Revista Iberoamericana De Micologia最新文献_第2页

Endocarditis due to Candida albicans in an immunocompromised patient: A case report 一例免疫功能低下患者因白色念珠菌引起的心内膜炎：一例报告。

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-04-01 DOI: 10.1016/j.riam.2023.06.001

José J. Flores-Patiño , Mikel J. Durán-Pacheco , Alondra M. Cázares-Marroquín , José M. Gastélum-Cano , María A. Islas-Osuna , José A. Arízaga-Berber

{"title":"Endocarditis due to Candida albicans in an immunocompromised patient: A case report","authors":"José J. Flores-Patiño , Mikel J. Durán-Pacheco , Alondra M. Cázares-Marroquín , José M. Gastélum-Cano , María A. Islas-Osuna , José A. Arízaga-Berber","doi":"10.1016/j.riam.2023.06.001","DOIUrl":"10.1016/j.riam.2023.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Fungal endocarditis is a low-frequency disease with a challenging diagnosis, as it can be mistaken with bacterial endocarditis. Fungal endocarditis causes higher mortality rates in immunocompromised patients. In the clinical practice, the endocarditis caused by fungi represents up to 10% of all infectious endocarditis cases and has a mortality rate of nearly 50%.</p></div><div><h3>Case report</h3><p>Here we present the case of a 53-year-old woman under corticosteroid therapy with a history of rheumatic heart disease, aortic valve replacement, and rheumatoid arthritis, who presented with fungal endocarditis caused by <span><em>Candida albicans</em></span>. Even though the patient received 3 years of antifungal prophylaxis with fluconazole, had valve replacement surgery, and received intensive care, the patient finally worsened and died.</p></div><div><h3>Conclusions</h3><p>Comorbidities and corticosteroid therapy predisposed the patient to acquire fungal endocarditis. This case highlights the importance of implementing procedures for the isolation and identification of fungi, and for carrying out antifungal-susceptibility testing, as well as establishing surveillance programs to identify infection-causing species and drug resistance patterns in hospitals. Moreover, designing and upgrading the algorithm for infectious endocarditis is the key to future improvements in diagnosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41109919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the MALDI-TOF mass spectrometry technique for the identification of dermatophytes: Use of an extended database 评价MALDI-TOF质谱技术鉴定皮肤真菌:使用扩展数据库。

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-04-01 DOI: 10.1016/j.riam.2021.01.006

Ivana Maldonado , Silvia Relloso , Liliana Guelfand , Bárbara Fox , Natalia Azula , Vanesa Romano , Agostina Cantore , Rubén Barrios , Susana Carnovale , Ezequiel Nuske , Patricia Minervini , members of the Red de Micología de la Ciudad Autónoma de Buenos Aires [Mycology Network of the Autonomous City of Buenos Aires] (RMCABA)

{"title":"Evaluation of the MALDI-TOF mass spectrometry technique for the identification of dermatophytes: Use of an extended database","authors":"Ivana Maldonado , Silvia Relloso , Liliana Guelfand , Bárbara Fox , Natalia Azula , Vanesa Romano , Agostina Cantore , Rubén Barrios , Susana Carnovale , Ezequiel Nuske , Patricia Minervini , members of the Red de Micología de la Ciudad Autónoma de Buenos Aires [Mycology Network of the Autonomous City of Buenos Aires] (RMCABA)","doi":"10.1016/j.riam.2021.01.006","DOIUrl":"10.1016/j.riam.2021.01.006","url":null,"abstract":"<div><h3>Background</h3><p>Identification of dermatophytes is usually performed through morphological analyses. However, it may be hindered due to the discovery of new species and complexes and, with some isolates, by the absence of fructification. Matrix-assisted laser desorption/ionisation-time-of-flight mass spectrometry (MALDI-TOF MS) seems to be an option for improving identification.</p></div><div><h3>Aims</h3><p>To develop a database (DB) for the identification of dermatophytes with MALDI-TOF MS, including 32 isolates from the Red de Micología de la Ciudad Autónoma de Buenos Aires [Mycology Network of the Autonomous City of Buenos Aires] (RMCABA) and one reference isolate (RMCABA DB), and evaluate its performance when added to the DB from the supplier, Bruker (Bruker DB).</p></div><div><h3>Methods</h3><p>All the isolates in the RMCABA DB were identified based on morphology and sequencing. To evaluate the performance of the extended DB (Bruker DB plus RMCABA DB), 136 clinical isolates were included.</p></div><div><h3>Results</h3><p>The percentages of identification at the species level increased from 45% to 88%, but the identification at the genus level decreased from 23% to 7%.</p></div><div><h3>Conclusions</h3><p>MALDI-TOF MS yielded better performance in the identification of dermatophytes after including the RMCABA DB, which encompassed local isolates.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida bloodstream infection in patients with cancer: A retrospective analysis of an 11-year period 癌症患者的念珠菌血流感染:11年的回顾性分析

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-01-01 DOI: 10.1016/j.riam.2022.12.002

Rodrigo Vázquez-Olvera , Patricia Volkow , Consuelo Velázquez-Acosta , Patricia Cornejo-Juárez

{"title":"Candida bloodstream infection in patients with cancer: A retrospective analysis of an 11-year period","authors":"Rodrigo Vázquez-Olvera , Patricia Volkow , Consuelo Velázquez-Acosta , Patricia Cornejo-Juárez","doi":"10.1016/j.riam.2022.12.002","DOIUrl":"10.1016/j.riam.2022.12.002","url":null,"abstract":"<div><h3>Background</h3><p><em>Candida</em> bloodstream infection (CBSI) is a growing problem among patients with cancer.</p></div><div><h3>Aim</h3><p>To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.</p></div><div><h3>Methods</h3><p>We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital. Analysis was done according to the <em>Candida</em> species found. Multivariate logistic regression analysis was used to determine the risk factors associated with 30-day mortality.</p></div><div><h3>Results</h3><p>There were 147 CBSIs diagnosed, 78 (53%) in patients with hematologic malignancies. The main <em>Candida</em> species identified were <span><em>Candida albicans</em></span> (<em>n</em>  =40) and <span><em>Candida tropicalis</em></span> (<em>n</em>  <!-->29). <em>C. tropicalis</em> had been mainly isolated from patients with hematologic malignancies (79.3%) who had received chemotherapy recently (82.8%), and in patients with severe neutropenia (79.3%). Seventy-five (51%) patients died within the first 30 days, and the multivariate analysis showed the following risk factors: severe neutropenia, a Karnofsky Performance Scale score under 70, septic shock, and not receiving appropriate antifungal treatment.</p></div><div><h3>Conclusions</h3><p>Patients with cancer who develop CBSI had a high mortality related with factors associated with their malignancy. Starting an empirical antifungal therapy the soonest is essential to increase the survival in these patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A surprising finding: The curious case of a tongue lesion misdiagnosed as paracoccidioidomycosis 一个令人惊讶的发现:舌头病变误诊为副球孢子菌病的奇怪病例

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-01-01 DOI: 10.1016/j.riam.2022.11.002

Bert Gerrits van den Ende , Anderson Messias Rodrigues , Rosane Christine Hahn , Ferry Hagen

{"title":"A surprising finding: The curious case of a tongue lesion misdiagnosed as paracoccidioidomycosis","authors":"Bert Gerrits van den Ende , Anderson Messias Rodrigues , Rosane Christine Hahn , Ferry Hagen","doi":"10.1016/j.riam.2022.11.002","DOIUrl":"10.1016/j.riam.2022.11.002","url":null,"abstract":"<div><h3>Background</h3><p>Paracoccidioidomycosis is an endemic mycosis caused by members of the <em>Paracoccidioides</em> genus. Brazil remains the focus area and, to a lesser extent, the disease has been reported from Argentina, Colombia and Venezuela.</p></div><div><h3>Aims</h3><p>A Venezuelan <em>Paracoccidioides brasiliensis</em> strain, isolated from a patient diagnosed with chronic multifocal paracoccidioidomycosis, was subjected to whole genome sequencing to provide more insight about <em>Paracoccidioides</em> outside the endemic focus area.</p></div><div><h3>Methods</h3><p><em>P. brasiliensis</em> strain CBS 118890 was whole genome sequenced using nanopore; library preparation with the ‘native barcoding genomic DNA kit’ was followed by sequencing on Flongle and MinION flowcells. Batches of strain CBS 118890 were re-identified by sequencing the internal transcribed spacer (ITS) region, and final identification was made based on phylogenetic analysis.</p></div><div><h3>Results</h3><p>Surprisingly, the Venezuelan <em>P. brasiliensis</em> strain CBS 118890 turned out to be a <em>Nannizziopsis</em> species. The batches of this strain were ITS sequenced followed by phylogenetic analysis and resulted in the final identification of <em>Nannizziopsis arthrosporioides</em>.</p></div><div><h3>Conclusions</h3><p><em>Nannizziopsis</em> infections are commonly seen in a wide variety of reptiles, but are particularly rare in human infections. This case underlines the need for molecular characterization of cases that clinically mimic paracoccidioidomycosis but that are serologically negative for <em>Paracoccidioides</em>.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed candidemia in a pediatric patient with Hirschsprung's disease 儿童先天性巨结肠患者的混合性念珠菌血症

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-01-01 DOI: 10.1016/j.riam.2022.12.003

Bryan Ortiz , Kateryn Aguilar , Marco Luque , Kevin Díaz , Celeste Galindo , Daniel Rivera , Roque López , Gustavo Fontecha

引用次数: 0

A promising candidate vaccine for coccidioidomycosis 一种有希望的球孢子菌病候选疫苗

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2023-01-01 DOI: 10.1016/j.riam.2022.03.002

F. Javier Cabañes

引用次数: 0

Advances and challenges in the management of feline sporotrichosis 猫孢子虫病治疗的进展与挑战

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2022-07-01 DOI: 10.1016/j.riam.2022.05.002

Isabella Dib Ferreira Gremião , Luisa Helena Monteiro de Miranda , Gabriela Reis Pereira-Oliveira , Rodrigo Caldas Menezes , Ana Caroline de Sá Machado , Anderson Messias Rodrigues , Sandro Antonio Pereira

{"title":"Advances and challenges in the management of feline sporotrichosis","authors":"Isabella Dib Ferreira Gremião , Luisa Helena Monteiro de Miranda , Gabriela Reis Pereira-Oliveira , Rodrigo Caldas Menezes , Ana Caroline de Sá Machado , Anderson Messias Rodrigues , Sandro Antonio Pereira","doi":"10.1016/j.riam.2022.05.002","DOIUrl":"10.1016/j.riam.2022.05.002","url":null,"abstract":"<div><p>The domestic cat is the most susceptible host to <span><em>Sporothrix</em></span> infection, developing severe clinical forms. Few effective antifungal agents are available for treating feline sporotrichosis, and cases of treatment failure are common. Treatment success depends on cat health status, therapy-related factors, as well as social/economic issues, but it is mainly contingent upon the host–fungus interaction. The owner's adherence is critical and should be reinforced throughout the treatment to increase the chances of a successful outcome. The antifungal agents described for feline sporotrichosis are most often used in monotherapy regimens. Due to cases in which the treatment with itraconazole failed, the use of antifungal agents in combination should be considered to achieve synergy. The combination of itraconazole and potassium iodide represents an important option for the treatment of <em>naïve</em> cats presenting multiple cutaneous lesions, nasal mucosal lesions and/or respiratory signs, as well as for refractory cases. However, the therapeutic options for unsuccessfully treated cases are scarce. Therefore new options are needed, even more taking into account that there are many <em>in vitro</em> potential molecules not available for use in cats yet. More studies are necessary to correlate <em>in vitro</em> antifungal susceptibility tests results and the outcome of cats treated due to sporotrichosis. This review will briefly discuss both the antifungal drugs and treatment protocols used in cats with sporotrichosis, as well as the determinants of treatment failure.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10379857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Reversal of itraconazole resistance in Sporothrix brasiliensis and Sporothrix schenckii by nonsteroidal anti-inflammatory drugs 非甾体抗炎药逆转巴西孢子菌和申克孢子菌对伊曲康唑的耐药性

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2022-07-01 DOI: 10.1016/j.riam.2022.01.003

Gabriela Seibert , Ana Luisa Reetz Poletto , Jennifer Veppo Prade , Débora Nunes Mario , Cheila Denise Ottonelli Stopiglia

{"title":"Reversal of itraconazole resistance in Sporothrix brasiliensis and Sporothrix schenckii by nonsteroidal anti-inflammatory drugs","authors":"Gabriela Seibert , Ana Luisa Reetz Poletto , Jennifer Veppo Prade , Débora Nunes Mario , Cheila Denise Ottonelli Stopiglia","doi":"10.1016/j.riam.2022.01.003","DOIUrl":"10.1016/j.riam.2022.01.003","url":null,"abstract":"<div><h3>Background</h3><p>The emergence of resistant isolates has brought challenges to the treatment of sporotrichosis, prompting the search for new therapeutic strategies. Previous studies reported that nonsteroidal anti-inflammatory drugs (NSAIDs) show in vitro activity against several pathogenic fungi, including species of <em>Candida</em>, <span><em>Cryptococcus</em></span>, and <span><em>Trichosporon</em></span>.</p></div><div><h3>Aims</h3><p>This study aimed to investigate the in vitro efficacy of three NSAIDs (acetylsalicylic acid, diclofenac sodium, and ibuprofen), alone and in combination with itraconazole, against eleven clinical isolates of <em>Sporothrix brasiliensis</em> and <span><em>Sporothrix schenckii</em></span>.</p></div><div><h3>Methods</h3><p>Minimal inhibitory concentrations were determined by the broth microdilution method. Drug interactions and the fractional inhibitory concentration index of NSAIDs and itraconazole were assessed by the checkerboard method.</p></div><div><h3>Results</h3><p>When used alone, ibuprofen was the most active NSAID, followed by acetylsalicylic acid. Combinations of NSAIDs with itraconazole showed synergistic antifungal activity against nine isolates. It was also found that itraconazole combined with acetylsalicylic acid, diclofenac sodium, or ibuprofen, led to resistance reversal in two, three, and five of the six drug-resistant isolates, respectively.</p></div><div><h3>Conclusions</h3><p>The results indicate that the combination of itraconazole and the evaluated NSAIDs are a promising strategy for the treatment of sporotrichosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Manuel Pereiro Miguens (1921-2022)

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2022-07-01 DOI: 10.1016/j.riam.2022.11.001

引用次数: 0

Lobomycosis and paracoccidioidomycosis meet again 额孢子菌病和副球孢子菌病再次相遇

IF 1.9 4区生物学

Revista Iberoamericana De Micologia Pub Date : 2022-07-01 DOI: 10.1016/j.riam.2022.01.002

F. Javier Cabañes

引用次数: 2