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Autophagy, SMAD-1, and apoptotic pathways are correlated with L-carnitine protective effect against dexamethasone-induced osteoporosis in Wistar rats Wistar大鼠自噬、SMAD-1和凋亡通路与左旋肉碱对地塞米松所致骨质疏松的保护作用相关
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.150356.1155
Sanaa A. Ahmed, Dalia A. Elbahy
{"title":"Autophagy, SMAD-1, and apoptotic pathways are correlated with L-carnitine protective effect against dexamethasone-induced osteoporosis in Wistar rats","authors":"Sanaa A. Ahmed, Dalia A. Elbahy","doi":"10.21608/rpbs.2022.150356.1155","DOIUrl":"https://doi.org/10.21608/rpbs.2022.150356.1155","url":null,"abstract":"Osteoporosis (O.P) is a metabolic bone disease characterized by bone mass loss and bone weakness. The cofactor in fatty acid beta-oxidation, L-carnitine (L-C), has been found to regulate osteoblast activity. Therefore, this work aimed to investigate the potential defensive properties of L-C versus dexamethasone (DEXA) induced O.P, as well as the underlying mechanisms. Thirty female Wistar rats were divided randomly into three equal groups (n = 10). The control group: received saline throughout the study; the DEXA-treated group: received DEXA (7 mg/kg/week) I.M. for four successive weeks; the L-C + DEXA treated group: received L-C (100 mg/kg/day, orally) for two weeks followed by L-C+ DEXA for a further four successive weeks simultaneously in the same previous doses and routes. L-C treatment attenuated the decline in femur and body weights, calcium, osteoprotegerin (OPG), and total antioxidant capacity resulting from DEXA administration. In contrast, L-C ameliorated DEXA-induced elevation in alkaline phosphatase and oxidative stress. Furthermore, L-C reduced the expression of an apoptosis-related gene; caspase-3, however, augmented the expression of autophagy-related genes ATG-5 and Smad-1 in rat bone. Histopathological findings further supported the protective effects of LC against DEXA-induced O.P. In conclusion, the current study findings demonstrated the protective effects of L-C on DEXA-induced O.P due to the reduction of oxidative stress, apoptosis, and increasing autophagy and smad-1 protein gene expression. Consequently, L-C can be used as an additive in the treatment of O.P.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90829929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of Alzheimer's disease 阿尔茨海默病的分子机制
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.165136.1176
Salma M Selim, Reem M Hazem, Norhan M. El-Sayed, Hassan M. ElFayoumi
{"title":"Molecular mechanisms of Alzheimer's disease","authors":"Salma M Selim, Reem M Hazem, Norhan M. El-Sayed, Hassan M. ElFayoumi","doi":"10.21608/rpbs.2022.165136.1176","DOIUrl":"https://doi.org/10.21608/rpbs.2022.165136.1176","url":null,"abstract":"Streszczenie: Choroba Alzheimera jest jednym z najbardziej rozpowszechnionych schorzeñ neurodegeneracyjnych na œwiecie. Etiologia tej choroby nie zosta3a jeszcze wyjaœniona. Cech1 charakterystyczn1 tego schorzenia s1 zmiany morfologiczne, obecnoœæ p3ytek starczych (zewn1trzkomórkowe agregaty peptydu amyloidu β – Aβ) oraz splotów neurofibrylarnych (wewn1trzkomórkowe kompleksy hyperfosforylowanego bia3ka Tau), które s1 zlokalizowane w rejonach mózgu odpowiedzialnych za pamiêæ, uczenie siê oraz emocje. Krytyczne zmiany, które s1 istotne dla rozwoju choroby Alzheimera, powodowane s1 przez peptydy amyloidu β. W literaturze opisano szereg potencjalnych mechanizmów neurotoksycznoœci ró¿nych form Aβ. Najwa¿niejsze z nich dotycz1 dysfunkcji mitochondriów, generacji wolnych rodników oraz zaburzeñ integralnoœci b3on biologicznych. Peptydy Aβ powstaj1 w wyniku proteolitycznej obróbki bia3ka APP przez sekretazy: β oraz γ. Proces ten zachodzi przez ca3e ¿ycie cz3owieka. Upoœledzenie mechanizmów zaanga¿owanych w zachowanie stê¿enia Aβ na nietoksycznym poziomie jest g3ówn1 przyczyn1 choroby Alzheimera. Znane s1 genetyczne oraz œrodowiskowe czynniki ryzyka zachorowania na to schorzenie. Œmieræ komórek nerwowych jest prawdopodobnie skorelowana równie¿ z chronicznym stanem zapalnym stymulowanym w mózgu przez stale obecny Aβ. Liczne dowody wskazuj1 jednak na korzystne dzia3anie cytokin prozapalnych w aspekcie tego schorzenia. Rola mediatorów reakcji zapalnej w patogenezie choroby Alzheimera jest bardzo skomplikowana i nie do koñca wyjaœniona. Ostatnio dokonano du¿ego postêpu w zrozumieniu molekularnych mechanizmów le¿1cych u podstaw choroby Alzheimera. Dziêki temu mo¿liwe by3o opracowanie szeregu potencjalnych terapeutyków, które mog1 mieæ zastosowanie w leczeniu przyczynowym tego schorzenia.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80543797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Molecular mechanisms of cisplatin induced nephrotoxicity 顺铂致肾毒性的分子机制
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.145126.1152
Mariam H Fawzy, Dina M. Khodeer, Norhan M. El-Sayed, Noha M. Saeed, Yasser Ahmed
{"title":"Molecular mechanisms of cisplatin induced nephrotoxicity","authors":"Mariam H Fawzy, Dina M. Khodeer, Norhan M. El-Sayed, Noha M. Saeed, Yasser Ahmed","doi":"10.21608/rpbs.2022.145126.1152","DOIUrl":"https://doi.org/10.21608/rpbs.2022.145126.1152","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77853215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mechanisms of Cadmium-Induced Testicular Damage 镉致睾丸损伤的机制
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.121915.1124
Mohamed El gammal, Reem M Hazem, Y. Moustafa
{"title":"Mechanisms of Cadmium-Induced Testicular Damage","authors":"Mohamed El gammal, Reem M Hazem, Y. Moustafa","doi":"10.21608/rpbs.2022.121915.1124","DOIUrl":"https://doi.org/10.21608/rpbs.2022.121915.1124","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76915789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occult Hepatitis C Virus Infection: Is it time to get more attention!? 隐蔽性丙型肝炎病毒感染:是时候得到更多关注了吗?
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.135633.1135
Kholoud A. Elkashef
{"title":"Occult Hepatitis C Virus Infection: Is it time to get more attention!?","authors":"Kholoud A. Elkashef","doi":"10.21608/rpbs.2022.135633.1135","DOIUrl":"https://doi.org/10.21608/rpbs.2022.135633.1135","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84595970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular carcinoma pathogenesis: Epigenetics and relationship with cancer hallmarks 肝细胞癌的发病机制:表观遗传学及其与癌症特征的关系
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.168918.1180
Tohada Al Noshokaty, Noha Mesbah, D. Abo-Elmatty, A. Abulsoud, A. Abdel-Hamed
{"title":"Hepatocellular carcinoma pathogenesis: Epigenetics and relationship with cancer hallmarks","authors":"Tohada Al Noshokaty, Noha Mesbah, D. Abo-Elmatty, A. Abulsoud, A. Abdel-Hamed","doi":"10.21608/rpbs.2022.168918.1180","DOIUrl":"https://doi.org/10.21608/rpbs.2022.168918.1180","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84051548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological Evaluation of Minocycline Microspheres on the Type and Number of Bacteria in the Treatment of Chronic Periodontitis Using Multiplex PCR and Viable Counting: An in-Vivo study 二甲胺四环素微球对慢性牙周炎治疗中细菌类型和数量的微生物学评价:多重PCR和活菌计数的体内研究
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.140001.1140
M. Azab, Marina W. Naguib, H. Shalaby
{"title":"Microbiological Evaluation of Minocycline Microspheres on the Type and Number of Bacteria in the Treatment of Chronic Periodontitis Using Multiplex PCR and Viable Counting: An in-Vivo study","authors":"M. Azab, Marina W. Naguib, H. Shalaby","doi":"10.21608/rpbs.2022.140001.1140","DOIUrl":"https://doi.org/10.21608/rpbs.2022.140001.1140","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77140042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical approaches for the determination of Nebivolol 内比沃洛尔的含量测定方法
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.164715.1174
A. Radwan, M. Salim, Mahmoud M. Elkhoudary, Ghada M. Hadad, F. Belal
{"title":"Analytical approaches for the determination of Nebivolol","authors":"A. Radwan, M. Salim, Mahmoud M. Elkhoudary, Ghada M. Hadad, F. Belal","doi":"10.21608/rpbs.2022.164715.1174","DOIUrl":"https://doi.org/10.21608/rpbs.2022.164715.1174","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82087250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial activity of Rubia tinctorum extracts. 薄荷提取物的抑菌活性研究。
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.141348.1146
Aya El Tanahy
{"title":"Antibacterial activity of Rubia tinctorum extracts.","authors":"Aya El Tanahy","doi":"10.21608/rpbs.2022.141348.1146","DOIUrl":"https://doi.org/10.21608/rpbs.2022.141348.1146","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81151733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An evaluation of the effects of ethosomes in the delivery of transdermal drugs 脂质体在经皮给药中的作用评价
Records of Pharmaceutical and Biomedical Sciences Pub Date : 2022-04-01 DOI: 10.21608/rpbs.2022.141371.1147
S. Gad, Ibrahim N. Mousa, T. Hamadi, Osama Sayed
{"title":"An evaluation of the effects of ethosomes in the delivery of transdermal drugs","authors":"S. Gad, Ibrahim N. Mousa, T. Hamadi, Osama Sayed","doi":"10.21608/rpbs.2022.141371.1147","DOIUrl":"https://doi.org/10.21608/rpbs.2022.141371.1147","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73606126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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