Records of Pharmaceutical and Biomedical Sciences最新文献_第9页

Gender dependent gut microbiome in obese Egyptian individuals 肥胖的埃及人肠道微生物组的性别依赖性

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.10975.1024

Mohammed Salah Ali

引用次数: 3

Review article on Chemical constituents and Biological activity of Thymelaea hirsuta 百里菊的化学成分及生物活性研究综述

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.11644.1029

A. Badawy

{"title":"Review article on Chemical constituents and Biological activity of Thymelaea hirsuta","authors":"A. Badawy","doi":"10.21608/RPBS.2019.11644.1029","DOIUrl":"https://doi.org/10.21608/RPBS.2019.11644.1029","url":null,"abstract":"Drug discovery and development has a long history and dates back to the early days of human civilization. In those ancient times, drugs were not just used as physical remedies but were also associated with religious and spiritual healing. Thymelaeaceae family have been the subject of numerous phytochemical studies. Initially, interest may have been due to the marked toxicity of these plants, but the widespread use of some species medicinally was certainly a reason for this interest. Thymelaea hirsuta is a perennial, evergreen and dioecious shrub, which is native to North Africa. Thymelaea hirsuta is a widespread invasive weed, is commonly known as “Methnane” and has been used traditionally as having antiseptic, antimelanogenesis, antioxidant and diabetic. There are numerous phytochemical studies lead to its richness in a variety of different classes of natural products, especially, coumarins, lignans, steroids and flavones. In addition, it used as a new fiber source for handmade paper. Therefore, in this review, we have mainly summarized the recent chemical constituent's isolated and biological activity identified from Thymelaea hirsuta. We hope that this review will provide further information for understanding the expected isolated compounds and its possible potent activity.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83385400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An ecofriendly green liquid chromatographic method for simultaneous determination of Amoxicillin, Metronidazole and Ciprofloxacin; application to dosage form and human urine 绿色液相色谱法同时测定阿莫西林、甲硝唑和环丙沙星的含量适用于剂型和人尿

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/rpbs.2019.66749

S. Farahat, R. A. Salam, Ghada M. Hadad, A. El-Gindy, Tamer H. Hassan

{"title":"An ecofriendly green liquid chromatographic method for simultaneous determination of Amoxicillin, Metronidazole and Ciprofloxacin; application to dosage form and human urine","authors":"S. Farahat, R. A. Salam, Ghada M. Hadad, A. El-Gindy, Tamer H. Hassan","doi":"10.21608/rpbs.2019.66749","DOIUrl":"https://doi.org/10.21608/rpbs.2019.66749","url":null,"abstract":"Green liquid chromatographic method using cyano column and ethanol and 0.5% acetic acid in water (pH 2.8) as mobile phase in gradient mode has been developed for analysis of Amoxicillin, Metronidazole and Ciprofloxacin in human urine. Quantification was carried out using a diode-array UV detector. The detection wavelength was 255 nm. The retention times and detection limits for each antibiotic were 4.9 min and 0.5 μg/mL for Amoxicillin, 6.035 min and 0.14 μg/mL for Metronidazole, 8.03 min and 3.07 μg/mL for Ciprofloxacin, respectively. The developed method was applied to examine the urinary excretion pattern of Amoxicillin, Metronidazole and Ciprofloxacin in healthy male volunteer after an oral administration of Metronidazole and Ciprofloxacin in their combination tablets (Ciprodiazole) and combination tablets of Ciprofloxacin and Amoxicillin (Helicocin). The developed HPLC method was successfully used for the analysis of the selected drugs in their dosage forms and human urine without interference from the excipients or urine matrix. The proposed method was rapid, specific, precise, accurate, environmentally friendly and suitable for bioequivalence and pharmacokinetic studies.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75833366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigating Pirfenidone and Vitamin D for Targeting Cardiac and Renal Fibrotic Pathways in Experimentally-Induced Animal Model 吡非尼酮和维生素D在实验性动物模型中靶向心脏和肾脏纤维化通路的研究

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/rpbs.2019.5575.1015

S. Antar, M. El-Azab, Reem M Hazem, M. Saleh

引用次数: 2

Identification methods of Candida isolated from vaginal infections 阴道感染念珠菌分离鉴定方法

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.9792.1021

aya ahmed mousa, A. Abdel-Rahman, M. Azab

引用次数: 0

Shotgun Metagenomic analysis of cutaneous microbiome in patients with atopic dermatitis 特应性皮炎患者皮肤微生物群的散弹枪宏基因组分析

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.7002.1020

M. Ramadan, S. Solyman, M. Yones, Hamada Halaby, Yaser Abdalla, Amr Hanora

{"title":"Shotgun Metagenomic analysis of cutaneous microbiome in patients with atopic dermatitis","authors":"M. Ramadan, S. Solyman, M. Yones, Hamada Halaby, Yaser Abdalla, Amr Hanora","doi":"10.21608/RPBS.2019.7002.1020","DOIUrl":"https://doi.org/10.21608/RPBS.2019.7002.1020","url":null,"abstract":"Atopic dermatitis (AD) is a chronic complex inflammatory skin disorder. AD characterized by multiple contributing factors, such as impairment in skin barrier integrity, participation of either innate or adaptive immunity arms, in addition to the pivotal roles of cutaneous microbiome. The analysis of cutaneous microbiota was performed using shotgun metagenomic sequencing on an Illumina HiSeq platform in parallel with 16s rRNA genes using MiSeq sequencing. Two samples for each sequencing technique were collected from one child and one adult subjects with AD. Metagenomic data from 16srRNA was in accordance with those from shotgun sequencing. Taxonomic profile of samples at genus level showed overrepresentation of Streptococcus in child and Staphylococcus in adults. Species level analysis of reads revealed monoclonality of Staphylococcus aureus community in comparison to heterogeneity of Staphylococcus epidermidis. 16S rRNA gene based analysis was unable to provide comprehensive description of bacterial communities, while shotgun metagenomic analyses described the composition of microbiota with high resolution at different taxonomic levels especially subspecies and single nucleotide variants levels. Finally, further studies using shotgun metagenomic approaches will be required for characterization of microbiome in healthy and diseased subjects.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75713649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmaceutical Counterfeit drugs: (The growing threat) 制药业假药:(日益严重的威胁)

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.6684.1019

R. A. Salam, Ghada M. Hadad, D. Abo-El-Matty, Mohamed Abdel Shakour

引用次数: 3

Insight in some herbals and herbal combinations used by Saudi females for improving fertility and enhance pregnancy 洞察一些草药和草药组合使用的沙特妇女提高生育能力和提高怀孕

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.11635.1028

Hala H Zaatout

{"title":"Insight in some herbals and herbal combinations used by Saudi females for improving fertility and enhance pregnancy","authors":"Hala H Zaatout","doi":"10.21608/RPBS.2019.11635.1028","DOIUrl":"https://doi.org/10.21608/RPBS.2019.11635.1028","url":null,"abstract":"Delayed pregnancy is one of the main problems that may threaten the relationship between married people especially in Arab region. Finding a cure for this problem started after a period of time after the marriage without pregnancy. In some cases, herbs from tradition can be used in order to promote fertility and stimulate pregnancy. There are limited data for herbal remedies used by women in KSA that is concerned with pregnancy. This study was aimed at determining the prevalence rate and kind of herbal remedies used among female culture. First, a pre-structured questionnaire was administered among 430 Saudi females which revealed that 25% of them have used traditional herbals as a tool for enhancing the fertility. Then asking apothecary and dealers in that field, collecting samples and data were recorded. Finally, investigating the data collected in attempts to evaluate the efficacy and safety of such herbs and herbal mixtures. Rose of Jericho, Juniper, Myrrh, Black cumin and garden cress were the most commonly used remedies recorded from respondents. This study focuses on possible warning and precaution. Recommendations were suggested to control any hazards.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79594341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Growth and Alkaloids Accumulation in Hyoscyamus muticus L. Callus Cultures by High Salt Concentration 高盐浓度对水仙愈伤组织生长和生物碱积累的促进作用

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.9807.1022

E. Abdelrazik, M. El-hamahmy, Enas E Eltamany, Islam hassan Abuelsoud, E. Ali, Akram Abu-seidah

{"title":"Enhancement of Growth and Alkaloids Accumulation in Hyoscyamus muticus L. Callus Cultures by High Salt Concentration","authors":"E. Abdelrazik, M. El-hamahmy, Enas E Eltamany, Islam hassan Abuelsoud, E. Ali, Akram Abu-seidah","doi":"10.21608/RPBS.2019.9807.1022","DOIUrl":"https://doi.org/10.21608/RPBS.2019.9807.1022","url":null,"abstract":"The effect of different concentrations of NaCl (6, 8 and 10 dS/m) on growth and alkaloids production in 21 days-old callus of Egyptian henbane (Hyoscyamu muticus L.) was studied. Results showed that 10 dS/m of NaCl increased fresh and dry weight by 4.1 and 2.8 fold more than control, respectively. Two fold Total alkaloids increased by 2 fold at 10 dS/m compared to control or wild leaves. In contrary, wild leaves had the highest amount of hyosyamine (2.8 mg/g DW) followed by 6 dS/m stressed-callus (1.14 mg/g DW) as detected by HPTLC. Peroxidase and superoxide dismutase activity were increased by 2.6 and 2.3 fold, respectively in highly salt stressed callus than control while catalase activity (CAT) was decreased. Anthocyanin concentration was increased 3 fold in 10 dS/m of NaCl stressed callus compared to control. Glutathione content was increased by 33.8% under low level of NaCl more than control. Reduction of photosynthetic pigments under all NaCl levels led to decrease the total carbohydrate and protein content. Protein band with molecular weight 109 KDa was a unique band in 10dS/m of NaCl treated callus with high expression of protein bands with MW 44, 38 and 32. Histologically, callus cells under high level of NaCl had amoeboid shape and start in senescence with formation of lysiogenous intercellular spaces.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80180919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Levels of chemerin and asymmetric dimethylarginine (ADMA) in obese type 2 diabetic patients. 肥胖2型糖尿病患者的趋化素和不对称二甲基精氨酸(ADMA)水平

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/RPBS.2019.5244.1012

A. Youssef, E. Mehanna, D. Abo-Elmatty

引用次数: 0