Revista da Sociedade Brasileira de Medicina Tropical最新文献

{"title":"Erratum: Accuracy of diagnostic strategies for detecting Schistosoma mansoni infection in Brazil: A systematic review and meta-analysis.","authors":"","doi":"10.1590/0037-8682-0466b-2025","DOIUrl":"10.1590/0037-8682-0466b-2025","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0037-8682-0466-2025].</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 ","pages":"e0466b2025"},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of MK-886, an inhibitor of the 5-lipoxygenase-activating protein, on peripheral blood mononuclear cells from patients with Chagas' heart disease.","authors":"Wanessa Maria Dos Santos, Thaís Soares Farnesi de Assunção, João Batista Camargo Neto, Haline Ogata, Maxelle Martins Teixeira, Gabriel Alves Borges Dos Santos, Rodrigo Cunha de Sousa, Dalmo Correia Filho, Virmondes Rodrigues Junior, Lucia Helena Faccioli, Alexandre de Paula Rogério","doi":"10.1590/0037-8682-0130-2026","DOIUrl":"10.1590/0037-8682-0130-2026","url":null,"abstract":"<p><strong>Background: </strong>Chagas disease, caused by Trypanosoma cruzi, remains a major public health challenge in Latin America. Lipid mediators, including leukotrienes, play a key role in modulating the immune response during infection. 5-Lipoxygenase deficiency has been associated with cardioprotective effects in mouse models. Accordingly, this study evaluated the effects of MK-886, a 5-lipoxygenase-activating protein inhibitor, on the immune response of cells from patients with Chagas heart disease.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cells (PBMCs) from patients with chronic Chagas disease were stimulated with T. cruzi antigen in the presence or absence of MK-886. Cytokine production (interferon [IFN]-γ, interleukin [IL]-13, IL-17, IL-10, and tumor necrosis factor [TNF]-α), apoptosis, necrosis, and cell proliferation were assessed.</p><p><strong>Results: </strong>T. cruzi antigen significantly increased cytokine production, cell death, and proliferation in PBMCs from patients with chronic Chagas disease. MK-886 significantly reduced IFN-γ, IL-13, and IL-17 production without altering IL-10 or TNF-α production. Additionally, MK-886 treatment markedly reduced apoptosis, necrosis, and proliferation in T. cruzi-stimulated PBMCs from patients with chronic Chagas disease.</p><p><strong>Conclusions: </strong>MK-886 has the potential to reduce tissue-damaging inflammation and fibrosis associated with Th1, Th2, and Th17 responses without inducing immunosuppression, while IL-10 and TNF-α production remained unchanged in PBMCs from patients with chronic Chagas disease. Accordingly, targeting the leukotriene pathway may delay the progression of cardiac damage in Chagas disease.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 ","pages":"e01302026"},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted ORF8-N Sanger Sequencing as a SARS-CoV-2 Surveillance Contingency During Supply Shortages.","authors":"Brenno Vinícius Martins Henrique, Helder Andrey Rocha Gomes, Marina da Costa Ribeiro, Bruna Cândido Guido, Ricardo Camargo, Lucas Luiz Vieira, Mariana Matos Roll, Jordan Barros da Silva, Glaura Regina de Castro E Caldo Lima, Fabiano José Queiroz Costa, Agenor de Castro Moreira Dos Santos Júnior","doi":"10.1590/0037-8682-0591-2025","DOIUrl":"10.1590/0037-8682-0591-2025","url":null,"abstract":"<p><strong>Background: </strong>Global shortages of next-generation sequencing (NGS) reagents threatened SARS-CoV-2 genomic surveillance in low- and middle-income countries during the COVID-19 pandemic.</p><p><strong>Methods: </strong>During the 2021 NGS reagent shortages, we implemented targeted ORF8-N Sanger sequencing for SARS-CoV-2 variant surveillance in Brazilian public health laboratories.</p><p><strong>Results: </strong>In silico analysis of whole-genome sequencing (WGS)-derived SARS-CoV-2 genomes from the Federal District, Brazil, showed that the ORF8-N target discriminated the major 2021 lineages (Gamma and Delta) and enabled analysis of ˃300 samples despite constrained NGS access.</p><p><strong>Conclusions: </strong>Targeted ORF8-N Sanger sequencing was a useful temporary contingency during NGS reagent shortages but offered lower phylogenetic resolution than WGS.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 ","pages":"e05912025"},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human sporotrichosis in the Amazon: an emerging zoonosis and its clinical-epidemiological challenges.","authors":"Ana Carolina Magalhães Nascimento, Luiza Rennó Rocha De Oliveira, Maria Amélia Lopes Dos Santos, Elcilane Gomes Silva, Francisca Regina Oliveira Carneiro, Renata Mie Oyama Okajima, Carla Andrea Avelar Pires","doi":"10.1590/0037-8682-0560-2025","DOIUrl":"10.1590/0037-8682-0560-2025","url":null,"abstract":"<p><strong>Background: </strong>The number of sporotrichosis cases in Brazil has been continuously increasing, primarily due to zoonotic transmission in urban areas. This study aimed to analyze the occurrence of human sporotrichosis in a reference center in the Amazon region.</p><p><strong>Methods: </strong>This case series study analyzed the medical records of patients diagnosed with sporotrichosis at a dermatology reference service in Northern Brazil.</p><p><strong>Results: </strong>Most patients presented with the localized cutaneous form. Diagnosis was confirmed using clinical and epidemiological criteria, histopathology, and/or culture.</p><p><strong>Conclusions: </strong>Diagnostic suspicion, especially in endemic areas, and early treatment are essential to reduce morbidity, sequelae, and adverse outcomes.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 ","pages":"e05602025"},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sustained \"re-enchantment\" of research in tropical medicine in the Brazilian Amazon.","authors":"Wuelton Monteiro","doi":"10.1590/0037-8682-0406-2026","DOIUrl":"10.1590/0037-8682-0406-2026","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 suppl 1","pages":"e04062026"},"PeriodicalIF":2.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV/AIDS in the state of Amazonas, Brazilian Amazon: decentralization, third-party support and community action.","authors":"Adele Schwartz Benzaken, Zeca Manuel Salimo, Maria Eduarda Leão Farias, Aretha Gomes Omena, Ronaldo Campos Hallal, Renato Chuster Hamed Humar, Beto de Jesus, Izabella Picinin Safe, Marcus Vinícius Guimarães Lacerda","doi":"10.1590/0037-8682-0048-2026","DOIUrl":"10.1590/0037-8682-0048-2026","url":null,"abstract":"<p><p>Amazonas is Brazil's largest state and a paradigmatic tropical medicine setting: vast territories connected mainly by rivers, high cultural and linguistic diversity, and multiple co-endemic infections. The state comprises 62 municipalities and roughly 4.3 million inhabitants, with approximately half of its inhabitants residing in Manaus, the capital, where specialized human immunodeficiency virus (HIV ) services have historically been concentrated. However, the HIV/ acquired immunodeficiency syndrome (AIDS) epidemic has shown sustained interiorization beyond the capital and a high AIDS mortality coefficient, reflecting late diagnosis and gaps in retention in care. Over the last decade, expanded testing, rapid initiation of antiretroviral therapy (ART), the introduction of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), HIV self-testing, and decentralized municipal services in partnership with third parties, such as the AIDS Healthcare Foundation (AHF), have coincided with declining AIDS mortality, yet heterogeneity across municipalities remains pronounced, including in predominantly Indigenous areas and border regions. This review synthesizes key programmatic inflection points and highlights the complementary roles of the public sector, third-party organizations, and civil society in implementing combination prevention, improving linkage to care and monitoring loss to follow-up. In this narrative review, we argue that HIV in the Brazilian Amazon should be understood through a syndemic lens encompassing tuberculosis co-infection, mobility and geographic dispersion, and that progress toward 95-95-95-aligned targets will require differentiated service delivery, integrated tuberculosis (TB)/HIV strategies, and supply-chain and workforce resilience tailored to riverine, rural and Indigenous contexts.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 suppl 1","pages":"e00482026"},"PeriodicalIF":2.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Biomarkers for the Human Diagnosis of Neglected Tropical Diseases: A Systematic Review.","authors":"Jéssica Burlamaque Maciel, Rebeca Linhares Abreu Netto, Victor Irungu Mwangi, Camila Fabbri, Asenate Aline Xavier Adrião, Zeca Manuel Salimo, Michael Nosano Yakubu, Luíz Gustavo Araújo Gardinassi, Lúcia Helena Faccioli, Hector Henrique Ferreira Koolen, Gisely Cardoso de Melo, Marco Aurélio Sartim, Wuelton Marcelo Monteiro","doi":"10.1590/0037-8682-0298-2025","DOIUrl":"10.1590/0037-8682-0298-2025","url":null,"abstract":"<p><p>Neglected tropical diseases (NTDs) affect more than 1.6 billion people worldwide and remain major contributors to morbidity, disability, stigma, and poverty. Metabolomics has emerged as a promising approach for investigating disease-associated biochemical alterations and identifying biomarkers for diagnosis, prognosis, and treatment monitoring. This systematic review evaluated the available evidence on metabolomic profiles in WHO-defined NTDs and their potential clinical applications. MEDLINE/PubMed, Web of Science, and Scopus were searched through March 2026. Observational studies investigating metabolomic profiles in human subjects with NTDs were included, and methodological quality was assessed using a modified QUADOMICS tool. Seventy-four studies met the inclusion criteria. Most were conducted in China and Brazil and focused on dengue, onchocerciasis, schistosomiasis, leprosy, and Chagas disease. Across diseases, metabolomic alterations were predominantly observed in amino acid, lipid, carbohydrate, and energy metabolism pathways. Several candidate biomarkers were identified, including N-acetyltyramine-O-β-glucuronide for onchocerciasis, bile acid derivatives for schistosomiasis, amino acids and peptides for Chagas disease, lipid mediators for leprosy, and lipid- and serotonin-related metabolites for dengue. However, most studies remained exploratory, and only two validated biomarkers in independent populations. Risk-of-bias assessment revealed frequent methodological limitations, including inadequate reporting of pre-analytical procedures, insufficient characterization of study populations, and lack of strategies to address overfitting. Human metabolomics studies were absent for several WHO-defined NTDs, highlighting major research gaps. Future research should prioritize standardized methodologies, multicenter validation studies, and greater inclusion of underrepresented diseases and endemic populations to translate metabolomic discoveries into clinically useful tools for NTD diagnosis, monitoring, and control.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 suppl 1","pages":"e02982025"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Chagas disease in Amazonas: an integrated approach.","authors":"Maria das Graças Vale Barbosa Guerra, Flávio Renan Paula da Costa Alcântara, Alba Regina Jorge Brandão, Rômulo Freire de Morais, Jessica Vanina Ortiz, Gabriela Maciel Alencar, Nádelly Karoline Martins Derze, Cássia Camila de Oliveira Araújo, Lara Isabelli Oliveira da Silva, Susan Smith Doria, Lucely Paiva Rodrigues da Silva, Mônica Regina Hosannah da Silva E Silva, Kátia do Nascimento Couceiro, João Marcos Bemfica Barbosa Ferreira, Jorge Augusto de Oliveira Guerra","doi":"10.1590/0037-8682-0581-2025","DOIUrl":"10.1590/0037-8682-0581-2025","url":null,"abstract":"<p><p>In the Amazon, Chagas disease (CD) transmission is associated with the consumption of contaminated foods -most notably açaí-and constitutes an important public health concern. In Brazil, the state of Amazonas ranks third in acute-phase notifications among states in the region, with 25% of municipalities having already reported acute CD cases, predominantly in outbreaks in rural areas. This study describes the current overview of knowledge on CD in Amazonas, bringing together research findings from the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), developed in partnership with the graduate program in Tropical Medicine at the Universidade do Estado do Amazonas (UEA). The findings show that, in addition to oral transmission, accidental contact with the traditional vector (Triatominae) has been reported. The predominant transmission pattern represents an important shift in the dynamics of the disease and reinforces the need for surveillance strategies focused on controlling foodborne transmission. Among the main challenges are logistical difficulties for post-treatment clinical follow-up, especially in remote areas, and the absence of a structured and specialized network for continuous case monitoring and detection of new outbreaks. Added to this is the lack of systematic CD screening in women of childbearing age during prenatal care, which hinders surveillance of vertical transmission. These issues highlight the urgency of strengthening surveillance and preventing new incidences.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 suppl 1","pages":"e05812025"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute respiratory viral diseases in Amazonas, Brazil: epidemiological patterns and implications for health surveillance.","authors":"Rahyja Teixeira, Felipe Nery, Erica Carvalho, Ivana Andrade Vieira Neves, Fernando Val, Monique Freire, Felipe Murta, Maria Paula Gomes Mourão, Wuelton Monteiro, Vanderson Sampaio","doi":"10.1590/0037-8682-0102-2026","DOIUrl":"10.1590/0037-8682-0102-2026","url":null,"abstract":"<p><strong>Background: </strong>Acute respiratory viral diseases are a major public health challenge in the Brazilian Amazon, where ecological, logistical, and social factors shape patterns of transmission and response.</p><p><strong>Methods: </strong>This study aimed to analyze the epidemiological patterns and temporal-spatial distribution of Influenza-like illness (ILI) and severe acute respiratory syndrome (SARS) in the state of Amazonas, Brazil, between 2015 and 2025, distinguishing SARS-CoV-2 and non-SARS-CoV-2 etiologies using data from OpenDataSUS.</p><p><strong>Results: </strong>Incidence peaks occurred in early 2021 and 2022, with pronounced regional disparities. The highest burdens were concentrated in specific municipalities, with Manaus exhibiting an intermediate incidence and playing a central role in case notifications and healthcare provision.</p><p><strong>Discussion: </strong>We describe the integration of surveillance systems, laboratory networks, and healthcare infrastructure, which enabled improvements in diagnosis, monitoring, and care. The region's response model, centered in Manaus, includes primary-to-tertiary care coordination, molecular diagnostics, telemedicine, and mobile health units for Indigenous and remote areas. Research efforts during the COVID-19 pandemic provided critical insights into therapeutic strategies, immunopathology, and long-term sequelae, while also highlighting persistent inequities and diagnostic gaps. Our findings underscore the co-circulation of multiple respiratory pathogens and the need for continued genomic and syndromic surveillance. Future strategies must address regional disparities, support decentralized diagnostics, and expand clinical research. Strengthening integrated health systems in the Brazilian Amazon is essential for timely, equitable responses to emerging respiratory threats.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 suppl 1","pages":"e01022026"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERRATUM: Dr. João Carlos Pinto Dias, master and mentor! (★1948 †2021).","authors":"","doi":"10.1590/0037-8682-e0076b-2026","DOIUrl":"10.1590/0037-8682-e0076b-2026","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0037-8682-0076-2026].</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"59 ","pages":"e0076b2026"},"PeriodicalIF":2.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}