Revista Brasileira De Ciencias Farmaceuticas最新文献_第4页

Biomarker methods in drug discovery and development 药物发现和开发中的生物标志物方法

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300029

Carlota Oliveira Rangel Yagui

引用次数: 0

Teores de chumbo e cdmio em chs comercializados na regio metropolitana de Belo Horizonte 贝洛奥里藏特都市区销售的chs中的铅和镉含量

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300012

Irma Regina Carrara Vulcano, Josianne Nicácio Silveira, E. M. Alvarez-Leite

{"title":"Teores de chumbo e cdmio em chs comercializados na regio metropolitana de Belo Horizonte","authors":"Irma Regina Carrara Vulcano, Josianne Nicácio Silveira, E. M. Alvarez-Leite","doi":"10.1590/S1516-93322008000300012","DOIUrl":"https://doi.org/10.1590/S1516-93322008000300012","url":null,"abstract":"This research aims at evaluating the levels of lead and cadmium in industrialized and non-industrialized samples of tea traded in the metropolitan area of Belo Horizonte, due to the constant use of different kinds of tea by the Brazilians. Camomile and mate have been selected and analyzed as tea-infusion and digested-plant. The levels of Pb and Cd were determined by spectrometry of atomic absorption with graphite furnace and Zeeman background corrector. The average levels of Pb and Cd in samples of camomile and mate tea-infusion were below the values established by the Brazilian legislation for metals in soft drinks (0.2 mg/L). The concentrations of metals in plant-digested camomile samples (0.15 µg/g to Cd and 0.42 µg/g to Pb) and plant-digesgted mate samples (0.53 µg/g) were considered normal according to the literature with exception of Cd levels in plant-digested mate samples (2.59 µg/g). Difference was not found significant between the levels of quantified Cd and Pb in samples of industrialized and not industrialized tea-infusion camomile and mate teas. The concentrations of metals were higher in industrialized digested-plant camomile and mate, when compared with not industrialized. There was no significant difference among tea-infusion samples.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89035425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Capacidade da matriz extracelular da medula óssea de induzir proliferação de células mielóides in vitro no modelo de desnutrição protéica em camundongos 骨髓细胞外基质在小鼠蛋白质营养不良模型中诱导髓细胞增殖的能力

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300020

Cidônia de Lourdes Vituri, Marcio Alvarez-Silva, Andréa Gonçalves Trentin, P. Borelli

{"title":"Capacidade da matriz extracelular da medula óssea de induzir proliferação de células mielóides in vitro no modelo de desnutrição protéica em camundongos","authors":"Cidônia de Lourdes Vituri, Marcio Alvarez-Silva, Andréa Gonçalves Trentin, P. Borelli","doi":"10.1590/S1516-93322008000300020","DOIUrl":"https://doi.org/10.1590/S1516-93322008000300020","url":null,"abstract":"The aim of this study was to verify the capacity of the extracellular matrix (ECM) obtained from bone marrow of malnourished mice to sustain survival and to induce the proliferation of myeloid cells. We also verified the capacity of the tests to interact with in vitro hematopoietic cytokines. Male \"Swiss\" mice were submitted to protein malnutrition with a diet content of '4% casein until they lost 20% of the original weight, while the group-control was kept with a diet content of 14% of casein. The bone marrow was extracted with 1.0 mg of aprotinin/mL in PBS. The proliferation tests were carried out with myeloid cell line FDCP-1, by the colorimetric method of reduction of the MTT. The obtained ECM from nourished and undernourished mice induced cellular proliferation invitro. Tests performed with Il-3 and GM-CSF cytokines in a concentration of 10 and 500 ρg/mL displayed synergic and regulatory effects respectively. The ECM obtained from the malnourished group submitted to the binding to GM-CSF demonstrated higher cellular proliferation than the ECM obtained from the control group (p<0.05). The results suggest that the alterations in the composition of ECM of bone marrow caused by malnutrition might lead to modification of the GM-CSF activity modulation.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"506 Pt B 1","pages":"493-501"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83494012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Design and release characteristics of sustained release tablet containing metformin HCl 盐酸二甲双胍缓释片的设计与释药特性

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300018

S. Basak, K. S. Kumar, M. Ramalingam

{"title":"Design and release characteristics of sustained release tablet containing metformin HCl","authors":"S. Basak, K. S. Kumar, M. Ramalingam","doi":"10.1590/S1516-93322008000300018","DOIUrl":"https://doi.org/10.1590/S1516-93322008000300018","url":null,"abstract":"Metformin hydrochloride (metformin HCl) was formulated as a hydrophobic matrix sustained release tablet employing wax materials and the sustained release behavior of the fabricated tablet was investigated. Sustained release matrix tablets containing 500 mg metformin HCl were developed using different bees wax combinations. The tablets were prepared by wet granulation technique. The formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced monolithic tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. Statistically significant differences were found among the drug release profile from different bees wax combination matrices. The results of dissolution studies indicated that formulations F-III, F-IV and F-V (bees wax and cetyl alcohol combination matrices), exhibited drug release pattern very close to theoretical release profile. Applying kinetic equation models, the mechanism of release of the drug from the three formulations was found to be followed Higuchi model, as the plots showed high linearity, with correlation coefficient (R2) value of 0.98 or more. Tablet matrices containing cetyl alcohol gave better release of the drug than other materials studied. However, the rate of release varied with amount of cetyl alcohol in the matrix. The 'n' value lies below 0.5 (Korsmeyer-Peppas model) demonstrating that the mechanism controlling the drug release was the quasi Fickian. Therefore, the results of the kinetic study obtained permit us to conclude that the fabricated hydrophobic matrix tablets, in this case, delivers the drug through diffusion dominated mechanism.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"60 1","pages":"477-483"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77442253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Prof. Dr. Paulo Suyoshi Minami (1940-2008)

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300002

Sunao Sato

引用次数: 0

Development and in vitro evaluation of tablets based on the antichagasic benznidazole 以抗恰加斯基苯并硝唑为基础的片剂的研制及体外评价

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300007

J. L. S. Sobrinho, Luciana Neiva Antunes Lima, Diego Cavalcanti Perrelli, J. L. Silva, F. P. M. Medeiros, M. Soares, P. R. Neto

{"title":"Development and in vitro evaluation of tablets based on the antichagasic benznidazole","authors":"J. L. S. Sobrinho, Luciana Neiva Antunes Lima, Diego Cavalcanti Perrelli, J. L. Silva, F. P. M. Medeiros, M. Soares, P. R. Neto","doi":"10.1590/S1516-93322008000300007","DOIUrl":"https://doi.org/10.1590/S1516-93322008000300007","url":null,"abstract":"O trabalho teve como objetivo a verificacao das possiveis interferencias dos excipientes utilizados na obtencao do comprimido de liberacao imediata a base de benznidazol por meio do processo de compressao direta e realizacao de estudo comparativo entre os comprimidos obtidos e o medicamento de referencia Rochagan®, obtido por meio da granulacao por via umida. Sete lotes de bancada (LB) foram produzidos e aspectos, tais como compressibilidade, fluxo do pos, peso medio, friabilidade, desintegracao, dureza, teor, dissolucao, uniformidade de conteudo, cinetica de liberacao in vitro (dissolucao) e compatibilidade fisico-quimica farmaco/excipiente foram avaliados. Diante dos resultados obtidos pode-se verificar que os pos analisados apresentaram caracteristicas adequadas para o processo da compressao direta, alem da comprovacao da nao existencia de interacao de natureza fisico-quimica entre o farmaco e os excipientes testados. Os comprimidos obtidos a partir do LB I e III foram escolhidos para o estudo comparativo frente ao medicamento de referencia, demonstrando semelhanca com os resultados observados, tratados estatisticamente. Torna-se, assim, uma alternativa para a producao de medicamento destinado ao tratamento da doenca de Chagas com um custo reduzido e qualidade satisfatoria.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"144 1","pages":"383-389"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86019951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The nutritional biochemistry of chromium (III) 铬(III)的营养生化

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300028

J. Tirapegui

引用次数: 22

Efeito do extrato bruto das folhas de Smallanthus sonchifolius (yacon) sobre a glicemia de ratos diabéticos 雪莲叶粗提物对糖尿病大鼠血糖的影响

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300024

Silmara Baroni, Fumie Suzuki-Kemmelmeier, S. M. Caparroz-Assef, R. Cuman, C. A. Bersani-Amado

{"title":"Efeito do extrato bruto das folhas de Smallanthus sonchifolius (yacon) sobre a glicemia de ratos diabéticos","authors":"Silmara Baroni, Fumie Suzuki-Kemmelmeier, S. M. Caparroz-Assef, R. Cuman, C. A. Bersani-Amado","doi":"10.1590/S1516-93322008000300024","DOIUrl":"https://doi.org/10.1590/S1516-93322008000300024","url":null,"abstract":"The present study investigated the effect of crude extracts from yacon leaves, obtained by aqueous cold (YC) or hot (YH) extraction, or hydro-ethanolic extraction (YE), on glycemia of the diabetic (induced by streptozotocine, 50 mg/kg, ip) and nondiabetic rats. The animals were treated orally with the extracts (400 mg/kg) or water for 3, 7, 10, and 14 days. After this period, the animals were anesthetized and blood samples were collected for measurement of plasmatic glucose and creatinine and activity of the enzymes (AST, ALT, ALP). Also were evaluated the consumption of food, water, urine volume, body weight of the animals and LD50 of YE. Treatment with YE for 14 days reduced glycemia in diabetic and nondiabetic animals. No similar reduction was observed in animals treated with YC or YH. Additionally, YE restored the activity of the plasmatic enzymes that were altered, and improved weight gain in the diabetic animals. These results showed that the effectiveness of the yacon extracts is related to the method of preparation and to the time of treatment. The effect of YE on glycemia in diabetic rats is not related to reduction of food intake or to interference of the extract with intestinal absorption of carbohydrates.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"37 1","pages":"521-530"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85791567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Ciclização intramolecular: uma estratégia promissora no desenvolvimento de pró-fármacos 分子内环化:开发前药的一种有前途的策略

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300004

Cledir Santos

引用次数: 2

Principles of molecular oncology 分子肿瘤学原理

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-09-01 DOI: 10.1590/S1516-93322008000300026

M. Aizenstein

引用次数: 0