Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders.

2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2023-01-01 DOI:10.1007/112_2022_72

Aya A Ghazy, Omar A Soliman, Aya I Elbahnasi, Aya Y Alawy, Amira Ma Mansour, Mennatallah A Gowayed

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引用次数: 3

Abstract

Oxytocin has recently gained significant attention because of its role in the pathophysiology and management of dominant neuropsychiatric disorders. Oxytocin, a peptide hormone synthesized in the hypothalamus, is released into different brain regions, acting as a neurotransmitter. Receptors for oxytocin are present in many areas of the brain, including the hypothalamus, amygdala, and nucleus accumbens, which have been involved in the pathophysiology of depression, anxiety, schizophrenia, autism, Alzheimer's disease, Parkinson's disease, and attention deficit hyperactivity disorder. Animal studies have spotlighted the role of oxytocin in social, behavioral, pair bonding, and mother-infant bonding. Furthermore, oxytocin protects fetal neurons against injury during childbirth and affects various behaviors, assuming its possible neuroprotective characteristics. In this review, we discuss some of the concepts and mechanisms related to the role of oxytocin in the pathophysiology and management of some neuropsychiatric, neurodegenerative, and neurodevelopmental disorders.

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催产素在不同神经精神、神经退行性和神经发育障碍中的作用。

由于催产素在主要神经精神疾病的病理生理学和治疗中的作用，它最近得到了极大的关注。催产素是一种在下丘脑合成的肽激素，它被释放到大脑的不同区域，作为一种神经递质。催产素受体存在于大脑的许多区域，包括下丘脑、杏仁核和伏隔核，它们与抑郁症、焦虑症、精神分裂症、自闭症、阿尔茨海默病、帕金森病和注意缺陷多动障碍的病理生理有关。动物研究已经强调了催产素在社会、行为、伴侣关系和母婴关系中的作用。此外，催产素在分娩过程中保护胎儿神经元免受损伤，并影响各种行为，假设其可能具有神经保护特性。在这篇综述中，我们讨论了催产素在一些神经精神、神经退行性和神经发育障碍的病理生理和治疗中的作用的一些概念和机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews of Physiology Biochemistry and Pharmacology 医学-生化与分子生物学

CiteScore

11.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.