Reviews of Physiology Biochemistry and Pharmacology最新文献

Golgi pH and Ion Homeostasis in Health and Disease. 健康和疾病中的高尔基酸碱度和离子稳态。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2020_49

Elham Khosrowabadi, Sakari Kellokumpu

引用次数: 6

Patterns of Ciliation and Ciliary Signaling in Cancer. 癌症中纤毛和纤毛信号的模式。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2020_36

Anna A Kiseleva, Anna S Nikonova, Erica A Golemis

{"title":"Patterns of Ciliation and Ciliary Signaling in Cancer.","authors":"Anna A Kiseleva, Anna S Nikonova, Erica A Golemis","doi":"10.1007/112_2020_36","DOIUrl":"https://doi.org/10.1007/112_2020_36","url":null,"abstract":"Among the factors that have been strongly implicated in regulating cancerous transformation, the primary monocilium (cilium) has gained increasing attention. The cilium is a small organelle extending from the plasma membrane, which provides a localized hub for concentration of transmembrane receptors. These receptors transmit signals from soluble factors (including Sonic hedgehog (SHH), platelet-derived growth factor (PDGF-AA), WNT, TGFβ, NOTCH, and others) that regulate cell growth, as well as mechanosensory cues provided by flow or extracellular matrix. Ciliation is regulated by cell cycle, with most cells that are in G0 (quiescent) or early G1 ciliation and cilia typically absent in G2/M cells. Notably, while most cells organized in solid tissues are ciliated, cancerous transformation induces significant changes in ciliation. Most cancer cells lose cilia; medulloblastomas and basal cell carcinomas, dependent on an active SHH pathway, rely on ciliary maintenance. Changes in cancer cell ciliation are driven by core oncogenic pathways (EGFR, KRAS, AURKA, PI3K), and importantly ciliation status regulates functionality of those pathways. Ciliation is both influenced by targeted cancer therapies and linked to therapeutic resistance; recent studies suggest ciliation may also influence cancer cell metabolism and stem cell identity. We review recent studies defining the relationship between cilia and cancer.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"185 ","pages":"87-105"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications. 不同脂肪库在代谢调节中的作用及其病理意义。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2022_73

Bijayashree Sahu, Ojas Tikoo, Benudhara Pati, Unmod Senapati, Naresh C Bal

{"title":"Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications.","authors":"Bijayashree Sahu, Ojas Tikoo, Benudhara Pati, Unmod Senapati, Naresh C Bal","doi":"10.1007/112_2022_73","DOIUrl":"https://doi.org/10.1007/112_2022_73","url":null,"abstract":"People suffering from obesity and associated metabolic disorders including diabetes are increasing exponentially around the world. Adipose tissue (AT) distribution and alteration in their biochemical properties play a major role in the pathogenesis of these diseases. Emerging evidence suggests that AT heterogeneity and depot-specific physiological changes are vital in the development of insulin resistance in peripheral tissues like muscle and liver. Classically, AT depots are classified into white adipose tissue (WAT) and brown adipose tissue (BAT); WAT is the site of fatty acid storage, while BAT is a dedicated organ of metabolic heat production. The discovery of beige adipocyte clusters in WAT depots indicates AT heterogeneity has a more central role than hither to ascribed. Therefore, we have discussed in detail the current state of understanding on cellular and molecular origin of different AT depots and their relevance toward physiological metabolic homeostasis. A major focus is to highlight the correlation between altered WAT distribution in the body and metabolic pathogenesis in animal models and humans. We have also underscored the disparity in the molecular (including signaling) changes in various WAT tissues during diabetic pathogenesis. Exercise-mediated beneficial alteration in WAT physiology/distribution that protects against metabolic disorders is evolving. Here we have discussed the depot-specific biochemical adjustments induced by different forms of exercise. A detailed understanding of the molecular details of inter-organ crosstalk via substrate utilization/storage and signaling through chemokines provide strategies to target selected WAT depots to pharmacologically mimic the benefits of exercise countering metabolic diseases including diabetes.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"186 ","pages":"135-176"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10633835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics. 影响肾近端小管的内溶酶体疾病:新的机制见解和治疗方法。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2020_57

Beatrice Paola Festa, Marine Berquez, Daniela Nieri, Alessandro Luciani

{"title":"Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics.","authors":"Beatrice Paola Festa, Marine Berquez, Daniela Nieri, Alessandro Luciani","doi":"10.1007/112_2020_57","DOIUrl":"https://doi.org/10.1007/112_2020_57","url":null,"abstract":"Epithelial cells that line the proximal tubule of the kidney rely on an intertwined ecosystem of vesicular membrane trafficking pathways to ensure the reabsorption of essential nutrients. To function effectively and to achieve homeostasis, these specialized cells require the sorting and recycling of a wide array of cell surface proteins within the endolysosomal network, including signaling receptors, nutrient transporters, ion channels, and polarity markers. The dysregulation of the endolysosomal system can lead to a generalized proximal tubule dysfunction, ultimately causing severe metabolic complications and kidney disease.In this chapter, we highlight the biological functions of the genes that code endolysosomal proteins from the perspective of understanding - and potentially reversing - the pathophysiology of endolysosomal disorders affecting the proximal tubule of the kidney. These insights might ultimately lead to potential treatments for currently intractable diseases and transform our ability to regulate kidney homeostasis and health.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"185 ","pages":"233-257"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_57","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9201765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4. 瞬时受体电位香草素4型促疼痛谱的研究进展。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2022_75

John P M White, Mario Cibelli, Istvan Nagy, Bernd Nilius, James Graham McGeown

{"title":"The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4.","authors":"John P M White, Mario Cibelli, Istvan Nagy, Bernd Nilius, James Graham McGeown","doi":"10.1007/112_2022_75","DOIUrl":"https://doi.org/10.1007/112_2022_75","url":null,"abstract":"Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which mediate a wide range of physiological functions and are activated and modulated by a diverse array of stimuli. One of this ion channel's least discussed functions is in relation to the generation and maintenance of certain pain sensations. However, in the two decades which have elapsed since the identification of this ion channel, considerable data has emerged concerning its function in mediating pain sensations. TRPV4 is a mediator of mechanical hyperalgesia in the various contexts in which a mechanical stimulus, comprising trauma (at the macro-level) or discrete extracellular pressure or stress (at the micro-level), results in pain. TRPV4 is also recognised as constituting an essential component in mediating inflammatory pain. It also plays a role in relation to many forms of neuropathic-type pain, where it functions in mediating mechanical allodynia and hyperalgesia.Here, we review the role of TRPV4 in mediating pain sensations.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"186 ","pages":"57-93"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9204307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Endocannabinoid System in Caenorhabditis elegans. 秀丽隐杆线虫的内源性大麻素系统。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2021_64

Rubén Estrada-Valencia, María Eduarda de Lima, Aline Colonnello, Edgar Rangel-López, Nariani Rocha Saraiva, Daiana Silva de Ávila, Michael Aschner, Abel Santamaría

引用次数: 5

Stress Granules in Cancer. 癌症中的应激颗粒

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2020_37

Min-Seok Song, Elda Grabocka

{"title":"Stress Granules in Cancer.","authors":"Min-Seok Song, Elda Grabocka","doi":"10.1007/112_2020_37","DOIUrl":"10.1007/112_2020_37","url":null,"abstract":"The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes. Recent evidence, however, has added a new layer of flexibility to cellular compartmentalization. As such, in response to specific stimuli, liquid-liquid phase separations can lead to the rapid rearrangements of the cytoplasm to form membraneless organelles. Stress granules (SGs) are one such type of organelle that form specifically when cells are faced with stress stimuli, to aid cells in coping with stress. Inherently, altered SG formation has been linked to the pathogenesis of diseases associated with stress and inflammatory conditions, including cancer. Exciting discoveries have indicated an intimate link between SGs and tumorigenesis. Several pro-tumorigenic signaling molecules including the RAS oncogene, mTOR, and histone deacetylase 6 (HDAC6) have been shown to upregulate SG formation. Based on these studies, SGs have emerged as structures that can integrate oncogenic signaling and tumor-associated stress stimuli to enhance cancer cell fitness. In addition, growing evidence over the past decade suggests that SGs function not only to regulate the switch between survival and cell death, but also contribute to cancer cell proliferation, invasion, metastasis, and drug resistance. Although much remains to be learned about the role of SGs in tumorigenesis, these studies highlight SGs as a key regulatory hub in cancer and a promising therapeutic target.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"185 ","pages":"25-52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10595461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders. 催产素在不同神经精神、神经退行性和神经发育障碍中的作用。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2022_72

Aya A Ghazy, Omar A Soliman, Aya I Elbahnasi, Aya Y Alawy, Amira Ma Mansour, Mennatallah A Gowayed

{"title":"Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders.","authors":"Aya A Ghazy, Omar A Soliman, Aya I Elbahnasi, Aya Y Alawy, Amira Ma Mansour, Mennatallah A Gowayed","doi":"10.1007/112_2022_72","DOIUrl":"https://doi.org/10.1007/112_2022_72","url":null,"abstract":"Oxytocin has recently gained significant attention because of its role in the pathophysiology and management of dominant neuropsychiatric disorders. Oxytocin, a peptide hormone synthesized in the hypothalamus, is released into different brain regions, acting as a neurotransmitter. Receptors for oxytocin are present in many areas of the brain, including the hypothalamus, amygdala, and nucleus accumbens, which have been involved in the pathophysiology of depression, anxiety, schizophrenia, autism, Alzheimer's disease, Parkinson's disease, and attention deficit hyperactivity disorder. Animal studies have spotlighted the role of oxytocin in social, behavioral, pair bonding, and mother-infant bonding. Furthermore, oxytocin protects fetal neurons against injury during childbirth and affects various behaviors, assuming its possible neuroprotective characteristics. In this review, we discuss some of the concepts and mechanisms related to the role of oxytocin in the pathophysiology and management of some neuropsychiatric, neurodegenerative, and neurodevelopmental disorders.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"186 ","pages":"95-134"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10637121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools. 斑马鱼的遗传性室性心律失常:遗传模型和表型工具。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2021_65

Ewa Sieliwonczyk, Vladimir V Matchkov, Bert Vandendriessche, Maaike Alaerts, Jeroen Bakkers, Bart Loeys, Dorien Schepers

{"title":"Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools.","authors":"Ewa Sieliwonczyk, Vladimir V Matchkov, Bert Vandendriessche, Maaike Alaerts, Jeroen Bakkers, Bart Loeys, Dorien Schepers","doi":"10.1007/112_2021_65","DOIUrl":"https://doi.org/10.1007/112_2021_65","url":null,"abstract":"In the last years, the field of inheritable ventricular arrhythmia disease modelling has changed significantly with a push towards the use of novel cellular cardiomyocyte based models. However, there is a growing need for new in vivo models to study the disease pathology at the tissue and organ level. Zebrafish provide an excellent opportunity for in vivo modelling of inheritable ventricular arrhythmia syndromes due to the remarkable similarity between their cardiac electrophysiology and that of humans. Additionally, many state-of-the-art methods in gene editing and electrophysiological phenotyping are available for zebrafish research. In this review, we give a comprehensive overview of the published zebrafish genetic models for primary electrical disorders and arrhythmogenic cardiomyopathy. We summarise and discuss the strengths and weaknesses of the different technical approaches for the generation of genetically modified zebrafish disease models, as well as the electrophysiological approaches in zebrafish phenotyping. By providing this detailed overview, we aim to draw attention to the potential of the zebrafish model for studying arrhythmia syndromes at the organ level and as a platform for personalised medicine and drug testing.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"184 ","pages":"33-68"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10531891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function. 自分泌、旁分泌和内分泌信号可改变肺泡巨噬细胞功能。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI: 10.1007/112_2022_76

Yue Yang, Yun Wang

引用次数: 0