Research Journal of Pharmacy and Technology最新文献

{"title":"Association between Homocysteine Level and Vitamin D Deficiency with Acute Coronary Syndrome in Indonesia","authors":"Teguh Satrio, Puspa Wardhani, Muhamad Robiul Fuadi, H. Susilo, Atika Atika","doi":"10.52711/0974-360x.2024.00108","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00108","url":null,"abstract":"Background: Acute coronary syndrome (ACS) is an acute subset of coronary heart disease that requires immediate treatment. ACS is at a high prevalence in Indonesia. Homocysteine is another product of methionine metabolism. Hyperhomocysteinemia is known to cause ACS through several mechanisms, namely inducing oxidative stress, endothelial injury, and increased likelihood of plaque rupture. Vitamin D is a hormone needed by the body that comes from food or is produced through the metabolism of Vitamin D. Vitamin D functions as an anti-inflammatory, anti-thrombotic and anti-atherosclerotic agent. This study aimed to analyze the relationship between homocysteine level and Vitamin D deficiency with acute coronary syndrome incidence. Methods: This study was a cross-sectional, observational analysis study with 90 subjects. Subjects were enrolled into two groups; patients with ACS and patients with health control based on age. All subjects were selected from Universitas Airlangga Hospital, Surabaya. Serum homocysteine level and Vitamin D deficiency were calculated using an enzyme-linked immunosorbent assay (ELISA). The relationship between serum homocysteine level and Results: Ninety subjects were obtained in this study. The mean age was 62.1±10.9 years (among patients with ACS) and 60.1±10.3 years (healthy persons), with 55.6% male patients. The traditional risk factors i.e., diabetes, hypertension, and dyslipidemia were 62.2%, 91.1%, and 75.6%, respectively. The Chi-square analysis results showed homocysteine level and ACS obtained a contingency coefficient of 0.270 (p = 0.008) and Vitamin D with ACS had a contingency coefficient of 0.468 (p = < 0.001). Conclusions: There was a weak association between homocysteine level and ACS and a moderate association between Vitamin D deficiency and ACS.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"290 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Enamel Surface Roughness after Orthodontic Brackets Debonding and Surface Polishing with Restorative and Orthodontic Composites","authors":"Mohammad Reza Soltani, Parisa Kazemi, Amir Mohammad Shirkhani","doi":"10.52711/0974-360x.2024.00114","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00114","url":null,"abstract":"Introduction: Emergence of superficial enamel roughness following orthodontic bracket debonding leads to the accumulation of microbial plaque, resulting in the development of dental caries and compromising the aesthetics and health of the tooth enamel. The objective of this current study is to investigate the Enamel Surface Roughness after Orthodontic Brackets Debonding and Surface Polishing with Restorative and Orthodontic Composites. Materials and Methods: In the present study, three types of composites were used for bonding metal orthodontic brackets. The samples were randomly divided into three cure groups: XT, GC, and SHOFU. Subsequently, the brackets were debonded, and the target surfaces were treated using a carbide bur for one minute by an operator to remove adhesive remnants and be prepared for bonding. The superficial enamel roughness was then examined. Furthermore, the samples were evaluated for the Adhesive Remnant Index before and after adhesive removal and enamel surface preparation. The data were analyzed using ANOVA test and SPSS software version 22. Results: The results indicated that there was no significant difference in surface roughness among the tested groups. However, a significant difference was observed between the surface roughness of the experimental groups and the healthy enamel surface (P<0.05). Moreover, among the different experimental groups, there were statistically significant differences in the Adhesive Remnant Index (ARI) after bracket debonding, before and after enamel surface cleaning. These differences were primarily due to distinctions between the XT and SHOFU groups, as well as between the GC and SHOFU groups. However, there was no significant difference in ARI before and after enamel surface cleaning between the XT and GC groups (P>0.05). Conclusion: The results of the present study indicate a desirable and acceptable performance of the composite material. It is suggested that future studies focus on a comparative investigation of several cleaning and surface preparation systems.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"292 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Verapamil Hydrochloride Sustain Release Tablet","authors":"Aishwarya S. Patil, Suvarna S. Joshi.","doi":"10.52711/0974-360x.2024.00124","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00124","url":null,"abstract":"Verapamil hydrochloride, a calcium channel blocker, is used to treat hypertension, supraventricular arrhythmia and myocardial infarction Verapamil hydrochloride (VPH) sustain release tablets were developed for this study in order to maintain plasma concentrations, enhance bioavailability, and avoid repeated dosing. Materials and procedures Tablets containing a fixed amount of VPH were made using the direct compression method and various combinations and ratios of the polymers hydroxypropyl methyl cellulose (HPMC K15) and ethyl cellulose. The tablets were then tested for thickness, weight variation, hardness, uniformity of the drug content, drug release, and potential ingredient interactions. Regarding thickness, weight variation, hardness, and medication content, all tablets were satisfactory. It may be determined from formulations comprising HPMCK15 and ethyl cellulose that the two polymers functioned well together, controlling the first burst and improving the drug's release throughout the first three hours. A study of in vitro drug release followed the formulation of the 32 factorial planned batches. The formulations F5, F6, and F8 demonstrated better drug release up to 24hours and minimal burst release with more than 80% release in 24hours. They were composed of HPMC K15 60mg, 60 mg, and 75mg, respectively, and ethyl cellulose 30mg, 45mg, and 30mg, respectively. Thus, the F5 formulation with somewhat lower polymer content was chosen as the optimal formulation and they contained HPMC K15 60mg and ethyl cellulose 30mg.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"152 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Synthesis of Copper Nanoparticles from flower extract and their Cell Cytotoxic Potential","authors":"Ajay Kasivishwanathan Chandrasekar, Nishu Sekar, Selvakumar Dharmaraj, Hariprasath Lakshmanan","doi":"10.52711/0974-360x.2024.00119","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00119","url":null,"abstract":"In order to overcome the negative potential risks of conventional nanoparticles and achieve the goal of human therapeutic uses, sustainable nanoparticles must be synthesized. In this paper, we have created a simple method for producing copper nanoparticles using green chemistry. With the use of Cassia auriculata's floral aqueous extract, copper nanoparticles (CuNPs) were effectively produced. In a UV-Visible Spectrophotometer, sythesized CuNPs detect absorbance at 276 nm, a hallmark of copper nanoparticles. The relevant functional groups involved in lowering and stabilizing CuNPs were found using Fourier Transform Infrared Spectroscopy. CuNPs shape, crystalline phase, and elemental composition were seen using scanning and transmission electron microscopy, energy dispersive analysis spectroscopy, and other techniques. Moreover, CuNPs' antibacterial and antifungal properties produced good inhibitory action against the pathogens that were put to the test. Furthermore, at low doses, CuNPs had no effect on the cytotoxicity of the cell lines MDCK and Caco-2. CuNPs may thus be turned into nano-drugs for the treatment of infectious diseases and tumour research.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"132 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention, Control and Treatment of Tobacco use Addiction: A Literature Review Article","authors":"Rami A. Elshatarat, Raghad Abdelkader, Hanadi A. Alahmadi, Majed S Al-Za'areer, Nora H. Elneblawi, Mudathir Mohamedahmed Eltayeb, Doaa El Sayed Fadila, Amaal Samir Abdelmaksoud, Howaida Amin Elsaba, Mohammed Mubarak Alhejaili, Rami Sameer Aloufi, Inas A. Ebeid","doi":"10.52711/0974-360x.2024.00144","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00144","url":null,"abstract":"This comprehensive literature review delves into the multifaceted realm of preventing, controlling, and treating tobacco use addiction. Synthesizing a vast array of scholarly works, the study navigates through the complexities of tobacco dependence, shedding light on diverse strategies employed globally. Pharmacological interventions, such as nicotine replacement therapy and emerging medications, are scrutinized alongside non-pharmacological approaches, including health education programs, psychological counseling, and cognitive-behavioral therapy. The review underlines the imperative to comprehend the neurobiology of tobacco addiction, emphasizing its pivotal role in crafting targeted and individualized treatments. By amalgamating evidence-based practices, the study contributes to the advancement of knowledge in the ongoing quest for efficacious prevention and treatment strategies for tobacco use addiction. The review study investigates the role of health institutions and government agencies in collaborating to control tobacco use, highlighting the variation in smoking cessation policies across countries and the legal counteraction of the tobacco industry's aggressive marketing. In detailing the treatment landscape, the review explores both pharmacological and non-pharmacological interventions. Pharmacologically, nicotine replacement therapy, prescription medications, and novel drugs like Varenicline are expounded upon. Non-pharmacological approaches encompass health education programs, psychological counseling, cognitive-behavioral therapy, and psychosocial support, underscoring the importance of counseling as a non-pharmacological intervention. The study concludes by discussing the ongoing trials for nicotine vaccines and cannabinoid CB1 receptor antagonists as promising avenues for future pharmacotherapeutic interventions. Overall, this literature review consolidates diverse insights to provide a holistic understanding of tobacco use addiction and its comprehensive management.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"208 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Review of Nanosponge Based Formulation System from The perspective of Brain Targeted Drug Delivery","authors":"Sourav Das, Sukanta Roy, Sangeeta Choudhury, A. Bose, Sudip Khila, Dibya Das, Parag Ghosh, Sanjay Kumar Dhaker, Subhasish Mondal","doi":"10.52711/0974-360x.2024.00147","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00147","url":null,"abstract":"Brain tumor causes of millions of life every year due to poor treatment options. The blood-brain barrier prevents most of the treatment molecules to reach the tumor region. Tight junctions within adjacent brain endothelial cell lines including other components make the brain highly impermeable to all the unwanted and foreign materials. The antineoplastic drug molecules which has a molecular weight of less than 400 daltons and have less than 8 hydrogen bonds are only able to access the brain without any hindrance. Hence, most of the small and large anti-cancer drug molecules hardly can cross the barrier. To overcome these problems formulation scientists have adopted various strategies and techniques so that the intended drug molecule can reach the target region of the brain tumor. Among them nanosponges drug delivery is highly appreciated as emerging brain tumor targeted drug delivery. Nanosponges are tiny sponge in the size of nano range with a vesicle filled with various types of drugs. These kinds of the formulation can circulate throughout the blood and reach the target region where drugs are released in a controlled manner. This review article highlights the unique features of blood-brain barrier and novel strategies based on drug formulation to access the core of the brain tumor by overcoming the resistance rendered by blood brain barrier. In addition, it also demonstrates how nanosponges is emerging as one of the best options to prevail over various challenges associated with penetration of the blood-brain barrier.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"71 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making a Case for Hypnosis: Using the RE-AIM Framework to Recognize Hypnosis as a Stand-Alone Therapeutic Intervention within Healthcare and Educational Systems","authors":"Sheila Menon, V. Bhagat","doi":"10.52711/0974-360x.2024.00148","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00148","url":null,"abstract":"Hypnosis is emerging as a valuable therapeutic tool with significant potential for recognition and application across medical settings. Of particular note are the evidenced benefits when addressing pervasive challenges such as chronic pain, anxiety, and emotional distress, which are often exacerbated by medical procedures. However, despite its potential for wide utilization in medical contexts, recognition of hypnotherapy's efficacy remains slow and hypnosis is often a second choice, last resort or offered as an adjuvant or supporting role alongside other treatments. One reason is that hypnosis lacks a well-defined role within the healthcare system. This gap persists even as mounting evidence suggests that hypnosis offers the capacity to bring about relief and positive outcomes across diverse issues and populations. Author Sheila Menon, Principal and Administrator of a clinical hypnosis Training and Clinical Facility draws upon extensive experience in clinical intervention and administration to extract scientific values from empirically driven experiences and data. In this paper the RE-AIM Framework is utilised to explore the multifaceted potential of hypnosis in medical settings, shedding light on the need for a more clearly defined integration of this intervention into mainstream healthcare practices. The authors draw from the evidence to make a case that the time is right to recognise hypnosis as a stand-alone psychotherapy and that this will enhance its adoption, reach and efficacy. It is further suggested that rebranding or relabeling this intervention will remove unnecessary biases and make it easier to implement and maintain for the benefit of patients and to improve treatment outcomes. Purpose: the purpose of this study is to use the RE-AIM Framework to evaluate the existing research that consistently provides evidence for better inclusion of hypnosis and to identify new insights into how this useful treatment can be more easily adopted and utilized in the healthcare system based on its interventional strength. Methodology: This is a descriptive study based on secondary data collected from literature following a descriptive analysis. The RE-AIM Framework is used as a mechanism for evaluating hypnosis interventions and to establish a rationale for relabeling them as psychotherapy based on treatment outcomes, interventional strengths and its operative usage in the healthcare system The literature search extracts information from the electronic database to make the study more robust and the literature selected is drawn from those published in the past two decades using keywords such as hypnosis intervention, RE-AIM, hypnosis in health care, mental health, and hypnosis interventions in a medical setup. Conclusion: This study uses the RE-AIM to present a case for relabeling or rebranding hypnosis as a psychotherapy in its own right to enhance its adoption and reach within a wide range of healthcare settings. The research supports the intervent","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"105 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the effects of Lemongrass (Cymbopogon nardus) extract on Sperm Quality and Testosterone Level in Mice Induced with Staphylococcus aureus","authors":"Lilis Maghfuroh, Putri AyuIka Setiyowati, Rofiatun Solekha, Alif’iyah Mar’ Atus Sholikhah, Angella Ananda Saputra, Eka Febrianti Wulandari","doi":"10.52711/0974-360x.2024.00136","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00136","url":null,"abstract":"There are a variety of causes for male infertility. Among them is microbial infection. Lemongrass (C. nardus) contains natural antioxidants and flavonoids that have the ability to preserve the male reproductive system. This study examined the effects of different C. nardus extract dosages on mouse sperm quality. The male Balb/C mice were separated into five groups of equal size. The negative control group was injected with 0.01ml of Na-CMC 0.5% over the course of 28 days, the positive control group was injected with 0.2ml of Staphylococcus aureus (S. aureus) on days 10, 17, and 24, and the treatment groups were injected with 0.2ml of S. aureus on days 10, 17, and 24, followed by 0.01ml of C. nardus. After the experiment, mice were slaughtered, and sperm suspension was obtained from the cauda epididymal to measure morphology, concentration, and motility. The testis was fixed in a fixative solution to analyze the spermatogenic cells, and intracardiac blood was drawn to determine the level of testosterone. Significant differences (p 0.05) were seen in the morphology, concentration, and motility of spermatozoa when C. nardus extract was administered. Given the low and middle concentrations of C. nardus extract, it can repair sperm damage caused by S. aureus infection.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"96 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioequivalence Study and Bioanalytical Method Development of Remogliflozin etabonate tablets in wistar rat plasma using RP-HPLC Method","authors":"N. Tamilselvi, K. Kanagapriya","doi":"10.52711/0974-360x.2024.00122","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00122","url":null,"abstract":"A new RP-HPLC method for the bioequivalence study of two RGE (Remogliflozin etabonate) formulations in wistar rat plasma has been developed using Rosuvastatin as internal standard and validated as per ICH guidelines. The plasma samples were extracted with methanol and chromatographic separation was achieved on phenomenex C18 (250 x 4.6mm, 5μ) analytical column with a mobile phase of methanol: 0.2% TEA (pH adjusted to 3 with orthophosphoric acid) in the ratio of 78:22% v/v and detection at 227nm. Calibration curve was linear in the range of 100-600ng/ml and the r2 value was found to be 0.9906. The extraction efficiency of RGE from rat plasma at the concentration of 50, 100 and 150% was found to be 99.6%, 99.9% and 98.05%. The Intra-day precision and interday precision was found to be 0.14 - 0.777% and 0.0070% - 0.0572% respectively. The maximum concentration (Cmax) obtained for two brands ( selected brand 1 & 2) formulation are 57.04 and 51.99 ng/ml respectively. The half life (t1/2) of two brands are calculated as 1 h. Area under the curve AUC 0- t of brand 1 and brand 2 is calculated as 343.235 and 310.1775ng h/ml and AUC 0-∞ is calculated to be 465.3665 and 501.4235ng h/ml respectively. The present study shows no significant difference in pharmacokinetic parameters between two products so the two formulations are considered to be bioequivalent.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"253 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Evaluation of Anticancer Activity of Karanthai Legium (Kl) – A Siddha Medicine for Cervical Carcinoma against Hela Cell Line By MTT Assay","authors":"Carolin P, M. A, Meena Kumari R","doi":"10.52711/0974-360x.2024.00125","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00125","url":null,"abstract":"Cervical cancer become a major global burden and of course considered one of the leading causes of cancer-related deaths in women, particularly in developing countries. Viral induction of human papilloma viruses (HPV) can disturb the basic cellular mechanism of growth control. Currently medicinal plants have become the source of drug discovery in research for treating cancer. Siddha medicine is an ancient medical system of India which classifies diseases into 4448 types. In Siddha literature, Cancer is mentioned as Vippuruthinoipadalam (Carcinoma like illness), Kiranthi noi, Mega Katti, Pilavai and Putru noi (tumour). Literary evidences have a classic collection of herbal, mineral, herbo- mineral medicines for Cancer. Many anti-cancerous drugs are now in practice in Siddha medicine. Among them, Karanthai Legium (KL) a classical herbo mineral drug having anticancer potential is mentioned in Siddha Literature. The main objective of this study is to evaluate anti- cancer activity against HeLa cell using MTT assay. Present study revealed that, Karanthailegium (KL) at high as 200µg/ml showed high cytotoxicity activity as high as 72.44% against HeLa cell lines. IC50 of the tested KL against HeLa cells was calculated as104.90µg/ml. It was concluded from the result of the present study that the formulation KL possesses promising anti-cancer activity.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140445714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}