Records of Pharmaceutical and Biomedical Sciences最新文献_第10页

Insights into Novel Drug Targets in Mycobacterium tuberculosis: Where Do We Stand and Where Do We Go from Here? 对结核分枝杆菌新药物靶点的洞察:我们的立场是什么，我们将从这里走向何方?

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-30 DOI: 10.21608/RPBS.2018.3874.1004

Safaa M Kishk, M. Helal, M. Gomaa, I. Salama, S. Moustafa, C. Simons

{"title":"Insights into Novel Drug Targets in Mycobacterium tuberculosis: Where Do We Stand and Where Do We Go from Here?","authors":"Safaa M Kishk, M. Helal, M. Gomaa, I. Salama, S. Moustafa, C. Simons","doi":"10.21608/RPBS.2018.3874.1004","DOIUrl":"https://doi.org/10.21608/RPBS.2018.3874.1004","url":null,"abstract":"Tuberculosis (TB) is the ninth leading cause of death worldwide and the leading cause from a single infectious agent, ranking above HIV/AIDS with 6.3 million new cases of TB reported in 2016. TB is an air-borne disease associated with the aerobic bacterium Mycobacterium tuberculosis (Mtb), which mainly infects the lungs. Aerosolization of diseased pulmonary secretions, by coughing, sneezing and speaking, discharge the Mtb bacilli into the atmosphere. Infected aerosol droplet nuclei sized 1-10 μm are largely trapped in the upper nasal passages or are expelled into the pharynx by the mucociliary mechanism of the lower respiratory tract and are harmlessly swallowed and digested. Infected persons may overcome the initial TB infection, resulting in the development of asymptomatic latent TB. About 10% of individuals may develop the active disease after infection; where the bacteria undergo more rapid growth and overcome the host immune system. In cases of multi-drug resistant (MDR) strains, and extreme drug-resistant (XDR) strains, treatment fails, and the bacteria propagate and attack the host, leading to death from systemic infection. Due to the increased spread of TB worldwide, both the academic and industrial communities have initiated intensive research to develop new therapeutics targeting new enzymes such as cytochrome P450s in Mtb.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87633343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of leucine supplementation on the skeletal muscles of streptozotocin (STZ)diabetic rats 补充亮氨酸对链脲佐菌素(STZ)糖尿病大鼠骨骼肌的影响

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-30 DOI: 10.21608/RPBS.2018.3642.1001

Naglaa K gawada

引用次数: 0

Phytochemical and Biological Investigation of Narcissus pseudonarcissus Cultivated in Egypt 埃及栽培水仙的植物化学和生物学研究

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-30 DOI: 10.21608/RPBS.2018.3769.1002

E. Shawky, H. Hammoda, Amina Abou Donia, S. Toaima, Erii Kinoshita, H. Takayama

{"title":"Phytochemical and Biological Investigation of Narcissus pseudonarcissus Cultivated in Egypt","authors":"E. Shawky, H. Hammoda, Amina Abou Donia, S. Toaima, Erii Kinoshita, H. Takayama","doi":"10.21608/RPBS.2018.3769.1002","DOIUrl":"https://doi.org/10.21608/RPBS.2018.3769.1002","url":null,"abstract":"A phytochemical investigation of the alkaloidal content of the bulbs of Narcissus pseudonarcissus cultivated in Egypt resulted in the isolation of the alkaloid; 9-O-demethyl-7-O-methyllycorenine (5) in addition to the eight known alkaloids; homolycorine (1), 7-O-methyloduline (2), 7-O-methyllycorenine (3), hippeastrine (4), 9-O-demethylhomolycorine (6), galanthamine (7), haemanthamine (8) and lycorine. Structural determination of the isolated alkaloids was established by different spectral analyses (UV, MS, NMR and 2D-NMR). The isolation of 9-O-demethyl-7-O-methyllycorenine (5) is reported here for the first time from family Amaryllidaceae. The chemotaxonomic significance of the isolated alkaloids was also studied; six of the isolated alkaloids belong to the homolycorine series which is a distinctive feature for the section Pseudonarcissi. The alkaloids of the homolycorine series are absent from some tribes of the Amaryllidaceae, such as the Amaryllideae or Hemantheae. Moreover, all the Narcissus alkaloids of the homolycorine series display a B/C ring junction with a cis stereochemistry Furthermore, the antimicrobial activity of some isolated alkaloids has been studied. It is noteworthy that this is the first phytochemical and biological investigation to be carried out on the Amaryllidaceae plant N. pseudonarcissus grown in Egypt.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89240807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Spectrophotometric method for determination of Glucosamine Sulphate in dosage forms by derivatization using Quality by Design approach 用设计质量法衍生化分光光度法测定剂型中硫酸氨基葡萄糖的含量

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-30 DOI: 10.21608/RPBS.2018.4273.1006

Rasha M. Ahmed, Ghada M. Hadad, A. El-Gendy, A. Ashour

{"title":"Spectrophotometric method for determination of Glucosamine Sulphate in dosage forms by derivatization using Quality by Design approach","authors":"Rasha M. Ahmed, Ghada M. Hadad, A. El-Gendy, A. Ashour","doi":"10.21608/RPBS.2018.4273.1006","DOIUrl":"https://doi.org/10.21608/RPBS.2018.4273.1006","url":null,"abstract":"A Quality by Design approach was used to develop a sensitive spectrophotometric method for determination of glucosamine Sulphate in pharmaceutical dosage forms and optimize a derivatization reaction of glucosamine with o-phthalaldhyde. This strategy was focused on derivatization process understanding and analytical method development and validation. Both of them were evaluated by applying risk assessment and Design Space tools. The scouting step was carried out by analyzing different derivatizing agents, type of buffers, pH of buffers, and time of reaction. Five critical process parameters (CPPs) were selected related to, pH of borate buffer, volume of 2-mercaptoethanol (ME), volume of o-phthalaldhyde (OPA), and the time of reaction. The effect of different levels of CPPs on critical quality attributes (CQAs) (the absorbance of derivative) was evaluated in the screening design using fractional factorial design. Using response surface methodology and contour plots the optimum values of the selected factors were determined and the design space of the method was defined. Finally, control strategy was designed and the method was validated and applied to a real sample of glucosamine dosage forms using the optimum derivatization conditions of the reaction; pH of borate buffer 10.5, concentration of buffer 0.05M, Time of reaction 10.7 minutes, volume of ME 100μL, and volume of OPA 5.1mL at room temperature. The results of the present study clearly shown that the developed method was sensitive relative to the other published spectrophotometric and HPLC methods with identification of the most significant factors affecting the derivatization reaction.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81499147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Exogenous Anabolic Androgenic Steroids on Testosterone Epitestosterone Ratio and its Application on Athlete Biological Passport in Egypt 外源性合成代谢雄激素类固醇对睾酮表睾酮比率的影响及其在埃及运动员生物护照上的应用

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/RPBS.2018.5337.1013

hanim ameer, D. Abo-Elmatty, R. Alemany, N. Mesbah

{"title":"Effect of Exogenous Anabolic Androgenic Steroids on Testosterone Epitestosterone Ratio and its Application on Athlete Biological Passport in Egypt","authors":"hanim ameer, D. Abo-Elmatty, R. Alemany, N. Mesbah","doi":"10.21608/RPBS.2018.5337.1013","DOIUrl":"https://doi.org/10.21608/RPBS.2018.5337.1013","url":null,"abstract":"The use of Anabolic Androgenic Steroid agents is evident within the competitive sport in senior and junior age groups, where they are taken by non-elite as well as elite participants. They are also taken in non-sporting contexts by individuals seeking to ‘improve’ their physique through an increase in muscle and/or decrease in fat mass. No accurate data is available for the prevalence of anabolic steroid misuse among athletes, studies suggest the illicit use of doping agents by athletes and non-athletes may be 1–5% in the population and greater than 50% in some groups; with the prevalence being higher in males. Many studies documented side effects and health hazards with the misusing of anabolic steroids, where these were accused as a cause of deaths among athletes. Intake of exogenous anabolic steroids disturbed the T/E ratio causing its evaluation above the normal level. This review will outline the anabolic steroids, its side effects and health impacts in both the sporting and physique development contexts. It also provides a brief review of the history of AAS as doping agents and athlete biological passport.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"50 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91476781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HPLC determination of Metronidazole in pure form, pharmaceutical dosage form and spiked urine. 高效液相色谱法测定甲硝唑纯品、制剂剂型及加药后尿液的含量。

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/RPBS.2018.6184.1017

K. Afify, Randa A. Abdel-Salam, Ghada M. Hadad

引用次数: 1

A Brief review of Circulating MicroRNAs and Essential Hypertension 循环microrna与原发性高血压的研究综述

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/RPBS.2018.5986.1016

Heba K. Badawy, Noha Mesbah, D. Abo-Elmatty

{"title":"A Brief review of Circulating MicroRNAs and Essential Hypertension","authors":"Heba K. Badawy, Noha Mesbah, D. Abo-Elmatty","doi":"10.21608/RPBS.2018.5986.1016","DOIUrl":"https://doi.org/10.21608/RPBS.2018.5986.1016","url":null,"abstract":"Essential hypertension is a chronic medical condition affecting thousands of people worldwide. It is polygenic and multi-factorial disease resulting from the interaction between genetic and environmental factors. Essential hypertension is implicated in cerebrovascular, cardiovascular and renal diseases. MicroRNAs are considered endogenous, non-coding regulators of gene expression by targeting specific mRNAs for degradation and/ or translational repression. MicroRNAs participate in a variety of developmental processes as metabolism, cell proliferation, and apoptosis. Many studies have reported the possibility of using miRNAs as new biological markers for polygenic diseases as cancer, stem cell aging, coronary heart disease, and essential hypertension. The stability of these miRNAs as miRNA let-7e, miRNA 296-5p, miRNA 605, and miRNA 623 in biological fluids makes them amenable to detection and quantification. This review summarizes the mechanisms by which miRNAs can control normal cellular processes and gene expression and the association of some circulating miRNAs with the incidence of different diseases, particularly essential hypertension.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90891951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent Analytical Approaches in Quality Control of Cannabis sativa L. and Its Preparations 大麻及其制剂质量控制的最新分析方法

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/RPBS.2018.5518.1014

E. Ibrahim, Ghada M. Hadad, R. A. Salam, A. Ibrahim, Safwat Ahmed, M. Radwan, W. Gul, M. Elsohly

{"title":"Recent Analytical Approaches in Quality Control of Cannabis sativa L. and Its Preparations","authors":"E. Ibrahim, Ghada M. Hadad, R. A. Salam, A. Ibrahim, Safwat Ahmed, M. Radwan, W. Gul, M. Elsohly","doi":"10.21608/RPBS.2018.5518.1014","DOIUrl":"https://doi.org/10.21608/RPBS.2018.5518.1014","url":null,"abstract":"Cannabis sativa L. is annually herbal plant belonging to the family Cannabaceae gaining more and more attention all over the world, due to its long historical clinical practice and its recent legalization either for recreational or medicinal uses. The quality control of the plant is a critical for its legalization and globalization. This review deals with the recent analytical methods (years 2015-2018) in the quality control of Cannabis, including the traditional chromatographic methods like HPLC, LC/MS/MS, UPLC, GC/FID, and GC/MS; and spectrophotometric, including FT-IR, NIR and NMR techniques as well as the most recent advanced techniques. The comprehensive methods, such as fingerprint and multi-component quantification are emphasized; hyphenated techniques, like HPLC, LC/MS/MS, GC/FID, GC-MS, LC-NMR, chemometric methods. In few words, the analysis and quality control of cannabis biomass, extracts and/or preparations is moving towards an integrative and comprehensive direction, in order to better address the inherent holistic nature of cannabis.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85079183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives 含布美他胺衍生物的新型腙和1,3,4-恶二唑的合成及抗菌评价

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/RPBS.2018.23373

I. Salem, S. Mostafa, Osama I. El-Sabbag, T. Ibrahim, Ahmed Abdulrahmanf, M. M. Bendary

{"title":"Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives","authors":"I. Salem, S. Mostafa, Osama I. El-Sabbag, T. Ibrahim, Ahmed Abdulrahmanf, M. M. Bendary","doi":"10.21608/RPBS.2018.23373","DOIUrl":"https://doi.org/10.21608/RPBS.2018.23373","url":null,"abstract":"The aim of this study is to synthesize new benzenesulfonamide derivatives that possess antibacterial activity using Bumetanide as a precursor of benzenesulfonamide. A novel series of hydrazones containing benzenesulfonamides (4a-i) and 1,3,4 oxadiazole containing benzenesulfonamides (5a-e) were prepared and their antibacterial and antifungal activities were measured using microplate broth assay against Gram-positive: Staphylococcus aureus, Gram-negative: Escherichia coli and Pseudomonas aeruginosa and Fungi: Aspergillus fumigates and Candida albicans. The results showed that some of the prepared compounds exhibit a good to excellent activity against the mentioned bacteria, however all the series showed no activity against fungi. Among the series, Compound (4i) demoed an excellent antibacterial activity better than that of the standard reference (Sulfamethoxazole) against Escherichia coli, while compounds (4c, 4e, 4g) showed good activity against all tested bacterial strains equals to Sulfamethoxazole activity. Moreover, compounds (4g, 5d) exert an antimicrobial activity equals to that of Sulfamethoxazole against Pseudomonas aeruginosa, while compounds (4a, 4b, 4c, 4f, 4g, 4h) exhibit similar activity to Sulfamethoxazole against Escherichia coli.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79662529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Review article on nanoemulsions and nanostructured lipid carriers 纳米乳剂和纳米结构脂质载体的研究进展

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2018-09-01 DOI: 10.21608/rpbs.2018.5223.1011

Samar H. Faheim, A. Gardouh, A. Nouh, M. Ghorab

引用次数: 2