Prostaglandins & other lipid mediators最新文献_第3页

Exploring the Unique Role of Specialized Pro-Resolving Mediators in Cancer Therapeutics. 探索特殊促溶解介质在癌症治疗中的独特作用。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-12-23 DOI: 10.1016/j.prostaglandins.2024.106944

Katherine M Quinlivan, Isabella V Howard, Franciska Southan, Rachel L Bayer, Kimberly L Torres, Charles N Serhan, Dipak Panigrahy

{"title":"Exploring the Unique Role of Specialized Pro-Resolving Mediators in Cancer Therapeutics.","authors":"Katherine M Quinlivan, Isabella V Howard, Franciska Southan, Rachel L Bayer, Kimberly L Torres, Charles N Serhan, Dipak Panigrahy","doi":"10.1016/j.prostaglandins.2024.106944","DOIUrl":"https://doi.org/10.1016/j.prostaglandins.2024.106944","url":null,"abstract":"<p><p>Unresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and metastasis in various cancer types. In contrast to blocking inflammation, stimulation of resolution of inflammation is an entirely novel approach to \"resolve\" inflammation. Resolution of inflammation mechanisms in cancer includes clearance of tumor debris, counter-regulation of pro-inflammatory eicosanoids and cytokines, and suppression of leukocyte infiltration. Conventional cytotoxic chemotherapy, radiation, anti-angiogenic therapy, and immune checkpoint inhibitors directly or indirectly can lead to the generation of pro-tumorigenic cellular debris. Over the past two decades, a potential paradigm shift has emerged in the inflammation field with the discovery of specialized pro-resolving mediators (SPMs), including resolvins, lipoxins, maresins, and protectins. SPMs are structurally distinct families of mediators grouped together by their pro-resolving \"debris-clearing\" functions. \"Pro-resolving\" therapies are in clinical development for various inflammation-driven diseases, including cancer. SPMs, as novel cancer therapeutics, have tremendous potential to enhance current cancer therapy. The mechanisms of SPMs as anti-cancer therapeutics are under active investigation by various laboratories worldwide. Here, we explore the current appreciation of the SPMs as innovative potential treatments designed to harness the unique anti-cancer activity of SPMs.</p>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":" ","pages":"106944"},"PeriodicalIF":2.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats 迷迭香酸可减轻高脂饮食致高胆固醇血症大鼠心脏异常

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-11-28 DOI: 10.1016/j.prostaglandins.2024.106936

R Sundaram , K Muthu

{"title":"Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats","authors":"R Sundaram , K Muthu","doi":"10.1016/j.prostaglandins.2024.106936","DOIUrl":"10.1016/j.prostaglandins.2024.106936","url":null,"abstract":"<div><div>Hyperlipidemia is a well-known risk factor for atherosclerosis and subsequent atherosclerotic cardiovascular diseases that are associated with high morbidity and mortality in obese and diabetic patients worldwide. The current study looked on rosmarinic acid's cadioprotective effects in rats fed a high-fat diet as there was no study on this aspect. The rats were given a high-fat diet comprising of 84.3 % conventional laboratory rat chow, 5 % lard, 10 % egg yolk powder, 0.2 % cholesterol, and 0.5 % bile salt to produce hypercholesterolemia. Over a span of eight weeks. The plasma lipid profile, cardiac marker enzymes, membrane bound ATPases, lysosomal enzymes, CRP, fibrinogen, proinflammatory cytokines (IL-1β, IL-6,TNF-α, NF-κB),anti-inflammatory cytokine(IL-10) lipid peroxidation markers, enzymatic and non-enzymatic antioxidant enzymes activity were examined. The thoracic aorta's histopathology was also analyzed. It was discovered that the rats fed a high-fat diet had hypercholesterolemia and showed aberrant values in the aforementioned parameters. However, rats given rosmarinic acid (100 mg/kg b.w.) had these anomalies reversed to near-normal levels. The biochemical investigation was corroborated by enhanced histological examination of the thoracic aorta in rats suffering from hypercholestolemia. The effects of rosmarinic acid on a number of measures were similar to those of the prescription medication simvastatin. These findings revealed that rosmarinic acid is an important component in the cardiovascular system's defence against a high-fat diet induced hypercholesterolemia</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106936"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis 补充葡萄糖甘露聚糖是否会对成人血清脂质状况产生有利影响？系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-11-09 DOI: 10.1016/j.prostaglandins.2024.106934

Zhu Haijun , Zhang Ke , Zhang Dawei , Amir Reza Haedi , Elika Poorasadollah , Cheng Cheng

{"title":"Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis","authors":"Zhu Haijun , Zhang Ke , Zhang Dawei , Amir Reza Haedi , Elika Poorasadollah , Cheng Cheng","doi":"10.1016/j.prostaglandins.2024.106934","DOIUrl":"10.1016/j.prostaglandins.2024.106934","url":null,"abstract":"<div><div>Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: −2.26; 95 % CI: −2.98, −1.55, p <0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: −2.57; 95 % CI: −3.41, −1.74; p<0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: −0.33; 95 % CI: −0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: −0.16; 95 % CI: −0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106934"},"PeriodicalIF":2.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age "维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响"。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-11-08 DOI: 10.1016/j.prostaglandins.2024.106920

Juanjuan Zhu , Bingbing Wang , Sanaz Asemani , Shiwei Bao , Niannian Tian

{"title":"The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age","authors":"Juanjuan Zhu , Bingbing Wang , Sanaz Asemani , Shiwei Bao , Niannian Tian","doi":"10.1016/j.prostaglandins.2024.106920","DOIUrl":"10.1016/j.prostaglandins.2024.106920","url":null,"abstract":"<div><h3>Objective</h3><div>The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children’s serum calcium, alkaline Phosphatase, and bone Age.</div></div><div><h3>Methods</h3><div>The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.</div></div><div><h3>Results</h3><div>Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P<0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.</div></div><div><h3>Conclusion</h3><div>The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106920"},"PeriodicalIF":2.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials 补充蜂胶对炎症生物标志物的影响：随机对照临床试验的荟萃分析和系统回顾

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-28 DOI: 10.1016/j.prostaglandins.2024.106915

LUO Zhong-yong , Deng ZHi-qing , Xia Li-qiong , Elika Poorasadollah , Shabnam Shirvani

{"title":"The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials","authors":"LUO Zhong-yong , Deng ZHi-qing , Xia Li-qiong , Elika Poorasadollah , Shabnam Shirvani","doi":"10.1016/j.prostaglandins.2024.106915","DOIUrl":"10.1016/j.prostaglandins.2024.106915","url":null,"abstract":"<div><div>Recent interventional investigations suggest the beneficial impact of propolis supplementation on inflammatory biomarkers; however, the results have not been summarized in a comprehensive meta-analysis. We conducted this meta-analysis to summarize all available data and provide clear evidence for whether propolis supplementation affects inflammatory biomarkers. This systematic review with meta-analysis was performed by searching databases (PubMed/Medline, Web of Science, Scopus, and Embase) until February 2024. It included randomized clinical trials (RCTs) assessing the effects of propolis supplementation on inflammatory biomarkers in adults. This review included 20 RCTs with a total of 1139 participants. The propolis supplementation significantly reduced IL-6 (WMD = −2.48; 95 % CI: −4.62, −0.34; P = 0.023) and TNF-α (WMD = −0.86; 95 % CI: −1.45, −0.26; P = 0.005) compared with control groups. Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: −0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks. These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology. Due to the limited number of studies, clinical diversity, and other limitations, it is necessary to conduct more high-quality studies to provide more precise and comprehensive recommendations.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106915"},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between dietary inflammatory index with risk rheumatoid arthritis: A case-control study 膳食炎症指数与类风湿性关节炎之间的关系：一项病例对照研究。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106916

Zhejianyi Gao , Farhad Alishahi , Amirabbas Faridpour , Saeed Nezamoleslami , Shokufeh Nezamoleslami , Reza Ghiasvand , Ariyo Movahedi , Nitin Shivappa , James R. Hébert , Mahsa Jalalinejad , Asal Ataie-Jafari

{"title":"The association between dietary inflammatory index with risk rheumatoid arthritis: A case-control study","authors":"Zhejianyi Gao , Farhad Alishahi , Amirabbas Faridpour , Saeed Nezamoleslami , Shokufeh Nezamoleslami , Reza Ghiasvand , Ariyo Movahedi , Nitin Shivappa , James R. Hébert , Mahsa Jalalinejad , Asal Ataie-Jafari","doi":"10.1016/j.prostaglandins.2024.106916","DOIUrl":"10.1016/j.prostaglandins.2024.106916","url":null,"abstract":"<div><div>Diet represents an important set of potential risk factors for rheumatoid arthritis (RA), a known inflammatory condition. This case-control study examined the association between the inflammatory potential of diet, as determined by the dietary inflammatory index (DII®), and RA risk in an Iranian population. The present Case–control study was conducted on 100 RA patients and 200 age- and sex-matched controls in Isfahan, Iran. The presence of RA was determined by expert Rheumatologist assessment based on the American College of Rheumatology definitions. A 168-item food frequency questionnaire was used to collect dietary intake from which DII scores were computed. Odds ratios (OR) and 95 % confidence intervals (CI) for the association between the DII, expressed in tertiles, and RA risk were estimated by two multivariable logistic regression models, one crude model and one in which we controlled for important potential confounders. In the crude model, individuals in the top DII tertile (most pro-inflammatory diet) had more than triple the risk of RA compared to those in the lowest tertile (OR<sub>tertile3vs1</sub>= 3.57; 95 % CI, 1.95–6.53; p<strong><</strong> 0.001<strong>)</strong>. The association was essentially unchanged after controlling for potential confounders (OR <sub>tertile3vs1</sub> = 3.83; 95 % CI, 1.66–8.81; p<strong><</strong>0.001<strong>)</strong>. We found that a pro<strong>-</strong>inflammatory diet is associated with increased risk of RA. Higher volume studies are needed to confirm the results.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106916"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation 选择性 mTORC2 抑制通过 IKKα/IκB-α/NF-κB 激活对 Zymosan 引起的低血压和全身炎症的保护作用。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-24 DOI: 10.1016/j.prostaglandins.2024.106918

Zainab Sabrie , Meryem Temiz-Resitoglu , Taskin Kalkan , Banu Kilic , Bahar Tunctan , Kafait U. Malik , Seyhan Sahan-Firat

{"title":"Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation","authors":"Zainab Sabrie , Meryem Temiz-Resitoglu , Taskin Kalkan , Banu Kilic , Bahar Tunctan , Kafait U. Malik , Seyhan Sahan-Firat","doi":"10.1016/j.prostaglandins.2024.106918","DOIUrl":"10.1016/j.prostaglandins.2024.106918","url":null,"abstract":"<div><div>Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1) signaling pathway exerts potent anti-inflammatory activity, little is known about mTORC2’s contribution to non-septic shock. Thus, our research aims to investigate mTORC2's contribution and associated changes of IκB kinase (IKKα)/inhibitor κB (IκB-α)/nuclear factor-ĸB (NF-κB) pathway on Zymosan (ZYM)-induced non-septic rat model using the novel mTORC2 selective inhibitor JR-AB2–011. Rats were given saline (4 ml/kg), dimethylsulfoxide (DMSO) (4 ml/kg), ZYM (500 mg/kg), and (or) JR-AB2–011 (1 mg/kg). Mean arterial pressure (MAP) and heart rate (HR) of rats were recorded. JR-AB2–011 reversed both ZYM-induced reduction in MAP and increase in HR. Protein expression and/or phosphorylation of rictor, protein kinase B (Akt), IκB-α, IKKα, NF-κB p65, inducible nitric oxide synthase (iNOS), nitrotyrosine, cyclooxygenase 2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, besides prostaglandin (PG) E<sub>2</sub> levels were measured. The enhanced expression of the proteins mentioned above has been inhibited by JR-AB2–011. These data suggest mTORC2’s promising role in ZYM-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB pathway.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106918"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials 马齿苋对 2 型糖尿病患者 C 反应蛋白、血脂状况和血糖控制的影响：对随机对照试验进行 GRADE 评估的系统综述和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-23 DOI: 10.1016/j.prostaglandins.2024.106917

Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang

{"title":"The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials","authors":"Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang","doi":"10.1016/j.prostaglandins.2024.106917","DOIUrl":"10.1016/j.prostaglandins.2024.106917","url":null,"abstract":"<div><div>Although numerous trials have demonstrated the benefits of purslane on patients with type 2 diabetes mellitus (T2DM), the results of some studies reject such effect. We elucidated the influence of purslane on c-reactive protein (CRP), lipid profile, and glycemic control in patients with T2DM. We conducted a systematic search on Web of Sciences, Scopus, the Cochrane Library, PubMed, and Embase, to identify studies published from their inception to February 10, 2024. The random effect model was used to calculate the combined effect, the weighted mean differences (WMDs) and its 95 % confidence interval (CI). Purslane supplementation significantly reduced fasting blood glucose (FBG) levels (WMD: −15.01; 95 % CI: −25.31, −4.71, p= 0.004), total cholesterol (TC) (WMD: −17.75; 95 % CI: −26.06, −9.45; p< 0.001), triglyceride (TG) (WMD: −21.30; 95 % CI: −32.59, −10.00; p< 0.001), low-density lipoprotein cholesterol (LDL-C) (WMD: −6.10; 95 % CI: −9.52, −2.68; p< 0.001), and CRP levels (WMD: −1.44; 95 % CI: −2.25, −0.63; p< 0.001), and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 6.17; 95 % CI: 2.53, 9.80; p< 0.001). Also, purslane did not significant effect on serum levels of insulin, hemoglobin A1C (HbA1c), and homeostatic model Assessment for insulin resistance (HOMA-IR). The results of our study showed that purslane supplementation improved FBG, and lipid profile levels, but did not affect HOMA-IR, insulin, and HbA1c levels. However, high-quality trials are needed to approve our results.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106917"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials 陈年大蒜提取物对高血压患者血压的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-20 DOI: 10.1016/j.prostaglandins.2024.106914

Mohamed J. Saadh , Muthena Kariem , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Shirin Hasaanzadeh

{"title":"Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Mohamed J. Saadh , Muthena Kariem , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Shirin Hasaanzadeh","doi":"10.1016/j.prostaglandins.2024.106914","DOIUrl":"10.1016/j.prostaglandins.2024.106914","url":null,"abstract":"<div><h3>Background</h3><div>There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients.</div></div><div><h3>Methods</h3><div>We searched English web databases including, PubMed, Scopus, Embase, Web of Science until August 2024. Random-effects meta-analysis was used to pool weighted mean differences (WMD) and 95 % CI for the outcomes.</div></div><div><h3>Results</h3><div>Overall, nine RCTs with584 participants met inclusion criteria. AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: −4.03; %95CI: −6.87, −1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: −1.44; 95 % CI= −2.87, −0.02; P = 0.052; I<sup>2</sup>: 36.8 %; P: 0.105). Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.</div></div><div><h3>Conclusion</h3><div>The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day. To confirm these results, well-designed future trials will be needed.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106914"},"PeriodicalIF":2.5,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis 维生素 D 补充剂对多囊卵巢综合征患者血脂和荷尔蒙功能的影响：总括性系统综述和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-10-09 DOI: 10.1016/j.prostaglandins.2024.106913

Tong Yin , Weixiong Lin , Kangwen Ming , Hnag Lv , Yinxin Wang , LI Yuanchao , Hao Zhen , Junyun Yuan , Hassan Asadi

{"title":"Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis","authors":"Tong Yin , Weixiong Lin , Kangwen Ming , Hnag Lv , Yinxin Wang , LI Yuanchao , Hao Zhen , Junyun Yuan , Hassan Asadi","doi":"10.1016/j.prostaglandins.2024.106913","DOIUrl":"10.1016/j.prostaglandins.2024.106913","url":null,"abstract":"<div><div>Vitamin D has the potential to therapeutically affect the lipid profile and endocrine parameters of polycystic ovary syndrome (PCOS) patients. However, results from prior studies have been inconsistent. Therefore, we conducted an umbrella meta-analysis of randomized controlled trials (RCTs) to better understand the effectiveness of vitamin D in treating PCOS. We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and Scopus, from their inception to January 2, 2024. Random-effects models were used to perform the umbrella meta-analysis. The analysis included 15 meta-analyses of RCTs. Vitamin D demonstrated a significant reduction in TG levels (SMD = -0.23; 95 % CI: −0.42, −0.04, p = 0.02, and WMD = −8.76, 95 % CI: −11.81, −5.72; p <0.001), TC (SMD = −0.47, 95 % CI: −0.80, −0.13; p = 0.007, and WMD = −8.89, 95 % CI: −13.18, −4.59; p < 0.001), LDL-c (SMD = −0.24, 95 % CI: −0.38, −0.10; p = 0.001, and WMD = −3.83, 95 % CI: −6.49, −1.16; p = 0.005), TT (SMD = −0.15, 95 % CI: −0.29 to −0.01; p = 0.02), and DHEA (WMD: −28.03; 95 % CI: −56.9 to −0.36; p = 0.04). However, no significant effect on HDL-c, insulin, and BMI. The present meta-analysis revealed that vitamin D supplementation might significantly affect TG, TC, LDL-c, DHEA, and TT while it is not effective in improving BMI, HDL-c, and insulin. Vitamin D showed noteworthy effects in preventing lipid profile and enhancing hormonal function in patients with PCOS.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"175 ","pages":"Article 106913"},"PeriodicalIF":2.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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