Lutein, a non-provitamin A carotenoid, reduces cisplatin-induced cardiotoxicity

Abstract

Cardiovascular complications resulting from cisplatin (CS) are a significant factor that can disrupt the treatment plan associated with this chemotherapy. This information led us to investigate the effectiveness of lutein (LT), which has antioxidant effects, in preventing CS-induced cardiotoxic effects. After 28 rats were randomly divided into four equal groups, saline (1 ml/day) was administered to the control group, LT (100 mg/kg/day) to the LT group, CS (10 mg/kg) to the CS group, and active agents in the LT and CS groups were administered to the CS + LT group in the same dose and manner. The examinations determined that MDA, cardiac biomarkers (CK-MB, BNP, LDH, and cTn-I) levels, TNF-α and caspase-3 expressions, and apoptosis significantly increased in the CS group. In contrast, GSH, SOD, and CAT levels were decreased. In addition, histopathological changes characterized by interstitial edema, leukocyte infiltration, and vacuolar degeneration were detected in the heart tissues of this group. It was determined that LT application prevented the above-mentioned CS-induced cardiotoxic effects to a significant extent, although not completely. The findings obtained in this study show that LT may reduce CS-induced cardiac damage thanks to its ROS-reducing, anti-inflammatory, anti-apoptotic, and cytoprotective characteristics.