Records of Pharmaceutical and Biomedical Sciences最新文献_第8页

Phytochemical constituents and biological activities of Jasonia montana (Asteraceae) 茉莉属植物化学成分及生物活性研究

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2021-01-01 DOI: 10.21608/RPBS.2020.41471.1075

Eman El-Bsoumy, Eman S. Habib, A. Ibrahim, Safwat Ahmed

引用次数: 0

Phytochemistry and Pharmacological Effects of Plants in Genus Sonchus (Asteraceae) 菊属植物的植物化学和药理作用

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2020-03-01 DOI: 10.21608/rpbs.2019.18952.1046

Heba Saber Mohammed

{"title":"Phytochemistry and Pharmacological Effects of Plants in Genus Sonchus (Asteraceae)","authors":"Heba Saber Mohammed","doi":"10.21608/rpbs.2019.18952.1046","DOIUrl":"https://doi.org/10.21608/rpbs.2019.18952.1046","url":null,"abstract":"ABSTRACT Medicinal plants have been used since ancient times for treatment of various diseases. Many of the drugs available on the market today originated either directly or indirectly from bioactive compounds isolated from plants. Family Asteraceae is one of the largest families of flowering plants, comprising 1600 genera and almost 30000 species worldwide (Bisht et al., 2010). The genus Sonchus is a genus of flowering plants in the dandelion tribe of the Asteraceae Family. It consists mostly of annual herbs, but a few are perennial or woody herbs. Annual herbs, known as sow thistles, were used as food stock for animals, particularly for rabbits. They are also edible to humans as a leafy vegetable. In Chinese folk medicine, sow thistles have been used for the treatment of fever, inflammation, for detoxication and improvement of blood circulation. Recent advances in the ethnomedicinal, phytochemical, and pharmacological studies of this genus are reviewed in this paper (Muhammed et .,al 2012 ). Results showed that secondary metabolites isolated and identified from genus Sonchus were mainly terpenes, sterols, flavonoids, and coumarins. In vivo and in vitro pharmacological studies have shown that plants belonging to this genus exhibit various biological activities, including antioxidant, anti-inflammatory, antibacterial, antidepressant, anxiolytic, and anti-tumor activities (Jain et al., 2014). Further attention should be given to the study of species belonging to genus Sonchus especially regarding toxicological effects. Further research on Sonchus plants should be conducted using bioactivity-guided isolation strategies to isolate and identify the bioactive metabolites in this genus.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"337 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141228269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of sepsis in adult Patients in Intensive care units in Ismailia Main Hospitals 伊斯梅利亚主要医院重症监护室成年患者败血症发病率

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2020-03-01 DOI: 10.21608/rpbs.2019.16511.1037

Mohammed Yehya Farag, Ali A. Abdelrahman, Emad Eldin Ahmed Ibrahim, E. Toraih, Marwa Azab

引用次数: 0

Recent Updates in Treatment of Diabetic Neuropathy 糖尿病性神经病变治疗的最新进展

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/RPBS.2019.12385.1033

Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed

{"title":"Recent Updates in Treatment of Diabetic Neuropathy","authors":"Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed","doi":"10.21608/RPBS.2019.12385.1033","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12385.1033","url":null,"abstract":"Diabetic neuropathy (DN) is a common complication of diabetes mellitus and is associated with structural changes in the nerves. Nerve damage happen as a result of many factors including metabolic disorders, oxidative and nitrosative stress, changes in the blood vessels that supply the peripheral nerves and changes in ion channel expression in peripheral fibres. However, the molecular basis for DN is poorly understood. Adenosine monophosphate activated protein kinase (AMPK) has been shown to regulate the activity of some kinases including protein kinase B (AKT), mitogen-activated protein kinases (MAPK) and mammalian target of rapamycin complex 1 (mTORC1) that represent important signalling pathways modulating the function of peripheral nociceptive neurons. Donepezil can activate AMPK and exerts neuroprotective effects. Diabetic mice showed reduced expression of p-AMPK in sciatic nerves with consequent activation of AKT/MAPK/4EBP1. In addition, a significant upregulation of the N-Methyl-D-aspartate (NMDA) receptors in spinal cord of diabetic mice was observed. Therefore, Donepezil could be a potential pharmacological agent for management of DN.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78764450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis And Pollution Assessment of Some Trace Heavy Metals in Freshwater, Drinking Water, Fish, and Sediments Samples in Suez Canal Region, Egypt by Flame Atomic Absorption Spectrometer 埃及苏伊士运河地区淡水、饮用水、鱼类和沉积物样品中痕量重金属的火焰原子吸收光谱分析及污染评价

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/rpbs.2019.17031.1039

R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad

{"title":"Analysis And Pollution Assessment of Some Trace Heavy Metals in Freshwater, Drinking Water, Fish, and Sediments Samples in Suez Canal Region, Egypt by Flame Atomic Absorption Spectrometer","authors":"R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad","doi":"10.21608/rpbs.2019.17031.1039","DOIUrl":"https://doi.org/10.21608/rpbs.2019.17031.1039","url":null,"abstract":"Monitoring of pollution levels of heavy metals in freshwater is significant to human health and environmental management. The objective of the current study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates like heavy metals residues. The concentrations of some heavy metals (As, Cd, Cr, Pb, Hg, Ni, Cu, Mn) were determined in freshwater, treated water, in muscle of fish species (Tilapia nilotica) and sediment. The results of the study revealed that , all heavy metals concentrations in freshwater and treated water were within the permissible limits except, Lead concentration in treated water was higher than the permissible limits. In Port Said, all metals concentrations in both freshwater and treated water samples were within the permissible limits. Fish samples collected from the three governorates showed an increase in Cd and Pb levels. The heavy metals concentrations in sediment samples were remarkably high.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"45 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73039383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dеsign and Synthеsis of somе Azolеs Incorporating Sulphadiazinе Dеrivativеs as Protеin Tyrosinе Phosphatasе-1B inhibitors 含磺胺吡啶类磷酸酯- 1b抑制剂的磺胺吡啶类磷酸酯的研制与合成

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/rpbs.2019.17049.1040

Nagat Ghareb, M. Elgawish

引用次数: 0

Assessment of Physicochemical parameters of Freshwater and Tap Water in Suez Canal Region, Egypt 埃及苏伊士运河地区淡水和自来水理化参数评价

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/rpbs.2019.17028.1038

R. Moustafa

引用次数: 0

OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION 肥胖和3型糖尿病:营养途径和治疗意义

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-06-08 DOI: 10.21608/RPBS.2019.10144.1023

A. T. Sakr

{"title":"OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION","authors":"A. T. Sakr","doi":"10.21608/RPBS.2019.10144.1023","DOIUrl":"https://doi.org/10.21608/RPBS.2019.10144.1023","url":null,"abstract":"Over nutrition induced diseases such as obesity and type 2 diabetes involve neural deregulation of metabolic physiology. Many findings describe the roles of over nutrition-associated hypothalamic inflammation in neurodegeneration and impaired adult neurogenesis as well as defective neural stem cell regeneration and their significance in obesity and related disease. Metabolic disorders include oxidative stress, insulin resistance, obesity and inflammation. Collectively, metabolic syndrome perturbs brain function and increases the incidence of neurodegenerative diseases, reflecting the possible involvement of obesity induced metabolic syndrome in development of Alzheimer's disease (AD) which is the most common form of dementia. Its key symptoms include progressive decline in the memory, impairment in speech, language, spatial orientation and dysfunction in the sensor motor system . Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually start slowly and worsens over time. It is the cause of 60-70% of cases of dementia . Several mechanisms have been described to understand pathology of AD including damaging groups of cholinergic neurons with down regulation of cholinergic markers accumulation of amyloid beta peptide (Aβ) forming extracellular senile plaques, aggregation of hyperphosphorylated tau to form intracellular neurofibrillary tangles and oxidative stress .","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84394009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract 埃及枸杞甲醇提取物的植物化学、抗氧化和抗炎筛选

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.12251.1032

Hala H Zaatout, D. Ghareeb, Alshimaa Abd-Elgwad, A. Ismael

引用次数: 5

Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease 题目:2型糖尿病与阿尔茨海默病的生化联系

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.12031.1031

S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez

{"title":"Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease","authors":"S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez","doi":"10.21608/RPBS.2019.12031.1031","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12031.1031","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a common disease in the elderly, affecting around 20% of geriatrics. In cross-sectional studies, T2DM had various adverse health effects, including cognitive impairment. The association of T2DM with decreased cognitive function suggests that T2DM can contribute to Alzheimer's disease (AD) The relationship between T2DM and AD continues to grow rapidly. It has been suggested that AD can be considered \"type 3 diabetes”. Along with the processing of amyloid precursor protein (APP) and tau phosphorylation, the molecular links between T2DM and AD provide clues for new therapeutic targets such as glucagon-like peptide-1 (GLP-1), butyrylcholinesterase and receptor for advanced glycosylation end products (AGE). A possible mechanism correlating T2DM and AD is the alteration in insulin signaling in the brain. Insulin signaling is involved in several neuronal functions, and plays a vital role in the pathophysiology of AD. Therefore, the modification of neuronal insulin signaling by diabetic conditions may contribute to AD progression. Another possible mechanism is cerebrovascular changes, a common pathological change observed in both diseases. The importance of amyloid beta peptide (Aβ) induced cerebrovascular dysfunction in AD has been reported, indicating that pathological interactions between AGE receptor and Aβ have a role in this disorder.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91239308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0