Nayara Ragi Baldoni, Nayara Dornela Quintino, Claudia Di Lorenzo Oliveira, José Luiz Padilha da Silva, Ariela Mota Ferreira, Antonio Luiz Pinho Ribeiro, Ester Cerdeira Sabino, Clareci Silva Cardoso
{"title":"Chagas disease and perceived quality of life: a cross-sectional study.","authors":"Nayara Ragi Baldoni, Nayara Dornela Quintino, Claudia Di Lorenzo Oliveira, José Luiz Padilha da Silva, Ariela Mota Ferreira, Antonio Luiz Pinho Ribeiro, Ester Cerdeira Sabino, Clareci Silva Cardoso","doi":"10.1590/0037-8682-0206-2023","DOIUrl":"10.1590/0037-8682-0206-2023","url":null,"abstract":"<p><strong>Background: </strong>Chagas disease (ChD) is a neglected tropical disease that is caused by the protozoan parasite Trypanosoma cruzi and can negatively impact quality of life (QoL). This study aimed to assess and compare QoL between individuals with and without ChD.</p><p><strong>Methods: </strong>This cross-sectional study was performed within a concurrent cohort study (REDS). The participants were derived from two blood donation centers: São Paulo capital and Montes Claros, Minas Gerais, Brazil. Participants with ChD were identified in blood donations by serological diagnosis between 2008 and 2010, and those without ChD were donors with negative serology identified during the same period. QoL was assessed using the World Health Organization Quality of Life-BREF questionnaire. Logistic regression was used to compare sociodemographic and clinical characteristics between the groups, and mean, standard deviation, and beta regression were used to compare QoL.</p><p><strong>Results: </strong>In total, 611 individuals participated in the study (328 with ChD and 283 without ChD). Participants with ChD had lower QoL in the physical (p=0.02) and psychological (p<0.01) domains than did individuals without CD.</p><p><strong>Conclusions: </strong>Individuals with ChD had worse QoL perceptions. These results provide a comprehensive understanding of the impact of ChD on individuals' QoL, while also highlighting potential opportunities for improving the care and treatment of those affected.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e02062023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.","authors":"Larissa Marchi Zaniolo, Amílcar Sabino Damazo","doi":"10.1590/0037-8682-0265-2023","DOIUrl":"https://doi.org/10.1590/0037-8682-0265-2023","url":null,"abstract":"<p><p>While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e02652023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Larissa Nobre Lopes de Lima, Fernando Carlos Santos de Almeida, Diogo Goulart Corrêa
{"title":"Computed Tomography Features of Parotid Tuberculosis.","authors":"Larissa Nobre Lopes de Lima, Fernando Carlos Santos de Almeida, Diogo Goulart Corrêa","doi":"10.1590/0037-8682-0455-2023","DOIUrl":"https://doi.org/10.1590/0037-8682-0455-2023","url":null,"abstract":"A 27-year-old man presented with enlargement of the left","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e04552023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regielle Luiza de Medeiros, Adriana da Silva Rezende Moreira, Ana Carolina de Oliveira Jeronymo Neves, Viviane de Jesus Leite, Isabela Neves de Almeida, Fernanda Carvalho de Queiroz Mello, Afrânio Kritski
{"title":"Analysis of catastrophic costs incurred by patients with multidrug-resistant tuberculosis in an outpatient clinic in the state of Rio de Janeiro.","authors":"Regielle Luiza de Medeiros, Adriana da Silva Rezende Moreira, Ana Carolina de Oliveira Jeronymo Neves, Viviane de Jesus Leite, Isabela Neves de Almeida, Fernanda Carvalho de Queiroz Mello, Afrânio Kritski","doi":"10.1590/0037-8682-0148-2023","DOIUrl":"https://doi.org/10.1590/0037-8682-0148-2023","url":null,"abstract":"<p><strong>Background: </strong>Multidrug-resistant tuberculosis (MDR-TB) is a serious global public health concern associated with social vulnerability. In Brazil, the Unified Health System (SUS, Portuguese) provides free diagnosis and treatment for MDR-TB; however, other expenses may still be incurred for patients and their families which, according to the World Health Organization (WHO), can be catastrophic when these costs surpass 20.0% of the annual household income. This study aimed to assess the extent of catastrophic costs related to the diagnostic and therapeutic aspects of MDR-TB among patients receiving care at an outpatient clinic in Rio de Janeiro.</p><p><strong>Methods: </strong>This prospective study used convenience sampling from July 2019 to June 2021. Data regarding direct and indirect costs were collected using a standardized questionnaire endorsed by the WHO. To analyze any impoverishment occurred from MDR-TB, a threshold established by the Brazilian Institute of Geography and Statistics for 2019 and 2020 of US$ 79,562 and US$ 94,5273, respectively, was applied. Descriptive statistics were used for data analysis, including mean; standard deviation; variation coefficient; median; and maximum, minimum, and interquartile ranges.</p><p><strong>Results: </strong>A total of 65 patients were interviewed. Among the participants, 73.8% experienced catastrophic costs, with indirect costs exerting the most significant impact (median: US$ 3,825.9), in contrast to direct costs (median: US$ 542.7). When comparing the periods before and after diagnosis, the prevalence of poverty increased from 12.0% to 28.0%.</p><p><strong>Conclusions: </strong>Despite the support from the SUS in Brazil, diagnostic and therapeutic cascades incur additional costs, exacerbating social vulnerability among patients with MDR-TB.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e01482023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Alves Ribeiro Oliveira, Miguel Junior Sordi Bortolini, Ernesto Akio Taketomi, Rafael de Oliveira Resende
{"title":"COVID-19 self-testing in Brazil and the imminent risk of underreporting cases.","authors":"Laura Alves Ribeiro Oliveira, Miguel Junior Sordi Bortolini, Ernesto Akio Taketomi, Rafael de Oliveira Resende","doi":"10.1590/0037-8682-00287-2023","DOIUrl":"10.1590/0037-8682-00287-2023","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e02872023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Candida albicans renal abscesses predisposed by staghorn calculi.","authors":"Chee Yik Chang","doi":"10.1590/0037-8682-0421-2023","DOIUrl":"10.1590/0037-8682-0421-2023","url":null,"abstract":"A 73-year-old man with type 2 diabetes mellitus and hypertension presented with fever, lethargy, and reduced oral intake for two weeks. The patient was febrile and hemodynamically stable upon arrival. Otherwise, physical examination results were unremarkable. Blood cultures revealed no growth, whereas urine cultures revealed Candida albicans. Abdominal and pelvic computed tomography (CT) revealed left renal abscesses, left staghorn calculi, and hydroureter (Figure 1). The left renal abscess was aspirated and the pus was drained, revealing Candida albicans, which is sensitive to fluconazole. The patient underwent left retrograde pyelography and ureteric stenting. The patient was initially treated with intravenous fluconazole, followed by oral fluconazole for four weeks. Follow-up CT revealed resolution of the renal abscess.","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e04212023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
João Luiz Veloso Mourão, Alessa Andrade Santana, Marcelo de Carvalho Ramos, Lucieni Conterno, Fabiano Reis
{"title":"Post-infectious inflammatory response syndrome related to cryptococcal meningoencephalitis.","authors":"João Luiz Veloso Mourão, Alessa Andrade Santana, Marcelo de Carvalho Ramos, Lucieni Conterno, Fabiano Reis","doi":"10.1590/0037-8682-0438-2023","DOIUrl":"10.1590/0037-8682-0438-2023","url":null,"abstract":"Authors’ contribution: JLVM: acquisition of data and writing the initial drafts of the manuscript. AAS: acquisition of data and writing the initial drafts of the manuscript. MCR: acquisition of data and critical revision. LC: acquisition of data and critical revision. FR: concept, acquisition of data and critical revision of the manuscript for intellectual content. The authors approved the final version to be published and agreed to be accountable for all aspects of the work.","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e04382023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thrombosed umbilical vein varix in newborn with congenital syphilis.","authors":"Merve Erkan, İpek Güney Varal","doi":"10.1590/0037-8682-0406-2023","DOIUrl":"10.1590/0037-8682-0406-2023","url":null,"abstract":"Received 20 August 2023 ● Accepted 19 September 2023 FIGURE 1: (A-B) Sonographic examination showing a heterogeneous partially solid and cystic tubular mass (arrow) arising from the left lobe of the liver to the umbilicus along the tract of the umbilical vein (interrupted arrow). (C) No flow was detected in the lesion on Doppler US (arrow). Thrombosed umbilical vein varix in newborn with congenital syphilis","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e04062023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum.","authors":"","doi":"10.1590/0037-8682-0221B-2021","DOIUrl":"https://doi.org/10.1590/0037-8682-0221B-2021","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0037-8682-0211-2023].</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"56 ","pages":"e0221b2023"},"PeriodicalIF":2.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}