{"title":"Advancements in Viral Genomics: Gated Recurrent Unit Modeling of SARS-CoV-2, SARS, MERS, and Ebola viruses.","authors":"Abhishak Raj Devaraj, Victor Jose Marianthiran","doi":"10.1590/0037-8682-0178-2024","DOIUrl":"10.1590/0037-8682-0178-2024","url":null,"abstract":"<p><strong>Background: </strong>Emerging infections have posed persistent threats to humanity throughout history. Rapid and unprecedented anthropogenic, behavioral, and social transformations witnessed in the past century have expedited the emergence of novel pathogens, intensifying their impact on the global human population.</p><p><strong>Methods: </strong>This study aimed to comprehensively analyze and compare the genomic sequences of four distinct viruses: SARS-CoV-2, SARS, MERS, and Ebola. Advanced genomic sequencing techniques and a Gated Recurrent Unit-based deep learning model were used to examine the intricate genetic makeup of these viruses. The proposed study sheds light on their evolutionary dynamics, transmission patterns, and pathogenicity and contributes to the development of effective diagnostic and therapeutic interventions.</p><p><strong>Results: </strong>This model exhibited exceptional performance as evidenced by accuracy values of 99.01%, 98.91%, 98.35%, and 98.04% for SARS-CoV-2, SARS, MERS, and Ebola respectively. Precision values ranged from 98.1% to 98.72%, recall values consistently surpassed 92%, and F1 scores ranged from 95.47% to 96.37%.</p><p><strong>Conclusions: </strong>These results underscore the robustness of this model and its potential utility in genomic analysis, paving the way for enhanced understanding, preparedness, and response to emerging viral threats. In the future, this research will focus on creating better diagnostic instruments for the early identification of viral illnesses, developing vaccinations, and tailoring treatments based on the genetic composition and evolutionary patterns of different viruses. This model can be modified to examine a more extensive variety of diseases and recently discovered viruses to predict future outbreaks and their effects on global health.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e004012024"},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Gabriela Miranda Barbosa, José Antonio da Silva Júnior, Ellany Gurgel Cosme do Nascimento, Mariana de Moura Góes, Antônio Almeida Dos Santos Filho, Rodrigo Alves de Melo, Remerson Russel Martins, Thales Allyrio Araújo de Medeiros Fernandes, Micássio Fernandes de Andrade, Cléber de Mesquita Andrade
{"title":"New parameter for QRS complex low voltage in chagasic cardiomyopathy: the ADOC index.","authors":"Ana Gabriela Miranda Barbosa, José Antonio da Silva Júnior, Ellany Gurgel Cosme do Nascimento, Mariana de Moura Góes, Antônio Almeida Dos Santos Filho, Rodrigo Alves de Melo, Remerson Russel Martins, Thales Allyrio Araújo de Medeiros Fernandes, Micássio Fernandes de Andrade, Cléber de Mesquita Andrade","doi":"10.1590/0037-8682-0216-2024","DOIUrl":"10.1590/0037-8682-0216-2024","url":null,"abstract":"<p><strong>Background: </strong>Low QRS complex voltage is an important predictor of death in Chagas disease. However, the parameters applied to the low-voltage classification were described by the Minnesota Code and not specifically for Chagas disease. This study aimed to analyze low QRS voltage by determining the ADOC index and averages in the frontal and horizontal electrocardiographic planes, establishing possible clinical implications.</p><p><strong>Methods: </strong>A cross-sectional study of patients with Chagas disease was performed using the Mann-Whitney U test and Spearman's correlation. The amplitudes of each QRS were analyzed, and the sum of the DII and V5 derivations of the ADOC index and the arithmetic means of the QRS complexes in the frontal and horizontal planes were determined.</p><p><strong>Results: </strong>The ADOC index was correlated with the highest risk of stroke and death according to the Rassi score. The ADOC index (p=0.046) and mean mQRS were inversely proportional to the Rassi risk of death score (p=0.038). The ADOC index proved to be more sensitive (75.0%) and accurate (67.4%) in identifying patients at elevated death risk using the Rassi score. Finally, a positive correlation was observed between the QRSFm and QRSHm indicators and ADOC index (r=0.590 and r=0.857, respectively).</p><p><strong>Discussion: </strong>The ADOC index and mean of the QRS complexes are possible tools correlated with the Rassi score and risk of stroke in patients with Chagas disease.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e004002024"},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thiago Elias Ferrari Khouri, Gabriel Chahade Sibanto Simões, Adriano Fregonesi
{"title":"Paracoccidioidomycosis of the testis.","authors":"Thiago Elias Ferrari Khouri, Gabriel Chahade Sibanto Simões, Adriano Fregonesi","doi":"10.1590/0037-8682-0232-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0232-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iara de Melo Freire, Carolina Souza de Oliveira, Marcella Caldeira Camisasca Souza, Virgínia Vilasboas Figueiras, Luciana Mendes Dos Santos
{"title":"Acral Exogenous Cutaneous Pigmentation Caused by Contact with a Darkling Beetle (Coleoptera: Tenebrionidae) in a Young Patient in the state of Amazonas.","authors":"Iara de Melo Freire, Carolina Souza de Oliveira, Marcella Caldeira Camisasca Souza, Virgínia Vilasboas Figueiras, Luciana Mendes Dos Santos","doi":"10.1590/0037-8682-0298-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0298-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atypical manifestation of leprosy in a pediatric patient.","authors":"Gabriel Castro Tavares","doi":"10.1590/0037-8682-0278-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0278-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priscilla Filippo Alvim de Minas Santos, Felipe Tavares Rodrigues, Leticia Hastenreiter
{"title":"Diagnosis of larval migration using imaging tests.","authors":"Priscilla Filippo Alvim de Minas Santos, Felipe Tavares Rodrigues, Leticia Hastenreiter","doi":"10.1590/0037-8682-0326-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0326-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}