Revista da Sociedade Brasileira de Medicina Tropical最新文献

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The big and small ball sign: Ultraviolet-Induced Fluorescence Dermoscopy for the diagnosis of scabies.
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/0037-8682-0238-2024
Kaique Arriel, Thaís Barros Felippe Jabour, Rafael Rubinho, Thais Kohatsu Yanase, Fernanda Rytenband
{"title":"The big and small ball sign: Ultraviolet-Induced Fluorescence Dermoscopy for the diagnosis of scabies.","authors":"Kaique Arriel, Thaís Barros Felippe Jabour, Rafael Rubinho, Thais Kohatsu Yanase, Fernanda Rytenband","doi":"10.1590/0037-8682-0238-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0238-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donor-derived Cryptococcus gattii complex infection after liver transplantation.
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/0037-8682-0297-2024
Bruno Hassunuma Carneiro, Giovanni Luis Breda, Regielly Caroline Raimundo Cognialli, Germana Davila Dos Santos, Vania Aparecida Vicente, Eduardo Gnoatto Perondi, João Cesar Beenke França, Flávio Queiroz-Telles
{"title":"Donor-derived Cryptococcus gattii complex infection after liver transplantation.","authors":"Bruno Hassunuma Carneiro, Giovanni Luis Breda, Regielly Caroline Raimundo Cognialli, Germana Davila Dos Santos, Vania Aparecida Vicente, Eduardo Gnoatto Perondi, João Cesar Beenke França, Flávio Queiroz-Telles","doi":"10.1590/0037-8682-0297-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0297-2024","url":null,"abstract":"<p><p>Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C. neoformans complex, predominantly in kidney recipients, but also after liver transplantation. We report the first documented case of donor-derived, early-onset C. gattii complex meningoencephalitis following liver transplantation in a 54-year-old woman, successfully treated with amphotericin B and fluconazole, and review the relevant literature.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptococcus neoformans in the sputum: a noninvasive diagnostic method.
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/0037-8682-0250-2024
Simone Rachid de Souza, Diogo Goulart Corrêa
{"title":"Cryptococcus neoformans in the sputum: a noninvasive diagnostic method.","authors":"Simone Rachid de Souza, Diogo Goulart Corrêa","doi":"10.1590/0037-8682-0250-2024","DOIUrl":"https://doi.org/10.1590/0037-8682-0250-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental Crisis and the Emergence of the Oropouche: A Potential Public Health Problem. 环境危机和大鼠的出现:一个潜在的公共健康问题。
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0295-2024
Marina Dos Santos Barreto, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Govindasamy Hariharan, Bernardo Ferreira Brasileiro, Ricardo Queiroz Gurgel, Dalmo Correia, Cleverson Luciano Trento, Lysandro Pinto Borges
{"title":"Environmental Crisis and the Emergence of the Oropouche: A Potential Public Health Problem.","authors":"Marina Dos Santos Barreto, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Govindasamy Hariharan, Bernardo Ferreira Brasileiro, Ricardo Queiroz Gurgel, Dalmo Correia, Cleverson Luciano Trento, Lysandro Pinto Borges","doi":"10.1590/0037-8682-0295-2024","DOIUrl":"10.1590/0037-8682-0295-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e011032024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report. 获得性免疫缺陷综合征患者伴骨关节受累的播散性孢子菌病:1例报告。
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0120-2024
Ana Paula Freitas Bahia Dos Santos, Ana Carolina de Oliveira Mota, Gabriel Ramalho de Jesus, Matheus Dias Girão Rocha, Daniela de Freitas Pereira Calheiros Ângelo Durço, Luis Guilherme Rosifini Alves Rezende, Anna Christina Tojal da Silva, Fernando Crivelenti Vilar, Valdes Roberto Bollela, Roberto Martinez
{"title":"Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report.","authors":"Ana Paula Freitas Bahia Dos Santos, Ana Carolina de Oliveira Mota, Gabriel Ramalho de Jesus, Matheus Dias Girão Rocha, Daniela de Freitas Pereira Calheiros Ângelo Durço, Luis Guilherme Rosifini Alves Rezende, Anna Christina Tojal da Silva, Fernando Crivelenti Vilar, Valdes Roberto Bollela, Roberto Martinez","doi":"10.1590/0037-8682-0120-2024","DOIUrl":"10.1590/0037-8682-0120-2024","url":null,"abstract":"<p><p>Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii. The patient underwent reconstructive surgery and 9 months of treatment with amphotericin B and itraconazole, and showed complete wound healing and improved hand functionality. Suspicion of the disease is necessary in immunosuppressed patients living in endemic areas.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008092024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Panstrongylus guentheri Berg, 1879 (Hemiptera, Reduviidae, Triatominae): first record in Mato Grosso, Brazil. guentheri Panstrongylus Berg, 1879(半翅目,褐家蝇科,褐家蝇科):在巴西马托格罗索首次记录。
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0230-2024
Mirian Francisca Martins, Sinara Cristina de Moraes, Sirlei Franck Thies, Veruska Nogueira de Brito, Rodrigo Gurgel-Gonçalves, Cleber Galvão
{"title":"Panstrongylus guentheri Berg, 1879 (Hemiptera, Reduviidae, Triatominae): first record in Mato Grosso, Brazil.","authors":"Mirian Francisca Martins, Sinara Cristina de Moraes, Sirlei Franck Thies, Veruska Nogueira de Brito, Rodrigo Gurgel-Gonçalves, Cleber Galvão","doi":"10.1590/0037-8682-0230-2024","DOIUrl":"10.1590/0037-8682-0230-2024","url":null,"abstract":"<p><strong>Background: </strong>This paper reports the occurrence of Panstrongylus guentheri Berg, 1879 in the State of Mato Grosso (MT).</p><p><strong>Methods: </strong>Triatomines were captured in rural environments in municipalities of MT. Specimens were identified, and Trypanosoma cruzi infection was investigated.</p><p><strong>Results: </strong>Nineteen specimens of Panstrongylus guentheri were found, primarily inside houses. The geographical distribution of this species was recorded in nine municipalities of Mato Grosso, and parasitological tests did not detect T. cruzi on P. guentheri.</p><p><strong>Conclusions: </strong>The distribution of this species in Brazil has been recently updated.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e007172024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain death due to intracranial hemorrhage in a child following suspected Bothrops snakebite. 儿童疑似被蛇咬伤后颅内出血导致脑死亡。
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0264-2024
Heloisa Dellandrea, Camilo Molino Guidoni, Arnildo Linck Junior, Edmarlon Girotto
{"title":"Brain death due to intracranial hemorrhage in a child following suspected Bothrops snakebite.","authors":"Heloisa Dellandrea, Camilo Molino Guidoni, Arnildo Linck Junior, Edmarlon Girotto","doi":"10.1590/0037-8682-0264-2024","DOIUrl":"10.1590/0037-8682-0264-2024","url":null,"abstract":"<p><p>Snakebites from the genus Bothrops are common and are responsible for the highest mortality rate in Brazil. Factors related to the species, treatment, and patient influence the clinical manifestations and prognosis of the condition. Young patients without comorbidities have better prognoses and rarely develop severe systemic complications. This report discusses a case of brain death of an 11-year-old boy due to intracranial hypertension following possible Bothrops snakebite. Despite receiving antivenom therapy, the patient experienced seizures, mental confusion, and decreased consciousness. Autopsy, epidemiology, clinical presentation, and laboratory results indicated a snakebite with unconventional symptoms as the cause of death.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008102024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chikungunya chronic arthralgia: impact on general and mental health and absenteeism from work. 基孔肯雅慢性关节痛:对一般健康和精神健康的影响以及缺勤。
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0149-2024
Lorena Gomes Santos, Leile Camila Jacob-Nascimento, Rosângela Oliveira Anjos, Moyra Machado Portilho, Viviane Machicado Cavalcante, Adriane Souza Paz, Mittermayer Barreto Santiago, Cristiane Wanderley Cardoso, Mitermayer Galvão Reis, Guilherme Sousa Ribeiro
{"title":"Chikungunya chronic arthralgia: impact on general and mental health and absenteeism from work.","authors":"Lorena Gomes Santos, Leile Camila Jacob-Nascimento, Rosângela Oliveira Anjos, Moyra Machado Portilho, Viviane Machicado Cavalcante, Adriane Souza Paz, Mittermayer Barreto Santiago, Cristiane Wanderley Cardoso, Mitermayer Galvão Reis, Guilherme Sousa Ribeiro","doi":"10.1590/0037-8682-0149-2024","DOIUrl":"10.1590/0037-8682-0149-2024","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the self-rated general health, mental health, and work absenteeism among patients with laboratory-confirmed chikungunya.</p><p><strong>Methods: </strong>Telephone interviews were conducted with 63 patients ≥22 months after infection.</p><p><strong>Results: </strong>Patients who reported (N=42) or did not report (N=21) chronic arthralgia, defined by duration ≥90 days, had different frequencies for low scores for general health (68.3% vs. 30.0%, respectively; prevalence ratio, 95% confidence interval: 2.3, 1.1-4.6), symptoms of depression (31.7% vs. 15.0%; 2.1, 0.7-6.6), symptoms of anxiety (43.9% vs. 35.0%; 1.3, 0.6-2.5), and work absenteeism (76.5% and 40.0%; 1.9, 0.9-4.2).</p><p><strong>Conclusions: </strong>Chikungunya chronic arthralgia impacts long-term health and work.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e007162024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue Mimickers: Which Clinical Conditions Can Resemble Dengue Fever? 登革热模仿者:哪些临床情况与登革热相似?
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0334-2024
Luis Arthur Brasil Gadelha Farias, Lourrany Borges Costa, Pedro Pinheiro de Negreiros Bessa, Glaura Fernandes Teixeira de Alcântara, Jobson Lopes de Oliveira, Thalita do Nascimento Silva, Giuliana de Fátima Lima Morais, Lauro Vieira Perdigão Neto, Luciano Pamplona Góes Cavalcanti
{"title":"Dengue Mimickers: Which Clinical Conditions Can Resemble Dengue Fever?","authors":"Luis Arthur Brasil Gadelha Farias, Lourrany Borges Costa, Pedro Pinheiro de Negreiros Bessa, Glaura Fernandes Teixeira de Alcântara, Jobson Lopes de Oliveira, Thalita do Nascimento Silva, Giuliana de Fátima Lima Morais, Lauro Vieira Perdigão Neto, Luciano Pamplona Góes Cavalcanti","doi":"10.1590/0037-8682-0334-2024","DOIUrl":"10.1590/0037-8682-0334-2024","url":null,"abstract":"<p><p>Epidemics and outbreaks caused by the dengue virus pose risks to populations and have high mortality rates, causing burdens and economic costs worldwide. Brazil recently experienced an explosive increase in the number of dengue cases and fatalities. Dengue is an acute febrile illness that can progress to severe forms. It affects more than 100 countries, presenting ongoing challenges in Brazil and globally since its identification. Other conditions may be overlooked or mistaken for dengue. The most important differential diagnoses are other infectious diseases and rheumatological, hematological, gastroenterological, and neurological disorders. In this article, we discuss the primary differential diagnoses of dengue and offer a literature review highlighting the key clinical differences among clinicians. This review emphasizes the critical importance of differentiating dengue fever from infectious diseases such as meningococcemia and malaria and autoimmune and rheumatological conditions such as systemic lupus erythematosus to ensure timely and appropriate management.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e002062024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ecological Importance of Breeding Sites in Atlantic Forest Fragments: A Focus on Culicidae Diversity with Particular Attention to Vector Species. 大西洋森林片段繁殖地的生态重要性:库蚊多样性与媒介物种的关注
IF 1.8 4区 医学
Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0037-8682-0108-2024
Shayenne Olsson Freitas Silva, Cecilia Ferreira de Mello, Letícia de Mattos Pavão, Hélcio Reinaldo Gil-Santana, Jeronimo Alencar
{"title":"Ecological Importance of Breeding Sites in Atlantic Forest Fragments: A Focus on Culicidae Diversity with Particular Attention to Vector Species.","authors":"Shayenne Olsson Freitas Silva, Cecilia Ferreira de Mello, Letícia de Mattos Pavão, Hélcio Reinaldo Gil-Santana, Jeronimo Alencar","doi":"10.1590/0037-8682-0108-2024","DOIUrl":"10.1590/0037-8682-0108-2024","url":null,"abstract":"<p><strong>Background: </strong>Vector distribution influences arbovirus persistence. This study examined the diversity of mosquito breeding sites in an Atlantic Forest fragment in Rio de Janeiro, Brazil.</p><p><strong>Methods: </strong>Mosquito specimens were collected at Fazenda dos Cordeiros, Silva Jardim, Brazil. Tire, plastic, bamboo, and sapucaia traps were evaluated for oviposition preferences using ecological indices.</p><p><strong>Results: </strong>Tire traps had the highest density. Bamboo traps showed the highest diversity. Plastic container was the most divergent site. The key recorded vector species included Aedes albopictus and Haemagogus leucocelaenus.</p><p><strong>Conclusions: </strong>Identifying the breeding sites that contribute the most to mosquito density is essential for optimizing control strategies.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e007152024"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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