Prostaglandins & other lipid mediators最新文献

{"title":"Protective effect of misoprostol against paclitaxel-induced cardiac damage in rats","authors":"İbrahim Aktaş ,&nbsp;Fatih Mehmet Gur ,&nbsp;Sedat BİLGİÇ","doi":"10.1016/j.prostaglandins.2024.106813","DOIUrl":"10.1016/j.prostaglandins.2024.106813","url":null,"abstract":"<div><h3>Objective</h3><p>One of the most critical reasons for limiting cancer treatment is the toxic effects of anti-cancer drugs on healthy tissues and organs. This study aims to investigate the possible protective effects of misoprostol (MS) against the damage that arises from paclitaxel (PT), an anti-cancer pharmacological agent, in the rat heart using histopathological and biochemical analyses.</p></div><div><h3>Methods</h3><p>In this study, four groups, each containing seven animals, were formed by random selection from 28 Sprague Dawley female rats. Control group rats were administered 1 ml of normal saline orally and intraperitoneally (i.p.) for six days. While the PT group rats were administered PT at a dose of 2 mg/kg intraperitoneally (i.p.) on days 0, 2, 4, and 6, the MS group was administered MS at a dose of 0.2 mg/kg in 1 ml normal saline by oral gavage for six days. PT and MS were administered to the PT + MS group rats in the same dose and route as the previous groups.</p></div><div><h3>Results</h3><p><span><span><span>Administration of PT increased serum lactate dehydrogenase (LDH), cardiac </span>troponin I<span><span> (cTn-I), creatine kinase<span> isoenzyme MB (CK-MB), and </span></span>brain natriuretic peptide<span> (BNP) levels. PT administration also decreased the levels of glutathione (GSH), superoxide dismutase (SOD) and </span></span></span>catalase (CAT) in the heart tissue while increasing the level of malondialdehyde (MDA) (</span><em>p</em> &lt; 0.05). In histopathological examinations, pathological changes, such as edema, congestion, hemorrhage, apoptosis, and degeneration, occurred in the heart tissue of PT-treated rats. The negative changes in histopathological and biochemical parameters that occurred in the PT group were almost not observed in the PT + MS group (<em>p</em> &lt; 0.005).</p></div><div><h3>Conclusion</h3><p>When the findings were evaluated, it was concluded that MS protects the heart tissue from the harmful effects of PT, probably due to its antioxidant, anti-apoptotic and TNF-alpha suppressive effects.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"171 ","pages":"Article 106813"},"PeriodicalIF":2.9,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted and temporal analysis of retinal lipidome in bacterial endophthalmitis","authors":"Zeeshan Ahmad ,&nbsp;Sukhvinder Singh ,&nbsp;Tae Jin Lee ,&nbsp;Ashok Sharma ,&nbsp;Todd A. Lydic ,&nbsp;Shailendra Giri ,&nbsp;Ashok Kumar","doi":"10.1016/j.prostaglandins.2023.106806","DOIUrl":"10.1016/j.prostaglandins.2023.106806","url":null,"abstract":"<div><p>Bacterial endophthalmitis is a blinding infectious disease typically acquired during ocular surgery. We previously reported significant alterations in retinal metabolism during <em>Staphylococcus (S) aureus</em><span> endophthalmitis. However, the changes in retinal lipid composition during endophthalmitis are unknown. Here, using a mouse model of </span><em>S. aureus</em><span><span> endophthalmitis and an untargeted lipidomic<span> approach, we comprehensively analyzed temporal alterations in total lipids<span><span> and oxylipin in retina. Our data showed a time-dependent increase in the levels of lipid classes, </span>sphingolipids, glycerolipids, sterols, and non-esterified fatty acids, whereas levels of </span></span></span>phospholipids<span><span> decreased. Among lipid subclasses, phosphatidylcholine decreased over time. The oxylipin analysis revealed increased prostaglandin-E2, hydroxyeicosatetraenoic acids, </span>docosahexaenoic acid<span><span>, eicosapentaenoic acid, and α-linolenic acid. In-vitro studies using mouse bone marrow-derived macrophages showed increased </span>lipid droplets and lipid-peroxide formation in response to </span></span></span><em>S. aureus</em> infection. Collectively, these findings suggest that <em>S. aureus</em><span>-infection alters the retinal lipid profile, which may contribute to the pathogenesis of bacterial endophthalmitis.</span></p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"171 ","pages":"Article 106806"},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139104351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29","authors":"Mohamed Moustafa ,&nbsp;Abraham Khalil ,&nbsp;Noureldien H.E. Darwish ,&nbsp;Dao-Qi Zhang ,&nbsp;Amany Tawfik ,&nbsp;Mohamed Al-Shabrawey","doi":"10.1016/j.prostaglandins.2023.106805","DOIUrl":"10.1016/j.prostaglandins.2023.106805","url":null,"abstract":"<div><p><span>Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate network of cellular and molecular mechanisms. This study sought to explore the mechanisms by investigating the role of 12-hydroxyeicosatetraenoic acid (12-HETE), its receptor GPR31<span>, and microRNA (miR-29) in the context of DR, specifically focusing on their impact on Müller </span></span>glial cells<span>. We found that 12-HETE activates Müller cells (MCs), elevates glutamate production, and induces inflammatory and oxidative responses, all of which are instrumental in DR progression. The expression of GPR31, the receptor for 12-HETE, was prominently found in the retina, especially in MCs and retinal ganglion cells, and was upregulated in diabetes. Interestingly, miR29 showed potential as a protective agent, mitigating the harmful effects of 12-HETE by attenuating inflammation and oxidative stress, and restoring the expression of pigment epithelium-derived factor (PEDF). Our results underline the central role of 12-HETE in DR progression through activation of a neurovascular toxic pathway in MCs and illuminate the protective capabilities of miR-29, highlighting both as promising therapeutic targets for the management of DR.</span></p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"171 ","pages":"Article 106805"},"PeriodicalIF":2.9,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pomegranate seed oil mitigates liver and kidney damage in an experimental colitis model: Modulation of NF-κB activation and apoptosis","authors":"Açelya Gül Koyuncu ,&nbsp;Alev Cumbul ,&nbsp;Elvan Yilmaz Akyüz ,&nbsp;Müge Kopuz Alvarez Noval","doi":"10.1016/j.prostaglandins.2023.106804","DOIUrl":"10.1016/j.prostaglandins.2023.106804","url":null,"abstract":"<div><p>Pomegranate seed oil, extracted from pomegranate seeds, is a slightly fragrant yellow oil with a mild odor. Pomegranate seed oil is the main source of punicic acid (conjugated linolenic acid). Punicic acid is a long-chain omega-5 polyunsaturated fatty acid and a conjugated α-linolenic acid molecule. This acid is thought to provide many health benefits. This study evaluated the potential of pomegranate seed oil to attenuate damage to liver and kidney tissues in an acetic acid-induced colitis model. 32 male Sprague-Dawley rats were divided into 4 groups: control, colitis, 0.4 ml/kg, and 0.8 ml/kg pomegranate seed oil treatment after colitis. At the end of the experiment, histopathological and immunohistochemistry analyses of liver and kidney tissues were performed. Pomegranate seed oil treatment reduced damage in liver and kidney tissues, suppressed NF-κB activation, and regulated apoptosis. These findings support the potential effects of pomegranate seed oil against extraintestinal symptoms of colitis through its anti-inflammatory, and anti-apoptotic properties.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"171 ","pages":"Article 106804"},"PeriodicalIF":2.9,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138556116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolvin and lipoxin metabolism network regulated by Hyssopus Cuspidatus Boriss extract in asthmatic mice","authors":"Ping He ,&nbsp;Juan Hao ,&nbsp;Ling-Fei Kong ,&nbsp;Ayidana Wotan ,&nbsp;Pan Yan ,&nbsp;Yi-Cong Geng ,&nbsp;Yi Wang ,&nbsp;Zheng-Ying Li ,&nbsp;Shi-Xian Hu ,&nbsp;Bin Ren ,&nbsp;Xiao-Juan Rong ,&nbsp;Cai Tie","doi":"10.1016/j.prostaglandins.2023.106803","DOIUrl":"10.1016/j.prostaglandins.2023.106803","url":null,"abstract":"<div><p><span>Resolvin (Rv) and lipoxin<span> (Lx) play important regulative roles in the development of several inflammation-related diseases. The dysregulation of their metabolic network is believed to be closely related to the occurrence and development of asthma. The </span></span><em>Hyssopus Cuspidatus</em><span><span> Boriss extract (SXCF) has long been used as a treatment for asthma, while the mechanism of anti-inflammatory and anti-asthma action targeting Rv and Lx has not been thoroughly investigated. In this study, we aimed to investigate the effects of SXCF on Rv, Lx in ovalbumin (OVA)-sensitized asthmatic mice. The changes of Rv, Lx before and after drug administration were analyzed based on high sensitivity chromatography-multiple response monitoring (UHPLC-MRM) analysis and multivariate statistics. The pathology exploration included behavioral changes of mice, IgE in serum, cytokines in BALF, and lung tissue sections stained with H&amp;E. It was found that SXCF significantly modulated the metabolic disturbance of Rv, Lx due to asthma. Its modulation effect was significantly better than that of </span>dexamethasone and rosmarinic acid which is the first-line clinical medicine and the main component of </span><em>Hyssopus Cuspidatus</em> Boriss, respectively. SXCF is demonstrated to be a potential anti-asthmatic drug with significant disease-modifying effects on OVA-induced asthma. The modulation of Rv and Lx is a possible underlying mechanism of the SXCF effects.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106803"},"PeriodicalIF":2.9,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new R,R-RvD6 isomer with protective actions following corneal nerve injury","authors":"Haydee E.P. Bazan,&nbsp;Thang L. Pham","doi":"10.1016/j.prostaglandins.2023.106802","DOIUrl":"10.1016/j.prostaglandins.2023.106802","url":null,"abstract":"<div><p><span><span>The transparent cornea is the most densely innervated tissue in the body, primarily by sensory nerves originating from the trigeminal ganglia (TG). Damage to corneal nerves reduces sensitivity and tear secretion and results in dry eye. Consequently, ocular pain, for which no satisfactory therapies exist, arises in many cases. Treatment of injured corneas with pigment epithelium-derived factor (PEDF) combined with </span>docosahexaenoic acid (DHA) stimulates </span>nerve regeneration<span> in models of refractive surgery, which damages nerves. The mechanism involves the synthesis of a stereoisomer<span><span><span> of resolvin D6 (R,R-RvD6) formed after incorporating DHA into membrane lipids. Activation of a PEDF receptor (PEDF-R) with </span>phospholipase activity releases DHA to synthesize the new resolvin isomer, which is secreted via tears. Topical treatment of mice corneas with R,R-RvD6 shows higher bioactivity in regenerating nerves and increasing sensitivity compared to PEDF+DHA. It also stimulates a </span>transcriptome in the TG that modulates genes involved in ocular pain. Our studies suggest an important therapeutic role for R,R-RvD6 in regenerating corneal nerves and decreasing pain resulting from dry eye.</span></span></p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106802"},"PeriodicalIF":2.9,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oleifera leaves extract loaded gold nanoparticles offers a promising approach in protecting against experimental nephrotoxicity","authors":"Jihan Hussein ,&nbsp;Mona El-Bana ,&nbsp;Yasmin Abdel-Latif ,&nbsp;Samah El-Sayed ,&nbsp;Sahar Shaarawy ,&nbsp;Dalia Medhat","doi":"10.1016/j.prostaglandins.2023.106800","DOIUrl":"10.1016/j.prostaglandins.2023.106800","url":null,"abstract":"<div><p>Cisplatin is one of the most important antitumor drugs, however; it has numerous adverse effects like nephrotoxicity which is considered one of cisplatin uses .</p><p>The study was planned to evaluate the nephroprotective effect of <em>M. oleifera</em> leaves extract loaded gold nanoparticles (Au-NPs) against cisplatin-induced nephrotoxicity in rats.</p><p><span>Initially, total phenolic contents (TPC) and the antioxidant activity of the </span><em>M. oleifera</em> leaves extract were evaluated and recorded 8.50 mg/g and 39.89 % respectively. After that, the dry leaves of <em>M. oleifera</em> were grinded into fine powder and extracted using water extraction system. Then, different volumes (0.5, 1 and 2 mL) of <em>M. Oleifera</em> were blended with constant volume of Au-NPs (1 mL). Both Au-NPs and <em>M. oleifera</em><span> extract loaded Au-NPs were investigated using transmission electron microscope (TEM) that illustrated the deposition of </span><em>M. Oleifera</em> onto Au-NPs.</p><p><span>The experimental study was performed on seventy male albino rats alienated into seven groups. Group I healthy rats, group II injected with one dose of cisplatin (CisPt), groups from III to VII treated groups received CisPt then received </span><em>M. Oleifera</em> leaves extract alone and /or Au-NPs with different ratios and concentrations.</p><p><span>After the experiment’ time, serum urea and creatinine, kidney injury molecule-1 (KIM-1), advanced </span>oxidation<span> protein products (AOPP), monocyte<span> chemoattractant protein-1 (MCP-1), tumor necrotic factor-α (TNF-α), and interleukin-6 (IL-6) were evaluated as markers of renal nephrotoxicity. The kidneys of rats were excised for malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) assessments.</span></span></p><p>Induction of CisPt showed a highly significant disturbance in oxidant/anti-oxidant balance and inducing inflammatory cascades supporting nephrotoxicity, while treatment with <em>M. Oleifera</em><span> leaves extract, Au-NPs, and the different concentrations of the extract loaded on Au-NPs had a crucial role in attenuating oxidative stress, enhancing antioxidant systems, and reducing inflammatory biomarkers, although the most significant results showed a powerful scavenging activity against nephrotoxicity induced by CisPt was obtained with </span><em>M. Oleifera</em> leaves extract loaded on Au-NPs with a concentration of 2:1 respectively.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106800"},"PeriodicalIF":2.9,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the therapeutic effect of Cangfu Daotan Decoction combined with drospirenone and ethinylestradiol tablets (II) on patients with polycystic ovary syndrome","authors":"Yanhong Fu ,&nbsp;Pengpeng Xie ,&nbsp;Qingping Yang ,&nbsp;Peng Chen ,&nbsp;Jingwei Yu","doi":"10.1016/j.prostaglandins.2023.106801","DOIUrl":"10.1016/j.prostaglandins.2023.106801","url":null,"abstract":"<div><h3>Objective</h3><p>This study was designed to investigate the therapeutic effect of Cangfu Daotan Decoction (CDD) combined with drospirenone and ethinylestradiol tablets (II) on patients with polycystic ovary syndrome (PCOS).</p></div><div><h3>Methods</h3><p>Patients with PCOS were gathered from September 2020 to September 2022 and divided into the experimental group (n = 36), treated with CDD combined with drospirenone and ethinylestradiol tablets (II), and the control group (n = 41), received only drospirenone and ethinylestradiol tablets (II). Levels of sex hormone, obesity, blood glucose, blood lipid were detected and compared between the two groups pre- and post-treatment. The treatment efficacy, Traditional Chinese Medicine (TCM) syndrome score, adverse drug reactions, and pregnancy rate were compared as well.</p></div><div><h3>Results</h3><p>After treatment, the experimental group had a higher treatment efficacy (94.44% vs 73.17%, <em>P</em> &lt; 0.05) and a higher pregnancy rate (44.44% vs 21.95%, <em>P</em> &lt; 0.05) than the control group, but the difference in the incidence of adverse drug reactions was not statistically significant (<em>P</em><span> &gt; 0.05). Compared with control group, TCM syndrome score and levels of fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and waist circumference of the experimental group after treatment displayed remarkable reduction (</span><em>P</em> &lt; 0.05), while the levels of estradiol (E2) and high-density lipoprotein cholesterol (HDL-C) showed a remarkable increase (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>CDD in combination with drospirenone and ethinylestradiol tablets (II) may be effective in treating PCOS by improving obesity, glucose metabolism and lipid metabolism with no serious adverse events, making it a feasible clinical practice option.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106801"},"PeriodicalIF":2.9,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of specialized pro-resolving mediators (SPMs) in inflammatory arthritis: A therapeutic strategy","authors":"Mohammad Natami ,&nbsp;Seyed Mehdi Hosseini ,&nbsp;Raghad Abdulsalam Khaleel ,&nbsp;Tamara Shamil Addulrahman ,&nbsp;Mehdi Zarei ,&nbsp;Sahar Asadi ,&nbsp;Sepideh Gholami ,&nbsp;Amir Mehrvar","doi":"10.1016/j.prostaglandins.2023.106798","DOIUrl":"10.1016/j.prostaglandins.2023.106798","url":null,"abstract":"<div><p><span><span>Rheumatoid arthritis (RA) is classified as a persistent inflammatory autoimmune disorder leading to the subsequent erosion of articular cartilage and bone tissue originating from the synovium. The fundamental objective of therapeutic interventions in RA has been the suppression of inflammation. Nevertheless, conventional medicines that lack target specificity may exhibit unpredictable effects on cell metabolism. In recent times, there has been evidence suggesting that specialized pro-resolving mediators (SPMs), which are lipid metabolites, have a role in facilitating the resolution of inflammation and the reestablishment of tissue </span>homeostasis. SPMs are synthesized by </span>immune cells through the enzymatic conversion of omega-3 fatty acids. In the context of RA, there is a possibility of dysregulation in the production of these SPMs. In this review, we delve into the present comprehension of the endogenous functions of SPMs in RA as lipids that exhibit pro-resolutive, protective, and immunoresolvent properties.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106798"},"PeriodicalIF":2.9,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega fatty acid ratios and neurodegeneration in a healthy environment","authors":"H. Dere Yelken ,&nbsp;M.P. Elci ,&nbsp;P.F. Turker ,&nbsp;S. Demirkaya","doi":"10.1016/j.prostaglandins.2023.106799","DOIUrl":"10.1016/j.prostaglandins.2023.106799","url":null,"abstract":"<div><p><span><span><span>Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis pose substantial public health challenges. While genetics play a primary role, recent research emphasizes the impact of environmental factors, particularly diet and lifestyle. This study investigates the initiating effects of Omega (ω)− 3 and Omega (ω)− 6 fatty acids on neuroinflammation, potentially contributing to these diseases. Using BV-2 microglial cells, we explored the influence of different </span>fatty acid compositions and ratios on </span>cell viability<span>, cytokine production, morphological changes, and </span></span>lipid peroxidation<span>. Notably, a 2/1 ω-6:ω-3 ratio led to decreased cell viability. Fatty acid compositions influenced cytokine secretion, with reduced TNF-α suggesting anti-inflammatory effects. IL-17 increased, while IL-4 and IL-10 decreased in the 15/1 ω-6:ω-3 ratio, indicating complex cytokine interactions. This study found that polyunsaturated fatty acids interventions induced microglial activation, altering cell morphology even without immunostimulants. These findings demonstrate the intricate nature of fatty acid interactions with microglial cells and their potential implications for neuroinflammation. Further research is needed to clarify mechanisms and their relevance to neurodegenerative diseases, informing possible therapeutic strategies.</span></p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"170 ","pages":"Article 106799"},"PeriodicalIF":2.9,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}