Prostaglandins & other lipid mediators最新文献

{"title":"The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials","authors":"Qiujin Cheng ,&nbsp;Xiao Yan ,&nbsp;Kousalya Prabahar ,&nbsp;Zhu Ye","doi":"10.1016/j.prostaglandins.2024.106919","DOIUrl":"10.1016/j.prostaglandins.2024.106919","url":null,"abstract":"<div><h3>Background and aim</h3><div>In view of the favorable effect of hormone replacement therapy (HRT) on the lipid profile in postmenopausal women, and the discrepancies that exist on the effect of medroxyprogesterone acetate (MPA) on lipoprotein concentrations and cardiovascular disease (CVD) risk, we conducted this meta-analysis of randomized controlled trials (RCT) to assess the efficacy of MPA on apolipoprotein and lipoprotein(a) concentrations in healthy postmenopausal women.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across multiple databases, including for English-language papers published up to September 2023 comparing the effect of MPA on ApoA-I, Apo-AII, and Lp(a) levels with those of a control group. A meta-analysis was conducted using a random-effects model, reporting the results as the weighted mean difference (WMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>The current meta-analysis included 11 publications. the comprehensive findings indicated a noteworthy reduction in ApoA-I (WMD:-8.70 mg/dL,95 %CI: −12.80, −4.59,P&lt;0.001), a significant increase in Lp(a) concentrations (WMD: 1.36 mg/dL, 95 % CI: 0.10, 2.63, P=0.033), and a non-significant increase in ApoB concentrations (WMD: 0.57 mg/dL, 95 %CI: −1.25, 2.40, P=0.539) after the administration of MPA in postmenopausal women. In addition, a significant reduction in ApoB levels was identified in studies with a mean participant BMI ≥25 kg/m2 (WMD: −4.94 mg/dL, 95 %CI: −5.71 to −4.18,P&lt; 0.001) and a greater impact on ApoA-1 and Lp(a) levels was observed in trials with doses of 5 mg/day compared with 2.5 mg/day.</div></div><div><h3>Conclusion</h3><div>MPA administration resulted in a significant increase in Lp(a) and decrease in ApoA-I levels and a non-significant increase in ApoB levels in healthy postmenopausal women.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106919"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high seizure burden increases brain concentrations of specialized pro-resolving mediators in the Scn1a+/- mouse model of Dravet syndrome","authors":"Ka Lai Yip ,&nbsp;Cilla Zhou ,&nbsp;Lyndsey L. Anderson ,&nbsp;Nicole A. Hawkins ,&nbsp;Jennifer A. Kearney ,&nbsp;Jonathon C. Arnold","doi":"10.1016/j.prostaglandins.2024.106943","DOIUrl":"10.1016/j.prostaglandins.2024.106943","url":null,"abstract":"<div><h3>Objective</h3><div>Dravet syndrome is a severe, intractable epilepsy in which 80 % of patients have a <em>de novo</em> mutation in the gene <em>SCN1A</em>. We recently reported that a high seizure burden increased hippocampal concentrations of an array of pro-inflammatory prostaglandins in the <em>Scn1a</em>^<em>+/-</em> mouse model of Dravet syndrome. This raised the possibility that a high seizure burden might also trigger the accumulation of specialized pro-resolving mediators that facilitate the resolution of neuroinflammation and brain repair. The present study therefore aimed to examine whether a high seizure burden increased hippocampal concentrations of various specialized pro-resolving mediators in the <em>Scn1a</em>^<em>+/-</em> mouse model of Dravet syndrome.</div></div><div><h3>Methods</h3><div><em>Scn1a</em>^<em>+/-</em> mice at postnatal day 21 (P21) were primed with a single hyperthermia-induced seizure event to induce a high seizure burden. On P24 primed <em>Scn1a</em>^<em>+/-</em> mice with a high seizure burden, unprimed naïve <em>Scn1a</em>^<em>+/-</em> mice and wild-type (WT) mice were euthanized and hippocampal tissue was collected for analysis of various specialized pro-resolving mediators using liquid chromatography mass spectrometry.</div></div><div><h3>Results</h3><div><em>Scn1a</em>^<em>+/-</em> mice with a high seizure burden showed increased hippocampal concentrations of the pro-inflammatory leukotrienes B4 and E4. Further, a high seizure burden increased hippocampal concentrations of various special pro-resolving mediators, including the maresins (maresin1), D-series resolvins (RVD1 and RVD4), and protectin (PCTR1). To further characterize these changes, we determined the mRNA expression of lipoxygenase genes, as these synthetic enzymes are common across classes of specialized pro-resolving mediators. However, hippocampal expression of <em>Alox5</em>, <em>Alox12</em> and <em>Alox15</em> were not influenced by a high seizure burden.</div></div><div><h3>Significance</h3><div>We report for the first time that a high seizure burden increases the hippocampal concentrations of various specialized pro-resolving mediators in <em>Scn1a</em>^<em>+/-</em> mice. This provides a platform for future studies to examine whether modulation of these mediators might be exploited to reduce seizures and facilitate brain repair in intractable epilepsy syndromes.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106943"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation","authors":"Stefania Lamon-Fava","doi":"10.1016/j.prostaglandins.2025.106948","DOIUrl":"10.1016/j.prostaglandins.2025.106948","url":null,"abstract":"<div><div>Cardiovascular disease (CVD), the leading cause of death in the United States and globally, is a chronic inflammatory disease likely caused by an impaired ability to resolve inflammation. Pre-clinical studies have provided strong evidence of the activating role of specialized pro-resolving lipid mediators (SPMs) derived from the omega-3 fatty acids eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) on the resolution of inflammation. However, there is a dearth of information on the role of SPMs on inflammation in humans. Therefore, the aim of this study was to assess whether plasma concentrations of omega-3 fatty acids and their derived SPMs are associated with inflammatory markers in subjects with low-grade chronic inflammation (C-reactive protein &gt;2 µg/mL). The plasma phospholipid content of omega-3 fatty acids, a marker of dietary intake, plasma concentrations of SPMs, and serum concentrations of inflammatory markers were measured in 21 older men and postmenopausal women (age 53–73 y) at the end of a four-week placebo phase (3 g/day high oleic acid sunflower oil). The phospholipid DHA content was inversely related to interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and IL-10 concentrations. Moreover, MCP-1 was inversely associated with the DHA-derived 14-HDHA and 4-HDHA, and IL-10 was inversely associated with EPA-derived 18-HEPE, 12-HEPE and 5-HEPE, DPA-derived Rv5_DPA, and DHA-derived 4-HDHA. These findings support the anti-inflammatory effect of dietary omega-3 fatty and suggest that lipid mediators derived from EPA, DPA, and DHA participate in the regulation of inflammation in subjects with chronic inflammation.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106948"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of meal replacements formula on lipid profiles: A systematic review and meta-analysis of randomized controlled trials","authors":"Yu Qiao ,&nbsp;Xue Xiao ,&nbsp;Huijie Yu ,&nbsp;Junying Zhang ,&nbsp;Mohammad Hassan Sohouli ,&nbsp;Somaye Fatahi ,&nbsp;Nathalia Sernizon Guimarães","doi":"10.1016/j.prostaglandins.2024.106921","DOIUrl":"10.1016/j.prostaglandins.2024.106921","url":null,"abstract":"<div><h3>Background</h3><div>Although some evidence shows the beneficial effects of meal replacements (MRs) on dyslipidaemias, it is not completely clear. Therefore, we investigate the possible effects of total and partial MRs on lipid profiles.</div></div><div><h3>Methods</h3><div>For this systematic review and meta-analysis, we searched MEDLINE, Web of Science, SCOPUS, and Embase<strong>.</strong> We included randomized controlled trials (RCTs) that evaluated the effect of MRs on lipid profiles. A random-effects meta-analysis model was used to combine studies and calculate weighted mean difference and 95 % confidence intervals (95 % CI). Subgroup analysis was realized using intervention type, duration and average participant age.</div></div><div><h3>Results</h3><div>Fifty-one studies were included. The pooled findings showed that total and partial MRs significantly reduced triglycerides (TG) (WMD: −12.20 mg/dl, 95 % CI −17.46 to −6.93) and increased high-density lipoprotein (HDL) (WMD: 1.06 mg/dl, 95 % CI 0.35–1.77) compared to controls. However, total cholesterol (TC) (WMD: −1.40 mg/dl, 95 % CI: −3.90–1.10) and low-density lipoprotein (LDL) (WMD: −0.85 mg/dl, 95 % CI: −3.05–1.35) were not significant. In addition, the subgroup analysis shows a greater effect on TG reduction and HDL increase in the type of intervention with total MRs compared to partial MRs and during the intervention &gt;24 weeks compared to ≤24 weeks.</div></div><div><h3>Conclusions</h3><div>MRs lead to significant improvements in TG and HDL levels. These results may help strengthen programs for dyslipidaemias prevention/management.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106921"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials","authors":"Jitendra Gupta ,&nbsp;Munthar Kadhim Abosaoda ,&nbsp;Madhu Shukla ,&nbsp;Suhas Ballal ,&nbsp;Abhishek Kumar ,&nbsp;Mamata Chahar ,&nbsp;Suman Saini ,&nbsp;Ish Kapila ,&nbsp;Alireza Hadpoori","doi":"10.1016/j.prostaglandins.2024.106939","DOIUrl":"10.1016/j.prostaglandins.2024.106939","url":null,"abstract":"<div><h3>Background</h3><div>There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.</div></div><div><h3>Methods</h3><div>PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024. Data from RCTs were pooled using the generic inverse variance method and expressed as weighted mean differences (WMD) with 95 % confidence interval (CIs).</div></div><div><h3>Results</h3><div>Pooled data from 38 RCTs reporting patient outcomes were evaluated for mean effects. Results indicated that soluble fiber significantly altered TG (WMD: −16.97 mg/dL, 95 % CI: −29.16 to −4.78, P = 0.021), HDL-C (WMD: 1.74 mg/dL, 95 % CI: 1.02–2.46, P &lt; 0.001), LDL-C (WMD: −11.14 mg/dL, 95 % CI: −15.41 to −6.87, P &lt; 0.001), and TC (WMD: −13.87 mg/dL, 95 % CI: −17.99 to −9.75, P = 0.027).</div></div><div><h3>Conclusions</h3><div>Soluble fiber supplementation has the potential to improve lipid profile in patients with T2DM, and may provide a feasible approach for improving metabolic health in T2DM patients.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106939"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials","authors":"Kehao Yu ,&nbsp;Wentao Song ,&nbsp;Xinyu Tu ,&nbsp;Ke Zhou ,&nbsp;Kousalya Prabahar","doi":"10.1016/j.prostaglandins.2024.106938","DOIUrl":"10.1016/j.prostaglandins.2024.106938","url":null,"abstract":"<div><h3>Background and aim</h3><div>Previous studies have reported on the relationship between vitamin D and the lipid profile in individuals with obesity or overweight, but results have been inconsistent. Hence, we conducted this meta-analysis and systematic review of randomized controlled trials to assess the effect of vitamin D on the lipid profile in individuals with overweight or obesity.</div></div><div><h3>Methods</h3><div>A meticulous search strategy was used in various databases, and article published up to November 2023 were included. The DerSimonian and Laird random effects model was applied to compute the weighted mean difference (WMD) and 95 % confidence intervals (CI) of the intervention on each variable.</div></div><div><h3>Results</h3><div>Vitamin D supplementation did not yield significant alterations in LDL-C (WMD: 2.10 mg/dL, CI: −5.20–9.41, p = 0.572), HDL-C (WMD: 1.49 mg/dL, 95 % CI: −1.55–4.55, P = 0.337), and TC concentrations (WMD: −1.99 mg/dL, CI: −8.21–4.22, P = 0.530). Conversely, a significant decrease in TG levels was observed studies conducted in individuals with comorbidities (WMD: −6.03 mg/dL, 95 % CI: −11.92 to −0.15, p = 0.044), vitamin D doses of ≥ 50000 IU/week (WMD: −20.87 mg/dL, 95 % CI: −39.63 to −2.11, P = 0.029), and subjects with baseline TG concentrations ≥ 150 mg/dl (WMD: −25.95 mg/dL, 95 % CI: −51.51 to −0.40, p = 0.046).</div></div><div><h3>Conclusion</h3><div>According to our study findings, vitamin D has significant effect on the hypertriglyceridemia in individuals with obesity or overweight. However, vitamin D has no significant effect on the LDL-C, HDL-C, and TC concentrations in individuals with obesity or overweight.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106938"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the unique role of specialized pro-resolving mediators in cancer therapeutics","authors":"Katherine M. Quinlivan ,&nbsp;Isabella V. Howard ,&nbsp;Franciska Southan ,&nbsp;Rachel L. Bayer ,&nbsp;Kimberly L. Torres ,&nbsp;Charles N. Serhan ,&nbsp;Dipak Panigrahy","doi":"10.1016/j.prostaglandins.2024.106944","DOIUrl":"10.1016/j.prostaglandins.2024.106944","url":null,"abstract":"<div><div>Unresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and metastasis in various cancer types. In contrast to blocking inflammation, stimulation of resolution of inflammation is an entirely novel approach to “resolve” inflammation. Resolution of inflammation mechanisms in cancer includes clearance of tumor debris, counter-regulation of pro-inflammatory eicosanoids and cytokines, and suppression of leukocyte infiltration. Conventional cytotoxic chemotherapy, radiation, anti-angiogenic therapy, and immune checkpoint inhibitors directly or indirectly can lead to the generation of pro-tumorigenic cellular debris. Over the past two decades, a potential paradigm shift has emerged in the inflammation field with the discovery of specialized pro-resolving mediators (SPMs), including resolvins, lipoxins, maresins, and protectins. SPMs are structurally distinct families of mediators grouped together by their pro-resolving “debris-clearing” functions. \"Pro-resolving\" therapies are in clinical development for various inflammation-driven diseases, including cancer. SPMs, as novel cancer therapeutics, have tremendous potential to enhance current cancer therapy. The mechanisms of SPMs as anti-cancer therapeutics are under active investigation by various laboratories worldwide. Here, we explore the current appreciation of the SPMs as innovative potential treatments designed to harness the unique anti-cancer activity of SPMs.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"178 ","pages":"Article 106944"},"PeriodicalIF":2.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosmarinic acid alleviates the cardiac abnormalities in high fat diet induced hypercholesterolemic rats","authors":"R Sundaram ,&nbsp;K Muthu","doi":"10.1016/j.prostaglandins.2024.106936","DOIUrl":"10.1016/j.prostaglandins.2024.106936","url":null,"abstract":"<div><div>Hyperlipidemia is a well-known risk factor for atherosclerosis and subsequent atherosclerotic cardiovascular diseases that are associated with high morbidity and mortality in obese and diabetic patients worldwide. The current study looked on rosmarinic acid's cadioprotective effects in rats fed a high-fat diet as there was no study on this aspect. The rats were given a high-fat diet comprising of 84.3 % conventional laboratory rat chow, 5 % lard, 10 % egg yolk powder, 0.2 % cholesterol, and 0.5 % bile salt to produce hypercholesterolemia. Over a span of eight weeks. The plasma lipid profile, cardiac marker enzymes, membrane bound ATPases, lysosomal enzymes, CRP, fibrinogen, proinflammatory cytokines (IL-1β, IL-6,TNF-α, NF-κB),anti-inflammatory cytokine(IL-10) lipid peroxidation markers, enzymatic and non-enzymatic antioxidant enzymes activity were examined. The thoracic aorta's histopathology was also analyzed. It was discovered that the rats fed a high-fat diet had hypercholesterolemia and showed aberrant values in the aforementioned parameters. However, rats given rosmarinic acid (100 mg/kg b.w.) had these anomalies reversed to near-normal levels. The biochemical investigation was corroborated by enhanced histological examination of the thoracic aorta in rats suffering from hypercholestolemia. The effects of rosmarinic acid on a number of measures were similar to those of the prescription medication simvastatin. These findings revealed that rosmarinic acid is an important component in the cardiovascular system's defence against a high-fat diet induced hypercholesterolemia</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106936"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis","authors":"Zhu Haijun ,&nbsp;Zhang Ke ,&nbsp;Zhang Dawei ,&nbsp;Amir Reza Haedi ,&nbsp;Elika Poorasadollah ,&nbsp;Cheng Cheng","doi":"10.1016/j.prostaglandins.2024.106934","DOIUrl":"10.1016/j.prostaglandins.2024.106934","url":null,"abstract":"<div><div>Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: −2.26; 95 % CI: −2.98, −1.55, p &lt;0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: −2.57; 95 % CI: −3.41, −1.74; p&lt;0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: −0.33; 95 % CI: −0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: −0.16; 95 % CI: −0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106934"},"PeriodicalIF":2.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between vitamin D deficiency and childhood obesity and its impact on children’s serum calcium, alkaline phosphatase, and bone age","authors":"Juanjuan Zhu ,&nbsp;Bingbing Wang ,&nbsp;Sanaz Asemani ,&nbsp;Shiwei Bao ,&nbsp;Niannian Tian","doi":"10.1016/j.prostaglandins.2024.106920","DOIUrl":"10.1016/j.prostaglandins.2024.106920","url":null,"abstract":"<div><h3>Objective</h3><div>The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children’s serum calcium, alkaline Phosphatase, and bone Age.</div></div><div><h3>Methods</h3><div>The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.</div></div><div><h3>Results</h3><div>Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P&lt;0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.</div></div><div><h3>Conclusion</h3><div>The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.</div></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"176 ","pages":"Article 106920"},"PeriodicalIF":2.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}