Prostaglandins & other lipid mediators最新文献

{"title":"TFAP2A activates CTHRC1 to influence the migration of lung adenocarcinoma cells by modulating fatty acid metabolism","authors":"Xiaodong Zheng ,&nbsp;Junzheng Zhou ,&nbsp;Shiwei Nie ,&nbsp;Yuan Chen ,&nbsp;Xudong Wei ,&nbsp;Jinrui Zhang ,&nbsp;Xiaojuan Shen ,&nbsp;Weimin Zhang","doi":"10.1016/j.prostaglandins.2024.106941","DOIUrl":"10.1016/j.prostaglandins.2024.106941","url":null,"abstract":"<div><h3>Background</h3><div>Tumor metastasis is the main cause of death in lung adenocarcinoma (LAC) patients. It is known that the collagen triple helix repeats containing 1 (CTHRC1) protein is implicated in tissue remodeling and is tightly linked to the carcinogenesis and metastasis of solid tumors. However, the functional role of CTHRC1 and its potential mechanisms in LAC cell metastasis have not been fully explored.</div></div><div><h3>Methods</h3><div>The expression level of CTHRC1 in LAC was measured by using bioinformatics analysis combined with quantitative real-time polymerase chain reaction (qRT-PCR) and western blot (WB). Small interfering RNA and overexpression methods were employed to investigate the function and molecular mechanisms of CTHRC1 in LAC cells. Through bioinformatics analysis, qRT-PCR, WB, scratch healing assay, Transwell, assay kits, and flow cytometry, the downstream pathways and upstream regulatory genes of CTHRC1 in LAC cells were investigated. The binding sites were verified by using chromatin immunoprecipitation (ChIP) and dual luciferase reporter gene experiments.</div></div><div><h3>Results</h3><div>In this project, CTHRC1 was found to be abnormally upregulated in LAC tissues and cells. CTHRC1 promoted the migration and invasion of LAC cells. The promoting effect of CTHRC1 overexpression on LAC cell migration was weakened after the addition of orlistat (a fatty acid synthase inhibitor). Mechanistically, TF AP-2α (TFAP2A) was directly bound to the upstream sequence of the CTHRC1 promoter and promoted CTHRC1 expression. The TFAP2A-CTHRC1 axis induced the migration of LAC cells by activating fatty acid metabolism.</div></div><div><h3>Conclusion</h3><div>Our results indicated that TFAP2A activates fatty acid metabolism by positively modulating the expression of CTHRC1, thereby facilitating tumor cells’ migration and invasion. These findings provided novel insights into LAC treatment and future research.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106941"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory protein levels in asthmatic bronchitis: A study in the Duhok population, Iraq","authors":"Omar A.M. Al-Habib ,&nbsp;Hamdia Yousif Issa ,&nbsp;Taner Dastan ,&nbsp;Sevgi Durna Dastan ,&nbsp;Ali A. Ramadhan ,&nbsp;Zeliha Selamoglu","doi":"10.1016/j.prostaglandins.2024.106942","DOIUrl":"10.1016/j.prostaglandins.2024.106942","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to determine the levels of TNF-α, IGF-1, IL-6, and IL-10 protein in blood samples and their potential link to bronchitis-asthma diseases in the Iraq Duhok population, highlighting the prevalence of these long-term inflammatory diseases.</div></div><div><h3>Methods</h3><div>Sixty blood samples were used and separated into patients (n = 43) and control (n = 17) groups. Serum samples were separated for each individual. Elisa method was used in terms of 4 different proteins investigated in blood samples with the manufacturer’s instruction brand kits.</div></div><div><h3>Results</h3><div>This study evaluated TNF-α, IGF-1, IL-6, and IL-10 protein levels in blood samples from asthmatic bronchitis patients in Duhok. Although these levels were elevated compared to controls, the differences were not statistically significant.</div></div><div><h3>Conclusion</h3><div>The differences thought to be related to the bronchitis-asthma diseases could not be demonstrated between the patient and control groups in Iraq Duhok population. Future research should explore larger sample sizes and stratified patient groups to identify potential biomarkers.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106942"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches to eczema treatment: A review of Fevipiprant and its potential as a new therapeutic agent","authors":"Rahul Jaiswal ,&nbsp;Sageer Ahmad ,&nbsp;Supriya Pandey ,&nbsp;Asad Ali ,&nbsp;Rupali Jaiswal ,&nbsp;Reetu Yadav ,&nbsp;Reema Yadav ,&nbsp;Rabiya Ahsan ,&nbsp;Tapasya Dwivedi","doi":"10.1016/j.prostaglandins.2024.106946","DOIUrl":"10.1016/j.prostaglandins.2024.106946","url":null,"abstract":"<div><div>Eczema is also known as atopic dermatitis, which goes on to affect the skin as a chronic inflammatory disease. It is associated with a constant feeling of scratchiness, erthyma and disruption of the natural skin barrier. Treatment provided at present may improve some of the symptoms, for instance use of corticosteroids or immunosuppressive agents, however, there is an overwhelming need for better focused and effective methods of treatment with minimal adverse effects. Fevipiprant, a DP2 receptor antagonist, has emerged as a promising agent targeting prostaglandin D2 (PGD2) pathways, which play a crucial role in eczema pathophysiology.</div><div>This review examines the mechanism of action, pharmacological profile of Fevipiprant and present studies on preclinical and clinical development of Fevipiprant for treatment of eczema. Additionally, we provide a comparison of Fevipiprant with existing treatment options and evaluate its safety and tolerability. The evaluation gives a reason that targeting in the treatment of eczema by the use of Fevipiprant is able to effectively target the DP2 pathway which is associated with a good safetyl however presenting itself as a new treatment option in the management of eczema. Finally, long-term studies are essential to validate the feasibility, safety, and effectiveness of Fevipiprant compared to existing therapies for eczema. Novartis has taken advantage of this stat for comp… given the scarcity of effective therapies for paediatric atopic dermatitis in Japan. Exploring Fevipiprant from the Efficacy Perspective is also required because it will impact how it will enter clinical practice in therapy of eczema in the future.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106946"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials","authors":"Qiujin Cheng ,&nbsp;Xiao Yan ,&nbsp;Kousalya Prabahar ,&nbsp;Zhu Ye","doi":"10.1016/j.prostaglandins.2024.106919","DOIUrl":"10.1016/j.prostaglandins.2024.106919","url":null,"abstract":"<div><h3>Background and aim</h3><div>In view of the favorable effect of hormone replacement therapy (HRT) on the lipid profile in postmenopausal women, and the discrepancies that exist on the effect of medroxyprogesterone acetate (MPA) on lipoprotein concentrations and cardiovascular disease (CVD) risk, we conducted this meta-analysis of randomized controlled trials (RCT) to assess the efficacy of MPA on apolipoprotein and lipoprotein(a) concentrations in healthy postmenopausal women.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across multiple databases, including for English-language papers published up to September 2023 comparing the effect of MPA on ApoA-I, Apo-AII, and Lp(a) levels with those of a control group. A meta-analysis was conducted using a random-effects model, reporting the results as the weighted mean difference (WMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>The current meta-analysis included 11 publications. the comprehensive findings indicated a noteworthy reduction in ApoA-I (WMD:-8.70 mg/dL,95 %CI: −12.80, −4.59,P&lt;0.001), a significant increase in Lp(a) concentrations (WMD: 1.36 mg/dL, 95 % CI: 0.10, 2.63, P=0.033), and a non-significant increase in ApoB concentrations (WMD: 0.57 mg/dL, 95 %CI: −1.25, 2.40, P=0.539) after the administration of MPA in postmenopausal women. In addition, a significant reduction in ApoB levels was identified in studies with a mean participant BMI ≥25 kg/m2 (WMD: −4.94 mg/dL, 95 %CI: −5.71 to −4.18,P&lt; 0.001) and a greater impact on ApoA-1 and Lp(a) levels was observed in trials with doses of 5 mg/day compared with 2.5 mg/day.</div></div><div><h3>Conclusion</h3><div>MPA administration resulted in a significant increase in Lp(a) and decrease in ApoA-I levels and a non-significant increase in ApoB levels in healthy postmenopausal women.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106919"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high seizure burden increases brain concentrations of specialized pro-resolving mediators in the Scn1a+/- mouse model of Dravet syndrome","authors":"Ka Lai Yip ,&nbsp;Cilla Zhou ,&nbsp;Lyndsey L. Anderson ,&nbsp;Nicole A. Hawkins ,&nbsp;Jennifer A. Kearney ,&nbsp;Jonathon C. Arnold","doi":"10.1016/j.prostaglandins.2024.106943","DOIUrl":"10.1016/j.prostaglandins.2024.106943","url":null,"abstract":"<div><h3>Objective</h3><div>Dravet syndrome is a severe, intractable epilepsy in which 80 % of patients have a <em>de novo</em> mutation in the gene <em>SCN1A</em>. We recently reported that a high seizure burden increased hippocampal concentrations of an array of pro-inflammatory prostaglandins in the <em>Scn1a</em>^<em>+/-</em> mouse model of Dravet syndrome. This raised the possibility that a high seizure burden might also trigger the accumulation of specialized pro-resolving mediators that facilitate the resolution of neuroinflammation and brain repair. The present study therefore aimed to examine whether a high seizure burden increased hippocampal concentrations of various specialized pro-resolving mediators in the <em>Scn1a</em>^<em>+/-</em> mouse model of Dravet syndrome.</div></div><div><h3>Methods</h3><div><em>Scn1a</em>^<em>+/-</em> mice at postnatal day 21 (P21) were primed with a single hyperthermia-induced seizure event to induce a high seizure burden. On P24 primed <em>Scn1a</em>^<em>+/-</em> mice with a high seizure burden, unprimed naïve <em>Scn1a</em>^<em>+/-</em> mice and wild-type (WT) mice were euthanized and hippocampal tissue was collected for analysis of various specialized pro-resolving mediators using liquid chromatography mass spectrometry.</div></div><div><h3>Results</h3><div><em>Scn1a</em>^<em>+/-</em> mice with a high seizure burden showed increased hippocampal concentrations of the pro-inflammatory leukotrienes B4 and E4. Further, a high seizure burden increased hippocampal concentrations of various special pro-resolving mediators, including the maresins (maresin1), D-series resolvins (RVD1 and RVD4), and protectin (PCTR1). To further characterize these changes, we determined the mRNA expression of lipoxygenase genes, as these synthetic enzymes are common across classes of specialized pro-resolving mediators. However, hippocampal expression of <em>Alox5</em>, <em>Alox12</em> and <em>Alox15</em> were not influenced by a high seizure burden.</div></div><div><h3>Significance</h3><div>We report for the first time that a high seizure burden increases the hippocampal concentrations of various specialized pro-resolving mediators in <em>Scn1a</em>^<em>+/-</em> mice. This provides a platform for future studies to examine whether modulation of these mediators might be exploited to reduce seizures and facilitate brain repair in intractable epilepsy syndromes.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106943"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation","authors":"Stefania Lamon-Fava","doi":"10.1016/j.prostaglandins.2025.106948","DOIUrl":"10.1016/j.prostaglandins.2025.106948","url":null,"abstract":"<div><div>Cardiovascular disease (CVD), the leading cause of death in the United States and globally, is a chronic inflammatory disease likely caused by an impaired ability to resolve inflammation. Pre-clinical studies have provided strong evidence of the activating role of specialized pro-resolving lipid mediators (SPMs) derived from the omega-3 fatty acids eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) on the resolution of inflammation. However, there is a dearth of information on the role of SPMs on inflammation in humans. Therefore, the aim of this study was to assess whether plasma concentrations of omega-3 fatty acids and their derived SPMs are associated with inflammatory markers in subjects with low-grade chronic inflammation (C-reactive protein &gt;2 µg/mL). The plasma phospholipid content of omega-3 fatty acids, a marker of dietary intake, plasma concentrations of SPMs, and serum concentrations of inflammatory markers were measured in 21 older men and postmenopausal women (age 53–73 y) at the end of a four-week placebo phase (3 g/day high oleic acid sunflower oil). The phospholipid DHA content was inversely related to interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and IL-10 concentrations. Moreover, MCP-1 was inversely associated with the DHA-derived 14-HDHA and 4-HDHA, and IL-10 was inversely associated with EPA-derived 18-HEPE, 12-HEPE and 5-HEPE, DPA-derived Rv5_DPA, and DHA-derived 4-HDHA. These findings support the anti-inflammatory effect of dietary omega-3 fatty and suggest that lipid mediators derived from EPA, DPA, and DHA participate in the regulation of inflammation in subjects with chronic inflammation.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106948"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium channels mediate nitric oxide-induced vasorelaxation in arteries supplying colon cancer","authors":"Kamaran.H. Mohammed ,&nbsp;Sardar H. Arif ,&nbsp;Lina N. Adam ,&nbsp;Omar A.M. Al-Habib","doi":"10.1016/j.prostaglandins.2024.106937","DOIUrl":"10.1016/j.prostaglandins.2024.106937","url":null,"abstract":"<div><h3>Introduction</h3><div>Aberrant vascular function and cancer growth are closely related, with nitric oxide (NO) being a key factor in vascular tone regulation. This study provides Novel insights into the distinctive mechanisms underlying cancer-associated vascular dysfunction by investigating the involvement of potassium (K⁺) channels in NO-mediated vasorelaxation within arteries supplying colon cancer.</div></div><div><h3>Methods</h3><div>Arterial segments from colon cancer patients were isolated and sectioned into rings, these rings were mounted in an organ bath filled with Krebs' solution and maintained at 37°C. Isometric tension recordings were obtained using a force transducer connected to a PowerLab Data Acquisition System. Arterial segments were pre-incubated with a variety of K⁺ channel blockers, both individually and in combination, including glibenclamide (GLIB), barium chloride (BaCl₂), tetraethylammonium (TEA), and 4-aminopyridine (4-AP). Concentration-response curves were designed to evaluate how K⁺ channel blocking affected the vasodilation caused by NO.</div></div><div><h3>Results</h3><div>Sodium nitroprusside (SNP) induced vasorelaxation in arterial rings from colon cancer, influenced by specific K+ channels. Pre-incubation with TEA significantly reduced Emax to 60.22 ± 8.14 %, compared to 124.91 ± 15.07 % in controls, while GLIB decreased Emax to 113.10 ± 3.87 %. BaCl2 and 4-AP further diminished relaxation, and combined K⁺ channel blockers showed complex, non-additive effects. Distinct contributions of K_Ca and K_V channels to NO-induced vasodilation were elucidated. Additionally, interaction between NO and L-type calcium (Ca²⁺) channels suggested a novel vasorelaxation mechanism in cancerous tissues.</div></div><div><h3>Conclusion</h3><div>This research offers new perspectives on the intricate relationship between vascular biology and cancer development, emphasizing the promise of targeting potassium channels to address vascular abnormalities in cancer.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106937"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials","authors":"Jitendra Gupta ,&nbsp;Munthar Kadhim Abosaoda ,&nbsp;Madhu Shukla ,&nbsp;Suhas Ballal ,&nbsp;Abhishek Kumar ,&nbsp;Mamata Chahar ,&nbsp;Suman Saini ,&nbsp;Ish Kapila ,&nbsp;Alireza Hadpoori","doi":"10.1016/j.prostaglandins.2024.106939","DOIUrl":"10.1016/j.prostaglandins.2024.106939","url":null,"abstract":"<div><h3>Background</h3><div>There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.</div></div><div><h3>Methods</h3><div>PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024. Data from RCTs were pooled using the generic inverse variance method and expressed as weighted mean differences (WMD) with 95 % confidence interval (CIs).</div></div><div><h3>Results</h3><div>Pooled data from 38 RCTs reporting patient outcomes were evaluated for mean effects. Results indicated that soluble fiber significantly altered TG (WMD: −16.97 mg/dL, 95 % CI: −29.16 to −4.78, P = 0.021), HDL-C (WMD: 1.74 mg/dL, 95 % CI: 1.02–2.46, P &lt; 0.001), LDL-C (WMD: −11.14 mg/dL, 95 % CI: −15.41 to −6.87, P &lt; 0.001), and TC (WMD: −13.87 mg/dL, 95 % CI: −17.99 to −9.75, P = 0.027).</div></div><div><h3>Conclusions</h3><div>Soluble fiber supplementation has the potential to improve lipid profile in patients with T2DM, and may provide a feasible approach for improving metabolic health in T2DM patients.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106939"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of meal replacements formula on lipid profiles: A systematic review and meta-analysis of randomized controlled trials","authors":"Yu Qiao ,&nbsp;Xue Xiao ,&nbsp;Huijie Yu ,&nbsp;Junying Zhang ,&nbsp;Mohammad Hassan Sohouli ,&nbsp;Somaye Fatahi ,&nbsp;Nathalia Sernizon Guimarães","doi":"10.1016/j.prostaglandins.2024.106921","DOIUrl":"10.1016/j.prostaglandins.2024.106921","url":null,"abstract":"<div><h3>Background</h3><div>Although some evidence shows the beneficial effects of meal replacements (MRs) on dyslipidaemias, it is not completely clear. Therefore, we investigate the possible effects of total and partial MRs on lipid profiles.</div></div><div><h3>Methods</h3><div>For this systematic review and meta-analysis, we searched MEDLINE, Web of Science, SCOPUS, and Embase<strong>.</strong> We included randomized controlled trials (RCTs) that evaluated the effect of MRs on lipid profiles. A random-effects meta-analysis model was used to combine studies and calculate weighted mean difference and 95 % confidence intervals (95 % CI). Subgroup analysis was realized using intervention type, duration and average participant age.</div></div><div><h3>Results</h3><div>Fifty-one studies were included. The pooled findings showed that total and partial MRs significantly reduced triglycerides (TG) (WMD: −12.20 mg/dl, 95 % CI −17.46 to −6.93) and increased high-density lipoprotein (HDL) (WMD: 1.06 mg/dl, 95 % CI 0.35–1.77) compared to controls. However, total cholesterol (TC) (WMD: −1.40 mg/dl, 95 % CI: −3.90–1.10) and low-density lipoprotein (LDL) (WMD: −0.85 mg/dl, 95 % CI: −3.05–1.35) were not significant. In addition, the subgroup analysis shows a greater effect on TG reduction and HDL increase in the type of intervention with total MRs compared to partial MRs and during the intervention &gt;24 weeks compared to ≤24 weeks.</div></div><div><h3>Conclusions</h3><div>MRs lead to significant improvements in TG and HDL levels. These results may help strengthen programs for dyslipidaemias prevention/management.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106921"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials","authors":"Kehao Yu ,&nbsp;Wentao Song ,&nbsp;Xinyu Tu ,&nbsp;Ke Zhou ,&nbsp;Kousalya Prabahar","doi":"10.1016/j.prostaglandins.2024.106938","DOIUrl":"10.1016/j.prostaglandins.2024.106938","url":null,"abstract":"<div><h3>Background and aim</h3><div>Previous studies have reported on the relationship between vitamin D and the lipid profile in individuals with obesity or overweight, but results have been inconsistent. Hence, we conducted this meta-analysis and systematic review of randomized controlled trials to assess the effect of vitamin D on the lipid profile in individuals with overweight or obesity.</div></div><div><h3>Methods</h3><div>A meticulous search strategy was used in various databases, and article published up to November 2023 were included. The DerSimonian and Laird random effects model was applied to compute the weighted mean difference (WMD) and 95 % confidence intervals (CI) of the intervention on each variable.</div></div><div><h3>Results</h3><div>Vitamin D supplementation did not yield significant alterations in LDL-C (WMD: 2.10 mg/dL, CI: −5.20–9.41, p = 0.572), HDL-C (WMD: 1.49 mg/dL, 95 % CI: −1.55–4.55, P = 0.337), and TC concentrations (WMD: −1.99 mg/dL, CI: −8.21–4.22, P = 0.530). Conversely, a significant decrease in TG levels was observed studies conducted in individuals with comorbidities (WMD: −6.03 mg/dL, 95 % CI: −11.92 to −0.15, p = 0.044), vitamin D doses of ≥ 50000 IU/week (WMD: −20.87 mg/dL, 95 % CI: −39.63 to −2.11, P = 0.029), and subjects with baseline TG concentrations ≥ 150 mg/dl (WMD: −25.95 mg/dL, 95 % CI: −51.51 to −0.40, p = 0.046).</div></div><div><h3>Conclusion</h3><div>According to our study findings, vitamin D has significant effect on the hypertriglyceridemia in individuals with obesity or overweight. However, vitamin D has no significant effect on the LDL-C, HDL-C, and TC concentrations in individuals with obesity or overweight.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106938"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}