Psychiatry Investigation最新文献

{"title":"Evidence for Mental Health Promotion and Prevention in Korea: A Narrative Review.","authors":"Jongtae Kim, Hae Kook Lee","doi":"10.30773/pi.2025.0467","DOIUrl":"10.30773/pi.2025.0467","url":null,"abstract":"<p><strong>Objective: </strong>This review critically evaluates internationally indexed evidence on mental health promotion and prevention interventions in Korea and examines whether the growing national infrastructure is underpinned by a scientific foundation that meets global standards.</p><p><strong>Methods: </strong>A narrative review was conducted using PubMed, Embase, the Cochrane Library, and Web of Science to identify peer-reviewed quantitative studies published from database inception to August 8, 2025. Eligible studies evaluated programmatic or policy-level interventions explicitly designed to promote psychological well-being or prevent mental disorders among Koreans. Interventions were categorized according to the Institute of Medicine prevention framework and synthesized narratively.</p><p><strong>Results: </strong>A total of 135 studies were included. Research targeting adolescents was relatively sparse, with a marked lack of promotion-focused interventions. Although research activity increased sharply after 2020, the evidence base remains uneven in methodological rigor. Only 23.7% of studies employed randomized controlled designs. A structural disconnect was evident in the research pipeline, where pilot studies rarely progressed to full-scale efficacy trials. Furthermore, interventions delivered through core community mental health institutions were frequently bypassed in research, with recent studies shifting heavily toward digital and web-based platforms.</p><p><strong>Conclusion: </strong>While research volume has expanded, the field lacks the methodological and structural maturity required to guide national policy effectively. Establishing a robust scientific foundation is a prerequisite for transforming current national endeavors into a system delivering genuine population-level benefits. Future initiatives must prioritize rigorous evidence generation to align Korea's mental health promotion and prevention strategies with global standards.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"577-589"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Associations Between Religiosity and Cognition in the Korean Elderly With Alzheimer's Disease.","authors":"Minkyung Kim, Sooyeon Min, JaeHoon Jung, Chang Hyun Lee, Yoo Sun Moon, Do Hoon Kim","doi":"10.30773/pi.2025.0394","DOIUrl":"10.30773/pi.2025.0394","url":null,"abstract":"<p><strong>Objective: </strong>Recent studies have shown the beneficial effects of religiosity on the cognitive function of people with Alzheimer's disease (AD). We compared cognitive function among groups with different religious affiliations and investigated the relationship between religiosity and subdomains of cognitive function in patients with AD.</p><p><strong>Methods: </strong>We recruited 247 patients with AD from psychiatric outpatient clinic. The Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) was used to investigate different domains of cognitive function in patients with AD. Religiosity was measured using the Duke University Religion Index (DUREL), which assesses organizational religious activity (ORA), non-organizational religious activity (NORA), and intrinsic religiosity (IR). The cognitive functions of Christian, Buddhist, and religiously non-affiliated groups were compared. Additionally, hierarchical stepwise multiple regression was used to determine the relationship between ORA, NORA, and IR and the subdomains of cognitive function.</p><p><strong>Results: </strong>The Christian group showed better functioning in memory and constructional praxis than the religiously non-affiliated group after controlling for age, sex, and education, whereas the Buddhist group did not differ from the religiously non-affiliated group. ORA, NORA, and IR were significantly related to the Mini Mental Status Examination in the Korean version of CERAD (MMSE-KC), constructional praxis, and wordlist memory. In the multiple regression analysis, ORA showed positive relationships with constructional praxis and word-list memory, whereas NORA and IR were positively associated with MMSE-KC and word-list recall, respectively.</p><p><strong>Conclusion: </strong>Our results suggest that the superiority in the cognitive functions of the Christian group may be associated with a high level of religious activities and IR that significantly influences memory and visuospatial ability in the elderly with AD.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"677-684"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Pilot Evaluation of a Drug Abuse Prevention Program for Elementary School Children in Korea.","authors":"Jeewon Lee, Jaewon Yang, Areum Lee, Yujin Ko, Jae Kwang Shim, Soyoung Irene Lee","doi":"10.30773/pi.2025.0327","DOIUrl":"10.30773/pi.2025.0327","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the present study was to develop and pilot test a culturally tailored, developmentally appropriate, drug abuse prevention program for Korean elementary school children.</p><p><strong>Methods: </strong>By grounding the program in the framework of Social and Emotional Learning (SEL), the program aimed to prevent drug abuse by enhancing children's social and emotional competencies. Separate curricula were developed for lower and upper elementary to align with children's cognitive and socio-emotional developmental stages. Expert feedback was solicited from child psychiatrists and elementary school teachers. The program was implemented in an elementary school with 194 participants. Program feasibility and acceptability were assessed through facilitator evaluations and student satisfaction surveys. For upper elementary students (n=99), pre-post measures of self-esteem and attitudes toward drug abuse were also analyzed.</p><p><strong>Results: </strong>Experts and facilitators reported that the program was easy to implement, developmentally appropriate, and well understood by students. Satisfaction surveys indicated high levels of engagement and perceived learning. The mean self-esteem score increased from 27.3±4.2 to 28.2±3.9 (Cohen's d=0.21). The attitude toward drug abuse score also improved from 15.2±2.3 to 15.6±3.1 (Cohen's d=0.14). Although both changes did not reach statistical significance, the qualitative and quantitative data support the program's feasibility and positive trend.</p><p><strong>Conclusion: </strong>This pilot study suggests that an SEL-based, culturally adapted prevention program is feasible and well accepted in Korean elementary schools. While larger-scale studies are required, early implementation of interactive, developmentally sensitive programs holds promise for strengthening protective factors against drug abuse in children.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"704-709"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13211997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Body Roundness Index's Mediating Role in the Depression-Cognitive Performance Relationship Among US Adults (≥60 Years): Evidence From National Health and Nutrition Examination Survey.","authors":"Hongwei Liu, Wenzhi Niu, Peng Wei, Minheng Zhang, Zhinan Ye, Caidi He","doi":"10.30773/pi.2025.0375","DOIUrl":"10.30773/pi.2025.0375","url":null,"abstract":"<p><strong>Objective: </strong>Late-life depression is a known risk factor for cognitive decline, yet the role of central adiposity, measured by the body roundness index (BRI), remains unclear. This study examined whether BRI mediates the relationship between depressive symptoms and cognitive performance in older adults.</p><p><strong>Methods: </strong>Our analysis included 2,580 adults aged 60 and over, using data from NHANES. Depressive symptoms were assessed via the Patient Health Questionnaire-9 (PHQ-9), cognitive function was evaluated using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning and Delayed Recall (CERAD-WL/DR), Animal Fluency test (AFT), and Digit Symbol Substitution Test (DSST), and BRI was calculated from waist circumference and height. Analyses included weighted multivariable logistic regression, restricted cubic spline analyses, subgroup and sensitivity analyses, and mediation analyses.</p><p><strong>Results: </strong>Across all assessment modalities, there was a significant link between high PHQ-9 scores and cognitive performance. For continuous PHQ-9 scores, each 1-point increase corresponded to: CERAD (odds ratio [OR]=1.034, 95% confidence interval [CI]: 1.000-1.070, p=0.049), AFT (OR=1.046, 95% CI: 1.014-1.079, p=0.007), and DSST (OR=1.080, 95% CI: 1.040-1.123, p<0.001). Categorical analysis revealed particularly strong effects for moderate-to-severe depression (PHQ-9 ≥10) versus minimal symptoms (PHQ-9, 0-4): DSST (OR=2.562, 95% CI: 1.432-4.584, p=0.004), AFT (OR=1.834, 95% CI: 1.239-2.714, p=0.005), with CERAD showing marginal significance (OR=1.454, 95% CI: 0.936-2.259, p=0.090). Sensitivity analyses confirmed the stability of these associations in multiply imputed datasets. BRI exhibited a statistical mediation effect, accounting for 7.23% (β=-0.021, p=0.006) of the depression-DSST association, though mediation effects were nonsignificant for CERAD (6.21%, p=0.184) or AFT (4.41%, p=0.448).</p><p><strong>Conclusion: </strong>Depression severity was independently linked to lower cognitive performance, with BRI partially mediating this relationship.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"685-695"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Association Between Generalized Anxiety Disorder and Cognitive Change: A Meta-Analysis.","authors":"Jie Li, Leiyu Shi, Nan Jiang, Benqi Zhao, Yujie Wang, Zhuozhao Zheng","doi":"10.30773/pi.2025.0299","DOIUrl":"10.30773/pi.2025.0299","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to systematically evaluate the longitudinal relationship between generalized anxiety disorder (GAD) and cognitive function changes. Specifically, we examined whether GAD is an independent risk factor for sustained cognitive decline and explored the potential effects of cognitive behavioral therapy (CBT) on cognitive and emotional outcomes.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Embase, Web of Science, and the Cochrane Library for eligible longitudinal studies and randomized controlled trials published up to January 20, 2025. Meta-analyses were performed using RevMan 5.4.1. Effect sizes were estimated using mean differences (MD) and 95% confidence intervals. Heterogeneity was assessed with the I2 statistic. Sensitivity analyses and publication bias assessments were also conducted.</p><p><strong>Results: </strong>A total of 13 studies were included. The results showed no significant differences between GAD patients and controls on memory and attention subscores of the dementia rating scale (p>0.05). Total error scores also showed no significant difference. Subgroup analyses indicated that GAD patients receiving CBT demonstrated greater improvement in clinical symptoms than those receiving non-cognitive interventions (MD=-4.39, p=0.0004). Beck Depression Inventory score differences were statistically significant, while Penn State Worry Questionnaire score differences were not.</p><p><strong>Conclusion: </strong>This meta-analysis suggests that while GAD does not show consistent evidence of sustained cognitive decline, CBT may be associated with improvement in emotional symptoms. By integrating longitudinal data with treatment outcomes, this study offers preliminary insights into the potential indirect cognitive benefits of psychotherapy in GAD.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"588-596"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the K-WPPSI-IV Profiles Between Children With Attention-Deficit/Hyperactivity Disorder and Children With Autism Spectrum Disorder: A Retrospective Study.","authors":"Gaeun Kim, Soojin Ahn, Dong-Hui Park, Haejin Kim, Sungik Kim, Hyo-Won Kim","doi":"10.30773/pi.2025.0284","DOIUrl":"10.30773/pi.2025.0284","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to: 1) compare the cognitive profiles of children with autism spectrum disorder (ASD), attention-deficit/ hyperactivity disorder (ADHD), and comorbid ADHD+ASD with typically developing (TD) children; and 2) examine the associations between indices of the Korean Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (K-WPPSI-IV) and other clinical assessments.</p><p><strong>Methods: </strong>A retrospective chart review was conducted for 233 children aged 4-6 years who visited Asan Medical Center between April 2017 and September 2024. The study population included 74 children with ADHD+ASD, 46 with ASD, 84 with ADHD, and 29 TD children. The full-scale intellectual quotient, 5 indices, and 12 subtest scores of the K-WPPSI-IV were compared using analysis of covariance, adjusting for age. Correlations were analyzed between the K-WPPSI-IV indices and the symptom severity measures: Childhood Autism Rating Scale (CARS), ADHD Rating Scale (ARS), and Advanced Test of Attention (ATA) across the full population.</p><p><strong>Results: </strong>Children with ADHD+ASD, ASD, and ADHD scored significantly lower than TD peers on the Working Memory Index (WMI; p<0.001) and Processing Speed Index (PSI; p<0.001). The ASD group showed significantly lower scores than the ADHD group in Vocabulary (p=0.001) and Comprehension (p<0.001). CARS scores negatively correlated with the WMI, while ATA negatively correlated with the PSI.</p><p><strong>Conclusion: </strong>Both ADHD and ASD are associated with relative weakness in processing speed and working memory. Furthermore, ASD is characterized by additional difficulties in verbal abilities. These findings highlight distinct and overlapping cognitive features across these disorders.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"613-623"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion Regulation and Temperament Characteristics in Children and Adolescents Diagnosed With Migraine and Tension-Type Headache.","authors":"Hurşit Ferahkaya, Ayhan Bilgiç, Melek Türker, Fatih Mehmet Akif Özdemir, Doğukan Mustafa Keskin","doi":"10.30773/pi.2026.0028","DOIUrl":"10.30773/pi.2026.0028","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship between headache and psychiatric characteristics by comparing emotion regulation skills, temperament traits, and psychiatric symptom severity among children and adolescents diagnosed with migraine and tension- type headache (TTH) versus healthy controls.</p><p><strong>Methods: </strong>A total of 131 participants aged 9-18 years were included: 45 with migraine, 42 with TTH, and 44 healthy controls. Assessments included the Difficulties in Emotion Regulation Scale (DERS), the Early Adolescent Temperament Questionnaire-Revised, and the Revised Child Anxiety and Depression Scale.</p><p><strong>Results: </strong>Migraine patients had significantly higher scores on DERS subscales related to difficulty maintaining goal-directed behavior and developing effective coping strategies, as well as on major depressive disorder scores, compared to controls. TTH patients showed significantly lower effortful control scores, associated with attention and self-regulation, than the control group. No significant differences were found between the migraine and TTH groups in emotion regulation or temperament traits.</p><p><strong>Conclusion: </strong>The findings suggest that both migraine and TTH may be associated not only with secondary psychiatric disorders such as depression and anxiety, but also with innate structural predispositions (emotion regulation skills and temperament characteristics). These shared structural predispositions may contribute to the development of both headache types and psychiatric symptoms.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"658-666"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13211998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Death Anxiety and Spirituality Level on Psychological Well-Being of Geriatric Home Care Patients: Machine Learning Approach.","authors":"Mehmet Uçar, Metin Yildiz","doi":"10.30773/pi.2026.0010","DOIUrl":"10.30773/pi.2026.0010","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of death anxiety and spirituality on the psychological well-being of geriatric home care patients.</p><p><strong>Methods: </strong>A descriptive cross-sectional design was conducted between January and June 2024 with 280 individuals aged ≥65 years living in a provincial center in eastern Türkiye. Data were collected using the personal information form, Spiritual Orientation Scale, Psychological Well-being Scale, and Death Anxiety Scale. Descriptive statistics, t-tests, and machine learning based Shapley value analysis were applied.</p><p><strong>Results: </strong>Psychological well-being was significantly associated with death anxiety and spirituality. Lower death anxiety (t=-4.253, p<0.001) and higher spirituality (t=4.728, p<0.001) were linked to better psychological well-being. Shapley value analysis identified spirituality as the strongest predictor.</p><p><strong>Conclusion: </strong>Reducing death anxiety and enhancing spirituality may improve psychological well-being in geriatric home care patients. Integrating spirituality-based psychosocial interventions into geriatric care may strengthen emotional resilience and quality of life. Future longitudinal studies are recommended to better understand the causal relationships between death anxiety, spirituality, and psychological well-being in geriatric home care populations.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"696-703"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13211996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life's Essential 8 and Suicide Risk: A Population-Level Study of Cardiovascular Health as a Mental Health Indicator.","authors":"Suhyung Kim, Young-Chan Kim, Tae-Won Kim, Seung-Chul Hong, Ho Jun Seo, Jong-Hyun Jeong, Hyun Kook Lim, Kyungdo Han, Seung-Hyun Ko, Yoo Hyun Um","doi":"10.30773/pi.2025.0392","DOIUrl":"10.30773/pi.2025.0392","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular health (CVH), assessed through Life's Essential 8 (LE8), has been widely studied in relation to physical health outcomes. However, its association with mental health, including psychological distress, suicidal behavior, and mental health service utilization, remains underexplored. This study examined whether better CVH is associated with reduced risk of mental health problems and greater engagement with mental health services.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from 4,106 Korean adults aged ≥19 years from the 2021 Korea National Health and Nutrition Examination Survey. CVH was measured using LE8 and categorized into low (0-49), moderate (50-79), and high (80-100) groups. Mental health outcomes included perceived stress, depressive mood, suicidal ideation, suicide planning, suicide attempts, and mental health service utilization.</p><p><strong>Results: </strong>Higher LE8 scores were significantly associated with lower stress (p=0.041) and reduced odds of suicidal ideation (p=0.001). Compared to the low CVH group, adjusted odds ratios (ORs) for stress perception were 0.748 (95% confidence interval [CI]: 0.587-0.953) in the moderate group and 0.685 (95% CI: 0.491-0.956) in the high group. For suicidal ideation, the ORs were 0.517 (95% CI: 0.329-0.813) and 0.199 (95% CI: 0.078-0.507), respectively. LE8 health behaviors, not health factors, were significantly associated with stress perception and suicidal ideation.</p><p><strong>Conclusion: </strong>Better CVH is associated with lower psychological distress and suicidal behavior, with health behaviors in LE8 showing stronger associations with mental health outcomes than health factors. Further longitudinal studies are needed to confirm causality and underlying mechanisms.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 5","pages":"667-676"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality and Psychotic-Like Features in Post-Traumatic Stress Disorder With Severe Depression: An Minnesota Multiphasic Personality Inventory-2 Schizophrenia Scale Analysis.","authors":"Young Kyung Moon, Kayoung Song, Sora Lee, Hayun Choi","doi":"10.30773/pi.2025.0403","DOIUrl":"10.30773/pi.2025.0403","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify factors influencing the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Schizophrenia scale (T_Sc) among patients with post-traumatic stress disorder (PTSD) who underwent both Clinician Administered PTSD Scales (CAPS) and MMPI-2.</p><p><strong>Methods: </strong>We retrospectively reviewed 119 patients who underwent CAPS and MMPI-2 from May 2013 to November 2022 at Veteran Health Service Medical Center, Seoul, Korea. Based on the Korean-Beck Depression Inventory-II (K-BDI-II), the PTSD patients (n=64) were classified into severe depression group (K-BDI-II ≥29; n=43) and less-severe depression group (K-BDI-II <29; n=21). Correlations among K-BDI-II, CAPS, and MMPI-2 scales were examined, and multiple linear regression analyses were performed to identify predictors of T_Sc after adjusting for potential confounders (e.g., age, sex, CAPS scores, MMPI-2 scales).</p><p><strong>Results: </strong>The severe depression group had significantly higher T_Sc scores (p<0.001). T_Sc was strongly correlated with K-BDI-II scores (r=0.70, p<0.001). In regression analysis, PTSD patients with severe depression (K-BDI-II ≥29) showed higher T_Sc than those without severe depression after adjustment for age, sex, and CAPS; however, this association was attenuated after further adjustment for additional covariates. Multiple linear regression analyses revealed that MMPI-2 restructured clinical (RC) scales, -particularly Demoralization was associated with T_Sc score.</p><p><strong>Conclusion: </strong>PTSD patients frequently exhibit elevated T_Sc scores, particularly when severe depression coexists. However, the independent contribution of depression diminishes when underlying personality and psychopathological traits including demoralization are considered. These findings highlight the necessity of individualized MMPI-2 interpretation and tailored clinical strategies for this subgroup.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"23 4","pages":"520-529"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}