Luciana Vilela Gomide, João Paulo Turri Brufatto, Thiago Jessé Kucarz, Paulo Eduardo Neves Ferreira Velho, Andréa Fernandes Eloy da Costa França
{"title":"Managing leprosy reactions with secukinumab: Insights from a case series.","authors":"Luciana Vilela Gomide, João Paulo Turri Brufatto, Thiago Jessé Kucarz, Paulo Eduardo Neves Ferreira Velho, Andréa Fernandes Eloy da Costa França","doi":"10.1590/0037-8682-0118-2025","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.</p><p><strong>Methods: </strong>We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.</p><p><strong>Results: </strong>Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.</p><p><strong>Conclusions: </strong>Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e01182025"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479038/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Sociedade Brasileira de Medicina Tropical","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/0037-8682-0118-2025","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.
Methods: We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.
Results: Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.
Conclusions: Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.
期刊介绍：
The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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