Managing leprosy reactions with secukinumab: Insights from a case series.

IF 2.3 4区 医学 Q2 PARASITOLOGY
Luciana Vilela Gomide, João Paulo Turri Brufatto, Thiago Jessé Kucarz, Paulo Eduardo Neves Ferreira Velho, Andréa Fernandes Eloy da Costa França
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引用次数: 0

Abstract

Background: Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.

Methods: We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.

Results: Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.

Conclusions: Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.

用secukinumab管理麻风病反应:来自一系列病例的见解。
背景:麻风结节性红斑(ENL)是一种需要精确治疗的免疫炎症反应。顽固性病例,其对常规治疗的难治性和标准治疗的不良反应强调了探索替代治疗方案的必要性。方法:我们对2023年1月至2025年1月期间接受secukinumab治疗的5例患者进行了回顾性研究。结果:患者表现出临床改善,ENL频率降低,神经炎缓解,皮质类固醇节省。结论:Secukinumab具有良好的安全性,似乎是ENL有希望的皮质类固醇节省选择。需要进一步的研究来证实这种治疗方案的有效性和长期安全性。
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来源期刊
CiteScore
3.40
自引率
10.00%
发文量
195
审稿时长
3-8 weeks
期刊介绍: The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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