Retina Pub Date : 2024-05-22 DOI: 10.1097/iae.0000000000004161

M. G. Petrovič, Nika Vrabič, V. Kloboves, Simona Miceska, A. P. Rošar, N. V. Valentinčič

{"title":"SILICONE FINE NEEDLE ASPIRATION RETINAL BIOPSY: a novel surgical technique for vitreoretinal lymphoma","authors":"M. G. Petrovič, Nika Vrabič, V. Kloboves, Simona Miceska, A. P. Rošar, N. V. Valentinčič","doi":"10.1097/iae.0000000000004161","DOIUrl":"https://doi.org/10.1097/iae.0000000000004161","url":null,"abstract":"\u0000 \u0000 To describe a technique using a 41-gauge silicone fine needle aspiration biopsy (S-FNAB) and assess its value in diagnosing primary vitreoretinal lymphoma (PVRL).\u0000 \u0000 \u0000 \u0000 Retrospective review of seven consecutive patients who underwent vitreous biopsy and 41-gauge S-FNAB of retinal/subretinal lesions in a single tertiary center between January 2012 and March 2023.\u0000 \u0000 \u0000 \u0000 Of seven patients, S-FNAB confirmed the diagnosis of PVRL in six patients. In five of those patients, both vitreous biopsy (VB) and retinal/subretinal S-FNAB (performed at the same procedure) yielded positive results, with the retinal thickness at the biopsy site as small as 231 μm. Four of these five patients had one or more previous negative VB. In one patient, S-FNAB yielded positive results despite a negative VB. S-FNAB failed to confirm positive VB for PVRL in the remaining patient. The time from symptom onset to diagnosis of PVRL ranged from 18 days to 26 months. There were no severe complications associated with the procedure.\u0000 \u0000 \u0000 \u0000 S-FNAB might be a valuable method for obtaining a sufficient sample of viable cells to diagnose PVRL. It can be performed as a primary procedure along with VB. Further studies are warranted to determine where this technique could be most advantageous.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"52 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed pathophysiologies of lamellar macular holes and related diseases: a multimodal optical coherence tomography-based study 片状黄斑孔及相关疾病的混合病理生理：基于多模态光学相干断层扫描的研究

Retina Pub Date : 2024-05-22 DOI: 10.1097/iae.0000000000004166

Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Yuki Masuda, Shuhei Kimura, M. Hosokawa, Yusuke Shiode, Y. Morizane

{"title":"Mixed pathophysiologies of lamellar macular holes and related diseases: a multimodal optical coherence tomography-based study","authors":"Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Yuki Masuda, Shuhei Kimura, M. Hosokawa, Yusuke Shiode, Y. Morizane","doi":"10.1097/iae.0000000000004166","DOIUrl":"https://doi.org/10.1097/iae.0000000000004166","url":null,"abstract":"\u0000 \u0000 To investigate the characteristics of mixed pathophysiologies in lamellar macular holes (LMH) and related diseases using multimodal optical coherence tomography (OCT).\u0000 \u0000 \u0000 \u0000 Overall, 126 eyes diagnosed with LMH, epiretinal membrane foveoschisis (ERM-FS), or macular pseudohole (MPH) using the horizontal B-scan image according to the definition proposed by Hubschman et al. in 2020 were analyzed using multimodal OCT imaging including horizontal and vertical 5-line B-scan, radial scan, and macular three-dimensional volume scan images. If at least two diagnostic criteria for LMH, ERM-FS, or MPH were satisfied in these scans, the patient was diagnosed as having a \"mixed type.” Retinal traction force was quantitatively evaluated by measuring the maximum depth of the retinal folds (MDRF) using en-face images.\u0000 \u0000 \u0000 \u0000 Mixed types constituted 34.1% of the cases. The LMH-related mixed group demonstrated intermediate characteristics between the ERM-FS/MPH and true LMH groups in terms of retinal traction and LMH-specific features and had a significant positive correlation between the MDRF and mean M-CHARTS scores (P = 0.034).\u0000 \u0000 \u0000 \u0000 A thorough OCT analysis is necessary to accurately diagnose LMH and related diseases. A significant positive correlation was observed between the MDRF and the degree of metamorphopsia in the LMH-related mixed group.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"17 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141110012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interest of regular assays of aqueous humor Interleukin-10 levels in monitoring of Vitreoretinal Lymphoma 定期检测眼房水白细胞介素-10 水平对监测玻璃体视网膜淋巴瘤的意义

Retina Pub Date : 2024-05-22 DOI: 10.1097/iae.0000000000004165

Charline Metayer, Laurent Kodjikian, Anh-Minh Nguyen, O. Loria, Mayeul Chaperon, Hervé Ghesquières, T. Mathis

{"title":"Interest of regular assays of aqueous humor Interleukin-10 levels in monitoring of Vitreoretinal Lymphoma","authors":"Charline Metayer, Laurent Kodjikian, Anh-Minh Nguyen, O. Loria, Mayeul Chaperon, Hervé Ghesquières, T. Mathis","doi":"10.1097/iae.0000000000004165","DOIUrl":"https://doi.org/10.1097/iae.0000000000004165","url":null,"abstract":"\u0000 \u0000 To investigate the variation of interleukin-10 (IL-10) levels in the aqueous humor (AH) of patients with vitreoretinal lymphoma (VRL) throughout therapy and follow-up, and analyze the relation of these variations with VRL clinical course and relapse.\u0000 \u0000 \u0000 \u0000 We retrospectively included consecutive patients diagnosed with VRL in a single center. AH IL-10 samples, as well as patient clinical course were evaluated. The response to treatment was evaluated according to the criteria set by the International Primary CNS Lymphoma Collaborative Group.\u0000 \u0000 \u0000 \u0000 A total of 59 eyes of 34 patients were included. IL-10 levels decreased significantly at first AH sample after therapy induction (median [IQR] 3.0 [2.8-3.6] months) among patients in complete clinical remission (CCR) (p<0.001). Among patients in CCR with residual detectable IL-10 in AH after therapy induction (85.3% systemic chemotherapy, 11.8% intravitreal methotrexate, 2.9% palliative care), 87.5% experienced ocular relapse within 5 years. The detection of IL-10 in AH at the first visit post-induction for CCR obtained a sensitivity of 77.8% [95%CI 0.45-0.96] and a specificity of 96.4% [95%CI 0.82-0.99] to predict ocular relapse. For relapsing eyes (N=26), IL-10 significantly increased between the last IL-10 measurement and the time of the first ocular relapse (p<0.001). In 76.0% of cases, increase in IL-10 was detected earlier than clinical relapse with a mean (SD) of 4.0 (2.4) months.\u0000 \u0000 \u0000 \u0000 The present study suggested the usefulness of IL-10 in the prognosis of VRL. We showed a relation between IL-10 in AH and tumoral activity, and for the first time with disease relapse.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"60 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141112811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Enhanced Analysis of Retinal Vasculature in Age-Related Macular Degeneration 人工智能增强对老年性黄斑变性视网膜血管的分析

Retina Pub Date : 2024-05-20 DOI: 10.1097/iae.0000000000004159

Ryan S. Huang, Andrew Mihalache, Marko M. Popovic, Colyn Munn, I. M. Melo, Aurora Pecaku, Alon Friedman, David T. Wong, Rajeev H. Muni

{"title":"Artificial Intelligence-Enhanced Analysis of Retinal Vasculature in Age-Related Macular Degeneration","authors":"Ryan S. Huang, Andrew Mihalache, Marko M. Popovic, Colyn Munn, I. M. Melo, Aurora Pecaku, Alon Friedman, David T. Wong, Rajeev H. Muni","doi":"10.1097/iae.0000000000004159","DOIUrl":"https://doi.org/10.1097/iae.0000000000004159","url":null,"abstract":"\u0000 \u0000 To investigate associations between quantitative vascular measurements derived from intravenous fluorescein angiography (IVFA) and baseline characteristics on optical coherence tomography (OCT) in neovascular age-related macular degeneration (nAMD) patients.\u0000 \u0000 \u0000 \u0000 We prospectively recruited patients with active choroidal neovascularization (CNV) secondary to AMD over 50 years old, presenting to a single centre in Toronto, Canada from 2017-2023. Ultra-widefield IVFA images were processed using the artificial intelligence RETICAD FAassist system to extract quantitative information on blood flow, perfusion, and blood-retinal barrier (BRB) permeability. Associations between IVFA parameters with functional and anatomical outcomes were examined using univariable and multivariable regression models.\u0000 \u0000 \u0000 \u0000 81 nAMD eyes and seven healthy control eyes were included. Compared to healthy controls, BRB permeability in the central and peripheral retina was significantly higher in nAMD patients (p<0.001). On univariable analysis, BRB permeability measured centrally was significantly associated with CMT (p=0.035), while perfusion and blood flow measured centrally were significantly associated with macular volume (p=0.043 and 0.037, respectively). On multivariable analysis, BRB permeability remained significantly associated with CMT (p=0.026).\u0000 \u0000 \u0000 \u0000 Central BRB permeability measured on IVFA was significantly associated with baseline CMT in nAMD patients. Future work should longitudinally explore associations between IVFA parameters and clinical characteristics in diverse nAMD populations.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"59 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

En-face OCT morphology of macular pucker correlates with metamorphopsia: possible role of the Henle fiber layer. 黄斑皱褶的面内 OCT 形态与变形视觉相关：亨勒纤维层的可能作用。

Retina Pub Date : 2024-05-20 DOI: 10.1097/iae.0000000000004160

Andrea Govetto, Sara Lucchini, J. Sebag, Fiammetta Gianfrate, Stefano Ranno, Elisa Carini, Gianni Virgili, Mario R. Romano, David Sarraf, Paolo Radice

{"title":"En-face OCT morphology of macular pucker correlates with metamorphopsia: possible role of the Henle fiber layer.","authors":"Andrea Govetto, Sara Lucchini, J. Sebag, Fiammetta Gianfrate, Stefano Ranno, Elisa Carini, Gianni Virgili, Mario R. Romano, David Sarraf, Paolo Radice","doi":"10.1097/iae.0000000000004160","DOIUrl":"https://doi.org/10.1097/iae.0000000000004160","url":null,"abstract":"\u0000 \u0000 To describe macular pucker contraction patterns with en-face optical coherence tomography (OCT), to provide a correlation with metamorphopsia scores, and to discuss the protective role of the Henle fiber layer (HFL) against tangential traction.\u0000 \u0000 \u0000 \u0000 Retrospective, institutional, observational, and consecutive case series. Clinical charts, M-charts scores, structural and en-face OCT imaging of patients diagnosed with macular pucker were reviewed.\u0000 \u0000 \u0000 \u0000 A hundred and twenty eyes of 114 consecutive patients diagnosed with macular pucker were included. En-face OCT patterns of macular pucker contraction were foveal in 51/120 eyes (42.5%) and extrafoveal in 69/120 eyes (57.5%). Foveal macular puckers had regular, a concentric circle morphology in the HFL (46/51 eyes, 90.2%), while extrafoveal membranes had irregular, distorted circular HFL morphology (62/69 eyes, 89.8%; (p<0.001). Foveal contraction morphology and regular HFL pattern, as well as extrafoveal contraction morphology and an irregular HFL pattern were highly correlated one with another (p<0.001 in both cases). Foveal macular puckers with regular HFL patterns had significantly less vertical and horizontal M-charts scores as compared to extrafoveal membranes with irregular HFL (p<0.001 in both cases). Ellipsoid zone and external limiting membrane defects were rare in the parafoveal region (5/120 eyes, 4.2%). Visual acuity was not correlated with metamorphopsia scores (p=0.903).\u0000 \u0000 \u0000 \u0000 En-face OCT imaging identifies macular pucker contraction patterns that correlate with metamorphopsia scores and that can be used alongside the current structural OCT staging system to guide clinicians in the surgical decision-making process.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitreoretinal Outcomes Following Secondary Intraocular Lens Implantation with Pars Plana Vitrectomy 通过玻璃体旁切除术二次植入眼内透镜后的玻璃体视网膜疗效

Retina Pub Date : 2024-05-09 DOI: 10.1097/iae.0000000000004139

Gabriel T. Kaufmann, Omesh P Gupta, Julia Yu, Michael Nguyen, Crystal Y. Lee, Kathryn Achuck, Jason Hsu, Allen C. Ho, C. Regillo, Sunir J. Garg, M. Klufas, Sonia Mehta, David Xu, Michael N. Cohen, Yoshihiro Yonekawa, Ajay E Kuriyan, M. Starr

{"title":"Vitreoretinal Outcomes Following Secondary Intraocular Lens Implantation with Pars Plana Vitrectomy","authors":"Gabriel T. Kaufmann, Omesh P Gupta, Julia Yu, Michael Nguyen, Crystal Y. Lee, Kathryn Achuck, Jason Hsu, Allen C. Ho, C. Regillo, Sunir J. Garg, M. Klufas, Sonia Mehta, David Xu, Michael N. Cohen, Yoshihiro Yonekawa, Ajay E Kuriyan, M. Starr","doi":"10.1097/iae.0000000000004139","DOIUrl":"https://doi.org/10.1097/iae.0000000000004139","url":null,"abstract":"\u0000 \u0000 Retrospective cohort study of 561 adult patients undergoing secondary intraocular lens (IOL) implantation by vitreoretinal surgeons at a single institution from April 2015-December 2020.\u0000 \u0000 \u0000 \u0000 Patient historical factors, intraoperative/postoperative complications, and outcomes of IOL type (anterior chamber IOL (ACIOL) vs scleral sutured IOL (SSIOL) vs scleral fixated IOL (SFIOL) vs sulcus) were assessed. Primary outcomes were rates of postoperative retinal tears and rhegmatogenous retinal detachment (RRD). Secondary outcomes were rates of intraoperative endolaser, intraoperative retinal tear, and further IOL surgery.\u0000 \u0000 \u0000 \u0000 The incidence of intraoperative retinal tears was 7.3% and not significantly different between techniques. Rates of intraoperative endolaser use were 17.5% among all techniques and not significantly different between techniques. Rates of postoperative retinal tear were low (0-2.7%). Rates of postoperative RRD were not significantly different between techniques [ACIOL 9/198 (4.5%), SFIOL 1/54 (1.9%), SSIOL 14/274 (5.1%), sulcus 2/35 (5.7%), total 26/561 (4.6%), p=0.79]. Rates of repeat IOL surgery trended higher in sulcus lenses [ACIOL 5/198 (2.5%), SFIOL 4/54 (7.4%), SSIOL 16/274 (5.8%), sulcus 5/35 (14.3%), total 30/561 (5.3%), p=0.12].\u0000 \u0000 \u0000 \u0000 Intraoperative endolaser use and intraoperative retinal tear were not uncommon in secondary IOL surgery and underscore the importance of careful vitreoretinal management among these patients.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"148 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Significance of Acute Henle Fiber Layer Hyperreflectivity in Placoid Diseases Placoid 疾病中急性亨氏纤维层高反射的预后意义

Retina Pub Date : 2024-05-09 DOI: 10.1097/iae.0000000000004150

M. V. Cicinelli, M. Menean, A. Marchese, P. Ramtohul, Francesco Bandello, E. Miserocchi

{"title":"The Prognostic Significance of Acute Henle Fiber Layer Hyperreflectivity in Placoid Diseases","authors":"M. V. Cicinelli, M. Menean, A. Marchese, P. Ramtohul, Francesco Bandello, E. Miserocchi","doi":"10.1097/iae.0000000000004150","DOIUrl":"https://doi.org/10.1097/iae.0000000000004150","url":null,"abstract":"\u0000 \u0000 To investigate the pathophysiology and prognostic significance of acute Henle fiber layer (HFL) hyperreflectivity in placoid diseases by examining its relationship with impaired choroidal flow and persistent photoreceptor disruption.\u0000 \u0000 \u0000 \u0000 Retrospective-prospective observational study on patients with placoid diseases. Indocyanine green angiography (ICGA) and optical coherence tomography (OCT) were performed during the acute phase and follow-up. Impaired choroidal flow, HFL hyperreflectivity, and persistent EZ disruption, their colocalization index, and their associations with initial and final visual acuity (VA) were explored.\u0000 \u0000 \u0000 \u0000 Sixteen eyes from 8 patients (mean age 25.3±6.44 years) were included (median follow-up 13.5 months). Quantitative analysis revealed significant correlations between areas of impaired choroidal flow, HFL hyperreflectivity, and persistent EZ disruption (correlation coefficients of 0.69, 0.63, and 0.46, respectively). Impaired choroidal flow area exceeded HFL hyperreflectivity (p=0.002) and EZ disruption (p=0.003). A noteworthy 94% non-random overlap between HFL hyperreflectivity and EZ disruption was observed. Worse initial VA correlated with foveal involvement (p=0.0002), thicker choroid (p=0.001), larger impaired choroidal flow areas (p=0.02), and thinner outer retina post lesion inactivation (p=0.04).\u0000 \u0000 \u0000 \u0000 HFL hyperreflectivity predicted photoreceptor recovery potential in placoid diseases. If HFL hyperreflectivity corresponds to acute HFL damage, it may suggest more severe involvement of the entire photoreceptor length.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":" 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic yield of an inherited retinal disease gene panel in retinopathy of unknown origin 遗传性视网膜疾病基因面板对不明原因视网膜病变的诊断率

Retina Pub Date : 2024-05-09 DOI: 10.1097/iae.0000000000004155

Stéphane Abramowicz, Audrey Meunier, L. Postelmans, L. Caspers, Francis Corazza, M. De Bruyne, S. Van de Sompele, E. de Baere, Bart P Leroy, F. Willermain, D. Draganova

{"title":"Diagnostic yield of an inherited retinal disease gene panel in retinopathy of unknown origin","authors":"Stéphane Abramowicz, Audrey Meunier, L. Postelmans, L. Caspers, Francis Corazza, M. De Bruyne, S. Van de Sompele, E. de Baere, Bart P Leroy, F. Willermain, D. Draganova","doi":"10.1097/iae.0000000000004155","DOIUrl":"https://doi.org/10.1097/iae.0000000000004155","url":null,"abstract":"\u0000 \u0000 Evaluating the presence of class 3, 4 and 5 genetic variants in inherited retinal disease (IRD) genes in patients with retinopathy of unknown origin (RUO).\u0000 \u0000 \u0000 \u0000 Multicentric retrospective study of RUO cases diagnosed between January 2012 and February 2022. General and ophthalmological history, complete ophthalmological examination, anti-retinal antibodies and IRD gene panel results were analyzed in every patient. Four RUO categories were defined: non-paraneoplastic autoimmune retinopathy (npAIR), unilateral pigmentary retinopathy (UPR), asymmetrical pigmentary retinopathy (APR) and acute zonal occult outer retinopathy (AZOOR).\u0000 \u0000 \u0000 \u0000 We included 12 patients (9 females) across these four RUO categories. Mean age at inclusion was 45.6 years (20 – 68 years). Seven patients demonstrated class 3 variants in IRD genes. Of these, 2 also demonstrated class 5 variants in other IRD genes. The remaining 5 patients had negative panel results. IRD gene panel analysis allowed diagnosis refinement in 1 (8.3%) npAIR patient in our RUO cohort. When considering the npAIR subpopulation only, a higher diagnostic yield of 20% (1/5 patients) was achieved.\u0000 \u0000 \u0000 \u0000 Every suspected npAIR patient should benefit from gene panel testing in order not to overlook undiagnosed IRDs. In contrast, UPR, APR and AZOOR subpopulations did not benefit from genetic analysis in this study.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140997710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal Anti-Vascular Endothelial Growth Factor Treatment in Patients with Neovascular Age-Related Macular Degeneration and Poor Visual Acuity 视网膜内抗血管内皮生长因子治疗新生血管性老年黄斑变性和视力低下患者

Retina Pub Date : 2024-05-07 DOI: 10.1097/iae.0000000000004154

Jae Shin Song, M. Kim, Kwangsic Joo, S. Park, Se Joon Woo, Kyu Hyung Park

{"title":"Intravitreal Anti-Vascular Endothelial Growth Factor Treatment in Patients with Neovascular Age-Related Macular Degeneration and Poor Visual Acuity","authors":"Jae Shin Song, M. Kim, Kwangsic Joo, S. Park, Se Joon Woo, Kyu Hyung Park","doi":"10.1097/iae.0000000000004154","DOIUrl":"https://doi.org/10.1097/iae.0000000000004154","url":null,"abstract":"\u0000 \u0000 To investigate the significance of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD) and poor visual acuity (VA).\u0000 \u0000 \u0000 \u0000 Retrospective study of patients with nAMD with baseline best corrected VA of ≤ 20/200. Patients were divided into regular treatment (RT) and scarce treatment (ST) groups according to whether they underwent consecutive intravitreal anti-VEGF treatments at intervals of ≤ 4 months or not.\u0000 \u0000 \u0000 \u0000 A total of 131 eyes were included: 87 and 44 eyes in the RT and ST groups, respectively. RT group showed significantly improved preservation of lesion size at both years 1 and 2, with significantly fewer incidences of new subretinal hemorrhage (SRH). Improvements in VA, reduction in central subfield macular thickness (CST), and maximal height of choroidal neovascularization were significantly favorable in RT group at year 1, and CST was significantly decreased at year 2. Survival analysis revealed that RT group had significantly greater preservation of VA and lesion size than that in ST group.\u0000 \u0000 \u0000 \u0000 Maintaining intravitreal anti-VEGF treatment for patients with nAMD and poor vision showed significant advantages in VA and lesion size stability and reduced the incidence of new SRH, which suggests preservation of paracentral vision.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"140 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAMELLAR MACULAR HOLE CLOSED BY ASSOCIATED EPIRETINAL PROLIFERATION IN THE CONTEXT OF MICROVASCULAR ABNORMALITIES 在微血管异常的背景下，伴有视网膜上皮增生的片状黄斑孔被关闭

Retina Pub Date : 2024-05-07 DOI: 10.1097/iae.0000000000004158

Alberto Quarta, Pierpaolo Ferrante, M. L. Ruggeri, Matteo Gironi, Rossella D’Aloisio, Lisa Toto, Rodolfo Mastropasqua

引用次数: 0

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