Prostaglandins & other lipid mediators最新文献_第2页

The effects of ω−3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A systematic review and meta-analysis of controlled trials ω-3脂肪酸对2型糖尿病患者炎症和氧化应激标记物的影响：对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-09-05 DOI: 10.1016/j.prostaglandins.2024.106887

{"title":"The effects of ω−3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A systematic review and meta-analysis of controlled trials","authors":"","doi":"10.1016/j.prostaglandins.2024.106887","DOIUrl":"10.1016/j.prostaglandins.2024.106887","url":null,"abstract":"<div><h3>Background & aims</h3><p>Taking into account the anti-inflammatory and antioxidant properties of omega-3 fatty acids and the evidence indicating the role of chronic inflammation and oxidative stress in the pathophysiology diabetes, this study aimed to determine the effect of ω−3 fatty acids on oxidative stress and inflammatory markers in Type 2 diabetes mellitus (T2DM) patients.</p></div><div><h3>Methods</h3><p>A systematic search up to July 30, 2023 was completed in Scopus, PubMed, Web of Science, and Embase databases, to identify eligible RCTs. Heterogeneity tests of the selected studies were performed using the I<sup>2</sup>. Random effects models were assessed and pooled data were determined as standardized mean differences (SMD) with a 95 % CI.</p></div><div><h3>Results</h3><p>The meta-analysis of 23 trials, involving 1523 patients, demonstrated a significant decrease in TNF-α (SMD: −1.62, 95 % CI: −2.89 to −0.35, P= 0.013) and increase in TAC (SMD: 0.92, 95 % CI: 0.33–1.52, P = 0.002) following ω−3 fatty acids administration. Meanwhile, supplementation did not have beneficial effects on malondialdehyde, C-reactive protein (CRP), superoxide dismutase (SOD), and interlukin-6 levels. The subgroup analysis revealed a significant decrease in CRP levels and an increase in SOD levels in studies with durations of less than 12 weeks.</p></div><div><h3>Conclusions</h3><p>We found that ω−3 fatty acid intake can significantly decrease TNF-α and increase TAC levels, but this effect was not observed on other markers. Nevertheless, future well-designed with large sample size and long duration RCT studies with precise ω−3 fatty acids dose and ingredients are required to understand better the effects of these compounds and their constituents on oxidative stress and inflammatory markers in T2DM patients.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials 黑麦草补充剂对成人血糖状况的影响：随机对照试验的最新系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-22 DOI: 10.1016/j.prostaglandins.2024.106885

{"title":"The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials","authors":"","doi":"10.1016/j.prostaglandins.2024.106885","DOIUrl":"10.1016/j.prostaglandins.2024.106885","url":null,"abstract":"<div><p>This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of <em>Nigella sativa (N. sativa)</em> consumption on glycemic index in adults. A systematic literature search up to December 2023 was completed in PubMed, Scopus, and Web of Science, to identify eligible RCTs. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval. Finally, a total of 30 studies were found to be eligible for this meta-analysis. The pooled results using random effects model indicated that <em>N. sativa</em> supplementation significantly reduced FBS (SMD: −1.71; 95 % CI: −2.11, −1.31, p <0.001; <em>I</em><sup><em>2</em></sup>= 92.7 %, p-heterogeneity <0.001) and HA1c levels (SMD: −2.16; 95 % CI: <em>-</em>3.04, −1.29, p <0.001; <em>I</em><sup><em>2</em></sup>= 95.7 %, p-heterogeneity <0.001) but not effect on insulin (SMD = 0.48; 95 % CI: −0.53, 1.48, P = 0.353; <em>I</em><sup><em>2</em></sup>= 96.1 %, p-heterogeneity <0.001), and HOMA-<em>I</em>R (SMD: −0.56; 95 % CI: −1.47, 0.35, p=0.229; <em>I</em><sup><em>2</em></sup>= 95.0 %, p-heterogeneity <0.001).Overall, the evidence supports the consumption of <em>N. sativa</em> to reduce FBS and HA1c levels. Additional research, featuring extended durations and robust study designs, is necessary to determine the ideal dosage and duration of <em>N. sativa</em> supplementation for achieving a positive impact on glycemic markers.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucosal LTE4, PGD2 and 15(S)-HETE as potential prognostic markers for polyp recurrence in chronic rhinosinusitis 粘膜 LTE4、PGD2 和 15(S)-HETE 作为慢性鼻炎息肉复发的潜在预后标记。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-22 DOI: 10.1016/j.prostaglandins.2024.106886

{"title":"Mucosal LTE4, PGD2 and 15(S)-HETE as potential prognostic markers for polyp recurrence in chronic rhinosinusitis","authors":"","doi":"10.1016/j.prostaglandins.2024.106886","DOIUrl":"10.1016/j.prostaglandins.2024.106886","url":null,"abstract":"<div><h3>Background</h3><p>Altered biosynthesis of eicosanoids is linked to type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), but their role in recalcitrant NPs is unclear.</p></div><div><h3>Objectives</h3><p>We sought to identify endotypes that are linked to recalcitrant CRSwNP, based on eicosanoids, their biosynthetic enzymes, and receptors as well as cytokines and the presence of eosinophils and mast cells in recurrent NPs.</p></div><div><h3>Methods</h3><p>Mucosal tissue collected at the time of sinus surgery from 54 patients with CRSwNP and 12 non-CRS controls were analysed for leukotriene (LT) E4, prostaglandin (PG) D2, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) and 17 cytokines with ELISAs and Bio-Plex immunoassays. Patient subgroups were identified by cluster analysis and the probability of NP recurrence were tested with logistic regression analyses. Gene expressions were analysed with qPCR. Tryptase and eosinophil-derived neurotoxin (EDN) were measured with ELISAs as indications of the presence of mast cells and eosinophils, respectively.</p></div><div><h3>Results</h3><p>Clustering of patients showed that an inflammatory signature characterised by elevated LTE<sub>4</sub>, PGD<sub>2</sub>, 15(S)-HETE and IL-13 was associated with NP recurrence. Previous NP surgery as well as aspirin-exacerbated respiratory disease were significantly more common among these patients. Expression of cyclooxygenase 1 was the only gene associated with NP recurrence. Levels of EDN, but not tryptase, were significantly higher in patients with recurrent NPs.</p></div><div><h3>Conclusion</h3><p>Distinguishing endotypes that include LTE<sub>4</sub>, PGD<sub>2</sub>, 15HETE and conventional biomarkers of type 2 inflammation could help predict recurrent nasal polyposis and thus identify cases of recalcitrant CRSwNP.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1098882324000807/pdfft?md5=6dbc2959ecd21707948c43f42a28e232&pid=1-s2.0-S1098882324000807-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer activity of naringenin on human liposarcoma: An experimental and bioinformatic study 柚皮苷对人类脂肪肉瘤的抗癌活性：一项实验和生物信息学研究

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-21 DOI: 10.1016/j.prostaglandins.2024.106884

引用次数: 0

The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials 维生素 D2 对人体血脂概况、人体测量指数、血压以及炎症和血糖生物标志物的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-21 DOI: 10.1016/j.prostaglandins.2024.106883

{"title":"The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials","authors":"","doi":"10.1016/j.prostaglandins.2024.106883","DOIUrl":"10.1016/j.prostaglandins.2024.106883","url":null,"abstract":"<div><h3>Background and aim</h3><p>Even though the role of D2 (ergocalciferol) on cardiovascular disease risk components has been studied, conflicting results have been reported. Moreover, no single study has studied all these parameters and the role of vitamin D2 individually has not been assessed; hence, this systematic review and meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D2 supplementation on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans.</p></div><div><h3>Methods</h3><p>Web of Science, Scopus, PubMed/Medline, and Embase were searched from database inception to July 2024, and the random effects model, according to the DerSimonian and Laird method, was used to generate combined estimates of the intervention’s effect on the outcomes.</p></div><div><h3>Results</h3><p>After full-text analysis, 11 eligible articles were included in our meta-analyses. No statistically significant association was observed between vitamin D2 administration and BMI, WC<strong>,</strong> TC, HDL-C, LDL-C, TG, DBP or SBP; however, a statistically significant decrease in CRP (WMD: − 1.92 mg/dL, 95 % CI: − 3.30 to − 0.54, P = 0.006) and HbA1c levels (WMD: − 0.37 %, 95 % CI: − 0.66 to − 0.09, P = 0.009), and a non-statistically significant decrease in FBG (WMD: − 4.61 mg/dL, 95 % CI: − 14.71 to 5.47, P = 0.370, I2 = 90 %, P ˂ 0.001) and HOMA-IR (WMD: − 0.10, 95 % CI: − 0.17–0.03, P = 0.002) were detected.</p></div><div><h3>Conclusion</h3><p>In summary, our systematic review and meta-analysis discovered that vitamin D2 administration was associated with a statistically significant decrease in CRP and HbA1c levels, without a significant correlation with other outcomes.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress 网织红蛋白-1能减轻脂多糖诱导的炎症和牙周韧带干细胞的成骨分化，并通过抑制内质网应激减少M1巨噬细胞的极化。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-14 DOI: 10.1016/j.prostaglandins.2024.106882

{"title":"Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress","authors":"","doi":"10.1016/j.prostaglandins.2024.106882","DOIUrl":"10.1016/j.prostaglandins.2024.106882","url":null,"abstract":"<div><p>Periodontitis is featured as the periodontium’s pathologic destruction caused by the host’s overwhelmed inflammation. Omentin-1 has been reported to be aberrantly downregulated in patients with periodontitis, but the specific regulation of Omentin-1 during the pathogenesis of periodontitis remains unclear. In this study, human periodontal ligament stem cells (hPDLSCs) were stimulated by lipopolysaccharide (LPS) from <em>Porphyromonas gingivalis</em> to establish an in vitro inflammatory periodontitis model. hPDLSCs were treated with recombinant human Omentin-1 (250, 500 and 750 ng/mL) for 3 h before LPS stimulation. Results revealed that Omentin-1 significantly inhibited LPS-induced inflammation in hPDLSCs through reducing the production of proinflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6) and downregulating the expression of Cox2 and iNOS. Meanwhile, Omentin-1 significantly enhanced alkaline phosphatase (ALP) activity and Alizarin red-stained area, accompanied by increasing expression osteogenic markers BMP2, OCN and Runx2, confirming that Omentin-1 restores osteogenic differentiation in LPS-induced hPDLSCs. In addition, the conditioned medium (CM) from LPS-induced hPDLSCs was harvested to culture macrophages, which resulted in macrophage polarization towards M1, while CM from Omentin-1-treated hPDLSCs reduced M1 macrophages polarization and elevated M2 polarization. Furthermore, Omentin-1 also inhibited LPS-triggered endoplasmic reticulum (ER) stress in hPDLSCs, and additional treatment of the ER stress activator tunicamycin (TM) partially reversed the functions of Omentin-1 on inflammation, osteogenic differentiation and macrophages polarization. In summary, Omentin-1 exerted a protective role against periodontitis through inhibiting inflammation and enhancing osteogenic differentiation of hPDLSCs, providing a novelty treatment option for periodontitis.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysophospholipase D activity on oral mucosa cells in whole mixed human saliva involves in production of bioactive lysophosphatidic acid from lysophosphatidylcholine 全混合人类唾液中口腔黏膜细胞上的溶血磷脂酶 D 活性涉及从溶血磷脂酰胆碱中生成生物活性溶血磷脂酸。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-10 DOI: 10.1016/j.prostaglandins.2024.106881

引用次数: 0

Effect of PGE2 on TT cells viability and division PGE2 对 TT 细胞活力和分裂的影响。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-08 DOI: 10.1016/j.prostaglandins.2024.106880

{"title":"Effect of PGE2 on TT cells viability and division","authors":"","doi":"10.1016/j.prostaglandins.2024.106880","DOIUrl":"10.1016/j.prostaglandins.2024.106880","url":null,"abstract":"<div><p>Previous studies have shown prostaglandin E2 (PGE2) produced a marked increase in calcitonin secretion in human C-cells derived from medullary thyroid carcinoma. However, it’s unclear whether PGE2 can increase the growth of C cells. In this study, we use TT cells as a C cell model to investigate the effect of PGE2 on the growth of C cells. The results revealed that both PGE2 and arachidonic acid (AA) significantly increased the count of TT cells, whereas indomethacin and Dup697 reduced this count. Notably, an increase in the level of AA was associated with an increase in the number of proliferating TT cells, indicating a dose–response relationship. PGE2 and its receptor agonists (sulprostone and butaprost) enhanced the proliferation of TT cells. By contrast, 17-phenyl-trinor-PGE2 exerted no significant effect on TT cell proliferation, whereas L161982 suppressed it. The positive effect of AA on TT cell proliferation was inhibited by indomethacin, NS398, Dup697 (complete inhibition), and SC560. Both PGE2 and AA increased the level of p-STAT5a. The positive effect of AA on p-STAT5a was completely inhibited by Dup697 but not indomethacin, NS398, or SC560. Treatment with indomethacin or Dup697 alone reduced the level of STAT5a in TT cells. AA increased the level of STAT5a, but this effect was inhibited by indomethacin, NS398, and Dup697. Overall, this study confirms the effect of PGE2 on the proliferation of TT cells. This effect is likely mediated through EP2, EP3, and EP4 receptors and associated with an increase in p-STAT5a level within TT cells.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of sumac on cardiovascular risk factors in adults: A systematic review and meta-analysis of randomized controlled trials 苏木对成人心血管风险因素的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-08-07 DOI: 10.1016/j.prostaglandins.2024.106879

{"title":"The effect of sumac on cardiovascular risk factors in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"","doi":"10.1016/j.prostaglandins.2024.106879","DOIUrl":"10.1016/j.prostaglandins.2024.106879","url":null,"abstract":"<div><p>Clinical evidence suggests the beneficial effects of sumac on cardiovascular risk factors. However, these results are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to determine the effect of sumac supplementation on cardiovascular risk factors in adults<strong>.</strong> The PubMed, Embase, Web of Science, and Cochrane databases were searched from inception to 30 December 2023 to identify RCTs that were published in English. Data were presented as weighted mean difference (WMD) and associated 95 % confidence interval (CI). The quality of the included trials was measured using the Cochrane Collaboration's modified risk of bias tool. A pooled analysis of 16 trials showed that sumac consumption led to a significant reduction in fasting blood glucose (WMD: −6.03 mg/dl; 95 % CI: −9.67 to −2.39), hemoglobin A1c (WMD: −0.45 %; 95 % CI: −0.59 to −0.31), triglycerides (WMD: −9.07 mg/dL; 95 % CI: −16.19 to −1.94), low-density lipoprotein cholesterol (WMD: −5.58 mg/dL; 95 % CI: −11.27 to −0.12), BMI (WMD: −0.22 kg/m<sup>2</sup>; 95 % CI: −0.38 to −0.05), weight (WMD: −0.85 kg; 95 % CI: −1.44 to −0.27), waist circumference (WMD: −0.54 cm; 95 % CI: −0.92 to −0.15), and diastolic blood pressure (WMD: −2.72 mmHg; 95 % CI: −4.16 to −1.29). High-density lipoprotein-cholesterol level also increased significantly (WMD: 3.69 mg/dL; 95 % CI: 1.81–5.57). The overall results support possible protective and therapeutic effects of sumac on cardiovascular risk factors in adults. Additional prospective studies are suggested using longer intervention periods and higher supplementation doses to confirm these results.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetylsalicylic acid inhibition of the lipoxygenase pathway: Implications for HIV prevention 乙酰水杨酸抑制脂氧合酶途径：对预防艾滋病的影响。

IF 2.5 3区生物学

Prostaglandins & other lipid mediators Pub Date : 2024-07-29 DOI: 10.1016/j.prostaglandins.2024.106878

{"title":"Acetylsalicylic acid inhibition of the lipoxygenase pathway: Implications for HIV prevention","authors":"","doi":"10.1016/j.prostaglandins.2024.106878","DOIUrl":"10.1016/j.prostaglandins.2024.106878","url":null,"abstract":"<div><h3>Background</h3><p>1.5 million new HIV infections occurred in 2021, suggesting new prevention methods are needed. Inflammation increases the risk for HIV acquisition by attracting HIV target cells to the female genital tract (FGT). In a pilot study, acetylsalicylic acid (ASA/Aspirin) decreased the proportion of FGT HIV target cells by 35 %. However, the mechanism remains unknown.</p></div><div><h3>Methods</h3><p>Women from Nairobi, Kenya took low-dose ASA (81 mg) daily for 6-weeks. Free oxylipins in the plasma were quantified by high-performance liquid chromatography-tandem mass spectroscopy.</p></div><div><h3>Results</h3><p>Oxylipins from 9 fatty acid substrates were detected, with more than one analyte from 4 substrates reduced post-ASA. Summary analysis found ASA downregulated cyclooxygenase and lipoxygenase but not cytochrome P450 activity with a lower n-6/n-3 oxylipin profile, reflecting reduced inflammation post-ASA.</p></div><div><h3>Conclusions</h3><p>Inflammation is associated with increased lipoxygenase activity and HIV risk. Our data suggests ASA reduces inflammation through downregulation of oxylipins. Understanding how ASA reduces inflammation may lead to novel HIV prevention approaches.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0