Records of Pharmaceutical and Biomedical Sciences最新文献_第7页

Recent Updates in Treatment of Diabetic Neuropathy 糖尿病性神经病变治疗的最新进展

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/RPBS.2019.12385.1033

Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed

{"title":"Recent Updates in Treatment of Diabetic Neuropathy","authors":"Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed","doi":"10.21608/RPBS.2019.12385.1033","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12385.1033","url":null,"abstract":"Diabetic neuropathy (DN) is a common complication of diabetes mellitus and is associated with structural changes in the nerves. Nerve damage happen as a result of many factors including metabolic disorders, oxidative and nitrosative stress, changes in the blood vessels that supply the peripheral nerves and changes in ion channel expression in peripheral fibres. However, the molecular basis for DN is poorly understood. Adenosine monophosphate activated protein kinase (AMPK) has been shown to regulate the activity of some kinases including protein kinase B (AKT), mitogen-activated protein kinases (MAPK) and mammalian target of rapamycin complex 1 (mTORC1) that represent important signalling pathways modulating the function of peripheral nociceptive neurons. Donepezil can activate AMPK and exerts neuroprotective effects. Diabetic mice showed reduced expression of p-AMPK in sciatic nerves with consequent activation of AKT/MAPK/4EBP1. In addition, a significant upregulation of the N-Methyl-D-aspartate (NMDA) receptors in spinal cord of diabetic mice was observed. Therefore, Donepezil could be a potential pharmacological agent for management of DN.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78764450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis And Pollution Assessment of Some Trace Heavy Metals in Freshwater, Drinking Water, Fish, and Sediments Samples in Suez Canal Region, Egypt by Flame Atomic Absorption Spectrometer 埃及苏伊士运河地区淡水、饮用水、鱼类和沉积物样品中痕量重金属的火焰原子吸收光谱分析及污染评价

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/rpbs.2019.17031.1039

R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad

{"title":"Analysis And Pollution Assessment of Some Trace Heavy Metals in Freshwater, Drinking Water, Fish, and Sediments Samples in Suez Canal Region, Egypt by Flame Atomic Absorption Spectrometer","authors":"R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad","doi":"10.21608/rpbs.2019.17031.1039","DOIUrl":"https://doi.org/10.21608/rpbs.2019.17031.1039","url":null,"abstract":"Monitoring of pollution levels of heavy metals in freshwater is significant to human health and environmental management. The objective of the current study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates like heavy metals residues. The concentrations of some heavy metals (As, Cd, Cr, Pb, Hg, Ni, Cu, Mn) were determined in freshwater, treated water, in muscle of fish species (Tilapia nilotica) and sediment. The results of the study revealed that , all heavy metals concentrations in freshwater and treated water were within the permissible limits except, Lead concentration in treated water was higher than the permissible limits. In Port Said, all metals concentrations in both freshwater and treated water samples were within the permissible limits. Fish samples collected from the three governorates showed an increase in Cd and Pb levels. The heavy metals concentrations in sediment samples were remarkably high.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"45 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73039383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Assessment of Physicochemical parameters of Freshwater and Tap Water in Suez Canal Region, Egypt 埃及苏伊士运河地区淡水和自来水理化参数评价

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-09-01 DOI: 10.21608/rpbs.2019.17028.1038

R. Moustafa

引用次数: 0

OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION 肥胖和3型糖尿病:营养途径和治疗意义

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-06-08 DOI: 10.21608/RPBS.2019.10144.1023

A. T. Sakr

{"title":"OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION","authors":"A. T. Sakr","doi":"10.21608/RPBS.2019.10144.1023","DOIUrl":"https://doi.org/10.21608/RPBS.2019.10144.1023","url":null,"abstract":"Over nutrition induced diseases such as obesity and type 2 diabetes involve neural deregulation of metabolic physiology. Many findings describe the roles of over nutrition-associated hypothalamic inflammation in neurodegeneration and impaired adult neurogenesis as well as defective neural stem cell regeneration and their significance in obesity and related disease. Metabolic disorders include oxidative stress, insulin resistance, obesity and inflammation. Collectively, metabolic syndrome perturbs brain function and increases the incidence of neurodegenerative diseases, reflecting the possible involvement of obesity induced metabolic syndrome in development of Alzheimer's disease (AD) which is the most common form of dementia. Its key symptoms include progressive decline in the memory, impairment in speech, language, spatial orientation and dysfunction in the sensor motor system . Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually start slowly and worsens over time. It is the cause of 60-70% of cases of dementia . Several mechanisms have been described to understand pathology of AD including damaging groups of cholinergic neurons with down regulation of cholinergic markers accumulation of amyloid beta peptide (Aβ) forming extracellular senile plaques, aggregation of hyperphosphorylated tau to form intracellular neurofibrillary tangles and oxidative stress .","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84394009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract 埃及枸杞甲醇提取物的植物化学、抗氧化和抗炎筛选

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.12251.1032

Hala H Zaatout, D. Ghareeb, Alshimaa Abd-Elgwad, A. Ismael

引用次数: 5

Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease 题目:2型糖尿病与阿尔茨海默病的生化联系

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.12031.1031

S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez

{"title":"Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease","authors":"S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez","doi":"10.21608/RPBS.2019.12031.1031","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12031.1031","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a common disease in the elderly, affecting around 20% of geriatrics. In cross-sectional studies, T2DM had various adverse health effects, including cognitive impairment. The association of T2DM with decreased cognitive function suggests that T2DM can contribute to Alzheimer's disease (AD) The relationship between T2DM and AD continues to grow rapidly. It has been suggested that AD can be considered \"type 3 diabetes”. Along with the processing of amyloid precursor protein (APP) and tau phosphorylation, the molecular links between T2DM and AD provide clues for new therapeutic targets such as glucagon-like peptide-1 (GLP-1), butyrylcholinesterase and receptor for advanced glycosylation end products (AGE). A possible mechanism correlating T2DM and AD is the alteration in insulin signaling in the brain. Insulin signaling is involved in several neuronal functions, and plays a vital role in the pathophysiology of AD. Therefore, the modification of neuronal insulin signaling by diabetic conditions may contribute to AD progression. Another possible mechanism is cerebrovascular changes, a common pathological change observed in both diseases. The importance of amyloid beta peptide (Aβ) induced cerebrovascular dysfunction in AD has been reported, indicating that pathological interactions between AGE receptor and Aβ have a role in this disorder.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91239308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender dependent gut microbiome in obese Egyptian individuals 肥胖的埃及人肠道微生物组的性别依赖性

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.10975.1024

Mohammed Salah Ali

引用次数: 3

Review article on Chemical constituents and Biological activity of Thymelaea hirsuta 百里菊的化学成分及生物活性研究综述

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI: 10.21608/RPBS.2019.11644.1029

A. Badawy

{"title":"Review article on Chemical constituents and Biological activity of Thymelaea hirsuta","authors":"A. Badawy","doi":"10.21608/RPBS.2019.11644.1029","DOIUrl":"https://doi.org/10.21608/RPBS.2019.11644.1029","url":null,"abstract":"Drug discovery and development has a long history and dates back to the early days of human civilization. In those ancient times, drugs were not just used as physical remedies but were also associated with religious and spiritual healing. Thymelaeaceae family have been the subject of numerous phytochemical studies. Initially, interest may have been due to the marked toxicity of these plants, but the widespread use of some species medicinally was certainly a reason for this interest. Thymelaea hirsuta is a perennial, evergreen and dioecious shrub, which is native to North Africa. Thymelaea hirsuta is a widespread invasive weed, is commonly known as “Methnane” and has been used traditionally as having antiseptic, antimelanogenesis, antioxidant and diabetic. There are numerous phytochemical studies lead to its richness in a variety of different classes of natural products, especially, coumarins, lignans, steroids and flavones. In addition, it used as a new fiber source for handmade paper. Therefore, in this review, we have mainly summarized the recent chemical constituent's isolated and biological activity identified from Thymelaea hirsuta. We hope that this review will provide further information for understanding the expected isolated compounds and its possible potent activity.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83385400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An ecofriendly green liquid chromatographic method for simultaneous determination of Amoxicillin, Metronidazole and Ciprofloxacin; application to dosage form and human urine 绿色液相色谱法同时测定阿莫西林、甲硝唑和环丙沙星的含量适用于剂型和人尿

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/rpbs.2019.66749

S. Farahat, R. A. Salam, Ghada M. Hadad, A. El-Gindy, Tamer H. Hassan

{"title":"An ecofriendly green liquid chromatographic method for simultaneous determination of Amoxicillin, Metronidazole and Ciprofloxacin; application to dosage form and human urine","authors":"S. Farahat, R. A. Salam, Ghada M. Hadad, A. El-Gindy, Tamer H. Hassan","doi":"10.21608/rpbs.2019.66749","DOIUrl":"https://doi.org/10.21608/rpbs.2019.66749","url":null,"abstract":"Green liquid chromatographic method using cyano column and ethanol and 0.5% acetic acid in water (pH 2.8) as mobile phase in gradient mode has been developed for analysis of Amoxicillin, Metronidazole and Ciprofloxacin in human urine. Quantification was carried out using a diode-array UV detector. The detection wavelength was 255 nm. The retention times and detection limits for each antibiotic were 4.9 min and 0.5 μg/mL for Amoxicillin, 6.035 min and 0.14 μg/mL for Metronidazole, 8.03 min and 3.07 μg/mL for Ciprofloxacin, respectively. The developed method was applied to examine the urinary excretion pattern of Amoxicillin, Metronidazole and Ciprofloxacin in healthy male volunteer after an oral administration of Metronidazole and Ciprofloxacin in their combination tablets (Ciprodiazole) and combination tablets of Ciprofloxacin and Amoxicillin (Helicocin). The developed HPLC method was successfully used for the analysis of the selected drugs in their dosage forms and human urine without interference from the excipients or urine matrix. The proposed method was rapid, specific, precise, accurate, environmentally friendly and suitable for bioequivalence and pharmacokinetic studies.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75833366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigating Pirfenidone and Vitamin D for Targeting Cardiac and Renal Fibrotic Pathways in Experimentally-Induced Animal Model 吡非尼酮和维生素D在实验性动物模型中靶向心脏和肾脏纤维化通路的研究

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-03-01 DOI: 10.21608/rpbs.2019.5575.1015

S. Antar, M. El-Azab, Reem M Hazem, M. Saleh

引用次数: 2