Biogenic Synthesis of Copper Nanoparticles from flower extract and their Cell Cytotoxic Potential

Q3 Pharmacology, Toxicology and Pharmaceutics
Ajay Kasivishwanathan Chandrasekar, Nishu Sekar, Selvakumar Dharmaraj, Hariprasath Lakshmanan
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引用次数: 0

Abstract

In order to overcome the negative potential risks of conventional nanoparticles and achieve the goal of human therapeutic uses, sustainable nanoparticles must be synthesized. In this paper, we have created a simple method for producing copper nanoparticles using green chemistry. With the use of Cassia auriculata's floral aqueous extract, copper nanoparticles (CuNPs) were effectively produced. In a UV-Visible Spectrophotometer, sythesized CuNPs detect absorbance at 276 nm, a hallmark of copper nanoparticles. The relevant functional groups involved in lowering and stabilizing CuNPs were found using Fourier Transform Infrared Spectroscopy. CuNPs shape, crystalline phase, and elemental composition were seen using scanning and transmission electron microscopy, energy dispersive analysis spectroscopy, and other techniques. Moreover, CuNPs' antibacterial and antifungal properties produced good inhibitory action against the pathogens that were put to the test. Furthermore, at low doses, CuNPs had no effect on the cytotoxicity of the cell lines MDCK and Caco-2. CuNPs may thus be turned into nano-drugs for the treatment of infectious diseases and tumour research.
花提取物纳米铜粒子的生物合成及其细胞毒性潜力
为了克服传统纳米粒子的负面潜在风险,实现人类治疗用途的目标,必须合成可持续的纳米粒子。在本文中,我们创建了一种利用绿色化学生产纳米铜粒子的简单方法。利用决明子的花水提取物,有效地生产出了纳米铜粒子(CuNPs)。在紫外可见分光光度计中,制备的 CuNPs 在 276 纳米波长处检测到吸光度,这是铜纳米粒子的特征。利用傅立叶变换红外光谱法找到了降低和稳定 CuNPs 的相关官能团。利用扫描和透射电子显微镜、能量色散分析光谱等技术观察了 CuNPs 的形状、晶相和元素组成。此外,CuNPs 的抗菌和抗真菌特性对试验中的病原体产生了良好的抑制作用。此外,低剂量的 CuNPs 对 MDCK 和 Caco-2 细胞系的细胞毒性没有影响。因此,CuNPs 可转化为纳米药物,用于治疗传染病和肿瘤研究。
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来源期刊
Research Journal of Pharmacy and Technology
Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.
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