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Epigenetic Regulation Via Electrical Forces. 通过电力的表观遗传调控。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_15
Colin D McCaig
{"title":"Epigenetic Regulation Via Electrical Forces.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_15","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_15","url":null,"abstract":"<p><p>Multiple epigenetic modulations occur to chromatin rather than to DNA itself and these influence gene expression or gene silencing profoundly. Both the creation of these post-translational modifications and the mechanisms of their readout are regulated significantly by electrical forces several of which are discussed. They are also influenced by phase separation which itself is driven by electrical forces.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"251-272"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrical Forces Regulate Single-Cell Wound Healing. 电力调节单细胞伤口愈合。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_10
Colin D McCaig
{"title":"Electrical Forces Regulate Single-Cell Wound Healing.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_10","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_10","url":null,"abstract":"<p><p>Damage to the cell membrane can be life threatening for single-celled organisms. Several mechanisms of single-cell wound healing occur and aspects of these are regulated by electrical forces.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"103-113"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electricity in Space and on Earth. 太空和地球上的电。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_2
Colin D McCaig
{"title":"Electricity in Space and on Earth.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_2","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_2","url":null,"abstract":"<p><p>This covers the roles of electrical forces in space, in creating planets, including the Earth and in creating the conditions on Earth that make life possible.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appendix. 合同附件。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_22
Colin D McCaig
{"title":"Appendix.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_22","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_22","url":null,"abstract":"<p><p>Since the first Chapter dealt with the well-known charge-charge interactions familiar to biologists, this concluding Chapter introduces some key electrical forces, probably much less familiar, perhaps even unknown. LLPS (liquid liquid phase separation) which we have seen involved in so much of cell biology depends on multivalent, π-π and cation-π electrical forces. How these arise is dealt with here and may be especially useful as an aide memoir to return to when such issues arise within the bulk of the text.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"521-529"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Distance Electron Transport in Unicellular Organisms and Biofilms. 单细胞生物和生物膜中的远距离电子传递。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_4
Colin D McCaig
{"title":"Long-Distance Electron Transport in Unicellular Organisms and Biofilms.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_4","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_4","url":null,"abstract":"<p><p>Electrical forces are widespread in single-celled organisms and underpin sophisticated communication systems. Bacterial biofilm colonies, for example, attract new members electrically. Bacteria also join together end to end and engage in long-distance electron transport along bacterial filaments over centimetres. This transport of electrons across around 10,000 cells separates life-essential redox reactions spatially and keeps \"colleagues breathing\" in otherwise challenging aquatic sediments.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Electricity Prevents Us from Bleeding to Death. 电是如何防止我们流血致死的。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_11
Colin D McCaig
{"title":"How Electricity Prevents Us from Bleeding to Death.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_11","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_11","url":null,"abstract":"<p><p>Rapid tissue repair is also needed in the event of damage to blood vessels. Most of the essential steps that prevent us from bleeding to death involve the functions of Von Willebrand factor (VWF) and many of these are dependent on electrical forces.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"115-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electric Forces and ATP Synthesis. 电力和ATP合成。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_20
Colin D McCaig
{"title":"Electric Forces and ATP Synthesis.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_20","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_20","url":null,"abstract":"<p><p>ATP synthase is a rotary motor enzyme that drives the formation of ATP from ADP and P and uses multiple electrical forces to do this. This chapter outlines the exquisite use of these electrical forces to generate the high energy phosphates on which all our lives depend. Vacuolar ATPases and the ADP/ATP carrier also are explored.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"419-452"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrical Forces Improve Memory in Old Age. 电力可以提高老年人的记忆力。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_21
Colin D McCaig
{"title":"Electrical Forces Improve Memory in Old Age.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_21","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_21","url":null,"abstract":"<p><p>This penultimate chapter is based on a single paper published in Nature in 2022. I have used it specifically as an exemplar, in this case to show that memory improvement in old age may be regulated by a multiplicity of electrical forces. However, I include it because I believe that one could pick almost any other substantial single paper and show that a completely disparate set of biological mechanisms similarly depend crucially on multiple electrical forces.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"453-520"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleic Acids and Electrical Signals. 核酸与电信号。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_12
Colin D McCaig
{"title":"Nucleic Acids and Electrical Signals.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_12","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_12","url":null,"abstract":"<p><p>Nucleic acids are highly charged, and electrical forces are involved heavily in how our DNA is compacted and packaged into such a small space, how chromosomes are formed, and how DNA damage is repaired. In addition, electrical forces are crucial to the formation of non-canonical DNA structures called G-Quadruplexes which play multiple biological roles.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"147-193"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrical Forces in Biology Across Distances. 远距离生物学中的电作用力。
2区 医学
Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-68827-0_1
Colin D McCaig
{"title":"Electrical Forces in Biology Across Distances.","authors":"Colin D McCaig","doi":"10.1007/978-3-031-68827-0_1","DOIUrl":"https://doi.org/10.1007/978-3-031-68827-0_1","url":null,"abstract":"<p><p>This first chapter covers essentials needed to understand the multiple roles of electrical forces that impinge on biology, over very different distances. Other less familiar electrical forces are also covered in the last chapter.</p>","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"187 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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