Research Journal of Pharmacy and Technology最新文献

{"title":"Formulation and Evaluation of Verapamil Hydrochloride Sustain Release Tablet","authors":"Aishwarya S. Patil, Suvarna S. Joshi.","doi":"10.52711/0974-360x.2024.00124","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00124","url":null,"abstract":"Verapamil hydrochloride, a calcium channel blocker, is used to treat hypertension, supraventricular arrhythmia and myocardial infarction Verapamil hydrochloride (VPH) sustain release tablets were developed for this study in order to maintain plasma concentrations, enhance bioavailability, and avoid repeated dosing. Materials and procedures Tablets containing a fixed amount of VPH were made using the direct compression method and various combinations and ratios of the polymers hydroxypropyl methyl cellulose (HPMC K15) and ethyl cellulose. The tablets were then tested for thickness, weight variation, hardness, uniformity of the drug content, drug release, and potential ingredient interactions. Regarding thickness, weight variation, hardness, and medication content, all tablets were satisfactory. It may be determined from formulations comprising HPMCK15 and ethyl cellulose that the two polymers functioned well together, controlling the first burst and improving the drug's release throughout the first three hours. A study of in vitro drug release followed the formulation of the 32 factorial planned batches. The formulations F5, F6, and F8 demonstrated better drug release up to 24hours and minimal burst release with more than 80% release in 24hours. They were composed of HPMC K15 60mg, 60 mg, and 75mg, respectively, and ethyl cellulose 30mg, 45mg, and 30mg, respectively. Thus, the F5 formulation with somewhat lower polymer content was chosen as the optimal formulation and they contained HPMC K15 60mg and ethyl cellulose 30mg.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"152 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Synthesis of Copper Nanoparticles from flower extract and their Cell Cytotoxic Potential","authors":"Ajay Kasivishwanathan Chandrasekar, Nishu Sekar, Selvakumar Dharmaraj, Hariprasath Lakshmanan","doi":"10.52711/0974-360x.2024.00119","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00119","url":null,"abstract":"In order to overcome the negative potential risks of conventional nanoparticles and achieve the goal of human therapeutic uses, sustainable nanoparticles must be synthesized. In this paper, we have created a simple method for producing copper nanoparticles using green chemistry. With the use of Cassia auriculata's floral aqueous extract, copper nanoparticles (CuNPs) were effectively produced. In a UV-Visible Spectrophotometer, sythesized CuNPs detect absorbance at 276 nm, a hallmark of copper nanoparticles. The relevant functional groups involved in lowering and stabilizing CuNPs were found using Fourier Transform Infrared Spectroscopy. CuNPs shape, crystalline phase, and elemental composition were seen using scanning and transmission electron microscopy, energy dispersive analysis spectroscopy, and other techniques. Moreover, CuNPs' antibacterial and antifungal properties produced good inhibitory action against the pathogens that were put to the test. Furthermore, at low doses, CuNPs had no effect on the cytotoxicity of the cell lines MDCK and Caco-2. CuNPs may thus be turned into nano-drugs for the treatment of infectious diseases and tumour research.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"132 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention, Control and Treatment of Tobacco use Addiction: A Literature Review Article","authors":"Rami A. Elshatarat, Raghad Abdelkader, Hanadi A. Alahmadi, Majed S Al-Za'areer, Nora H. Elneblawi, Mudathir Mohamedahmed Eltayeb, Doaa El Sayed Fadila, Amaal Samir Abdelmaksoud, Howaida Amin Elsaba, Mohammed Mubarak Alhejaili, Rami Sameer Aloufi, Inas A. Ebeid","doi":"10.52711/0974-360x.2024.00144","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00144","url":null,"abstract":"This comprehensive literature review delves into the multifaceted realm of preventing, controlling, and treating tobacco use addiction. Synthesizing a vast array of scholarly works, the study navigates through the complexities of tobacco dependence, shedding light on diverse strategies employed globally. Pharmacological interventions, such as nicotine replacement therapy and emerging medications, are scrutinized alongside non-pharmacological approaches, including health education programs, psychological counseling, and cognitive-behavioral therapy. The review underlines the imperative to comprehend the neurobiology of tobacco addiction, emphasizing its pivotal role in crafting targeted and individualized treatments. By amalgamating evidence-based practices, the study contributes to the advancement of knowledge in the ongoing quest for efficacious prevention and treatment strategies for tobacco use addiction. The review study investigates the role of health institutions and government agencies in collaborating to control tobacco use, highlighting the variation in smoking cessation policies across countries and the legal counteraction of the tobacco industry's aggressive marketing. In detailing the treatment landscape, the review explores both pharmacological and non-pharmacological interventions. Pharmacologically, nicotine replacement therapy, prescription medications, and novel drugs like Varenicline are expounded upon. Non-pharmacological approaches encompass health education programs, psychological counseling, cognitive-behavioral therapy, and psychosocial support, underscoring the importance of counseling as a non-pharmacological intervention. The study concludes by discussing the ongoing trials for nicotine vaccines and cannabinoid CB1 receptor antagonists as promising avenues for future pharmacotherapeutic interventions. Overall, this literature review consolidates diverse insights to provide a holistic understanding of tobacco use addiction and its comprehensive management.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"208 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Review of Nanosponge Based Formulation System from The perspective of Brain Targeted Drug Delivery","authors":"Sourav Das, Sukanta Roy, Sangeeta Choudhury, A. Bose, Sudip Khila, Dibya Das, Parag Ghosh, Sanjay Kumar Dhaker, Subhasish Mondal","doi":"10.52711/0974-360x.2024.00147","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00147","url":null,"abstract":"Brain tumor causes of millions of life every year due to poor treatment options. The blood-brain barrier prevents most of the treatment molecules to reach the tumor region. Tight junctions within adjacent brain endothelial cell lines including other components make the brain highly impermeable to all the unwanted and foreign materials. The antineoplastic drug molecules which has a molecular weight of less than 400 daltons and have less than 8 hydrogen bonds are only able to access the brain without any hindrance. Hence, most of the small and large anti-cancer drug molecules hardly can cross the barrier. To overcome these problems formulation scientists have adopted various strategies and techniques so that the intended drug molecule can reach the target region of the brain tumor. Among them nanosponges drug delivery is highly appreciated as emerging brain tumor targeted drug delivery. Nanosponges are tiny sponge in the size of nano range with a vesicle filled with various types of drugs. These kinds of the formulation can circulate throughout the blood and reach the target region where drugs are released in a controlled manner. This review article highlights the unique features of blood-brain barrier and novel strategies based on drug formulation to access the core of the brain tumor by overcoming the resistance rendered by blood brain barrier. In addition, it also demonstrates how nanosponges is emerging as one of the best options to prevail over various challenges associated with penetration of the blood-brain barrier.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"71 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Evaluation of Anticancer Activity of Karanthai Legium (Kl) – A Siddha Medicine for Cervical Carcinoma against Hela Cell Line By MTT Assay","authors":"Carolin P, M. A, Meena Kumari R","doi":"10.52711/0974-360x.2024.00125","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00125","url":null,"abstract":"Cervical cancer become a major global burden and of course considered one of the leading causes of cancer-related deaths in women, particularly in developing countries. Viral induction of human papilloma viruses (HPV) can disturb the basic cellular mechanism of growth control. Currently medicinal plants have become the source of drug discovery in research for treating cancer. Siddha medicine is an ancient medical system of India which classifies diseases into 4448 types. In Siddha literature, Cancer is mentioned as Vippuruthinoipadalam (Carcinoma like illness), Kiranthi noi, Mega Katti, Pilavai and Putru noi (tumour). Literary evidences have a classic collection of herbal, mineral, herbo- mineral medicines for Cancer. Many anti-cancerous drugs are now in practice in Siddha medicine. Among them, Karanthai Legium (KL) a classical herbo mineral drug having anticancer potential is mentioned in Siddha Literature. The main objective of this study is to evaluate anti- cancer activity against HeLa cell using MTT assay. Present study revealed that, Karanthailegium (KL) at high as 200µg/ml showed high cytotoxicity activity as high as 72.44% against HeLa cell lines. IC50 of the tested KL against HeLa cells was calculated as104.90µg/ml. It was concluded from the result of the present study that the formulation KL possesses promising anti-cancer activity.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140445714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats","authors":"Shankar S. Khandare, Rajesh B. Jadhav, Kavita A. Pimpre, Anirudha V. Munde, Shivkanya S Chandrawanshi, Mahavir H Ghante","doi":"10.52711/0974-360x.2024.00109","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00109","url":null,"abstract":"Pithecellobium dulce (PD), commonly known as Jangli-jilebi, is a Manila tamarind belonging to the family Leguminosae. P. dulce (PD) is used to treat various diseases like diarrhea, asthma, leprosy, paralysis, inflammatory, anti-bacterial, spermicidal, anti-convulsant, etc. In this paper, we studied the activity of P. Dulce for depression, which is a debilitating, life-threatening, and common disease affecting different sections of the community. Chemical and synthetic medications used to treat this disease have significant negative side effects, and only 50–60% of patients fully recover. At the same time, the available scientific information about this species is scarce, and there are no reports related to its possible effects on the central nervous system. In this work, the effects of acetone and methanolic extracts of the stem bark of P. dulce (PD) were evaluated in mice and rats utilizing behavioral assays sensitive to clinically effective anti-depressant compounds. In both the forced swim test and the tail suspension test, the extracts (100 and 200 mg/kg) administered orally were able to shorten the immobility duration of mice and rats in a dose-dependent manner. According to the current study's findings, PD extract may have antidepressant potential and be useful in treating those who suffer from depressive disorders. These findings proved that PD has specifically anti-depressive in vivo effects.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"232 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140445996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making a Case for Hypnosis: Using the RE-AIM Framework to Recognize Hypnosis as a Stand-Alone Therapeutic Intervention within Healthcare and Educational Systems","authors":"Sheila Menon, V. Bhagat","doi":"10.52711/0974-360x.2024.00148","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00148","url":null,"abstract":"Hypnosis is emerging as a valuable therapeutic tool with significant potential for recognition and application across medical settings. Of particular note are the evidenced benefits when addressing pervasive challenges such as chronic pain, anxiety, and emotional distress, which are often exacerbated by medical procedures. However, despite its potential for wide utilization in medical contexts, recognition of hypnotherapy's efficacy remains slow and hypnosis is often a second choice, last resort or offered as an adjuvant or supporting role alongside other treatments. One reason is that hypnosis lacks a well-defined role within the healthcare system. This gap persists even as mounting evidence suggests that hypnosis offers the capacity to bring about relief and positive outcomes across diverse issues and populations. Author Sheila Menon, Principal and Administrator of a clinical hypnosis Training and Clinical Facility draws upon extensive experience in clinical intervention and administration to extract scientific values from empirically driven experiences and data. In this paper the RE-AIM Framework is utilised to explore the multifaceted potential of hypnosis in medical settings, shedding light on the need for a more clearly defined integration of this intervention into mainstream healthcare practices. The authors draw from the evidence to make a case that the time is right to recognise hypnosis as a stand-alone psychotherapy and that this will enhance its adoption, reach and efficacy. It is further suggested that rebranding or relabeling this intervention will remove unnecessary biases and make it easier to implement and maintain for the benefit of patients and to improve treatment outcomes. Purpose: the purpose of this study is to use the RE-AIM Framework to evaluate the existing research that consistently provides evidence for better inclusion of hypnosis and to identify new insights into how this useful treatment can be more easily adopted and utilized in the healthcare system based on its interventional strength. Methodology: This is a descriptive study based on secondary data collected from literature following a descriptive analysis. The RE-AIM Framework is used as a mechanism for evaluating hypnosis interventions and to establish a rationale for relabeling them as psychotherapy based on treatment outcomes, interventional strengths and its operative usage in the healthcare system The literature search extracts information from the electronic database to make the study more robust and the literature selected is drawn from those published in the past two decades using keywords such as hypnosis intervention, RE-AIM, hypnosis in health care, mental health, and hypnosis interventions in a medical setup. Conclusion: This study uses the RE-AIM to present a case for relabeling or rebranding hypnosis as a psychotherapy in its own right to enhance its adoption and reach within a wide range of healthcare settings. The research supports the intervent","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"105 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in Herbal Drug Delivery Systems: Enhancing Therapeutic Efficacy and patient compliance","authors":"Balram Balram, Navneet Kaur, Kamal Kamal, Gurvirender Singh, Deepika Aggarwal","doi":"10.52711/0974-360x.2024.00145","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00145","url":null,"abstract":"Herbal medicines have been widely used throughout history, and due to their decreased possibility of adverse effects when compared to modern drugs, both medical professionals and patients have recognized their superior therapeutic efficacy. A systematic strategy for delivering the elements over time is necessary for phytotherapeutics in order to maximizeadherence of patients and prevent repetitive administration. This might be accomplished by creating novel drug delivery systems (NDDSs) for herbal components. Through lowering toxicity and raising bioavailability, NDDSs contribute to increasing therapeutic efficacy by reducing the need for successive administrations to address non-compliance. Nanosized herbal medication delivery techniques may one day enhance performance and address problems with plant-based medicines. To fight other chronic illnesses, such as diabetes, cancer, and others, the conventional medical system must deploy nanocarriers as an NDDS. The article covers the numerous nano herbal drugs and nano herbal cosmetics currently available on the market, as well as the characteristics, benefits, and drawbacks of nano drug delivery systems.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"263 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Characterization, Solubility test, and Dissolution test of the Solid Dispersion System of the Andrographolide-chitosan system for effective treatment against colon cancer","authors":"A. Archana, Rohitas Deshmukh","doi":"10.52711/0974-360x.2024.00139","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00139","url":null,"abstract":"This work aimed to examine how varying concentrations of chitosan affect the physiochemical characteristics, and investigate the solubility and dissolving properties of the solid dispersion system including chitosan and andrographolide. A solid-state dispersion system including andrographolide and chitosan was synthesized using various drug-to-polymer ratios. The obtained data were examined for their morphology, physiological state, medication content, test for solubility, and rate of dissolution. The morphology of the system consists of a solid dispersion of andrographolide and chitosan was found to be spherical based on SEM analysis. The solid dispersion systems had infrared spectra with an absorption profile that closely approximated that of the active ingredient. The differences between DTA and XRD analysis indicated a decrease in both the point of melting and the strength of the crystal. The research found a 1.75-fold rise in the soluble state of the system consisting of solid dispersion of andrographolide and chitosan compared to the solubility of the andrographolide component. Furthermore, the chitosan-andrographolide solid dispersion system exhibited a dissolution rate that was 1.6 times higher compared to that of the pure andrographolide molecule. Increasing the amount of chitosan in the system consisting of a solid dispersion of chitosan-andrographolide resulted in a decrease in the degree of crystallinity as well as the andrographolide melting point. This has a beneficial impact on improving the solubility and dissolving rate of andrographolide. The optimized formulation shows a dose-dependent toxicity against HT29 cell lines.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"256 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the effects of Lemongrass (Cymbopogon nardus) extract on Sperm Quality and Testosterone Level in Mice Induced with Staphylococcus aureus","authors":"Lilis Maghfuroh, Putri AyuIka Setiyowati, Rofiatun Solekha, Alif’iyah Mar’ Atus Sholikhah, Angella Ananda Saputra, Eka Febrianti Wulandari","doi":"10.52711/0974-360x.2024.00136","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00136","url":null,"abstract":"There are a variety of causes for male infertility. Among them is microbial infection. Lemongrass (C. nardus) contains natural antioxidants and flavonoids that have the ability to preserve the male reproductive system. This study examined the effects of different C. nardus extract dosages on mouse sperm quality. The male Balb/C mice were separated into five groups of equal size. The negative control group was injected with 0.01ml of Na-CMC 0.5% over the course of 28 days, the positive control group was injected with 0.2ml of Staphylococcus aureus (S. aureus) on days 10, 17, and 24, and the treatment groups were injected with 0.2ml of S. aureus on days 10, 17, and 24, followed by 0.01ml of C. nardus. After the experiment, mice were slaughtered, and sperm suspension was obtained from the cauda epididymal to measure morphology, concentration, and motility. The testis was fixed in a fixative solution to analyze the spermatogenic cells, and intracardiac blood was drawn to determine the level of testosterone. Significant differences (p 0.05) were seen in the morphology, concentration, and motility of spermatozoa when C. nardus extract was administered. Given the low and middle concentrations of C. nardus extract, it can repair sperm damage caused by S. aureus infection.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"96 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}