En-face OCT morphology of macular pucker correlates with metamorphopsia: possible role of the Henle fiber layer.

Abstract

To describe macular pucker contraction patterns with en-face optical coherence tomography (OCT), to provide a correlation with metamorphopsia scores, and to discuss the protective role of the Henle fiber layer (HFL) against tangential traction. Retrospective, institutional, observational, and consecutive case series. Clinical charts, M-charts scores, structural and en-face OCT imaging of patients diagnosed with macular pucker were reviewed. A hundred and twenty eyes of 114 consecutive patients diagnosed with macular pucker were included. En-face OCT patterns of macular pucker contraction were foveal in 51/120 eyes (42.5%) and extrafoveal in 69/120 eyes (57.5%). Foveal macular puckers had regular, a concentric circle morphology in the HFL (46/51 eyes, 90.2%), while extrafoveal membranes had irregular, distorted circular HFL morphology (62/69 eyes, 89.8%; (p<0.001). Foveal contraction morphology and regular HFL pattern, as well as extrafoveal contraction morphology and an irregular HFL pattern were highly correlated one with another (p<0.001 in both cases). Foveal macular puckers with regular HFL patterns had significantly less vertical and horizontal M-charts scores as compared to extrafoveal membranes with irregular HFL (p<0.001 in both cases). Ellipsoid zone and external limiting membrane defects were rare in the parafoveal region (5/120 eyes, 4.2%). Visual acuity was not correlated with metamorphopsia scores (p=0.903). En-face OCT imaging identifies macular pucker contraction patterns that correlate with metamorphopsia scores and that can be used alongside the current structural OCT staging system to guide clinicians in the surgical decision-making process.