Retina最新文献_第3页

Transcorneal Vitrectomy in Eyes with Regressed Retinoblastoma 视网膜母细胞瘤患者的经角膜玻璃体切除术

Retina Pub Date : 2024-06-11 DOI: 10.1097/iae.0000000000004178

Yicheng K. Bao, Gisella M. Sanchez, Thomas C. Lee, Jesse L. Berry, Aaron Nagiel

{"title":"Transcorneal Vitrectomy in Eyes with Regressed Retinoblastoma","authors":"Yicheng K. Bao, Gisella M. Sanchez, Thomas C. Lee, Jesse L. Berry, Aaron Nagiel","doi":"10.1097/iae.0000000000004178","DOIUrl":"https://doi.org/10.1097/iae.0000000000004178","url":null,"abstract":"\u0000 \u0000 Current treatments for retinoblastoma facilitate globe salvage but can result in vitreoretinal disorders that may require surgery. There is controversy on surgical approaches in eyes with retinoblastoma. Here we describe a transcorneal vitrectomy approach that avoids the use of chemotherapy or cryotherapy.\u0000 \u0000 \u0000 \u0000 Retrospective chart review was performed on five consecutive patients with regressed retinoblastoma for >12 months (Group D/ct2b) at Children’s Hospital Los Angeles who had vitrectomy between November 2022 and December 2023.\u0000 \u0000 \u0000 \u0000 Five patients underwent 8 vitrectomies for various indications including IOL fibrosis, vitreous hemorrhage, cataract, retinal detachment, and silicone oil removal. Mean age at first vitrectomy was 6.2 years (range: 2-9 years); mean time from last retinoblastoma treatment was 50.4 months (range: 20-82 months). Radially oriented corneal incisions were made with the 23-gauge or 25-gauge trocar system and the Versa HD LenZ (Oculus) was utilized with the RESIGHT (Zeiss) for top-down visualization. Neither chemotherapy nor cryotherapy were utilized. Wounds were sutured parallel to the limbus with 10-0 polyglactin 910 suture (Vicryl, Ethicon), and a final water rinse was performed to lyse any potential retinoblastoma cells. Surgical objectives were achieved, vision remained stable, and no retinoblastoma spread was noted with a mean follow-up of 7.6 months (range: 3-12 months).\u0000 \u0000 \u0000 \u0000 This vitrectomy technique for eyes with regressed retinoblastoma permits top-down viewing with the Versa HD LenZ. Radial placement of corneal wounds avoids suturing through the uveal tract, and a postsurgical water rinse lyses any retinoblastoma cells. This approach may obviate the need for chemotherapeutics or cryotherapy.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"98 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141359258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reticular Pseudodrusen Disappearance after Development of Macular Neovascularization 黄斑新生血管形成后网状假性黄斑消失

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004173

M. Menean, R. Sacconi, Beatrice Tombolini, Gaia L’abbate, F. Beretta, Francesco Bandello, Giuseppe Querques

{"title":"Reticular Pseudodrusen Disappearance after Development of Macular Neovascularization","authors":"M. Menean, R. Sacconi, Beatrice Tombolini, Gaia L’abbate, F. Beretta, Francesco Bandello, Giuseppe Querques","doi":"10.1097/iae.0000000000004173","DOIUrl":"https://doi.org/10.1097/iae.0000000000004173","url":null,"abstract":"\u0000 \u0000 To explore changes in reticular pseudodrusen (RPD) number and location after the development of macular neovascularization (MNV) in eyes with prior intermediate age-related macular degeneration (iAMD), focusing on different retinal regions differently affected by MNV.\u0000 \u0000 \u0000 \u0000 This retrospective longitudinal study included iAMD eyes with RPD that developed MNV. RPD were assessed at baseline, when MNV was diagnosed (MNV stage), and after anti-VEGF treatment. Three regions of interest (ROI) were considered: MNV area, subretinal fluid (SRF) area, and a marginal area 1000 μm around SRF (marginal zone). RPD counts were compared with age- and gender-matched control eyes with RPD who did not develop MNV.\u0000 \u0000 \u0000 \u0000 RPD number exhibited a significant decrease after MNV development in the MNV area (p=0.048) and in the area with SRF (p=0.078). A statistically significant decrease was also disclosed in the marginal area around SRF (p=0.002), associated with larger SRF areas. Control eyes did not show any significant change in the RPD count.\u0000 \u0000 \u0000 \u0000 RPD reduction after MNV development suggests a complex interplay involving the MNV itself, the presence of SRF and trophic changes. Our results highlight the role of MNV in retinal nutritional balance and provide intriguing results in the RPD life-cycle.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"207 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Didanosine-Related Retinal Toxicity at an Urban Academic Center as Diagnosed with Ultra-Widefield Imaging 城市学术中心通过超宽场成像诊断出的与地达诺辛相关的视网膜毒性患病率

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004175

Joshua Seokju Kim, Jaffer Shah, Thanos Papakostas, M. Mahrous, Donald J. D'Amico, Szilárd Kiss, Kyle D Kovacs

{"title":"Prevalence of Didanosine-Related Retinal Toxicity at an Urban Academic Center as Diagnosed with Ultra-Widefield Imaging","authors":"Joshua Seokju Kim, Jaffer Shah, Thanos Papakostas, M. Mahrous, Donald J. D'Amico, Szilárd Kiss, Kyle D Kovacs","doi":"10.1097/iae.0000000000004175","DOIUrl":"https://doi.org/10.1097/iae.0000000000004175","url":null,"abstract":"\u0000 \u0000 Antiretroviral therapy (ART) has revolutionized HIV treatment with didanosine (DDI) as a pioneering drug. However, DDI has been associated with retinal toxicity, characterized by peripheral chorioretinal degeneration with macular sparing. Despite its clinical recognition, the prevalence and risk factors for Didanosine-induced retinopathy are not well described.\u0000 \u0000 \u0000 \u0000 This retrospective case series analyzed 127 DDI-treated patients at Weill Cornell Medicine Department of Ophthalmology. Inclusion criteria included at least 6 months of DDI use and available ultra-widefield imaging. Patients were categorized as Affected or Unaffected based on retinal imaging assessed by two reviewers. The Affected group was further divided into “probable” or “possible” retinopathy. Patient demographics, DDI usage characteristics, and imaging findings were analyzed with statistical comparisons drawn between Affected and Unaffected cohorts.\u0000 \u0000 \u0000 \u0000 Of the 127 patients, 9 (7%) showed signs of didanosine-induced retinal toxicity. On average, the Affected group was older compared to the Unaffected group (65.1 vs 56.5 years, p = 0.025), with lower BMI (23.2 vs. 27.4, p = 0.04), and older at the start of the treatment (51.6 vs. 40.8 years, p = 0.026). Mild phenotypes with peripheral pigmentary changes were also identified using ultra-widefield imaging.\u0000 \u0000 \u0000 \u0000 This pioneering academic study highlighted a notable prevalence of DDI-induced retinal toxicity. Statistical analysis demonstrated age, BMI, and age at treatment initiation as potential risk factors. Ultra-widefield autofluorescence emerged as a valuable tool in detecting and delineating findings. Follow-up studies are needed to determine the necessity of regular screening for individuals on or with a history of didanosine use.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of the proposed biosimilar aflibercept, SDZ-AFL, in patients with neovascular age-related macular degeneration: 52-week results from the Phase 3 Mylight study 拟议的生物仿制药aflibercept（SDZ-AFL）对新生血管性老年性黄斑变性患者的疗效和安全性：Mylight三期研究的52周结果

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004174

A. Bordon, Peter K. Kaiser, Armin Wolf, Liyi Cen, Jens Heyn, Dragan Urosevic, Francis Dodeller, Lisa Allmannsberger, Rufino Silva

{"title":"Efficacy and safety of the proposed biosimilar aflibercept, SDZ-AFL, in patients with neovascular age-related macular degeneration: 52-week results from the Phase 3 Mylight study","authors":"A. Bordon, Peter K. Kaiser, Armin Wolf, Liyi Cen, Jens Heyn, Dragan Urosevic, Francis Dodeller, Lisa Allmannsberger, Rufino Silva","doi":"10.1097/iae.0000000000004174","DOIUrl":"https://doi.org/10.1097/iae.0000000000004174","url":null,"abstract":"\u0000 \u0000 The Phase 3 Mylight study was designed to confirm clinical equivalence of proposed biosimilar aflibercept (SOK583A1; Sandoz [SDZ-AFL]) to its reference biologic (Eylea®; Regeneron Pharmaceuticals, Inc.; Bayer AG [Ref-AFL]).\u0000 \u0000 \u0000 \u0000 Mylight was a prospective, double-masked, 2-arm, parallel phase 3 study. Participants with neovascular age-related macular degeneration (nAMD) were randomized 1:1 to receive eight injections of SDZ-AFL (n=244) or Ref-AFL (n=240) over 48 weeks. The primary endpoint was mean change in best-corrected visual acuity (BCVA) score from Baseline to Week 8. Secondary endpoints included anatomical outcomes, BCVA at Weeks 24 and 52, safety, and pharmacokinetics.\u0000 \u0000 \u0000 \u0000 Similarity in mean change in BCVA score was established between SDZ-AFL (n=235) and Ref-AFL (n=226) at Week 8 (difference: –0.3 [90% CI: –1.5, 1.0]), and to Week 52. No clinically meaningful differences occurred between groups in anatomical outcomes. Safety profiles were similar, with comparable incidences of treatment-related adverse events (SDZ-AFL: 2.5%; Ref-AFL: 2.9%). The incidence of anti-drug antibodies was similar between groups. Systemic free aflibercept concentrations 24 hours post-dose were low, and comparable between SDZ-AFL and Ref-AFL.\u0000 \u0000 \u0000 \u0000 SDZ-AFL matched reference aflibercept in terms of efficacy, safety, and pharmacokinetics in participants with nAMD. Therefore, this Phase 3 study confirmed biosimilarity of SDZ-AFL to Ref-AFL.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Alternative Technique For Intraocular Lens Removal: Bimanual Cleavage In The Vitreous Chamber 眼内透镜摘除的替代技术：玻璃体腔内的双手劈开术

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004168

Matteo Mario Carlà, Carlos Mateo

{"title":"An Alternative Technique For Intraocular Lens Removal: Bimanual Cleavage In The Vitreous Chamber","authors":"Matteo Mario Carlà, Carlos Mateo","doi":"10.1097/iae.0000000000004168","DOIUrl":"https://doi.org/10.1097/iae.0000000000004168","url":null,"abstract":"\u0000 \u0000 We aimed to present a new technique for lens explantation, involving intraocular lens (IOL) cleavage in the vitreous chamber using two forceps and successive removal from the anterior chamber (AC).\u0000 \u0000 \u0000 \u0000 Retrospective mono-centric analysis of 10 eyes affected by IOL subluxation/luxation who underwent IOL explantation and 23G vitrectomy. After separating the capsular bag rests from the IOL using the vitrectomy probe, serrated forceps were used to grab the IOL, while microscissors performed an “initiation” cut at the midpoint of the lens plate. A second pair of serrated forceps grabbed the IOL plate on the other side. Then, the two forceps were slowly pulled one apart from the other, exerting a separative force perpendicular to the initiation cut and causing the IOL to cleave in two pieces. In case of asymmetric cleavage, a second cleavage was performed. The pieces of the IOL were then moved to the AC and removed through a clear corneal incision.\u0000 \u0000 \u0000 \u0000 Intraoperative mean IOL removal time was 14.1±6.5 minutes. The IOLs (seven 1-piece and three 3-pieces IOLs) were successfully explanted with this technique in all patients. Overall, 4 cases underwent exclusive IOL explantation and the eyes were left aphakic. Postoperatively, BCVA improved in all patients at 1 week follow-up and no intraoperative or postoperative adverse events were reported. Cornea was completely clear in every case since postoperative day 1.\u0000 \u0000 \u0000 \u0000 Bimanual cleavage technique for IOL removal ensured safer IOL handling in the larger vitreous chamber and minimized the procedures to be performed in the AC.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"115 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meniscus Micropyon: An Ophthalmoscopic Sign Possibly Associated with Epiretinal Proliferation After Retinal Surgery with Gas Tamponade 半月板微脓肿：视网膜手术与气体填塞术后可能与视网膜外增殖有关的眼底征象

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004176

Jonathan F. Russell, Benjamin J. Fowler, Hasenin Al-khersan, T. Lazzarini, Nimesh A. Patel, Nasreen A. Syed, Stephen R. Russell

{"title":"Meniscus Micropyon: An Ophthalmoscopic Sign Possibly Associated with Epiretinal Proliferation After Retinal Surgery with Gas Tamponade","authors":"Jonathan F. Russell, Benjamin J. Fowler, Hasenin Al-khersan, T. Lazzarini, Nimesh A. Patel, Nasreen A. Syed, Stephen R. Russell","doi":"10.1097/iae.0000000000004176","DOIUrl":"https://doi.org/10.1097/iae.0000000000004176","url":null,"abstract":"\u0000 \u0000 To describe an ophthalmoscopic sign, termed a meniscus micropyon, and its possible association with proliferative vitreoretinopathy (PVR)/epiretinal membrane (ERM) formation after retinal surgery with gas tamponade.\u0000 \u0000 \u0000 \u0000 Patients with intravitreal gas were examined postoperatively by 1 of 6 vitreoretinal surgeons from 4 institutions. A micropyon was defined as a white-yellow, solid-appearing consolidation along the meniscus (i.e., the fluid-gas interface).\u0000 \u0000 \u0000 \u0000 A micropyon was visualized and photographed in 49 patients who received intravitreal gas. Preoperatively, retinal breaks were present in all 49 eyes and rhegmatogenous retinal detachment (RRD) in 45 (92%). Postoperatively, 39 eyes (80%) developed epiretinal proliferation: 16 eyes (33%) developed recurrent RRD from PVR, 6 eyes (12%) re-detached without frank PVR, 9 eyes (18%) developed postoperative ERM/worsening and 8 eyes (16%) had postoperative ERM but no preoperative OCT to determine if the postoperative ERM was new or worsening. The single-operation anatomic success in eyes with a micropyon was 51%, which was lower than that of a contemporaneous RRD control group (91%) in which no micropyon was detected. In 2 patients, micropyons were biopsied during PPV and examined histopathologically; they consist predominantly of white blood cells (WBCs).\u0000 \u0000 \u0000 \u0000 The meniscus micropyon is an ophthalmoscopic sign that can occur after retinal surgery with gas tamponade. Features that distinguish a micropyon from post-vitrectomy fibrin/fibrinoid syndrome include delayed appearance, hyperautofluorescence, absence of translucent strands or sheets in the anterior chamber or vitreous cavity, and the histopathologic identification of WBCs. A clinically detectable micropyon may be a biomarker of PVR/ERM formation.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"56 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between OCT biomarkers and number of intravitreal ranibizumab injections in eyes with nAMD in the HARBOR study HARBOR 研究中 nAMD 患者的 OCT 生物标志物与玻璃体内注射雷尼珠单抗次数之间的关系

Retina Pub Date : 2024-06-04 DOI: 10.1097/iae.0000000000004171

Nianting Tong, Wenying Fan, Li Su, Adel Ebraheem, Akihito Uji, Kenneth Marion, Srinivas Sadda

{"title":"Relationship between OCT biomarkers and number of intravitreal ranibizumab injections in eyes with nAMD in the HARBOR study","authors":"Nianting Tong, Wenying Fan, Li Su, Adel Ebraheem, Akihito Uji, Kenneth Marion, Srinivas Sadda","doi":"10.1097/iae.0000000000004171","DOIUrl":"https://doi.org/10.1097/iae.0000000000004171","url":null,"abstract":"\u0000 \u0000 To correlate baseline spectral domain optical coherence tomography (SD-OCT) characteristics with the number of as-needed intravitreal injections of ranibizumab over a 24-month follow-up period in eyes with neovascular age-related macular degeneration (nAMD).\u0000 \u0000 \u0000 \u0000 236 eyes of 236 subjects with nAMD treated with ranibizumab 0.5 mg PRN in the HARBOR study were enrolled. Baseline SD-OCT images were evaluated by certified reading center graders for specific morphologic features of the macular neovascularization (MNV) lesion and surrounding retina. Baseline OCT features and patient demographics were correlated with the number of injections over the next two years.\u0000 \u0000 \u0000 \u0000 The mean number of injections in the 0.5mg PRN group was 8.07 (median 8, 3-12) after 12 months and 14.25 (median 14, 3-24) after 24 months of treatment. After multivariate linear regression analysis, the only baseline parameter that was independently associated with a higher injection frequency at both 12 and 24 months was a greater baseline SRF thickness.\u0000 \u0000 \u0000 \u0000 A greater SRF thickness at baseline was associated with a higher frequency of PRN injections over 12 and 24 months in eyes treated with ranibizumab for neovascular AMD. These findings may be of value in counseling patients who are about to initiate therapy for MNV.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillary layer detachment in a case of Purtscher retinopathy 一例普切尔视网膜病变中的棘层脱离

Retina Pub Date : 2024-05-23 DOI: 10.1097/iae.0000000000004163

Sampurna Bhattacharyya, K. Saurabh, Rupak Roy

引用次数: 0

Pars Plana Vitrectomy with External Drainage for Non Exudative Retinal Detachment 非渗出性视网膜脱离的玻璃体旁切除术与外部引流术

Retina Pub Date : 2024-05-22 DOI: 10.1097/iae.0000000000004164

A. Scupola, Claudia Fossataro, M. G. Sammarco, Federica Fossataro, Gustavo Savino, Stanislao Rizzo

{"title":"Pars Plana Vitrectomy with External Drainage for Non Exudative Retinal Detachment","authors":"A. Scupola, Claudia Fossataro, M. G. Sammarco, Federica Fossataro, Gustavo Savino, Stanislao Rizzo","doi":"10.1097/iae.0000000000004164","DOIUrl":"https://doi.org/10.1097/iae.0000000000004164","url":null,"abstract":"\u0000 \u0000 To describe a surgical technique for retinal detachment (RD) with undetected retinal breaks, which combines pars plana vitrectomy (PPV) and external subretinal fluid (SRF) drainage.\u0000 \u0000 \u0000 \u0000 In this retrospective observational study, patients with diagnosis of RD with undetected retinal breaks were enrolled. Standard three-port 25 Gauge (G) core and peripheral PPV was performed. Perfluorocarbon liquid was injected in the vitreous cavity to obtain posterior retinal flattening. Trans scleral 27G needle external drainage was performed approximately at 8 mm from limbus to drain SRF sub-conjunctivally. Prophylactic peripheral endolaser was performed on 360°. Sulfur hexafluoride 20% was used as tamponade.\u0000 \u0000 \u0000 \u0000 In fourteen out of 15 patients complete SRF drainage was obtained. In only one case SRF did not leak out in the sub-conjunctival space. Neither intraoperative nor postsurgical complications were recorded. Flat retina with no SRF was observed in all sample and no RD relapses were reported at each follow up.\u0000 \u0000 \u0000 \u0000 External drainage combined to PPV may represent a valid and safe option to drain SRF in RD cases with undetected retinal breaks. The advantages of the technique consisted in absence of retinal pigment epithelium cells dispersion in the vitreous chamber, prompt dry retina, low risk of postoperative retinal folds.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"35 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective trial of Home OCT guided management of treatment experienced nAMD patients 对有治疗经验的 nAMD 患者进行家庭 OCT 指导管理的前瞻性试验

Retina Pub Date : 2024-05-22 DOI: 10.1097/iae.0000000000004167

N. Holekamp, Anthony M. de Beus, W. L. Clark, J. Heier

{"title":"Prospective trial of Home OCT guided management of treatment experienced nAMD patients","authors":"N. Holekamp, Anthony M. de Beus, W. L. Clark, J. Heier","doi":"10.1097/iae.0000000000004167","DOIUrl":"https://doi.org/10.1097/iae.0000000000004167","url":null,"abstract":"\u0000 \u0000 To evaluate the impact of home OCT guided patient management on treatment burden and visual outcomes.\u0000 \u0000 \u0000 \u0000 An interventional trial was conducted to compare frequency of treatment and visual acuity (VA) for the neovascular age-related macular degeneration (nAMD) patients before and during use of home OCT over a period of 6 months. Patient adherence to regular scanning was measured by the number of scans performed per week. The characteristics of episodes of fluid recurrence and classification of typical fluid volume trajectories was performed.\u0000 \u0000 \u0000 \u0000 27 eyes (21 with diagnosis of nAMD and one converted during the study), of 15 pts. were monitored for 6 months, scanning at 6.2 times/week/eye and yielding 4,435 scans of which 91.2% were eligible for artificial intelligence-based fluid volume quantification. Total number of monitoring weeks prior and during the study were 1555 and 509. The mean (SD) number of weeks per injection before and during home OCT management were 8.0 (4.7) and 15.3 (8.5) (p=0.004) respectively. The mean (SD) VA change before and during home OCT based management was 3.5 (12.0) letters and 0.0 (9.5) letters (p=0.45) respectively, showing no significant impact on VA.\u0000 \u0000 \u0000 \u0000 For the first time, remote patient monitoring with a home OCT allowed personalized management of nAMD. This study showed significant reduction in treatment burden while maintaining stable VA.\u0000","PeriodicalId":21178,"journal":{"name":"Retina","volume":"52 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141110986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0