Reviews of Physiology Biochemistry and Pharmacology最新文献_第3页

A Review: Uses of Chitosan in Pharmaceutical Forms. 壳聚糖在制药中的应用综述。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2021_69

Olimpia Daniela Frenț, Laura Vicaș, Tunde Jurca, Stefania Ciocan, Narcis Duteanu, Annamaria Pallag, Mariana Muresan, Eleonora Marian, Adina Negrea, Otilia Micle

引用次数: 3

How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression. 肿瘤微环境和离子转运蛋白之间的相互作用如何驱动癌症进展。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_23

Line O Elingaard-Larsen, Michala G Rolver, Ester E Sørensen, Stine F Pedersen

{"title":"How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression.","authors":"Line O Elingaard-Larsen, Michala G Rolver, Ester E Sørensen, Stine F Pedersen","doi":"10.1007/112_2020_23","DOIUrl":"https://doi.org/10.1007/112_2020_23","url":null,"abstract":"Solid tumors comprise two major components: the cancer cells and the tumor stroma. The stroma is a mixture of cellular and acellular components including fibroblasts, mesenchymal and cancer stem cells, endothelial cells, immune cells, extracellular matrix, and tumor interstitial fluid. The insufficient tumor perfusion and the highly proliferative state and dysregulated metabolism of the cancer cells collectively create a physicochemical microenvironment characterized by altered nutrient concentrations and varying degrees of hypoxia and acidosis. Furthermore, both cancer and stromal cells secrete numerous growth factors, cytokines, and extracellular matrix proteins which further shape the tumor microenvironment (TME), favoring cancer progression.Transport proteins expressed by cancer and stromal cells localize at the interface between the cells and the TME and are in a reciprocal relationship with it, as both sensors and modulators of TME properties. It has been amply demonstrated how acid-base and nutrient transporters of cancer cells enable their growth, presumably by contributing both to the extracellular acidosis and the exchange of metabolic substrates and waste products between cells and TME. However, the TME also impacts other transport proteins important for cancer progression, such as multidrug resistance proteins. In this review, we summarize current knowledge of the cellular and acellular components of solid tumors and their interrelationship with key ion transport proteins. We focus in particular on acid-base transport proteins with known or proposed roles in cancer development, and we discuss their relevance for novel therapeutic strategies.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"182 ","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38216117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues. 肿瘤血管化中的钙渗透通道:微环境化学和物理线索的特殊传感器。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_32

Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, Alessandra Fiorio Pla

{"title":"Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues.","authors":"Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, Alessandra Fiorio Pla","doi":"10.1007/112_2020_32","DOIUrl":"https://doi.org/10.1007/112_2020_32","url":null,"abstract":"Calcium (Ca2+)-permeable channels are key players in different processes leading to blood vessel formation via sprouting angiogenesis, including endothelial cell (EC) proliferation and migration, as well as in controlling vascular features which are typical of the tumor vasculature.In this review we present an up-to-date and critical view on the role of Ca2+-permeable channels in tumor vascularization, emphasizing on the dual communication between growth factors (mainly VEGF) and Ca2+ signals. Due to the complexity of the tumor microenvironment (TME) as a source of multiple stimuli acting on the endothelium, we aim to discuss the close interaction between chemical and physical challenges (hypoxia, oxidative stress, mechanical stress) and endothelial Ca2+-permeable channels, focusing on transient receptor potential (TRP), store-operated Ca2+ channels (SOCs), and mechanosensitive Piezo channels. This approach will depict their crucial contribution in regulating key properties of tumor blood vessels, such as recruitment of endothelial progenitors cells (EPCs) in the early steps of tumor vascularization, abnormal EC migration and proliferation, and increased vascular permeability. Graphical abstract depicting the functional role of Ca2+-permeable TRP, SOCs and Piezo channels in the biological processes regulating tumor angiogenesis in presence of both chemical (oxidative stress and oxygen levels) and mechanical stimuli (ECM stiffness). SOCs store-operated Ca2+ channels, TRPA transient receptor potential ankyrin, TRPV transient receptor potential vanilloid, TRPC transient receptor potential canonical, TRPM transient receptor potential melastatin, TRPM transient receptor potential vanilloid, O2 oxygen, ECM extracellular matrix.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"182 ","pages":"111-137"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38276057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Ion Transporting Proteins and Cancer: Progress and Perspectives. 离子转运蛋白与癌症:进展与展望。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2021_66

Mustafa B A Djamgoz

{"title":"Ion Transporting Proteins and Cancer: Progress and Perspectives.","authors":"Mustafa B A Djamgoz","doi":"10.1007/112_2021_66","DOIUrl":"https://doi.org/10.1007/112_2021_66","url":null,"abstract":"Ion transporting proteins (ITPs) comprise a wide range of ion channels, exchangers, pumps and ionotropic receptors many of which are expressed in tumours and contribute dynamically to the different components and stages of the complex cancer process, from initiation to metastasis. In this promising major field of biomedical research, several candidate ITPs have emerged as clinically viable. Here, we consider a series of general issues concerning the oncological potential of ITPs focusing on voltage-gated sodium channels as a 'case study'. First, we outline some key properties of 'cancer' as a whole. These include epigenetics, stemness, metastasis, heterogeneity, neuronal characteristics and bioelectricity. Cancer specificity of ITP expression is evaluated in relation to tissue restriction, splice variance, functional specificity and macro-molecular complexing. As regards clinical potential, diagnostics is covered with emphasis on enabling early detection. For therapeutics, we deal with molecular approaches, drug repurposing and combinations. Importantly, we emphasise the need for carefully designed clinical trials. We highlight also the area of 'social responsibility' and the need to involve the public (cancer patients and healthy individuals) in the work of cancer research professionals as well as clinicians. In advising patients how best to manage cancer, and live with it, we offer the following four principles: Awareness and prevention, early detection, specialist, integrated care, and psychological support. Finally, we highlight four key prerequisites for commercialisation of ITP-based technologies against cancer. We conclude that ITPs offer significant potential as regards both understanding the intricacies of the complex process of cancer and for developing much needed novel therapies.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"183 ","pages":"251-277"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39926513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges. 靶向离子通道治疗癌症:当前进展和未来挑战。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_46

Alina L Capatina, Dimitris Lagos, William J Brackenbury

{"title":"Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges.","authors":"Alina L Capatina, Dimitris Lagos, William J Brackenbury","doi":"10.1007/112_2020_46","DOIUrl":"https://doi.org/10.1007/112_2020_46","url":null,"abstract":"Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility (via interactions with the cytoskeleton), invasion, signal transduction, transcriptional activity and cell cycle progression, leading to tumour progression and metastasis. Ion channels thus represent promising targets for cancer therapy. Ion channels are attractive targets because many of them are expressed at the plasma membrane and a broad range of existing inhibitors are already in clinical use for other indications. However, many of the ion channels identified in cancer cells are also active in healthy normal cells, so there is a risk that certain blockers may have off-target effects on normal physiological function. This review describes recent research advances into ion channel inhibitors as anticancer therapeutics. A growing body of evidence suggests that a range of existing and novel Na+, K+, Ca2+ and Cl- channel inhibitors may be effective for suppressing cancer cell proliferation, migration and invasion, as well as enhancing apoptosis, leading to suppression of tumour growth and metastasis, either alone or in combination with standard-of-care therapies. The majority of evidence to date is based on preclinical in vitro and in vivo studies, although there are several examples of ion channel-targeting strategies now reaching early phase clinical trials. Given the strong links between ion channel function and regulation of tumour growth, metastasis and chemotherapy resistance, it is likely that further work in this area will facilitate the development of new therapeutic approaches which will reach the clinic in the future.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"183 ","pages":"1-43"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_46","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38327338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer. pH调节蛋白和pH失调在前列腺癌中的作用。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_18

Larry Fliegel

{"title":"Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer.","authors":"Larry Fliegel","doi":"10.1007/112_2020_18","DOIUrl":"https://doi.org/10.1007/112_2020_18","url":null,"abstract":"Prostate cancer is the fourth most commonly diagnosed cancer, and although it is often a slow-growing malignancy, it is the second leading cause of cancer-associated deaths in men and the first in Europe and North America. In many forms of cancer, when the disease is a solid tumor confined to one organ, it is often readily treated. However, when the cancer becomes an invasive metastatic carcinoma, it is more often fatal. It is therefore of great interest to identify mechanisms that contribute to the invasion of cells to identify possible targets for therapy. During prostate cancer progression, the epithelial cells undergo epithelial-mesenchymal transition that is characterized by morphological changes, a loss of cell-cell adhesion, and invasiveness. Dysregulation of pH has emerged as a hallmark of cancer with a reversed pH gradient and with a constitutively increased intracellular pH that is elevated above the extracellular pH. This phenomenon has been referred to as \"a perfect storm\" for cancer progression. Acid-extruding ion transporters include the Na+/H+ exchanger NHE1 (SLC9A1), the Na+HCO3- cotransporter NBCn1 (SLC4A7), anion exchangers, vacuolar-type adenosine triphosphatases, and the lactate-H+ cotransporters of the monocarboxylate family (MCT1 and MCT4 (SLC16A1 and 3)). Additionally, carbonic anhydrases contribute to acid transport. Of these, several have been shown to be upregulated in different human cancers including the NBCn1, MCTs, and NHE1. Here the role and contribution of acid-extruding transporters in prostate cancer growth and metastasis were examined. These proteins make significant contributions to prostate cancer progression.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"182 ","pages":"85-110"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38257358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics. 癌症中的钾和氯离子通道:癌症治疗的新范式。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2021_62

Umberto Banderali, Luigi Leanza, Najmeh Eskandari, Saverio Gentile

引用次数: 3

Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk. 癌症中的离子通道:电信号和细胞串扰的协调者。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_48

Jerry J Fan, Xi Huang

引用次数: 9

Ion Transport and Radioresistance. 离子输运和辐射电阻。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2020_33

Bastian Roth, Stephan M Huber

引用次数: 3

Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? 循环肿瘤细胞:离子转运是否有助于血管内存活、粘附、外渗和转移性器官性?

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI: 10.1007/112_2021_68

Christian Stock

{"title":"Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?","authors":"Christian Stock","doi":"10.1007/112_2021_68","DOIUrl":"https://doi.org/10.1007/112_2021_68","url":null,"abstract":"Survival in the circulation, extravasation from vasculature, and colonizing new tissues represent major steps of the metastatic cascade and pose a big challenge for metastasizing tumor cells. Tumor cells circulating in blood and lymph vessels need to overcome anoikis, cope with mechanical stimuli including shear stress, and defeat attacks by the immune system. Once adhered to the vessel wall, a circulating tumor cell (CTC) can trick the endothelial cells into loosening their intercellular junctions so that the endothelium becomes penetrable for the tumor cell. Since tumor cells tend to metastasize to predestinated target organs and tissues, called organotropism, the distribution of metastases is anything but random. The molecular-physiological mechanisms underlying CTC survival, extravasation, and organotropism are very likely to include the presence and activity of ion channels/transporters due to the latter's key function in cytophysiological processes. To date, a very limited number of studies explicitly show the involvement of ion transport. This review describes the contribution of ion channels and transporters to CTC survival, extravasation, and organotropism where known and possible. In addition, supposed connections between ion transport and CTC behavior are demonstrated and imply the potential to be therapeutically taken advantage of.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"182 ","pages":"139-175"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39902284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3