Reumatismo最新文献_第7页

Discrepancies between clinical and pathological findings seen at renal biopsy in rheumatological diseases. 风湿病肾活检临床与病理结果的差异。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1586

R Deniz, N Güner, Ş A Ekmen, I N Mutlu, D S Özgür, B Karaalioğlu, G Akkuzu, F Yıldırım, K Kalkan, G Güzelant-Özköse, B İnce, M Erdoğan, Y Özlük, I Kılıçaslan, C Bes

{"title":"Discrepancies between clinical and pathological findings seen at renal biopsy in rheumatological diseases.","authors":"R Deniz, N Güner, Ş A Ekmen, I N Mutlu, D S Özgür, B Karaalioğlu, G Akkuzu, F Yıldırım, K Kalkan, G Güzelant-Özköse, B İnce, M Erdoğan, Y Özlük, I Kılıçaslan, C Bes","doi":"10.4081/reumatismo.2023.1586","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1586","url":null,"abstract":"Objective: Renal biopsy contributes to the diagnosis, follow-up, and treatment of many rheumatic conditions. This study assessed the diagnostic role and safety of renal biopsies in a tertiary rheumatology clinic.Methods: Renal biopsies performed between June 2020 and December 2022 were screened, and demographic, clinical, histopathological, and safety data were collected from patient records.Results: In this study, 33 males and 38 females were included. Except for 1 patient who received acetylsalicylic acid, antiaggregant, and/or anticoagulant drugs were stopped before the biopsy. Complications included a decrease of hemoglobin in 8 patients (11.3%) and microscopic hematuria in 40 patients (56.3%). Control ultrasonography was performed in 16 patients (22.5%), and a self-limiting hematoma was found in 4 of them (5.6%) without additional complications. While less than 10 glomeruli were obtained in 9 patients (9.9%), diagnosis success was 94.4%. Histopathological data were consistent with one of the pre-biopsy diagnoses in 54 of 67 cases (80.6%) but showed discrepancies in 19.4% (n=13) of patients. A repeat biopsy was performed in 7 patients for re-staging or insufficient biopsy.Conclusions: Renal biopsy significantly contributes to rheumatology practice, especially in patients with complex clinical and laboratory findings or in whom different treatments can be given according to the presence, severity, and type of renal involvement. Although the possibility of obtaining insufficient tissue and the need for re-staging and repeat biopsy in the follow-up might be expected, complication risk does not seem to be a big concern. Renal biopsy often evidenced discrepancies between pre-biopsy diagnosis and histopathological findings.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related. 对SARS-CoV-2疫苗接种后肌炎的反应比假设的更频繁，并可能有因果关系。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1623

H Quiñones-Moya, A Camargo-Coronel, M R Hernández-Zavala

引用次数: 0

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia. 无麸质饮食在降低纤维肌痛患者普遍疼痛指数和症状严重程度量表中的疗效。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1530

V Bruzzese, C Marrese, P Scolieri, J Pepe

{"title":"Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia.","authors":"V Bruzzese, C Marrese, P Scolieri, J Pepe","doi":"10.4081/reumatismo.2023.1530","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1530","url":null,"abstract":"Objective: Dietary interventions to improve fibromyalgia (FM) symptoms reported conflicting results. This study aimed to treat FM patients with a gluten-free diet (GFD), alternated with a non-restricted gluten-containing diet, followed by a rechallenge of the GFD.Methods: Twenty postmenopausal women with FM and no history of celiac disease participated. A GFD was assigned for 6 months. This was followed by 3 months of a non-restricted gluten-containing diet and then a new GFD for another 6 months. At each visit, the widespread pain index (WPI) and the symptom severity scale (SS) scores were evaluated.Results: The mean age of the patients enrolled was 53.9±10 years. None of the patients had a diagnosis of irritable bowel disease, although they reported vague gastrointestinal symptoms. After 6 months of a GFD, a statistically significant reduction was observed for the WPI (10.3±1.8 vs 7.7±1.4; p<0.0001) and the SS scale (6.4±1.8 vs 4.15±1.6; p=0.0002). The D percentage reduction of the WPI after 6 months of GFD was -24%±9%, while for the SS scale, it was -36%±21%. The following reintroduction of a gluten-containing diet brought about a statistically significant rise in the absolute SS scale and WPI, as well as a D modification of the WPI (21%±13%) and of the SS scale (74%±90%). The rechallenge of the GFD showed a significant improvement in absolute and D WPI (-24%±7%) and SS (-36%±11%). No modifications to the body mass index were found.Conclusions: A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia. 哥伦比亚接受重症监护的炎症性和自身免疫性风湿病患者的临床特征和结果

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1563

D G Fernández-Ávila, Ó R Vargas-Vanegas, L Galindo-Rozo, Á García-Peña, Ó Muñoz-Velandia

{"title":"Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia.","authors":"D G Fernández-Ávila, Ó R Vargas-Vanegas, L Galindo-Rozo, Á García-Peña, Ó Muñoz-Velandia","doi":"10.4081/reumatismo.2023.1563","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1563","url":null,"abstract":"Objective: Contemporary studies reporting outcomes of critical care in patients with inflammatory and autoimmune rheumatological diseases are scarce. This study describes 15 years of experience from 2005-2019 in a Colombian referral hospital.Methods: This observational, descriptive, consecutive case series study was performed on adult patients with inflammatory and autoimmune rheumatic diseases who were admitted to the intensive care unit (ICU) of the San Ignacio University Hospital in Bogotá (Colombia), from January 1, 2005, to December 21, 2019. We describe the sociodemographic characteristics, admission causes and criteria, lengths of stay, immunosuppressive treatment, systemic support, and mortality.Results: The study included 300 patients with a median age of 48 years [interquartile range (IQR) 31-62 years], predominantly female (76%). Disease exacerbations (30%), infections (17.6%), and cardiovascular diseases (15%) were the main causes of admission. Respiratory failure (23%) most commonly caused by septic shock (24%) was the principal indication for intensive care admission. The most frequent infections were community-acquired pneumonia (11.6%) and soft-tissue infections (9%). In 40.3% of patients, inotropic and vasopressor support was required. The median length of stay was 4 days (IQR 2-8), and global mortality was 21.6%.Conclusions: Rheumatic diseases in the ICU are still associated with high morbidity and mortality. Patients with inflammatory and autoimmune rheumatic diseases require a meticulous clinical approach, strict clinical monitoring, frequent assessment of complications, evaluation of systemic support needs, and specific management.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms. 氧化应激可能是纤维肌痛患者疼痛机制的一个促进因素。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1550

H Beyaztas, S Aktas, E M Guler, E Ata

{"title":"Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms.","authors":"H Beyaztas, S Aktas, E M Guler, E Ata","doi":"10.4081/reumatismo.2023.1550","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1550","url":null,"abstract":"Objective: The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin, has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of oxidative stress in FM patients and try to understand the association between FM and free radicals.Methods: This study was performed on 100 volunteers admitted to the University of Health Sciences, Sultan 2, Abdulhamid Han Health Application and Research Center Physical Therapy and Rehabilitation Clinic, including 50 healthy controls and 50 patients with FM. To analyze oxidative stress biomarkers, total oxidant status (TOS) and total antioxidant status (TAS) levels were measured. Total thiol (TT) and native thiol (NT) concentrations were measured to determine the relationship between thiol groups. Disulfide (DIS) and oxidative stress index (OSI) were calculated with mathematical formulas.Results: While TOS and OSI levels were statistically higher in FM patients, TAS levels were significantly lower compared to the healthy control group (p<0.001). In comparison to the healthy control group, FM patients had considerably decreased TT and NT levels. DIS levels were significantly higher in FM patients than in controls (p<0.001).Conclusions: Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal hemorrhage and non-ST elevation myocardial infarction: an antiphospholipid syndrome dilemma. 肾上腺出血和非st段抬高型心肌梗死:抗磷脂综合征困境。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1584

G El Hasbani, M Del Pilar Morel, B Tandoh, J F Vargas, R Crusio

引用次数: 0

Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report. 急性严重痛风性关节炎继发于异维甲酸毒性的年轻男性:一个病例报告。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1566

D S Meena, D Kumar, G K Bohra

引用次数: 0

Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Behçet's disease and autoinflammation. A viewpoint. 血管炎与腺苷脱氨酶2缺乏相关:在behet病和自身炎症之间的十字路口。一个观点。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1578

A Colangelo, F Tromby, G Cafaro, R Gerli, E Bartoloni, C Perricone

{"title":"Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Behçet's disease and autoinflammation. A viewpoint.","authors":"A Colangelo, F Tromby, G Cafaro, R Gerli, E Bartoloni, C Perricone","doi":"10.4081/reumatismo.2023.1578","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1578","url":null,"abstract":"Adenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene. The DADA2 phenotype is widely heterogeneous, and patients may present with fever, weight loss, livedo reticularis/racemosa, digital ischemia, cutaneous ulceration, peripheral neuropathy, abdominal pain, bowel perforation, and portal or nephrogenic hypertension. More specific manifestations include early-onset ischemic or hemorrhagic stroke, mild immunodeficiency and hypogammaglobinemia, cytopenia, and vision disturbances. Herein, we present the case of a young male with vasculitis associated with DADA2. The presence of HLA-B51 and the clinical features of this patient raised the question of similarities between ADA2 deficiency, Behçet's disease, and NOD2-associated diseases. Treatment of this rare monogenic disease is challenging and based on small case series. The long-term experience of this patient proved the difficulties of prednisone tapering and the lack of satisfactory therapeutic strategies.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related. 接种SARS-CoV-2疫苗后发生肌炎的频率比假设的要高，并且可能存在因果关系。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1601

J Finsterer, A S MohanaSundaram, F Scorza

引用次数: 1

Arthur Conan Doyle, Sherlock Holmes, and gout. 阿瑟·柯南·道尔，夏洛克·福尔摩斯，还有痛风。

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1570

E Damiani

{"title":"Arthur Conan Doyle, Sherlock Holmes, and gout.","authors":"E Damiani","doi":"10.4081/reumatismo.2023.1570","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1570","url":null,"abstract":"Arthur Conan Doyle, the creator of Sherlock Holmes, was an experienced physician who treated gouty patients. A gouty character appears in The Adventure of the Missing Three-Quarter, a Sherlock Holmes novel. This offers the possibility of discussing gout from the peculiar perspective of a medical writer in light of the historical-medical context of the time. This study was conducted using Conan Doyle's autobiographical, scientific, and literary primary sources, as well as past and current medical literature. The Adventure of the Missing Three-Quarter was autobiographical. Conan Doyle himself was a rugby player and his wife died of tuberculosis. Furthermore, in 1884, in The Lancet, he described the hereditary case of a female gouty patient, presenting with ocular manifestations. In agreement with the concept of rich man's gout, the gouty patient of Sherlock Holmes' story, Lord Mount James, was a rich irascible noble but he was not addicted to the pleasures of food and sex. Following the usual funny representation of gouty patients, Conan Doyle made fun of Lord Mount James, but he misquoted a true case of gout cited in the literature. In his scientific and literary production on gout, Conan Doyle stuck to the most updated medical concepts of the time, demonstrating an uncommon knowledge of scientific literature.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0