Revista da Sociedade Brasileira de Medicina Tropical最新文献

{"title":"Isoniazid use, effectiveness, and safety for treatment of latent tuberculosis infection: a systematic review.","authors":"Bárbara Manuella Cardoso Sodré-Alves, Melina Mafra Toledo, Ivan Ricardo Zimmermann, Wildo Navegantes de Araújo, Noemia Urruth Leão Tavares","doi":"10.1590/0037-8682-0504-2023","DOIUrl":"10.1590/0037-8682-0504-2023","url":null,"abstract":"<p><strong>Background: </strong>The treatment strategy for latent tuberculosis infection is to reduce the number of tuberculosis cases and consequently reduce the transmission of pathogenic bacteria. This study aimed to determine the safety, effectiveness, and adherence of isoniazid use for latent tuberculosis infection treatment.</p><p><strong>Methods: </strong>To identify studies on isoniazid use for latent tuberculosis infection, five electronic databases were searched. The methods and results are presented in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Results: </strong>Most studies (53) used isoniazid for 9 months. The prevalence of use and adherence to treatment varied considerably (18% to 100%), and were evaluated by participant completion of isoniazid treatment for latent tuberculosis infection. The adverse events most frequently reported were hepatotoxicity, gastric intolerance, and neuropathy; the rates of occurrence ranged from < 1% to 48%. In the studies that evaluated the effectiveness of isoniazid for latent tuberculosis infection, the rate varied from 0 to 19.7% for patients who did not have active tuberculosis after the follow-up period.</p><p><strong>Conclusions: </strong>The importance of maintaining follow up for patients using isoniazid should be emphasized due to the risk of developing adverse events. Despite the treatment challenges, the rates of patients who used isoniazid and developed active tuberculosis during the follow-up period were low. We believe that isoniazid continues to contribute to tuberculosis control worldwide, and better care strategies are required.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e004022024"},"PeriodicalIF":1.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of arbovirus infections in two riverine populations in the municipality of Humaitá, Amazonas, Brazil.","authors":"Jaqueline Carvalho de Oliveira Silva, Igor Rodrigo Ferreira Siqueira, Leormando Fortunato Dornelas, Cristhian Magalhães Ribeiro, João Pedro Berno Gomes, Iagor Wingenbah Guadagnin, Antonieta Relvas Pereira, Genimar Rebouças Julião, Juliana de Souza Almeida Aranha Camargo, Sergio Almeida Basano, Luís Marcelo Aranha Camargo","doi":"10.1590/0037-8682-0515-2023","DOIUrl":"10.1590/0037-8682-0515-2023","url":null,"abstract":"<p><strong>Background: </strong>The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in a riverside population in the Humaitá municipality of the Brazilian Amazon. More than 80% of the local population participated in this study. Entomological samples were collected to identify local mosquito vectors.</p><p><strong>Results: </strong>Analysis of 205 human serological samples revealed IgG antibodies against the dengue virus in 85 individuals. No molecular positivity was observed in human samples. Entomological analyses revealed 3,187 Diptera species, with Mansonia being the most frequent genus. Aedes aegypti and Aedes albopictus were not detected in the two collections.</p><p><strong>Conclusions: </strong>IgG antibodies against the dengue virus were highly prevalent, suggesting previous exposure. The absence of the arbovirus vectors Aedes aegypti and Aedes albopictus in the samples supports the hypothesis that the infections recorded likely occurred outside the riverside communities investigated.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e004032024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case of envenomation in humans caused by the banded cat-eyed snake Leptodeira annulata (Linnaeus, 1758) (Squamata: Dipsadidae) in Brazil.","authors":"Larissa Ferreira-Cunha, Mariana Fiszer, Walter Periard Junior, Pedro Henrique Pinna","doi":"10.1590/0037-8682-0555-2023","DOIUrl":"10.1590/0037-8682-0555-2023","url":null,"abstract":"<p><p>A 22-year-old female researcher was bitten by a Leptodeira annulata on the index finger of the left hand during a contention activity. After removing the snake, a little bleeding and redness was observed in the bite region, accompanied by fang marks. Thirty minutes later, edema had progressed to the dorsum of the hand. After four hours, edema persisted, but the bitten area was slightly whitened. Treatment consisted of antibiotics and anti-inflammatory drugs. The edema resolved completely and disappeared after 48 hours. Overall, this report presents the first case of envenomation in humans caused by Leptodeira annulata in Brazil.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008032024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of mixed Trypanosoma cruzi discrete typing units infection in Triatoma phyllosoma in the peri-urban environment of Oaxaca, Mexico.","authors":"Dulce Concepción Domínguez-Cruz, Doireyner Daniel Velázquez-Ramírez, Zendy Evelyn Olivo-Vidal, José Antonio De Fuentes-Vicente, Héctor Ochoa-Díaz-López","doi":"10.1590/0037-8682-0449-2023","DOIUrl":"10.1590/0037-8682-0449-2023","url":null,"abstract":"<p><strong>Background: </strong>Chagas disease, a zoonosis transmitted mainly by hematophagous insects of the subfamily Triatominae, is caused by Trypanosoma cruzi, classified into six discrete typing units (DTUs: TcI-TcVI and Tcbat).</p><p><strong>Methods: </strong>Insect vectors were collected from 84 human dwellings in the municipality of Santo Domingo Tehuantepec, Oaxaca, Mexico; 4.76% were infested. DTUs were determined using conventional and nested PCR.</p><p><strong>Results: </strong>The infection rate was 43.6%. All insects were infected with TcI while one specimen showed mixed infection with TcII.</p><p><strong>Conclusions: </strong>This is the first report of T. cruzi mixed infection in Triatoma phyllosoma, its main vector in the study region.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e007032024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spondylodiscitis caused by the Burkholderia cepacia complex.","authors":"Rulian Christi Souza Rodrigues Candido, Luiz Fernando Monte Borella, Marcelo de Carvalho Ramos, Lucieni Oliveira Conterno, Fabiano Reis","doi":"10.1590/0037-8682-0001-2024","DOIUrl":"10.1590/0037-8682-0001-2024","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e009112024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversed halo sign in a patient with septic embolism.","authors":"Louise Fátima Gomes-Almeida, Nathalia Christina Lopes Flores, Beatriz Rodrigues Bozza, Edson Marchiori","doi":"10.1590/0037-8682-0630-2023","DOIUrl":"10.1590/0037-8682-0630-2023","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e009102024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycosis Fungoides: A Necessary Differential Diagnosis in Infectious Disease and Dermatology Settings.","authors":"Claudio José Dos Santos Júnior, Aryanna Kelly Pinheiro Souza, Thiago José Matos Rocha","doi":"10.1590/0037-8682-0622-2023","DOIUrl":"10.1590/0037-8682-0622-2023","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e009092024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracoccidioidomycosis manifested by sarcoid-like cutaneous lesions with severe systemic disease: a rare and challenging diagnosis.","authors":"Bruna Dos Anjos Bortolini, Rachel Bertolani do Espírito Santo, Lucia Martins Diniz, Robson Dettmann Jarske, Natália Tebas de Castro","doi":"10.1590/0037-8682-0605-2023","DOIUrl":"10.1590/0037-8682-0605-2023","url":null,"abstract":"<p><p>Cutaneous involvement in paracoccidioidomycosis (PCM) can exhibit a highly polymorphic spectrum. The infiltrative pattern corresponds to up to 26.6% of observed skin lesions, including sarcoid-like plaques, a rare presentation of cutaneous lesions in PCM. This clinical expression is almost exclusively cutaneous, and its histology reveals a tuberculoid granuloma with a scarcity of fungi, leading to misdiagnosis as other granulomatous diseases. Here, we report a rare form of chronic multifocal paracoccidioidomycosis manifesting as sarcoid-like skin lesions misdiagnosed as granulomatous rosacea in a patient with severe systemic disease.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008042024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gnathostoma infection after ingestion of raw fish is a probable cause of eosinophilic meningitis in the Brazilian Amazon.","authors":"Carlos Graeff-Teixeira, Dayse Souza de Pauli, Carlos Alexandre Martins Zicarelli, Vanessa Fey Pascoal, Estefany de Paula Paiva-Novaes, João Pedro Sarcinelli Chagas, Betina Bolina Kersanach, David Jamil Hadad, Letícia Karolini Walger-Schultz","doi":"10.1590/0037-8682-0434-2023","DOIUrl":"10.1590/0037-8682-0434-2023","url":null,"abstract":"<p><p>We report a case of eosinophilic meningitis associated with the ingestion of raw fish (Cichla sp.) from the Brazilian Amazon, likely caused by Gnathostoma. A 36-year-old male visited Juruena river on a fishing trip. After 50 days, the patient presented with an intense frontal headache. A cerebrospinal fluid examination revealed 63% eosinophilia. Another individual who ingested raw fish developed linear dermatitis on the abdominal wall. Anti-Gnathostoma serum antibodies were detected, and the patient made a full recovery after treatment with corticosteroids and albendazole. To date, autochthonous Gnathostoma spp. infections in Latin American countries have only caused linear panniculitis. This report raises awareness of gnathostomiasis-causing meningitis.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008012024"},"PeriodicalIF":2.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural leprosy investigation using electroneuromyography and the ML Flow rapid test: a case report.","authors":"Roque Rafael de Oliveira Neto, Gabriela Belmonte Dorilêo, Ana Carolina da Silva Ferreira Mendonça, Amílcar Sabino Damazo","doi":"10.1590/0037-8682-0586-2023","DOIUrl":"10.1590/0037-8682-0586-2023","url":null,"abstract":"<p><p>Neural leprosy, which is characterized by nerve involvement without visible skin lesions, presents a diagnostic challenge. This case report examined the significance of diverse diagnostic modalities in the identification of pure neural leprosy. A 28-year-old patient with symptoms of edema, pain, paresthesia, and diminished sensitivity in the lower limbs underwent various tests. A stilt skin smear yielded negative results on bacilloscopy, whereas a Fast ML Flow leprosy test and electroneuromyography supported the diagnosis. This discussion highlights the importance of accessible methods for early investigation. This study emphasizes the multidisciplinary approach and value of the Fast ML Flow leprosy test and electroneuromyography for diagnosing neural leprosy.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"57 ","pages":"e008022024"},"PeriodicalIF":2.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}