Performance evaluation of rapid diagnostic tests for Chagas disease in Jutiapa, Guatemala.

IF 2.3 4区医学 Q2 PARASITOLOGY

Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI:10.1590/0037-8682-0065-2025

Karla Lange, Andrea Marchiol, Rafael Herazo, Marianela Menes, Carlota Monroy, Antonieta Rodas, Belter Alcántara, Karen Carrillo, María Jesús Pinazo

引用次数: 0

Abstract

Background: Chagas disease remains a public health problem in Guatemala, with ongoing transmission, both regionally and globally. Diagnosis is complex and often inaccessible. This study evaluated the performance of rapid diagnostic tests for Trypanosoma cruzi infection in Jutiapa.

Methods: Three rapid tests were performed, and the results were compared with those of a diagnostic algorithm for chronic infection.

Results: Although all tests had high specificity, their sensitivities were suboptimal. The combined use of RDTs (Rapid Diagnostic Tests) slightly improved the sensitivity, but it remained below the ideal thresholds.

Conclusions: Further evaluation of RDTs is necessary to enhance access and simplify diagnostic algorithms.

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危地马拉胡蒂亚帕恰加斯病快速诊断检测试剂盒的性能评价。

背景：恰加斯病仍然是危地马拉的一个公共卫生问题，在区域和全球都有持续传播。诊断是复杂的，往往难以获得。本研究评价了胡蒂亚帕市克氏锥虫感染快速诊断试验的性能。方法：采用三种快速检测方法，并与一种慢性感染诊断算法进行比较。结果：虽然所有的检测方法都有很高的特异性，但它们的灵敏度不是最佳的。rdt（快速诊断试验）的联合使用略微提高了灵敏度，但仍低于理想阈值。结论：有必要进一步评估RDTs，以提高可及性并简化诊断算法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista da Sociedade Brasileira de Medicina Tropical 医学-热带医学

CiteScore

3.40

自引率

10.00%

发文量

195

审稿时长

3-8 weeks

期刊介绍： The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.