be elucidated as a gold standard.</div></div><div><h3>Conclusions</h3><div><em>M. pleomorphosporum</em>, order Melanosporales, is reported here as the first endophytic species of <em>C. monogyna</em>.</div></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 4","pages":"Pages 45-50"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The number of species that cause blastomycosis is increasing","authors":"F. Javier Cabañes","doi":"10.1016/j.riam.2022.07.001","DOIUrl":"10.1016/j.riam.2022.07.001","url":null,"abstract":"","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 2","pages":"Pages 17-18"},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1130140622000316/pdfft?md5=f9dd7e2eb663f818949f544a68ce52b2&pid=1-s2.0-S1130140622000316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40453222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problemas clínicos en Micología Médica: problema número 56","authors":"Fernando Messina ,&nbsp;Emmanuel Marin ,&nbsp;Alejandro Sansostera ,&nbsp;Mercedes Romero ,&nbsp;Roxana Depardo ,&nbsp;Ricardo Negroni ,&nbsp;Blanca Leonel ,&nbsp;Gabriela Santiso","doi":"10.1016/j.riam.2022.12.001","DOIUrl":"10.1016/j.riam.2022.12.001","url":null,"abstract":"<div><p>We present the case of a twenty six year-old woman with rheumatoid arthritis, treated with certolizumab. She sought medical attention due to cough, fever and night sweats. X-ray exam showed a miliary pneumonia. She was treated for tuberculosis and 50<!--> <!-->days later she presented with aphasia. Magnetic nuclear resonance revealed brain lesions. <em>Histoplasma capsulatum</em> PCR test and urinary antigen were positive, so an antifungal treatment with voriconazole was started. Visual adverse effects forced to change the antifungal schedule in both the length of treatment and the antifungal drug. With this measure the patient progressed favorably. The test of urinary <em>Histoplasma capsulatum</em> antigen and PCR amplification were key to make a diagnosis and also for a follow-up.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 2","pages":"Pages 35-38"},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature","authors":"Muhammed Cihan Işık ,&nbsp;Oğuz Karcıoğlu ,&nbsp;Gülşen Hazırolan ,&nbsp;Dolunay Gülmez ,&nbsp;Mehmet Ruhi Onur ,&nbsp;Mehmet Mahir Kunt ,&nbsp;Sevtap Arikan-Akdagli ,&nbsp;Gökhan Metan","doi":"10.1016/j.riam.2023.05.001","DOIUrl":"10.1016/j.riam.2023.05.001","url":null,"abstract":"<div><h3>Background</h3><p>Immune checkpoint inhibitors (ICIs) are a promising new treatment for different types of cancer. The infectious complications in patients taking ICIs are rare.</p></div><div><h3>Case report</h3><p><span>A 58-year-old male who received chemotherapy consisting of pembrolizumab (PD-1 inhibitor) for esophagus squamous cell carcinoma one month before was admitted to the emergency room with shortness of breath soon after fiberoptic bronchoscopy, which was done for the inspection of the lower airway. A computed tomography of the chest revealed a progressive consolidation on the right upper lobe. </span><em>Salmonella</em> group D was isolated from the bronchoalveolar lavage (BAL) fluid culture. The fungal culture of the same clinical sample yielded <span><span>Aspergillus niger</span></span>; furthermore, a high titer (above the cut-off values) of <em>Aspergillus</em> antigen was found both in the BAL fluid and serum of the patient. Despite the effective spectrum and appropriate dose of antimicrobial treatment, the patient died due to disseminated intravascular coagulopathy.</p></div><div><h3>Conclusions</h3><p>Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 2","pages":"Pages 26-30"},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10265611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocarditis due to Candida albicans in an immunocompromised patient: A case report","authors":"José J. Flores-Patiño ,&nbsp;Mikel J. Durán-Pacheco ,&nbsp;Alondra M. Cázares-Marroquín ,&nbsp;José M. Gastélum-Cano ,&nbsp;María A. Islas-Osuna ,&nbsp;José A. Arízaga-Berber","doi":"10.1016/j.riam.2023.06.001","DOIUrl":"10.1016/j.riam.2023.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Fungal endocarditis is a low-frequency disease with a challenging diagnosis, as it can be mistaken with bacterial endocarditis. Fungal endocarditis causes higher mortality rates in immunocompromised patients. In the clinical practice, the endocarditis caused by fungi represents up to 10% of all infectious endocarditis cases and has a mortality rate of nearly 50%.</p></div><div><h3>Case report</h3><p>Here we present the case of a 53-year-old woman under corticosteroid therapy with a history of rheumatic heart disease, aortic valve replacement, and rheumatoid arthritis, who presented with fungal endocarditis caused by <span><em>Candida albicans</em></span>. Even though the patient received 3 years of antifungal prophylaxis with fluconazole, had valve replacement surgery, and received intensive care, the patient finally worsened and died.</p></div><div><h3>Conclusions</h3><p>Comorbidities and corticosteroid therapy predisposed the patient to acquire fungal endocarditis. This case highlights the importance of implementing procedures for the isolation and identification of fungi, and for carrying out antifungal-susceptibility testing, as well as establishing surveillance programs to identify infection-causing species and drug resistance patterns in hospitals. Moreover, designing and upgrading the algorithm for infectious endocarditis is the key to future improvements in diagnosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 2","pages":"Pages 31-34"},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41109919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the MALDI-TOF mass spectrometry technique for the identification of dermatophytes: Use of an extended database","authors":"Ivana Maldonado ,&nbsp;Silvia Relloso ,&nbsp;Liliana Guelfand ,&nbsp;Bárbara Fox ,&nbsp;Natalia Azula ,&nbsp;Vanesa Romano ,&nbsp;Agostina Cantore ,&nbsp;Rubén Barrios ,&nbsp;Susana Carnovale ,&nbsp;Ezequiel Nuske ,&nbsp;Patricia Minervini ,&nbsp;members of the Red de Micología de la Ciudad Autónoma de Buenos Aires [Mycology Network of the Autonomous City of Buenos Aires] (RMCABA)","doi":"10.1016/j.riam.2021.01.006","DOIUrl":"10.1016/j.riam.2021.01.006","url":null,"abstract":"<div><h3>Background</h3><p>Identification of dermatophytes is usually performed through morphological analyses. However, it may be hindered due to the discovery of new species and complexes and, with some isolates, by the absence of fructification. Matrix-assisted laser desorption/ionisation-time-of-flight mass spectrometry (MALDI-TOF MS) seems to be an option for improving identification.</p></div><div><h3>Aims</h3><p>To develop a database (DB) for the identification of dermatophytes with MALDI-TOF MS, including 32 isolates from the Red de Micología de la Ciudad Autónoma de Buenos Aires [Mycology Network of the Autonomous City of Buenos Aires] (RMCABA) and one reference isolate (RMCABA DB), and evaluate its performance when added to the DB from the supplier, Bruker (Bruker DB).</p></div><div><h3>Methods</h3><p>All the isolates in the RMCABA DB were identified based on morphology and sequencing. To evaluate the performance of the extended DB (Bruker DB plus RMCABA DB), 136 clinical isolates were included.</p></div><div><h3>Results</h3><p>The percentages of identification at the species level increased from 45% to 88%, but the identification at the genus level decreased from 23% to 7%.</p></div><div><h3>Conclusions</h3><p>MALDI-TOF MS yielded better performance in the identification of dermatophytes after including the RMCABA DB, which encompassed local isolates.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 2","pages":"Pages 19-25"},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surprising finding: The curious case of a tongue lesion misdiagnosed as paracoccidioidomycosis","authors":"Bert Gerrits van den Ende ,&nbsp;Anderson Messias Rodrigues ,&nbsp;Rosane Christine Hahn ,&nbsp;Ferry Hagen","doi":"10.1016/j.riam.2022.11.002","DOIUrl":"10.1016/j.riam.2022.11.002","url":null,"abstract":"<div><h3>Background</h3><p>Paracoccidioidomycosis is an endemic mycosis caused by members of the <em>Paracoccidioides</em> genus. Brazil remains the focus area and, to a lesser extent, the disease has been reported from Argentina, Colombia and Venezuela.</p></div><div><h3>Aims</h3><p>A Venezuelan <em>Paracoccidioides brasiliensis</em> strain, isolated from a patient diagnosed with chronic multifocal paracoccidioidomycosis, was subjected to whole genome sequencing to provide more insight about <em>Paracoccidioides</em> outside the endemic focus area.</p></div><div><h3>Methods</h3><p><em>P. brasiliensis</em> strain CBS 118890 was whole genome sequenced using nanopore; library preparation with the ‘native barcoding genomic DNA kit’ was followed by sequencing on Flongle and MinION flowcells. Batches of strain CBS 118890 were re-identified by sequencing the internal transcribed spacer (ITS) region, and final identification was made based on phylogenetic analysis.</p></div><div><h3>Results</h3><p>Surprisingly, the Venezuelan <em>P. brasiliensis</em> strain CBS 118890 turned out to be a <em>Nannizziopsis</em> species. The batches of this strain were ITS sequenced followed by phylogenetic analysis and resulted in the final identification of <em>Nannizziopsis arthrosporioides</em>.</p></div><div><h3>Conclusions</h3><p><em>Nannizziopsis</em> infections are commonly seen in a wide variety of reptiles, but are particularly rare in human infections. This case underlines the need for molecular characterization of cases that clinically mimic paracoccidioidomycosis but that are serologically negative for <em>Paracoccidioides</em>.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 1","pages":"Pages 10-14"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candida bloodstream infection in patients with cancer: A retrospective analysis of an 11-year period","authors":"Rodrigo Vázquez-Olvera ,&nbsp;Patricia Volkow ,&nbsp;Consuelo Velázquez-Acosta ,&nbsp;Patricia Cornejo-Juárez","doi":"10.1016/j.riam.2022.12.002","DOIUrl":"10.1016/j.riam.2022.12.002","url":null,"abstract":"<div><h3>Background</h3><p><em>Candida</em> bloodstream infection (CBSI) is a growing problem among patients with cancer.</p></div><div><h3>Aim</h3><p>To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.</p></div><div><h3>Methods</h3><p>We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital. Analysis was done according to the <em>Candida</em> species found. Multivariate logistic regression analysis was used to determine the risk factors associated with 30-day mortality.</p></div><div><h3>Results</h3><p>There were 147 CBSIs diagnosed, 78 (53%) in patients with hematologic malignancies. The main <em>Candida</em> species identified were <span><em>Candida albicans</em></span> (<em>n</em> <!-->=<!--> <!-->54), <span><em>Candida glabrata</em></span> (<em>n</em> <!-->=<!--> <!-->40) and <span><em>Candida tropicalis</em></span> (<em>n</em> <!-->=<!--> <!-->29). <em>C. tropicalis</em> had been mainly isolated from patients with hematologic malignancies (79.3%) who had received chemotherapy recently (82.8%), and in patients with severe neutropenia (79.3%). Seventy-five (51%) patients died within the first 30 days, and the multivariate analysis showed the following risk factors: severe neutropenia, a Karnofsky Performance Scale score under 70, septic shock, and not receiving appropriate antifungal treatment.</p></div><div><h3>Conclusions</h3><p>Patients with cancer who develop CBSI had a high mortality related with factors associated with their malignancy. Starting an empirical antifungal therapy the soonest is essential to increase the survival in these patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 1","pages":"Pages 3-9"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}